scholarly journals Assessment of Thyroid Functions in Late Preterm Infants of Mothers on Antenatal Steroids

2021 ◽  
Vol 2 (4) ◽  
pp. 18-29
Author(s):  
Rasha T Hamza ◽  
Amira I Hamed ◽  
Basma B B Hassan ◽  
Wafaa O Ahmed
Keyword(s):  
Preterm Infants ◽  
Late Preterm ◽  
Antenatal Corticosteroids ◽  
Free T4 ◽  
Cross Sectional ◽  
Late Preterm Infants ◽  
The Third ◽  
Antenatal Steroids ◽  
Serum T4 ◽  
Group 1

Purpose: The study examined the effect of antenatal steroids on thyroid functions in late preterm infants on the third to the seventh day of life. Patients and Methods: A comparative Cross-Sectional study was conducted on 75 neonates admitted to NICU in the first week of life. They were divided according to exposure to antenatal steroids into three groups. First group: exposed to complete course of ANS. Second group: exposed to partial course of ANS. The third group: not exposed to ANS. Serum samples were obtained from selected cases free T3, Free T4, and TSH levels in the third day of life, compared to the cut of levels currently available (the TSH reference range is (1.7 to 9.1 mU per L), T4 should be greater than( 10 mcg per dL). Using Eleusis and Cubase analyzers kits (Roche Diagnostics, Indianapolis, IN, USA) by ELISA (enzyme-linked immune sorbent assay) technique. Results: The study showed that there were significantly higher serum T4 levels in group 1 that was exposed to a complete course compared to group 2 (partial course) and 3 (Third group). There were no significant differences in serum TSH, T3 levels between groups. The current study found a decreased incidence of the ROP, NEC and BPD among group 1 as compared to the other two groups although was non statistically significant. In addition, the complete course of ANS had delayed the date of delivery (P=0.04) as compared to the partial course in the current study. Conclusion: Antenatal corticosteroids can influence thyroid function in late preterm infants as serum T4 was significantly higher in infants exposed to complete course compared to those who were exposed to partial course or did not receive antenatal corticosteroids.

scholarly journals Factors associated with the development of skin allergies in premature newborns in the first year of life

2021 ◽  
Vol 42 ◽  
Author(s):  
Leonardo Bigolin Jantsch ◽  
Bruna Paola de Lima Bridi ◽  
Giovana Dornelles Callegaro Higashi ◽  
Andrea Moreira Arrué ◽  
Diúlia Calegari de Oliveira ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Protective Factor ◽  
Newborn Infants ◽  
Late Preterm ◽  
First Year ◽  
Cross Sectional ◽  
Late Preterm Infants ◽  
Factors Associated ◽  
Skin Allergy ◽  
First Year Of Life

ABSTRACT Objective To identify the factors associated with the development of skin allergies in the first year of life in moderate and late preterm infants. Method: This is a cross-sectional study with 151 moderate and late preterm infants, born between May 2016 and May 2017. Participants were evaluated in the 3rd, 6th, 9th and 12th months of life, in telephone interviews. Statistical analyzes were performed in the SPSS software with frequency comparison tests and logistic regression. Results: The prevalence of skin allergy, in the perception of caregivers, among late and moderate preterm infants was 16%. Factors such as being admitted to neonatal intensive care (p = 0.006) and not being breastfed (p = 0.041) showed a significant association with the development of skin allergies in the 3rd and 12th months of life, respectively. Conclusion: Skin allergy, in the perception of caregivers, is more severe in newborn infants who have clinical respiratory and gastrointestinal manifestations, be it conditioning or cause-effect. Breastfeeding proved to be a protective factor in the first year of life.

scholarly journals Antenatal Corticosteroids for Late-Preterm Infants: A Decision-Analytic and Economic Analysis

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Jamie A. Bastek ◽  
Holly Langmuir ◽  
Laxmi A. Kondapalli ◽  
Emmanuelle Paré ◽  
Joanna E. Adamczak ◽  
...  
Keyword(s):  
At Risk ◽  
Cost Effectiveness ◽  
Preterm Infants ◽  
Cost Effective ◽  
Chronic Respiratory Disease ◽  
Late Preterm ◽  
Base Case ◽  
Antenatal Corticosteroids ◽  
Late Preterm Infants ◽  
Patients At Risk

Objectives. Antenatal corticosteroids (ACS) are not routinely administered to patients at risk for delivery between 34 and 36 6/7 weeks. Our objective was to determine whether ACS are cost-effective for late-preterm infants at risk for imminent preterm delivery. We hypothesized that the preferred strategy <36 weeks would include ACS while the preferred strategy ≥36 weeks would not. Methods. We performed decision-analytic and cost-effectiveness analyses to determine whether ACS was cost-effective at 34, 35, and 36 weeks. We conducted a literature review to determine probability, utility, and cost estimates absent of patient-level data. Base-case cost-effectiveness analysis, univariable sensitivity analysis, and Monte Carlo simulation were performed. A threshold of $100,000/QALY was considered cost-effective. Results. The incremental cost-effectiveness ratio favored the administration of a full course of ACS at 34, 35, and 36 weeks ($62,888.25/QALY, $64,425.67/QALY, and $64,793.71/QALY, resp.). A partial course of ACS was not cost-effective. While ACS was the consistently dominant strategy for acute respiratory outcomes, all models were sensitive to changes in variables associated with chronic respiratory disease. Conclusions. Our findings suggest that the administration of ACS to patients at risk of imminent delivery 34-36 weeks could significantly reduce the cost and acute morbidity associated with late-preterm birth.

scholarly journals Effects of Antenatal Steroids in Late Preterm Infants

2020 ◽  
Author(s):  
Olivia Janssen ◽  
Robert Green ◽  
Veniamin Ratner ◽  
Nathan Fox
Keyword(s):  
Preterm Infants ◽  
Late Preterm ◽  
Late Preterm Infants ◽  
Antenatal Steroids

Effectiveness of Antenatal Corticosteroids in Reducing Respiratory Disorders in Late Preterm Infants: Randomized Clinical Trial

2011 ◽  
Vol 66 (8) ◽  
pp. 473-474
Author(s):  
Ana Maria Feitosa Porto ◽  
Isabela Cristina Coutinho ◽  
Jailson Barros Correia ◽  
Melania Maria Ramos Amorim
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Preterm Infants ◽  
Late Preterm ◽  
Antenatal Corticosteroids ◽  
Respiratory Disorders ◽  
Late Preterm Infants

scholarly journals Perinatal Outcomes Associated with Latency in Late Preterm Premature Rupture of Membranes

2021 ◽  
Vol 18 (2) ◽  
pp. 672
Author(s):  
Eui Kyung Choi ◽  
So Yeon Kim ◽  
Ji-Man Heo ◽  
Kyu Hee Park ◽  
Ho Yeon Kim ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Latency Period ◽  
Perinatal Outcomes ◽  
Expectant Management ◽  
Late Preterm ◽  
Premature Rupture ◽  
Antenatal Corticosteroids ◽  
Preterm Premature Rupture ◽  
Antenatal Steroids ◽  
Significant Difference

This study aims to evaluate the perinatal outcomes of preterm premature rupture of membrane (PPROM) with latency periods at 33 + 0–36 + 6 weeks of gestation. This retrospective case-control study included women with singleton pregnancies who delivered at 33 + 0–36 + 6 weeks at Korea University Ansan Hospital in South Korea between 2006–2019. The maternal and neonatal characteristics were compared between different latency periods (expectant delivery ≥72 h vs. immediate delivery <72 h). Data were compared among 345 women (expectant, n = 39; immediate delivery, n = 306). There was no significant difference in maternal and neonatal morbidities between the groups, despite the younger gestational age in the expectant delivery group. Stratified by gestational weeks, the 34-week infants showed a statistically significant lower exposure to antenatal steroids (73.4% vs. 20.0%, p < 0.001), while the incidence of respiratory distress syndrome (12.8%) and the use of any respiratory support (36.8%) was higher than those in the 33-week infants, without significance. Our study shows that a prolonged latency period (≥72 h) did not increase maternal and neonatal morbidities, and a considerable number of preterm infants immediately delivered at 34 weeks experienced respiratory complications. Expectant management and antenatal corticosteroids should be considered in late preterm infants with PPROM.

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