scholarly journals Comparisons of tramadol with pethidine for prevention of post anaesthetic shivering in elective abdominal surgery

2012 ◽  
Vol 10 (3) ◽  
pp. 220-223
Author(s):  
SN Singh ◽  
BP Sah ◽  
A Ghimire ◽  
JN Prasad ◽  
DD Baral
Keyword(s):  
Clinical Trial ◽  
Adverse Effects ◽  
Abdominal Surgery ◽  
Respiratory Depression ◽  
Respiratory System ◽  
Nausea And Vomiting ◽  
Unknown Etiology ◽  
Double Blind ◽  
Elective Abdominal Surgery ◽  
Arterial O2 Saturation

Background: Postoperative shivering is a common event of unknown etiology. Objectives: To compare the efficiency of tramadol with that of pethidine in controlling post anaesthetic shivering. Methods: This double . blind randomized clinical trial was performed on 120 consecutive patients who received general anaesthesia for elective abdominal surgery. Intravenous tramadol (1mg.kg-1) or pethidine (0.5mg.kg-1) was administered to alternate subjects who developed post anaestheic shivering. They were monitored in the recovery room for 1 hour and the cessation time of shivering, recurrence of the events, duration of recovery, respiratory depression, arterial O2 saturation, nausea and vomiting were recorded. Results: Forty-eight patients (40%) had post anaesthetic shivering. In the tramadol group, shivering terminated within 5 minutes after injection. They had no recurrence of shivering, respiratory depression, reduction in SPO2, nausea and vomiting during the period of recovery. In the pethidine group, shivering terminated within 8 minutes after injection, but in 7 patients it recurred after 30 minutes. Similarly, 6 patients had respiratory depression, reduction in SPO2 and 10 patients had nausea, vomiting but none of them needed further medication. Conclusion: Tramadol is superior to pethidine as it induces a faster termination of post anaesthetic shivering and does not entail adverse effects on the respiratory system. DOI: http://dx.doi.org/10.3126/hren.v10i3.7139 Health Renaissance; September-December 2012; Vol 10 (No.3);220-223

Pirenzepine in Non-Ulcer Dyspepsia: A Double-Blind Multicentre Trial

1990 ◽  
Vol 18 (1) ◽  
pp. 16-20 ◽  
Author(s):  
P.M. Smith ◽  
A.H. Troughton ◽  
F. Gleeson ◽  
J. Walters ◽  
C.F. McCarthy
Keyword(s):  
Abdominal Pain ◽  
Placebo Group ◽  
Adverse Effects ◽  
Multicentre Study ◽  
Multicentre Trial ◽  
Nausea And Vomiting ◽  
Double Blind ◽  
Non Ulcer Dyspepsia ◽  
Upper Abdominal ◽  
To Receive

In a double-blind multicentre study to compare pirenzepine with placebo in non-ulcer dyspepsia, 71 patients were randomized to receive 50 mg pirenzepine or placebo given orally twice daily for 4 weeks. The trial was not completed by five patients in the pirenzepine group and six in the placebo group. There were no significant differences between the groups in respect to changes in total symptoms (upper abdominal pain, nausea and vomiting, early satiety and postprandial bloating, eructation and pyrosis) scores and outcome, although 27/35 (77%) patients receiving pirenzepine were cured or improved compared with 22/36 (61%) receiving the placebo. Adverse effects were reported by 13 (37%) patients treated with pirenzepine and by six (17%) treated with placebo, seven withdrawing due to adverse effects.

Randomized clinical trial of patient-controlled versus fixed regimen feeding after elective abdominal surgery

2001 ◽  
Vol 88 (12) ◽  
pp. 1578-1582 ◽  
Author(s):  
I. J. M. Han-Geurts ◽  
J. Jeekel ◽  
H. W. Tilanus ◽  
K. J. Brouwer
Keyword(s):  
Clinical Trial ◽  
Abdominal Surgery ◽  
Randomized Clinical Trial ◽  
Elective Abdominal Surgery

scholarly journals Historical, Botanical and Medicinal Perspectives on Ginger (Zingiber officinale)

2021 ◽  
pp. 44-67
Author(s):  
Adetutu Adewale ◽  
Adegbola Peter Ifeoluwa ◽  
Owoade Abiodun Olusoji ◽  
Aborisade Abiodun Bukunmi ◽  
Oyekunle Olubunmi Simeon
Keyword(s):  
Clinical Trial ◽  
Adverse Effects ◽  
Randomized Clinical Trial ◽  
Zingiber Officinale ◽  
Nausea And Vomiting ◽  
Anti Inflammatory ◽  
The Many ◽  
Toxic Potential

Ginger is one of the most valuable culinary medicinal spice with inestimable economic uses. Because it is, a well acknowledged plant both in folkloric and advanced medicine, there are no paucity of information on the many important uses of ginger in the literature. In this review, we conveyed important details on the chemistry, pharmacology, toxicity and clinical uses of ginger. Our review of over 171 articles showed that ginger use has a worldwide coverage. Randomized clinical trial studies on ginger are most prominent on the alleviation of pregnancy-induced nausea and vomiting with fascinating outcome. In addition, the prospective use as anti-inflammatory, thrombolytic, and anti-diabetic agent were well noticed. Although the dependent on plant as source of drug in the search for disease remedy is premised on their acclaimed effectiveness and safety, available data have showed plants may possess some toxic potential, overall, our review showed that ginger might be safe with no adverse effects when investigated in normal rodent and human.

Sign in / Sign up

Export Citation Format

Share Document