scholarly journals Understanding the function of the tumor microenvironment, and compounds from marine organisms for breast cancer therapy

2021 ◽  
Vol 12 (2) ◽  
pp. 15-37
Author(s):  
Rama Rao Malla ◽  
Batoul Farran ◽  
Ganji Purnachandra Nagaraju
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Marine Organisms ◽  
Breast Cancer Therapy

Heparanase-driven sequential released nanoparticles for ferroptosis and tumor microenvironment modulations synergism in breast cancer therapy

Biomaterials ◽  
2021 ◽  
Vol 266 ◽  
pp. 120429
Author(s):  
Jun Zhang ◽  
Jie Yang ◽  
Tiantian Zuo ◽  
Siyu Ma ◽  
Nadira Xokrat ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Breast Cancer Therapy

Mild-heat-inducible sequentially released liposomal complex remodels the tumor microenvironment and reinforces anti-breast-cancer therapy

2020 ◽  
Vol 8 (14) ◽  
pp. 3916-3925 ◽  
Author(s):  
Yue Qin ◽  
Tingting Liu ◽  
Mengfei Guo ◽  
Yuping Liu ◽  
Congyan Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Drug Release ◽  
Breast Cancer Therapy ◽  
Mild Heat

Heat-responsive drug release helps celastrol & STS-coloaded liposome activate the cascade of TME normalization and enhances the anti-tumor efficacy.

CDK1 in Breast Cancer: Implications for Theranostic Potential

2020 ◽  
Vol 20 (7) ◽  
pp. 758-767 ◽  
Author(s):  
Sepideh Izadi ◽  
Afshin Nikkhoo ◽  
Mohammad Hojjat-Farsangi ◽  
Afshin Namdar ◽  
Gholamreza Azizi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Cancer Progression ◽  
Cell Cycle Progression ◽  
Cancer Therapeutics ◽  
Detection Methods ◽  
Breast Cancer Therapy ◽  
Promising Target ◽  
Anti Cancer

Breast cancer has been identified as one of the main cancer-related deaths among women during some last decades. Recent advances in the introduction of novel potent anti-cancer therapeutics in association with early detection methods led to a decrease in the mortality rate of breast cancer. However, the scenario of breast cancer is yet going on and further improvements in the current anti-cancer therapeutic approaches are needed. Several factors are present in the tumor microenvironment which help to cancer progression and suppression of anti-tumor responses. Targeting these cancer-promoting factors in the tumor microenvironment has been suggested as a potent immunotherapeutic approach for cancer therapy. Among the various tumorsupporting factors, Cyclin-Dependent Kinases (CDKs) are proposed as a novel promising target for cancer therapy. These factors in association with cyclins play a key role in cell cycle progression. Dysregulation of CDKs which leads to increased cell proliferation has been identified in various cancers, such as breast cancer. Accordingly, the development and use of CDK-inhibitors have been associated with encouraging results in the treatment of breast cancer. However, it is unknown that the inhibition of which CDK is the most effective strategy for breast cancer therapy. Since the selective blockage of CDK1 alone or in combination with other therapeutics has been associated with potent anti-cancer outcomes, it is suggested that CDK1 may be considered as the best CDK target for breast cancer therapy. In this review, we will discuss the role of CDK1 in breast cancer progression and treatment.

A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy

2021 ◽  
Author(s):  
Qian Shen ◽  
Lei Xu ◽  
Rong Li ◽  
Guang Wu ◽  
Senlin Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Growth ◽  
Intracellular Delivery ◽  
Ph Responsive ◽  
Breast Cancer Therapy ◽  
Effective Inhibition ◽  
Inhibition Of Tumor Growth

A robust TME pH-responsive nanoplatform was herein developed. This nanoplatform could significantly improve intracellular delivery of cytotoxic saporin to achieve an effective inhibition of tumor growth of breast cancer.

Tumor microenvironment responsive VEGF-antibody functionalized pH sensitive liposomes of Docetaxel for augmented breast cancer therapy

2020 ◽  
pp. 111832
Author(s):  
Sanyog Jain ◽  
Sandip Vikram Deore ◽  
Rohan Ghadi ◽  
Dasharath Chaudhari ◽  
Kaushik Kuche ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Ph Sensitive ◽  
Breast Cancer Therapy ◽  
Augmented Breast

(TA)MUC1 as a potential new target for breast cancer therapy

2020 ◽  
Author(s):  
AS Heimes ◽  
P Fries ◽  
N Stergiou ◽  
R Attariya ◽  
A Hasenburg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Breast Cancer Therapy

Off-label drug use in breast cancer therapy

Oncoreview ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 83-87
Author(s):  
Tomasz Jankowski ◽  
Monika Urbaniak
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Drug Use ◽  
Breast Cancer Therapy ◽  
Off Label
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