scholarly journals A Comparative Study of Diagnostic Performance of CT and MRI for Abdominal Staging of Paediatric Renal Tumours-A Report from Tertiary Care Centre Hospital

2021 ◽  
pp. 1-6
Author(s):  
Debarpita Datta ◽  
◽  
Debashis Dakshit ◽  
Nupur Basu ◽  
Ruchi Bansal ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Diagnostic Performance ◽  
Tertiary Care ◽  
Tertiary Care Centre ◽  
Tumour Thrombus ◽  
Node Metastasis ◽  
Renal Tumours ◽  
Centre Hospital ◽  
Ct And Mri

Objective: To compare the diagnostic performance of CT and MRI for local staging of pediatric renal tumours. Materials and Methods: The study population was derived from our hospital Medical College Kolkata and Hospital. Baseline abdominal imaging performed with both CT and MRI.A retrospective review was done with 50 renal tumour cases selected and planned for nephrectomy over a study period of one year from October 2020 to November 2021. Each case was evaluated for capsular penetration, lymph node metastasis, tumour thrombus, preoperative tumour rupture, and synchronous contralateral lesions. The surgical and pathological findings were the reference gold standard. Results: The sensitivity of CT and MRI for detecting capsular penetration was 70% and 60%, respectively (P=0.73), while specificity was 84.3% and 84% (P=1.0). The sensitivity of CT and MRI for detecting lymph node metastasis was 80% and 53% (P=0.22), and specificity was 88% and 92% (P=1.0). Synchronous contralateral lesions were identified by CT in 5/12 cases and by MRI in 8/12 cases. Conclusion: CT and MRI have similar diagnostic performance for detection of lymph node metastasis and capsular penetration. MRI was more accurate in detecting contralateral synchronous lesions; how-ever these were observed in a very a smaller number of cases. Hence either modality can be used for initial loco–regional staging of paediatric renal tumours

scholarly journals Pitfalls in pre-operative prediction of lymph node metastasis in early endometrial cancer

2020 ◽  
Author(s):  
Pampapati Veena ◽  
Rajalakshmi Ilango ◽  
Jayalakshmi Durairaj
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tertiary Care ◽  
Myometrial Invasion ◽  
Tumor Grade ◽  
Nodal Metastasis ◽  
Lymph Nodal Metastasis ◽  
Node Metastasis ◽  
Lymphovascular Space Invasion

AbstractObjectiveThe role of lymphadenectomy in early stage endometrial cancer is controversial as it is associated with intra-operative complications and its therapeutic benefit is not established. Prediction of lymph nodal metastasis so as to perform selective lymph node dissection is desirable. This study was conducted to study grade of the tumor obtained by endometrial biopsy specimen and depth of myometrial invasion assessed by imaging pre-operatively as predictors of lymph nodal metastasis in early endometrial cancers.MethodsOur study was a cross sectional study done in a tertiary care center in south India, where 100 patients were studied from August 2016 to May 2018. After Ethical Committee clearance, all patients who were diagnosed with early endometrial cancer and who underwent surgery in our hospital were included in the study after getting informed consent. Pre-operative tumor grade and depth of myometrial invasion were studied as predictors of lymph nodal metastasis. They were also correlated with post-operative grade and myometrial invasion.ResultsThe present study recruited 100 women of which 3 cases were excluded because of non-endometrioid histology. The incidence of positive lymph node metastasis in our study was 18.6%. Both pre-operative tumor grade and depth of myometrial invasion were not significantly associated with lymph node metastasis. There was significant variation between pre-operative and post-operative tumor grade and depth of myometrial invasion. Among post-operative histopathological factors, only lymphovascular space invasion was found to be significantly associated with lymph node metastasis.ConclusionIn our study, neither pre-operative nor post-operative grade of the tumor and depth of myometrial invasion were significantly associated with lymph node metastasis. There was considerable variation between pre-op and post-op grade of the tumor making pre-op grade an unreliable factor in predicting lymph node metastasis in endometrial cancer. Among post-operative histopathological factors, only lymphovascular space invasion was found to be significantly associated with lymph node metastasis.Key messageConsiderable variation between pre-op and post-op grade of the tumor makes pre-op grade an unreliable factor in predicting lymph node metastasis in endometrial cancer

scholarly journals The Newest Diagnostic Imaging on the Tracheo-esophageal Diseases. CT and MRI Diagnoses of Lymph Node Metastasis in Esophageal Carcinoma.

1997 ◽  
Vol 48 (2) ◽  
pp. 111-118 ◽  
Author(s):  
Ikuo Kawahara ◽  
Kiminori Fujimoto ◽  
Jun Uozumi ◽  
Osamu Edamitsu ◽  
Masafumi Uchida ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Diagnostic Imaging ◽  
Esophageal Carcinoma ◽  
Esophageal Diseases ◽  
Node Metastasis ◽  
Ct And Mri

Diagnostic value of CT and MRI in the detection of paratracheal lymph node metastasis

Oral Oncology ◽  
2012 ◽  
Vol 48 (5) ◽  
pp. 450-455 ◽  
Author(s):  
Thomas T.A. Peters ◽  
Jonas A. Castelijns ◽  
Redina Ljumanovic ◽  
Birgit I. Witte ◽  
C. René Leemans ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Diagnostic Value ◽  
Node Metastasis ◽  
Paratracheal Lymph Node ◽  
Ct And Mri

scholarly journals Exosomes deep sequencing identifies miR-363-5p as a non-invasive biomarker of axillary lymph node metastasis and prognosis in breast cancer

2020 ◽  
Author(s):  
Xin Wang ◽  
Tianyi Qian ◽  
Siqi Bao ◽  
Hengqiang Zhao ◽  
Hongyan Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Cells ◽  
Deep Sequencing ◽  
Diagnostic Performance ◽  
Axillary Lymph ◽  
Aberrant Expression ◽  
Non Invasive ◽  
Node Metastasis

Abstract Background: Breast cancer is the most common malignant tumor in females. Axillary lymph node (ALN) metastasis is an independent risk factor of prognosis and correlates with distant metastasis. However, the false-negative rate and complications of the standard procedure are not neglectable hitherto. It is necessary to develop an accurate non-invasive approach for lymph node staging.Methods: In this study, circulating exosomal miRNA profiles in peripheral blood from 10 patients with breast cancer and 10 age-matched healthy women were obtained and analyzed using small RNA deep sequencing. Integrative profiles analysis and multiple cross-validation using in-house and external independent datasets were performed to evaluate the diagnostic performance. Functional assays were used to analyze cellular phenotypes and downstream targets of miR-363-5p.Results: We found that the aberrant expression of exosomal miR-363-5p is significantly associated with tumorigenesis (p=0.047) and ALN metastasis (p=0.019). Serum exosomal miR-363-5p demonstrated the consistent down-regulated expression pattern in LN positive patients compared with LN negative patients across multiple independent datasets, which achieved high diagnostic performance in predicting lymph node metastasis (AUC=0.621-0.958). Furthermore, patients with a high expression level of miR-363-5p had significantly improved overall survival (HR=0.63, ±95% CI=0.45-0.89, p=0.0075). Functional experiments discovered that miR-363-5p acts by inhibiting the migration ability of breast cancer cells. Here we further identified Platelet Derived Growth Factor Subunit B (PDGFB) as a downstream target of miR-363-5p.Conclusions: The miR-363-5p deficiency promoted metastasis via facilitating PDGFB expression, leading to overactivity of PDGF signaling in cancer cells. These results demonstrated that tumor metastasis is mediated by tumor-derived exosomes that affect cell growth signal regulation. Therefore, exosomal miR-363-5p may serve as a marker for ALN metastasis diagnosis in a non-invasive manner.

scholarly journals Research into the Value of B-Mode Ultrasound, CT and MRI Examinations in the Diagnosis of Preoperative Myometrial Infiltration of Endometrial Cancer and Lymph Node Metastasis

Open Medicine ◽  
2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Ren Lu ◽  
Sun Guixia
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Ultrasound Examination ◽  
Diagnostic Value ◽  
Pathological Diagnosis ◽  
Clinical Staging ◽  
Node Metastasis ◽  
Mri Examination ◽  
Ct And Mri

Abstract This study is conducted to observe the diagnostic value of B-mode ultrasound, CT and MRI examinations in preoperative myometrial infiltration of endometrial cancer and lymph node metastasis. Retrospectively analyze 50 cases of the patients from Oct. 2010 to Aug. 2013. Before operation all the patients received dilatation & curettage to determine pathological diagnosis and clinical staging. There were 150 cases of patients who received B-mode ultrasound examination, wherein, 93 cases received CT examination and 57 cases received MRI examination as well. In the diagnosis of MIEC the diagnostic indicies of individual MRI examination were higher than that of individual B-mode ultrasound and CT examinations. Consistency of individual MRI examination with pathological diagnosis was significantly higher than that of B-mode and CT examinations. The sensitivity of CT and MRI was significantly higher than that of B-mode ultrasound examination. However, diagnostic indicators of B-mode ultrasound and CT joint examination were higher than B-mode ultrasound examination alone. The consistency of both with pathological diagnosis was significantly increased. B-mode and CT can significantly improve the diagnostic accuracy and has a good consistency with pathological diagnosis, thereby applicable to the clinical diagnosis of preoperative myometrial infiltration of endometrial cancer and lymph node metastasis.

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