scholarly journals Role of Serum CYFRA 21-1 in the Diagnosis of Primary Lung Cancer

2017 ◽  
Vol 27 (Number 2) ◽  
pp. 13-18
Author(s):  
H Rashid ◽  
S Hossain ◽  
R K Chowdhury ◽  
S Rahman ◽  
M M Khan
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Lung Cancer ◽  
College Hospital ◽  
Histopathological Findings ◽  
The Mean ◽  
Diagnosis Of Lung Cancer

Majority of the lung cancer occurs in developing countries. In case of Bangladesh it's a burden for health in both serest. A definitive diagnosis of lung cancer can help the surgeons and physicians for making decisions about the plan of treatment. The rapidity of diagnosis also alleviates the patient's anxiety whether the lesion is nonmalignant or malignant Several studies proposed the role of CYFRA 21-1 level in diagnosis of lung cancer and its better management. To find the sensitive, feasible and cost effective test for detection of lung cancer and to evaluate the CYFRA 21-1 with their histopathological findings. This case control study was carried out in the department of Medicine of National Institute of Diseases of the Chest and Hospital (NIDCH) Dhaka and Enam Medical College Hospital, Savar, Dhaka during the period from January 2017 to September 2017. We included a total of 80 subjects among them 40 diagnosed cases of lung cancer and 40 controls with diseases other than lung cancer. The mean normal (< 3.5) serum CYFRA 21-1 level was (Mean *SD) 1.10 t 1.5 with ranging from 0.87 ng /ml — 1.5 ng lint Normal level of CYFRA 21-1 was found in all 40 (100%) of controls. The mean of high (> 3.5) serum CYFRA 21-1 level was (Mean +-SD) 18.20 ± 13.63 with rangingfrom 6.9 ng hnl — 49.30 ng/ml. High level of CYFRA 21-1 level was found in maximum 35(87.5%) cases. High (> 3.5 rig/m1) serum CYFRA 21-1 level was found maximum in squamous cell carcinoma (20), next adenocarcinoma (15). Among 40 cases diagnosed as malignant by histopathology, serum CYFRA 21-1 level was compared with histopathological findings. The sensitivity of serum CYFRA 21-1 level in case of squamous cell carcinoma, adenocarcinoma and combined were 90.90%, 83.33% and 87.5% respectively. The sensitivity and accuracy of serum CYFRA 21-1 for squamous cell carcinoma was more than that of adenocarcinoma. So serum CYFRA 21-1 level was highly sensitive for squamous cell carcinoma.

scholarly journals The Descriptive Epidemiology of Primary Lung Cancer in an Alberta Cohort with a Mutivariate Analysis of Survival to Two Years

2003 ◽  
Vol 10 (8) ◽  
pp. 435-441 ◽  
Author(s):  
Sandor J Demeter ◽  
Chester Chmielowiec ◽  
Wayne Logus ◽  
Pauline Benkovska-Angelova ◽  
Philip Jacobs ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
American Literature ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Lung Cancer ◽  
Case Fatality ◽  
Nonsmall Cell Lung Cancer ◽  
Small Cell ◽  
The Impact

BACKGROUND: Lung cancer contributes significantly to cancer morbidity and mortality. Although case fatality rates have not changed significantly over the past few decades, there have been advances in the diagnosis, staging and management of lung cancer.OBJECTIVE: To describe the epidemiology of primary lung cancer in an Alberta cohort with an analysis of factors contributing to survival to two years.PATIENTS AND METHODS: Six hundred eleven Albertans diagnosed with primary lung cancer in 1998 were identified through the Alberta Cancer Registry. Through a chart review, demographic and clinical data were collected for a period of up to two years from the date of diagnosis.RESULTS: The mean age at diagnosis was 66.5 years. The majority of cases (92%) were smokers. Adenocarcinoma, followed by squamous cell carcinoma, were the most frequent nonsmall cell lung cancer histologies. Adenocarcinoma was more frequent in women, and squamous cell carcinoma was more frequent in men. The overall two- year survival rates for nonsmall cell, small cell and other lung cancers were 24%, 10% and 13%, respectively. In multivariate analysis, stage, thoracic surgery and chemotherapy were significantly associated with survival to two years in nonsmall cell carcinoma; only stage and chemotherapy were significant in small cell carcinoma.CONCLUSIONS: This study provides a Canadian epidemiological perspective, which generally concurs with the North American literature. Continued monitoring of the epidemiology of lung cancer is essential to evaluate the impact of advances in the diagnosis, staging and management of lung cancer. Further clinical and economic analysis, based on data collected on this cohort, is planned.

scholarly journals Sleeve lobectomy for double primary lung cancer; Adenocarcinoma and early stage squamous cell carcinoma in one lobe.

Haigan ◽  
1990 ◽  
Vol 30 (1) ◽  
pp. 93-97
Author(s):  
Noriaki Tsubota ◽  
Takesi Hatta ◽  
Yosiki Takata ◽  
Kayoko Obayasi ◽  
Isamu Narabayasi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Primary Lung Cancer ◽  
Sleeve Lobectomy

scholarly journals Comparison of NCC-ST-439 with squamous cell carcinoma-related antigen, neuron-specific enolase and carcinoembryonic antigen in primary lung cancer.

Haigan ◽  
1989 ◽  
Vol 29 (7) ◽  
pp. 737-745
Author(s):  
Shinobu Hatakeyama ◽  
Akihiko Nagai ◽  
Yoshiaki Nakajima ◽  
Satoru Kioi ◽  
Masaaki Arakawa
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Carcinoembryonic Antigen ◽  
Squamous Cell ◽  
Primary Lung Cancer ◽  
Neuron Specific Enolase

scholarly journals Enlightenment for Clinicians From the Case of Digestive Tract Metastases From Primary Lung Cancer: a Case Report

2021 ◽  
Author(s):  
Shaochun Wang ◽  
Shuili Wang ◽  
Wei Zhang ◽  
Yeqin Zhang
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Small Intestine ◽  
Cell Carcinoma ◽  
Digestive Tract ◽  
Squamous Cell ◽  
Primary Lung Cancer ◽  
Primary Squamous Cell Carcinoma ◽  
Lower Quadrant ◽  
Small Intestinal

Abstract Background: About 50% of patients with initially diagnosed lung cancer have developed distant metastasis. The probability of occurrence of digestive tract metastases found by autopsy is rarely. This report presents a rare clinical case of small intestinal metastasis from primary squamous cell carcinoma of the lung. Case presentation: An 82-year-old male with aggravated cough and more acute shortness of breath than usual was diagnosed with primary squamous cell carcinoma of the lung Stage IV, because of the advanced age, underlying diseases, and poor cardiopulmonary function,the family refused the chemoradiotherapy.One month later, the patient gradually developed right lower quadrant pain. An upright abdominal X-ray suggested small intestinal obstruction and partial resection and anastomosis of the small intestine were performed. Postoperative pathology revealed poorly differentiated squamous-cell carcinoma of the small intestine. The patient died of sudden cardio-respiratory arrest one month later. Conclusions: We conclude that the real incidence of digestive tract metastases from lung cancer may be higher than the reported because of the symptoms of those patients are not obvious. Clinicians should select the appropriate examination methods (such as positron emission tomography) and pay attention to the assessment of abdominal hollow organs.

scholarly journals Lung cancer: 1 year experience at tertiary care centre with reference to cytodiagnostic approach

2017 ◽  
Vol 4 (1) ◽  
pp. 133
Author(s):  
Mansi Mehta ◽  
Nisha Gupta ◽  
Jaydeep Odhwani ◽  
Nandini Desai ◽  
P. M. Santwani
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Brush Cytology ◽  
Fine Needle ◽  
Bronchial Washing ◽  
Diagnosis Of Lung Cancer

Background: Lung cancer is the most common cancer incidence wise as well as leading cause of cancer related death in worldwide as well as in India. Cytological diagnosis plays an important role in patients having lung cancer. This study was conducted to evaluate sensitivity of various cytological methods in diagnosis of lung cancer, to study typing of lung cancer, age and gender wise distribution of lung cancer and its association with smoking.Methods: This study includes patients having clinical and radiological diagnosis of lung cancer. Total 150 cases of entire January 2015 to December 2015 are included. Methods obtaining samples includes, abrasive cytology by bronchoscope guided: bronchoalveolar lavage (BAL); brush cytology and bronchial washing, CT/USG guided transthoracic fine needle aspiration, trans- bronchial needle aspiration. Samples have been processed as per standard protocols and cytomorphology of samples are studied, along with these patient age, gender, and smoking habit have been recorded.Results: Sensitivity of various method: abrasive cytology by bronchoscope guided bronchoalveolar lavage (BAL); brush cytology and bronchial washing, trance bronchial needle aspiration, CT/USG guided transthoracic fine needle aspiration is 70%, 66%, 90% respectively. Adenocarcinoma is most common carcinoma followed by squamous carcinoma, having incident of 41%, 31.39% respectively. In male patient peak age is 5th decade, and in female peak age is 6th decade. Male:female ratio is 5.1:1. Adenocarcinoma is most common carcinoma is 10 times more common in non-smokers as compare to squamous cell carcinoma .But association of squamous cell carcinoma with smoking is 97%.Conclusions: CT/USG guided transthoracic fine needle aspiration method has highest sensitivity. In male patients peak age of presentation of lung carcinoma is 5th decade, and in female patient’s peak age is 6th decade. Lung carcinoma found to be more common in males than in females. Adenocarcinoma is most common carcinoma. It is 10 times more common in non-smokers as compare to squamous cell carcinoma. Association of squamous cell carcinoma with smoking is 97%.

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