A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy

2021 ◽  
Author(s):  
Qian Shen ◽  
Lei Xu ◽  
Rong Li ◽  
Guang Wu ◽  
Senlin Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Growth ◽  
Intracellular Delivery ◽  
Ph Responsive ◽  
Breast Cancer Therapy ◽  
Effective Inhibition ◽  
Inhibition Of Tumor Growth

A robust TME pH-responsive nanoplatform was herein developed. This nanoplatform could significantly improve intracellular delivery of cytotoxic saporin to achieve an effective inhibition of tumor growth of breast cancer.

Heparanase-driven sequential released nanoparticles for ferroptosis and tumor microenvironment modulations synergism in breast cancer therapy

Biomaterials ◽  
2021 ◽  
Vol 266 ◽  
pp. 120429
Author(s):  
Jun Zhang ◽  
Jie Yang ◽  
Tiantian Zuo ◽  
Siyu Ma ◽  
Nadira Xokrat ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Breast Cancer Therapy

scholarly journals A pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy

Drug Delivery ◽  
2021 ◽  
Vol 29 (1) ◽  
pp. 1-9
Author(s):  
Yun-Chang Zhang ◽  
Pei-Yu Zeng ◽  
Zhi-Qiang Ma ◽  
Zi-Yue Xu ◽  
Ze-Kun Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Drug Resistant ◽  
Ph Responsive ◽  
Breast Cancer Therapy ◽  
Organic Framework

Mild-heat-inducible sequentially released liposomal complex remodels the tumor microenvironment and reinforces anti-breast-cancer therapy

2020 ◽  
Vol 8 (14) ◽  
pp. 3916-3925 ◽  
Author(s):  
Yue Qin ◽  
Tingting Liu ◽  
Mengfei Guo ◽  
Yuping Liu ◽  
Congyan Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Drug Release ◽  
Breast Cancer Therapy ◽  
Mild Heat

Heat-responsive drug release helps celastrol & STS-coloaded liposome activate the cascade of TME normalization and enhances the anti-tumor efficacy.

scholarly journals Biological Evaluation of pH-Responsive Polymer-Caged Nanobins for Breast Cancer Therapy

ACS Nano ◽  
2010 ◽  
Vol 4 (9) ◽  
pp. 4971-4978 ◽  
Author(s):  
Sang-Min Lee ◽  
Richard W. Ahn ◽  
Feng Chen ◽  
Angela J. Fought ◽  
Thomas V. O’Halloran ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Biological Evaluation ◽  
Ph Responsive ◽  
Breast Cancer Therapy ◽  
Responsive Polymer

Targeted delivery of quercetin via pH-responsive zinc oxide nanoparticles for breast cancer therapy

2019 ◽  
Vol 100 ◽  
pp. 129-140 ◽  
Author(s):  
Pritam Sadhukhan ◽  
Mousumi Kundu ◽  
Sharmistha Chatterjee ◽  
Noyel Ghosh ◽  
Prasenjit Manna ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Zinc Oxide ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Ph Responsive ◽  
Breast Cancer Therapy

Multifunctional sharp pH-responsive nanoparticles for targeted drug delivery and effective breast cancer therapy

2019 ◽  
Vol 7 (4) ◽  
pp. 576-585 ◽  
Author(s):  
Yandan Yao ◽  
Phei Er Saw ◽  
Yan Nie ◽  
Ping-Pui Wong ◽  
Linjia Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Breast Cancer Therapy ◽  
Anticancer Drug Delivery ◽  
Targeted Drug

A new multifunctional pH-responsive NP platform was developed for targeted anticancer drug delivery and effective breast cancer therapy.

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