Formulation and Evaluation of Mouth Dissolving Tablet of Lornoxicam Using Novel Natural Superdisintegrants.

In the current investigations, mouth dissolving tablets (MDT) were developed by applying quality by design (QbD) approach. Direct compression method was applied for the preparation of MDT containing aspirin using 32 factorial design with quantity of drug, microcrystalline cellulose (MCC) and crosscarmellose sodium (CCS) as dependant variables. MCC and CCS were used as superdisintegrants. Sodium stearyl fumarate was used as lubricant. Developed MDT were evaluated for characteristics like hardness, friability, disintegration time (DT) and in vitro drug release . Design Expert 11.0 described adequately impact of selected variables (MCC and CCS) at various levels for response under study (DT and friability). The optimized batch showed disintegration time of 15-28 secs, friability within 1% and in vitro drug release of 75-98% after 30 mins, respectively. The present study of experimental design revealed that MCC and CCS are fruitful at low concentration to develop the optimized formulation. As per the results obtained from the experiments, it can be concluded that QbD is an effective and efficient approach for the development of quality into MDT with the application of QTPP, risk assessment and critical quality attributes (CQA). Dhaka Univ. J. Pharm. Sci. 20(1): 19-29, 2021 (June)

Download Full-text

Formulation, Evaluation and comparative study of Zolmitriptan Mouth Dissolving Tablet

Asian Journal of Pharmacy and Technology ◽

10.5958/2231-5713.2016.00031.3 ◽

2016 ◽

Vol 6 (4) ◽

pp. 207

Author(s):

V. S. Aher ◽

B. A. Bhairav ◽

R. B. Saudagar

Keyword(s):

Comparative Study ◽

Mouth Dissolving Tablet

Download Full-text

Development and Characterization of Mouth Dissolving Tablet of Zolmitriptan

Asian Pacific Journal of Tropical Disease ◽

10.1016/s2222-1808(12)60203-5 ◽

2012 ◽

Vol 2 ◽

pp. S457-S464 ◽

Cited By ~ 6

Author(s):

Sudarshan Singh ◽

Dhaval Shah

Keyword(s):

Mouth Dissolving Tablet

Download Full-text

OPTIMIZED FAST DISINTEGRATING TABLETS, BOOSTED OSELTAMIVIR PHOSPHATE ORALLY FAST DISINTEGRATING TABLETS

Journal of medical pharmaceutical and allied sciences ◽

10.22270/jmpas.v10i6.1479 ◽

2021 ◽

Vol 10 (6) ◽

pp. 3781-3788

Author(s):

Peeush Singhal

Keyword(s):

Direct Compression ◽

Compression Method ◽

Release Formulation ◽

Oral Tablet ◽

Talcum Powder ◽

Buccal Drug Delivery ◽

Oseltamivir Phosphate ◽

Evaluation Parameters ◽

Fast Disintegrating Tablets ◽

Mouth Dissolving Tablet

Background Around 33% of the populace (fundamentally pediatric and geriatric) has gulping hardships, bringing about helpless consistence with oral tablet drug treatment which prompts decreased in general treatment viability. For this explanation, tablets that can quickly break down or deteriorate in the oral cavity have drawn in a lot of consideration. Objective research was designed to develop and evaluate boosted orally fast disintegrating tablets (OFDT) for oro-buccal drug delivery of oseltamivir phosphate. Methods In the present study six formulations of mouth dissolving tablet of oseltamivir were prepared by direct compression method using SSG as a super disintegrating agent with lactose, talcum, mannitol, SLS and starch. The prepared tablets were then subjected to various evaluation parameters. Results every one of the outcomes was observed to be inside satisfactory reaches. The formulation F6 manufacturing utilizing SSG 50mg and SLS 10mg showed the higher medication content (98%), while the formulation F2 showed the least medication content (92%). It was seen that with the increment in SSG concentration, the medication content was additionally increased. SEM concentrate on showed request of expanding unpleasantness of tablet surface is F1<F2<F3<F4<F5<F6. The expanding unpleasantness may be answerable for higher % of medication release. Formulation F1 showed the most elevated medication discharge (97.735%), while the formulation F5 showed the least medication discharge (56.24%). Finally, it was inferred that SSG, SLS, D-mannitol, starch, lactose, and talcum powder can be effectively utilized in the formulation of Oseltamivir phosphate mouth dissolving tablets. Conclusion: From the above work it was presumed that the formulation of the Oseltamivir Phosphate was observed to be more achievable than the regular one.

Download Full-text

REVIEW ON FAST DISSOLVING TABLET BY SOLID DISPERSION APPROACH

Journal of medical pharmaceutical and allied sciences ◽

10.22270/jmpas.v10i3.1071 ◽

2021 ◽

pp. 2840-2845

Author(s):

V. Namitha

Keyword(s):

Solid Dispersion ◽

Dosage Form ◽

Solid Dispersions ◽

Water Soluble ◽

Water Soluble Drugs ◽

Poorly Water Soluble ◽

And Performance ◽

High Level ◽

Determining Factor ◽

Mouth Dissolving Tablet

Tablet is found to be the most popular dosage form among all existing dosage form. However, in certain occurrences as a result of the huge size of dosage forms, and in the uncooperative, pediatric and dysphasia patients, it might make a few problems, to avoid this issues, another type of dosage form is created, which is known as fast dissolving tablet or mouth dissolving tablet. These are the high level dosage form which breaks down within seconds when placed on the toungue. Mouth dissolving tablets have become impressive consideration as a better option in contrast to others because of better convenience to patients. This review discusses the method of preparation, properties, mechanisms; capsules to be incorporated inside the mouth dissolving pill and evaluation of the drugs are emphasized. The solid dispersion is one of the established solubilization techniques for poorly water-soluble drugs. It is basically the interaction between drug and polymer, and hence it is found to be the determining factor in its design and performance. This review additionally summarizes our knowledge on solid dispersions both in the solid as well as liquid state.

Download Full-text

FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF AMLODIPINE BESYLATE

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2019v11i4.31288 ◽

2019 ◽

pp. 132-139

Author(s):

MEGHAWATI R. BADWAR ◽

SANDHYA L. BORSE ◽

MANISH S. JUNAGADE ◽

ANIL G. JADHAV

Keyword(s):

Drug Release ◽

Research Work ◽

Disintegration Time ◽

In Vitro Drug Release ◽

Sodium Starch Glycolate ◽

Treatment Of Hypertension ◽

Croscarmellose Sodium ◽

Artery Disease ◽

Mouth Dissolving Tablet

Objective: The main objective of this research work was to formulate and evaluate the mouth dissolving tablet of amlodipine besylate for the treatment of hypertension and coronary artery disease. Methods: In this study, mouth dissolving tablet were prepared by direct compression method by using croscarmellose sodium and sodium starch glycolate as superdisintegrants. The designed tablets were subjected to various assessment parameters like friability test, hardness test, disintegration test, wetting time, in vitro drug release and drug content. Results: All the prepared formulations were subjected to various assessment parameters, and the findings obtain within the prescribed limit. The calibration curve of pure drug using various solvents like phosphate buffer pH 6.8, methanol was plotted. F1-F9 containing croscarmellose sodium and sodium starch glycolate in various concentration demonstrate the minimum disintegration time. Among all these formulations F9 shows disintegration time up to 22±1.12 seconds due to the high concentration of superdisintegrants. In vitro drug release was tested in phosphate buffer pH 6.8 at a time interval of 0, 1, 2, 3, 4, 5 min. The F9 shows drug release 100.22±1.08%. Accelerated stability study of optimized formulation (F9) up to 2 mo showed there was no change in disintegration time and percentage drug release. Conclusion: The results obtained in the research work clearly showed a promising potential of mouth dissolving tablets containing a specific ratio of croscarmellose sodium and sodium starch glycolate as superdisintegrants for the effective treatment of hypertension and coronary artery disease.

Download Full-text