Development and Validation of Tramadol Hydrochloride in Bulk and Pharmaceutical Dosage Form by Ultraviolet Spectroscopy
A simple, rapid, accurate, precise and economic spectrophotometric technique for estimation of tramadol hydrochloride in 0.1N HCl have been developed. Tramadol Hydrochloride exhibit absorbance most 270nm when 0.1N HCl used as solvent proportion, so absorbance was once measured at the identical wavelengths for the determination of Tramadol Hydrochloride obeys Beer Lambert’s law in the concentration range of 20-180µg/ml. The present study describes development and validation of simple and economic UV spectrophotometric method for the estimation of Tramadol Hydrochloride in bulk and injection dosage form using absorbance maxima method. Solubility studies indicated that a Tramadol Hydrochloride shows better solubility in proposed diluents i.e., 0.1N HCl solution the ? max of Tramadol Hydrochloride was found to be 270nm. Because of cost effective and minimal maintenance, the present UV spectrophotometric methods can be preferred at small scale industries as compared to other reported methods.