STUDY OF THE IMMUNOGENIC PROPERTIES OF THE VACCINE FOR THE SPECIFIC PREVENTION OF MYXOMATOSIS, BORDETELLIOSIS AND PASTEURELLOSIS OF RABBITS «RESPIMIX» IN PRODUCTION CONDITIONS

2021 ◽  
pp. 18-21
Author(s):  
O. N. Novikova ◽  
A. A. Zgirovskaya ◽  
Yu. V. Lomako ◽  
M. A. Ananchikov ◽  
D. S. Borisovets ◽  
...  
Keyword(s):  
Pasteurella Multocida ◽  
Myxoma Virus ◽  
Bordetella Bronchiseptica ◽  
Veterinary Drug ◽  
Veterinary Practice ◽  
Preventive Efficacy ◽  
Immunogenic Properties ◽  
Production Conditions

Production tests of the vaccine for the prevention of pasteurellosis, bordetelliosis and myxomatosis of rabbits «Respimix» in terms of immunogenic activity were carried out. It has been established that the «Respimix» vaccine is a harmless and immunogenic preparation, superior in its preventive efficacy to the «Rabbiwak-V» preparation taken by us as a control one. The administration of the Respimix vaccine to rabbits promotes the production of antibodies to all antigens included in the vaccine, namely to Pasteurella multocida and Bordetella bronchiseptica bacteria and to rabbit myxoma virus. The veterinary drug «Vaccine for the prevention of pasteurellosis, bordetelliosis and myxomatosis of rabbits “Respimix”» can be recommended for use in veterinary practice.

DEVELOPMENT OF REGIMES AND TECHNOLOGY OF AEROSOL DISINFECTION OF VETERINARY AND SANITARY OBJECTS BY PREPARATION ASTRADEZ BIOXY IN PRODUCTION CONDITIONS

2018 ◽  
Vol 1 (3) ◽  
pp. 34-38
Author(s):  
G. V. Filipenkova ◽  
◽  
A. A. Prokopenko ◽  
Keyword(s):  
Gold Medal ◽  
Veterinary Practice ◽  
Poultry Houses ◽  
Production Conditions

As a result of the tests, effective regimes and technology of aerosol disinfection of veterinary supervision by preparation Astradez Bioxy were developed. It was found that the aerosols of 8...10% of the preparation Astradez Bioxy disinfect the surfaces of the premises of the vivarium and poultry houses at consumption of 30 ml/m3 and an exposure of 6...24 hours. According to the results of the research, for veterinary practice, "Technology of disinfection of objects of veterinary and sanitary supervision with aerosols of the preparation "Astradez Bioxy" (approved by the RAS on 15.11.2016) was developed and approved by the RAS. The technology of aerosol disinfection was highly appreciated at the 19th Russian agroindustrial exhibition "Golden Autumn-2017", held in Moscow in VDNKh from October 4 to 7, 2017, was awarded a Diploma and a Gold Medal.

scholarly journals Isolation of Pasteurella multocida and Bordetella bronchiseptica from Atrophic Rhinitis Cases

1994 ◽  
Vol 47 (11) ◽  
pp. 835-838 ◽  
Author(s):  
Toshihiro USHIJIMA ◽  
Kazuya NAGAO ◽  
Kozo TAKASE ◽  
Akira TANENO ◽  
Shinji YAMADA
Keyword(s):  
Pasteurella Multocida ◽  
Bordetella Bronchiseptica ◽  
Atrophic Rhinitis

scholarly journals THE EFFECTIVENESS OF A COMPREHENSIVE TREATMENT REGIMEN USING SODIUM THIOSULFATE WITH GASTROINTESTINAL DISEASES IN CALVES WITH INTOXICATION SYNDROME

2019 ◽  
pp. 95-101
Author(s):  
A. Belko ◽  
M. Matsinovich ◽  
V. Petrov ◽  
A. Matsinovich
Keyword(s):  
Sodium Thiosulfate ◽  
Clinical Signs ◽  
Gastrointestinal Diseases ◽  
Veterinary Drug ◽  
Comprehensive Treatment ◽  
Sodium Thiosulphate ◽  
Endogenous Intoxication ◽  
Cattle Farms ◽  
Basic Treatment ◽  
Production Conditions

The aim of the research was to study the dependence of the severity on the degree of endogenous intoxication and the effectiveness of complex treatment of calves using sodium thiosulfate-based drugs for gastrointestinal diseases. Studies were carried out under production conditions in cattle farms of the Vitebsk, Liozno and Gorodok districts. As preparations based on sodium thiosulfate, the veterinary drug "Averon" produced by LLC Belekotekhnika RB and the veterinary preparation Antitox manufactured by ImmCont GmbH, Germany, were used. These drugs as an antitoxic agent, were administered once a day, intravenously, slowly at a dose of 25 ml, until the clinical signs of the disease disappeared in addition to the basic treatment taken in the farms with gastrointestinal diseases. The data obtained as a result of the analysis of the literature and the conduct of our own research showed that in the pathogenesis of gastrointestinal diseases of the calves, the link to the pathogenesis, which significantly determines the severity of their course and prognosis, is endogenous intoxication. It was found that in patients with calves, the MW content was higher at the height of the disease – 1.75–2 times with moderate severity and 1.94 and 2.47 times with severe. Laboratory criteria were established for predicting the severity of dyspepsia and abomasoenteritis in calves of 14 to 30 days of age. So, at a level higher than 0,120 conv. units in 100% of such calves, dyspepsia or gastroenteritis proceeded in a severe (toxic) form. The significant direct correlations between the concentration of MWS and LPO products (r ≥ 0.650) revealed at the height of the disease indicate the significance of LPO as a source in the development of endotoxication in gastrointestinal diseases in calves. It has been established that the use of drugs with antitoxic action based on sodium thiosulphate in the complex therapy of calves of patients with dyspepsia and abomasoenteritis can reduce the severity and lethality of calves with dyspepsia by 5% to 10%. Key words: calves, blood, endogenous intoxication, abomazoenteritis, dyspepsia, therapeutic efficacy, treatment.

scholarly journals Two-Color Hybridization Assay for Simultaneous Detection of Bordetella bronchiseptica and Toxigenic Pasteurella multocida from Swine

1998 ◽  
Vol 36 (11) ◽  
pp. 3342-3346 ◽  
Author(s):  
Karen B. Register ◽  
Ruby M. Lee ◽  
Cindy Thomson
Keyword(s):  
Pasteurella Multocida ◽  
Simultaneous Detection ◽  
Experimental Studies ◽  
Clinical Signs ◽  
Bordetella Bronchiseptica ◽  
Hybridization Assay ◽  
Atrophic Rhinitis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Primary Isolation ◽  
Comparison Of The Results

Bordetella bronchiseptica and toxigenicPasteurella multocida are the etiologic agents of swine atrophic rhinitis. Methods currently used for their identification are time-consuming and suffer from a lack of sensitivity. We describe a colony lift-hybridization assay for detection of B. bronchiseptica and toxigenic P. multocida that can be performed with a single colony lift derived from a primary isolation plate without the need for pure subcultures of suspect bacteria. Membranes are hybridized simultaneously to probes derived from the B. bronchiseptica alcA gene and the P. multocida toxA gene. A multicolor development procedure permits sequential detection of bound probes. The assay was tested with 84 primary isolation plates generated from nasal swabs from swine with clinical signs of atrophic rhinitis. Comparison of the results from the colony lift-hybridization assay with those from conventional testing, based on a combination of colony morphology, biochemical reactions, mouse lethality, and enzyme-linked immunosorbent assay, indicated that the colony lift assay has superior sensitivity and comparable specificity. This technique has wide application for diagnostic and experimental studies.

scholarly journals Efficacy of bacterial vaccines to prevent respiratory disease in swine: a systematic review and network meta-analysis

2019 ◽  
Vol 20 (2) ◽  
pp. 274-290 ◽  
Author(s):  
Jan M. Sargeant ◽  
Bhumika Deb ◽  
Michele D. Bergevin ◽  
Katheryn Churchill ◽  
Kaitlyn Dawkins ◽  
...  
Keyword(s):  
Systematic Review ◽  
Respiratory Disease ◽  
Pasteurella Multocida ◽  
Meta Analysis ◽  
Grey Literature ◽  
Antibiotic Use ◽  
Bordetella Bronchiseptica ◽  
Comparative Efficacy ◽  
Lung Lesions ◽  
Actinobacillus Suis

AbstractA systematic review and network meta-analysis (MA) was conducted to address the question, ‘What is the efficacy of bacterial vaccines to prevent respiratory disease in swine?’ Four electronic databases and the grey literature were searched to identify clinical trials in healthy swine where at least one intervention arm was a commercially available vaccine for one or more bacterial pathogens associated with respiratory disease in swine, including Mycoplasma hyopneumoniae, Actinobacillus pleuropneumonia, Actinobacillus suis, Bordetella bronchiseptica, Pasteurella multocida, Stretococcus suis, Haemophils parasuis, and Mycoplasma hyorhinis. To be eligible, trials had to measure at least one of the following outcomes: incidence of clinical morbidity, mortality, lung lesions, or total antibiotic use. There were 179 eligible trials identified in 146 publications. Network MA was undertaken for morbidity, mortality, and the presence or absence of non-specific lung lesions. However, there was not a sufficient body of research evaluating the same interventions and outcomes to allow a meaningful synthesis of the comparative efficacy of the vaccines. To build this body of research, additional rigor in trial design and analysis, and detailed reporting of trial methods and results are warranted.

DEVELOPMENT OF MEANS FOR THE SPECIFIC PREVENTION OF MYXOMATOSIS AND PASTEURELLOSIS IN RABBITS

2021 ◽  
pp. 9-17
Author(s):  
A. A. Zgirovskaya ◽  
O. N. Novikova ◽  
Yu. V. Lomako ◽  
M. A. Ananchikov ◽  
E. S. Tkalich ◽  
...  
Keyword(s):  
Cell Cultures ◽  
Virus Strain ◽  
Pasteurella Multocida ◽  
Myxoma Virus

In the course of the work, an epizootic strain of the rabbit myxoma virus was isolated, and its adaptation to continuous cell cultures was carried out. When assessing the possibility of using an epizootic strain of myxoma of rab-bits for the manufacture of a vaccine, it was found that the isolated strain has low immunogenicity. For the manufacture of a vaccine for the prevention of pasteurellosis, bordetelliosis and myxomatosis in rab-bits, the rabbit myxoma virus (strain KMIEV-V141), bacteria Pasteurella multocida (strain KMIEV-B166), and Bor-detella bronchiseptica (strain KMIEV-B212) were used; parameters of cultivation of strains of myxoma of rabbits, pas-teurella and bordetella were worked out, inactivants and adjuvants were selected, methods of inactivation of pasteurel-la and bordetella of rabbits were worked out. A vaccine sample for the prevention of pasteurellosis, bordetelliosis and myxomatosis in rabbits has been prepared.

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