Anthropometric Assessment and lipid metabolism biomarkers of Parents of Pediatric Patients with Chronic Rheumatic Diseases

Abstract Investigations into the serum protein patterns that occur in chronic rheumatic diseases, formerly made by salt-fractionation methods, are now revised with the aid of the superior technic of microelectrophoretic separation. Using the microelectrophoretic method, supplemented by a single salt-fractionation procedure, the concentrations of albumin, α1-globulin, α2-globulin, β-globulin and γ-globulin in the sera of 26 patients variously affected by chronic rheumatic diseases were determined. Normal protein patterns were found in all the 12 sera with normal total globulin content, whereas variously abnormal protein patterns were found in all of the 14 hyperglobulinemic sera. The hyperglobulinemia of chronic rheumatic diseases was found most frequently to be due to increments in γ-globulin, often accompanied also by increases in α2-globulin. Less frequently, increased amounts of β-globulin were found, and in some cases an elevation of α1-globulin. These abnormalities were all detectable electrophoretically, whereas the method for the salting-out of γ-globulin was unsatisfactory.

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AB1016 OUTCOME OF TRANSITION OF CARE IN YOUNG ADULTS WITH JUVENILE ONSET CHRONIC RHEUMATIC DISEASES

10.1136/annrheumdis-2019-eular.8130 ◽

2019 ◽

Author(s):

Patrícia Martins ◽

Sofia C. Barreira ◽

Ana Teresa Melo ◽

Raquel Campanilho-Marques ◽

Joao Eurico Fonseca ◽

...

Keyword(s):

Young Adults ◽

Rheumatic Diseases ◽

Transition Of Care ◽

Juvenile Onset ◽

Chronic Rheumatic Diseases

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Adverse drug reactions associated with treatment in patients with chronic rheumatic diseases in childhood: a retrospective real life review of a single center cohort

Advances in Rheumatology ◽

10.1186/s42358-020-00154-4 ◽

2020 ◽

Vol 60 (1) ◽

Author(s):

Manar Amanouil Said ◽

Liana Soido Teixeira e Silva ◽

Aline Maria de Oliveira Rocha ◽

Gustavo Guimarães Barreto Alves ◽

Daniela Gerent Petry Piotto ◽

...

Keyword(s):

Risk Factors ◽

Regression Model ◽

Children And Adolescents ◽

Adverse Drug Reactions ◽

Rheumatic Diseases ◽

Real Life ◽

Drug Reactions ◽

Wide Range ◽

Disease Modifying ◽

Chronic Rheumatic Diseases

Abstract Background Adverse drug reactions (ADRs) are the sixth leading causes of death worldwide; monitoring them is fundamental, especially in patients with disorders like chronic rheumatic diseases (CRDs). The study aimed to describe the ADRs investigating their severity and associated factors and resulting interventions in pediatric patients with CRDs. Methods A retrospective, descriptive and analytical study was conducted on a cohort of children and adolescents with juvenile idiopathic arthritis (JIA), juvenile systemic lupus erythematosus (JSLE) and juvenile dermatomyositis (JDM). The study evaluated medical records of the patients to determine the causality and the management of ADRs. In order to investigate the risk factors that would increase the risk of ADRs, a logistic regression model was carried out on a group of patients treated with the main used drug. Results We observed 949 ADRs in 547 patients studied. Methotrexate (MTX) was the most frequently used medication and also the cause of the most ADRs, which occurred in 63.3% of patients, followed by glucocorticoids (GCs). Comparing synthetic disease-modifying anti-rheumatic drugs (sDMARDs) vs biologic disease-modifying anti-rheumatic drugs (bDMARDs), the ADRs attributed to the former were by far higher than the latter. In general, the severity of ADRs was moderate and manageable. Drug withdrawal occurred in almost a quarter of the cases. In terms of risk factors, most patients who experienced ADRs due to MTX, were 16 years old or younger and received MTX in doses equal or higher than 0.6 mg/kg/week. Patients with JIA and JDM had a lower risk of ADRs than patients with JSLE. In the multiple regression model, the use of GCs for over 6 months led to an increase of 0.5% in the number of ADRs. Conclusions Although the ADRs highly likely affect a wide range of children and adolescents with CRDs they were considered moderate and manageable cases mostly. However, triggers of ADRs need further investigations.

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