Comparison of analgesic effects of gabapentin and paracetamol post-operatively in patients with hand injury

Journal of the Pakistan Medical Association ◽

10.47391/jpma.359 ◽

2021 ◽

Author(s):

Hyder Ali ◽

Naveed ◽

Bushra Perveen

Keyword(s):

Side Effects ◽

Computer Software ◽

Hand Injury ◽

Double Blind ◽

Key Words Pain ◽

Analgesic Effects ◽

Psychiatric Illnesses ◽

Consecutive Sampling ◽

Randomized Control ◽

Paired T Test

Objective: Compare the analgesic effects of Gabapentin and Paracetamol post-operatively in patients with hand injury. Methods: This double blind, randomized control trial was conducted at the Department of Plastic Surgery, Dow University of Health Sciences Karachi; during March to August 2019. Fifty participants with hand injury and age ranged 18-60 were enrolled through consecutive sampling; while patients with multiple traumas, psychiatric illnesses, epileptic and pregnant were excluded. Informed written consent was obtained before enrollment of participants. Participants were randomly divided into two groups. Gabapentin (600 mg) and Paracetamol (1000 mg) were provided through anonymous packaging. Pain intensity was assessed using Visual Analogue Scale (VAS) along with self-designed questionnaire which was filled twice post-operatively (first at the time of drug intake once orally allowed and 6 hours later). Computer software SPSS 22 was used for analysis and comparison of results. Results: The analgesic effects of both the groups were analyzed using paired ‘t’ test which revealed statistically significant value i.e. <0.001 for each group. Though; the correlation coefficient was slightly more promising towards Paracetamol group (0.873 and 0.743 for Paracetamol and Gabapentin respectively). While in Gabapentin group there were more change of peaks were observed. Clinically more side effects were found in Gabapentin group. Conclusion: Both the drugs were found to be effective in pain management but Paracetamol had better pain control with relatively less side-effects. Key words: Pain, Hand injury, Gabapentin, Paracetamol. Continuous...

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Perbandingan Efektivitas Anestesi Spinal dengan Bupivacain 12,5 Mg dan Bupivacain 5 Mg yang ditambah Fentanyl 50 Mcg pada Seksio Sesarea

Jurnal Anestesi Obstetri Indonesia ◽

10.47507/obstetri.v4i1.55 ◽

2021 ◽

Vol 4 (1) ◽

pp. 11-7

Author(s):

Fritzky Indradata ◽

Heri Dwi Purnomo ◽

Muh. Husni Thamrin ◽

Sugeng Budi Santoso ◽

Ardana Tri Arianto ◽

...

Keyword(s):

Side Effects ◽

Cesarean Section ◽

Spinal Anesthesia ◽

Randomized Control Trial ◽

Hyperbaric Bupivacaine ◽

Chi Square ◽

Double Blind ◽

Duration Of Action ◽

Significant Difference ◽

Randomized Control

Latar Belakang: Anestesi spinal mempunyai efek samping berupa hipotensi dan mual muntah. Tujuan: penelitian ini adalah membandingkan efek anestesi spinal bupivacain dosis normal 12,5 mg dan bupivacain dosis rendah 5 mg dengan fentanyl 50 mg pada seksio sesarea terhadap perubahan hemodinamik, ketinggian blok, onset, durasi dan efek samping. Subjek dan Metode: Penelitian double blind randomized control trial pada 36 pasien yang memenuhi kriteria. Pasien dibagi menjadi dua kelompok, yang masing-masing terdiri 18 pasien, kelompok 1 dilakukan anestesi spinal dengan bupivacain hiperbarik 5 mg ditambah adjuvan fentanyl 50 mcg, sedangkan kelompok 2 diberikan bupivacain hiperbarik 12,5 mg. Penilaian meliputi saat mula kerja blokade sensorik, mula kerja blokade motorik, durasi, tekanan darah, laju nadi, dan saturasi oksigen, lama kerja dan efek samping. Data hasil penelitian diuji secara statistik dengan uji chi-square. Hasil: Terdapat perbedaan signifikan pada onset dan durasi blokade sensorik dan motorik, bupivacain 12,5 mg lebih baik dibandingkan bupivacain 5 mg + fentanyl 50 mcg (p<0.05). Tidak ada perbedaan signifikan pada perubahan tanda vital dan efek samping (p>0.05). Simpulan: Bupivacain 12,5 mg menghasilkan onset lebih cepat dan durasi lebih lama dibandingkan bupivacain 5 mg + fentanil 50 mcg pada anestesi spinal untuk seksio sesarea Comparison of The Effectiveness Spinal Anesthesia with Bupivacaine 12,5 Mg and Bupivacaine 5 Mg added Fentanyl 50 Mcg in Caesarean Section Abstract Background: Spinal anesthesia has side effects such as hypotension and nausea and vomiting. Objective: The aim of this study was to compare the effects of spinal anesthesia with normal doses of 12,5 mg of bupivacaine and 5 mg of low-dose bupivacaine with fentanyl 50 mg in the cesarean section on hemodynamic changes, block height, onset, duration, and side effects. Subjects and Methods: Double-blind randomized control trial in 36 patients who met the criteria. Patients were divided into two groups, each consisting of 18 patients, group 1 underwent spinal anesthesia with 5 mg of hyperbaric bupivacaine plus 50 mcg of fentanyl adjuvant, while group 2 was given 12,5 mg of hyperbaric bupivacaine. Assessments include the initiation of sensory block action, onset of motor block action, duration, blood pressure, pulse rate, and oxygen saturation, duration of action, and side effects. The research data were statistically tested with the chi-square test. Results: There were significant differences in the onset and duration of sensory and motor blockade, bupivacaine 12,5 mg was better than bupivacaine 5 mg + fentanyl 50 mcg (p <0.05). There was no significant difference in changes in vital signs and side effects (p> 0.05). Conclusion: Bupivacaine 12,5 mg resulted in a faster onset and longer duration than bupivacaine 5 mg + fentanyl 50 mcg in spinal anesthesia for cesarean section.

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Comparison the Efficacy of Intranasal Ketamine Versus Intravenous Ketorolac on Acute Non-Traumatic Headaches: A Randomized Double-Blind Clinical Trial

10.21203/rs.3.rs-99460/v1 ◽

2020 ◽

Author(s):

Houman Rafiee Sarvari ◽

Hamidreza Baigrezaii ◽

Mohammad Nazarianpirdosti ◽

Amirhossein Meysami ◽

Roya Safari-Faramani

Keyword(s):

Clinical Trial ◽

Side Effects ◽

Double Blind ◽

Analgesic Effects ◽

Headache Severity ◽

Selective Approach ◽

Double Blind Clinical Trial ◽

Group B ◽

Short Time ◽

Intravenous Ketorolac

Abstract Introduction: Non - traumatic headaches are one of the most common causes of referral to hospital emergency. This study aimed to compare the efficacy of intranasal ketamine and intravenous ketorolac on acute non-traumatic headaches.Methods: This randomized and double-blind clinical trial in 2019 years. 140 people were randomly divided into intranasal ketamine (A) and intravenous ketorolac (B). Group (A) received ketamine intranasal (0.75 mg/kg, max 75mg), and group B received intravenous ketorolac (30 mg). Headache severity was measured on arrival, 30, 60, and 120 minutes after intervention with Visual Analogue Scale (VAS). The side effects were recorded an hour after the intervention.Result: The mean difference of pain intensity 30, 60, and 120 minutes after the intervention between the two groups were statistically significant (p<0.001). In the first 30 minutes, significant changes were observed in the VAS levels of the two groups. These changes were more and significant in the intranasal ketamine group (p <0.001). Side effects such as fatigue, dizziness, public discomfort, nausea, increased heart rate, and hypertension were significantly higher in the ketamine group (p <0.05).Conclusion: Intranasal ketamine and intravenous ketorolac both effectively reduced headaches. However, more analgesic effects of intranasal ketamine in a short time can be considered as a selective approach to reducing headaches.

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Comparison the Efficacy of Intranasal Ketamine Versus Intravenous Ketorolac on Acute Non-traumatic Headaches: A Randomized Double-Blind Clinical Trial

10.21203/rs.3.rs-97688/v1 ◽

2020 ◽

Author(s):

Houman Rafiee Sarvari ◽

Hamidreza Baigrezaii ◽

Mohammad Nazarianpirdosti ◽

Amirhossein Meysami ◽

Roya Safari-Faramani

Keyword(s):

Clinical Trial ◽

Side Effects ◽

Double Blind ◽

Analgesic Effects ◽

Headache Severity ◽

Selective Approach ◽

Double Blind Clinical Trial ◽

Group B ◽

Short Time ◽

Intravenous Ketorolac

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Interpleural Morphine vs Bupivacaine for Postthoracotomy Pain Relief

Asian Cardiovascular and Thoracic Annals ◽

10.1177/021849230801600506 ◽

2008 ◽

Vol 16 (5) ◽

pp. 370-374 ◽

Cited By ~ 5

Author(s):

Shideh Dabir ◽

Tahereh Parsa ◽

Badiozaman Radpay ◽

Mojgan Padyab

Keyword(s):

Side Effects ◽

Posterolateral Thoracotomy ◽

Morphine Group ◽

Double Blind ◽

Analgesic Effects ◽

Pain Scores ◽

Postthoracotomy Pain ◽

Intravenous Morphine ◽

American Society ◽

American Society Of Anesthesiologists

This prospective randomized double-blind trial was designed to compare the analgesic effects of interpleural bupivacaine and interpleural morphine for postthoracotomy pain management. Thirty-six American Society of Anesthesiologists class I and II patients undergoing an elective posterolateral thoracotomy were randomly divided into 2 groups of 18 each. Before chest closure, an interpleural catheter was inserted under direct vision. At the end of the operation and every 4 hours thereafter, they received either 0.25% bupivacaine with epinephrine or 0.2 mg·kg−1 morphine sulfate interpleurally for 24 hours. The chest tubes were clamped during injection and for 15 min afterwards. Supplementary doses of intravenous morphine were given on request. The pain severity was evaluated at rest and on coughing before and 30 min after each interpleural injection, using an 11-point visual analog scale. Supplemental analgesic consumption and side effects were recorded. Both interpleural morphine and bupivacaine significantly reduced pain scores 30 min after each injection. However, pain scores and supplementary analgesic requirements were significantly lower in the interpleural morphine group. No serious side effects were detected in either group. Interpleural morphine provides better pain control than interpleural bupivacaine after a posterolateral thoracotomy.

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Comparison of the efficacy of intranasal ketamine versus intravenous ketorolac on acute non-traumatic headaches: a randomized double-blind clinical trial

Head & Face Medicine ◽

10.1186/s13005-021-00303-0 ◽

2022 ◽

Vol 18 (1) ◽

Author(s):

Hooman Rafiei Sarvari ◽

Hamidreza Baigrezaii ◽

Mohammad Nazarianpirdosti ◽

Amirhossein Meysami ◽

Roya Safari-Faramani

Keyword(s):

Clinical Trial ◽

Side Effects ◽

Double Blind ◽

Analgesic Effects ◽

Headache Severity ◽

Selective Approach ◽

Double Blind Clinical Trial ◽

Group B ◽

Short Time ◽

Intravenous Ketorolac

Abstract Introduction Non - traumatic headaches are one of the most common causes of referral to hospital emergency. This study aimed to compare the efficacy of intranasal ketamine and intravenous ketorolac on acute non-traumatic headaches. Methods This randomized and double-blind clinical trial was conducted in 2019. One hundred and forty samples were randomly divided into intranasal ketamine (A) and intravenous ketorolac (B). Group (A) received ketamine intranasal (0.75 mg/kg, max 75 mg), and group B received intravenous ketorolac (30 mg). Headache severity was measured on arrival, 30, 60, and 120 min after intervention with Visual Analogue Scale (VAS). The side effects were recorded an hour after the intervention. Result The mean difference of pain intensity 30, 60, and 120 min after the intervention between the two groups was statistically significant (p < 0.001). In the first 30 min, significant changes were observed in the VAS levels of the two groups. These changes were significantly greater in the intranasal ketamine group (p < 0.001). Side effects such as fatigue, dizziness, general discomfort, nausea, increased heart rate, and hypertension were significantly higher in the ketamine group (p < 0.05). Conclusion Intranasal ketamine and intravenous ketorolac both effectively reduced headaches. However, more analgesic effects of intranasal ketamine in a short time can be considered as a selective approach to reducing headaches. Trial registration IRCT20180108038276N3, Registered 29 September 2019. Ethics committee reference number IR.KUMS.REC.1398.068.

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