scholarly journals Changes of Corneal Thickness and Intraocular Pressure in Type II Diabetic Patients

2021 ◽  
pp. 1-5
Author(s):  
Yasmena Abdulhadi
Keyword(s):  
Diabetic Retinopathy ◽  
Intraocular Pressure ◽  
Corneal Thickness ◽  
Diabetic Control ◽  
P Value ◽  
Diabetic Patients ◽  
Type Ii ◽  
Pressure Measurements ◽  
Diabetic Type ◽  
Central Cornea

Aims. The purpose of the present paper is to present the results of central corneal thickness & intraocular pressure measurements in diabetic patients with or without retinopathy, and compare the results with non-diabetic control patients. Methods. Total number was 152 patients were 152 eyes The study group was divided into 3 groups as following: 50 non diabetic (control). 50 diabetic type II with no diabetic retinopathy. 52 diabetic type II patient with diabetic retinopathy. Correlation analysis was performed to assess the association between glycosylated hemoglobin levels& Intraocular pressures and retinal changes among subgroups. Results. Demographic characteristics of study and control groups were similar (P>0.05). Mean CCT 553.62 with Std deviation (14.47) in control cases and 622.27 with Std deviation (507.09) in diabetic cases which is more than control however the distinction failed to reach applied math significance were (p value= > 0.05). additionally, CCT and diabetic retinopathy association was significant were CCT in diabetic patients with no retinal changes was 563.96 Std deviation (18.85) and in diabetic patients with retinopathy was 670.45 Std deviation (717.2) and P value = 0.004 (significant). There was significant correlation between increased corneal thickness and intraocular pressure were p-value = 0.002. Conclusions. We found that the central cornea of diabetic patients is thicker when compared with non-diabetic patients. Thicker central cornea associated with diabetes mellitus should be taken into consideration while obtaining accurate intraocular pressure measurements in diabetics.

scholarly journals Clinical Study on Correlation of HbA1c with Different Grades of Diabetic Retinopathy at S.V.R.R.G.G.H, Tirupati – A Hospital Based Descriptive Correlative Study

2021 ◽  
Vol 8 (23) ◽  
pp. 1949-1953
Author(s):  
Sidda Naik Bukke ◽  
Rama Lakshmi Badugu ◽  
Ramachandraiah Gurapa ◽  
Sree Pushpa Vani Gopavaram ◽  
Rama Thulasi Bukkacherla
Keyword(s):  
Diabetic Retinopathy ◽  
Serum Proteins ◽  
Diabetic Control ◽  
P Value ◽  
Diabetic Patients ◽  
Keywords Diabetic Retinopathy ◽  
Correlative Study ◽  
Department Of Ophthalmology ◽  
Hba1c Levels

BACKGROUND Patients with diabetic retinopathy (DR) are 25 times more likely to become blind than non-diabetics.1 One of the main difficulties in establishing a relationship between the degree of hyperglycemia and the long-term complications of diabetes is the lack of a reliable and objective method for the assessment of diabetic control. Recordings of glycated proteins, serum proteins, and primary hemoglobin, have added a new dimension to glycemia assessment. HbA1c has been known to be a marker to assess the long-term control of diabetes mellitus. Few studies have shown the correlation between HbA1c and different grades of DR in the past. The purpose of this study was to determine the correlation of HbA1c with different grades of diabetic retinopathy. METHODS A descriptive correlative study was conducted among 100 diabetic patients attending the Department of Ophthalmology in S.V.R.R.G.G. Hospital, Tirupathi, for a duration of one year. Relevant history regarding their diabetes was noted. The status of diabetic retinopathy in each patient was diagnosed by comprehensive ophthalmologic examination and classified according to the early treatment diabetic retinopathy study (ETDRS) system. Patients were evaluated for their HbA1c levels. RESULTS Out of 100 patients, 43 % of participants were females, and the remaining 57 % were males. A statistically significant correlation was found between different grades of diabetic retinopathy and HbA1c levels. The other factor which had a significant correlation was the duration of diabetes and grade of retinopathy (P – value < 0.05). Age of the patient, gender of the patient, did not significantly correlate when compared in different grades of diabetic retinopathy (P - value > 0.05). CONCLUSIONS A statistically significant correlation was found between HbA1c levels and the severity of diabetic retinopathy. Higher the level of HbA1c (indicating poor glycaemic control), the more severe is the grade of DR in those set of patients. KEYWORDS Diabetic Retinopathy, HbA1c, CSME

scholarly journals Diabetic Retinopathy and Central Corneal Thickness

2019 ◽  
Vol 3 (3) ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Diabetic Patients ◽  
Type I ◽  
Type Ii ◽  
The Mean

Background: Diabetes mellitus (DM) is a metabolic disease that can lead to many ocular complications such as increased Central Corneal Thickness (CCT), cataracts, and diabetic retinopathy. The aim of this study was to compare the CCT between subjects with type I and type II diabetes. Method: This was a retrospective study which included subjects with diabetes (with and without Diabetic Retinopathy (DR)) aged between 18 to 80 years old. The data collected were type and duration of diabetes mellitus, diabetes treatment, glycated hemoglobin level, visual acuity, CCT, and intra ocular pressure. Subjects were divided into subgroup (with and without DR). Statistical program (SPSS) was used to compare the central corneal thickness between the groups. Result: A total of 205 subjects with type I (n=100) and type II (n=105) diabetes were included in this study. In type 1 DM, the mean CCT was 547.06±27.3 microns in patients with diabetic retinopathy (DR) and 533.85±26.8 microns in patients without DR. In type 2 DM, the mean CCT was 542.85±39.3 microns in patients with DR and 532.44±27.4 microns in patients without DR. The CCT in type 1 diabetic patients was higher in both groups (with and without DR) than the CCT in type 2 diabetic patients in both groups (with and without DR). However, this was not statistically significant. Conclusion: The type of diabetes mellitus did not affect CCT. The presence of diabetic retinopathy in either type I or type II diabetes mellitus can affect the measurements of CCT.

scholarly journals Stringent glycemic control is still the key to evade diabetic retinopathy.

2020 ◽  
Vol 27 (05) ◽  
pp. 1011-1016
Author(s):  
Syed Munawar Alam ◽  
Sagheer Ahmed ◽  
Shazia Bano ◽  
Shahneela Perveen
Keyword(s):  
Diabetic Retinopathy ◽  
Glycemic Control ◽  
Proliferative Diabetic Retinopathy ◽  
Study Groups ◽  
Hplc Method ◽  
P Value ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Institutional Review

Objectives: The aim of this study was to evaluate the major determinants of diabetic retinopathy. Study Design: Cross sectional, case control study. Setting: Department of Biochemistry, Basic Medical Sciences Institute, Jinnah Post Graduate Medical Centre, Karachi. Period: March 2015 to April 2016. Material & Methods: Ethical approval was taken from the Institutional Review Board of JPMC. A total of 208 people including type 2 diabetic patients and healthy control subjects; of male gender, aged between ≥30 years and ≤ 60 years were recruited and assigned to four study groups. Each group comprise of 52 individuals, depending on the ophthalmoscopy findings, i.e. healthy controls, diabetic without retinopathy (NDR), diabetic with non-proliferative diabetic retinopathy (NPDR) and diabetic with proliferative diabetic retinopathy (PDR). Fasting blood sugar was estimated using GOD-PAP method, while HbA1c was estimated by HPLC method. Data was analyzed on SPSS software version 16. Results: Diabetics with Diabetic Retinopathy had a poor glycemic control as compare to Diabetics without Diabetic Retinopathy (FBS; 109.12 ± 13.81 vs. 184.29 ± 40.07 vs. 188.6 ± 47.68 vs. 217.06 ± 62.33; p-value = 0.001) (HbA1c; 6.73 ± 0.56 vs. 8.40 ± 1.77 vs. 9.71 ± 1.85 vs. 14.91 ± 3.87; p-value = 0.001). For Diabetic Retinopathy the odds ratio of glycemic control i.e. FBS was observed as 1.019 & HbA1c was recorded as 1.561; which was statistically significant. Conclusion: Glycemic indicators; including FBS and HbA1c, are found to be the major determinants of Diabetic Retinopathy in our study.

Intraocular pressure measurements in diabetes mellitus

2019 ◽  
Vol 30 (6) ◽  
pp. 1432-1439 ◽  
Author(s):  
Lisa Ramm ◽  
Robert Herber ◽  
Eberhard Spoerl ◽  
Lutz E Pillunat ◽  
Naim Terai
Keyword(s):  
Diabetes Mellitus ◽  
Intraocular Pressure ◽  
Healthy Subjects ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Applanation Tonometry ◽  
Goldmann Applanation Tonometry ◽  
Ocular Response Analyzer ◽  
Pressure Measurements ◽  
Corvis St

Purpose: To investigate the impact of diabetes mellitus–induced changes on intraocular pressure measurements using Goldmann applanation tonometry, Ocular Response Analyzer, and Corvis ST. Methods: Measurements were done using Goldmann applanation tonometry, Ocular Response Analyzer, and Corvis ST in 69 diabetic patients. Biomechanical-corrected intraocular pressure values by Ocular Response Analyzer (IOPcc) and Corvis ST (bIOP) were used. In addition, biometry and tomography were performed and information on diabetes mellitus specific factors was collected. Results were compared to an age-matched group of 68 healthy subjects. Results: In diabetes mellitus, Goldmann applanation tonometry intraocular pressure (P = 0.193) and central corneal thickness (P = 0.184) were slightly increased. Also, IOPcc (P = 0.075) and bIOP (P = 0.542) showed no significant group difference. In both groups, IOPcc was higher than Goldmann applanation tonometry intraocular pressure (P = 0.002, P < 0.001), while bIOP was nearly equal to Goldmann applanation tonometry intraocular pressure (P = 0.795, P = 0.323). Central corneal thickness showed a tendency to higher values in poorly controlled than in controlled diabetes mellitus (P = 0.059). Goldmann applanation tonometry intraocular pressure correlated to central corneal thickness, while IOPcc and bIOP were independent from central corneal thickness in both groups. All intraocular pressure values showed significant associations to corneal biomechanical parameters. Only in diabetes mellitus, bIOP was correlated to Pachy slope (P = 0.023). Conclusion: In diabetes mellitus, Goldmann applanation tonometry intraocular pressure was slightly, but not significantly, increased, which might be caused by a higher central corneal thickness and changes in corneal biomechanical properties. However, intraocular pressure values measured by Ocular Response Analyzer and Corvis ST were not significantly different between diabetes mellitus patients and healthy subjects. The bIOP showed a higher agreement with Goldmann applanation tonometry than IOPcc and was independent from central corneal thickness.

scholarly journals Central corneal thickness in type II diabetes mellitus: is it relatedto the severity of diabetic retinopathy?

2015 ◽  
Vol 45 ◽  
pp. 651-654 ◽  
Author(s):  
Okan TOYGAR ◽  
Selçuk SIZMAZ ◽  
Aysel PELİT ◽  
Baha TOYGAR ◽  
Özge YABAŞ KIZILOĞLU ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Type Ii Diabetes ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii

scholarly journals The Effect of Corneal Thickness, Densitometry and Curvature on Intraocular Pressure Measurements Obtained by Applanation, Rebound and Dynamic Contour Tonometry

Vision ◽  
2020 ◽  
Vol 4 (4) ◽  
pp. 45
Author(s):  
Marco Antonio de Castro Olyntho Junior ◽  
Lucas Bertazzi Augusto ◽  
Carolina P. B. Gracitelli ◽  
Andrew J. Tatham
Keyword(s):  
Intraocular Pressure ◽  
Prospective Study ◽  
Corneal Thickness ◽  
Applanation Tonometry ◽  
Corneal Astigmatism ◽  
Dynamic Contour Tonometry ◽  
Pressure Measurements ◽  
Cross Sectional ◽  
Corneal Densitometry ◽  
The Relationship

Evaluate the effect of corneal thickness, densitometry and curvature on intraocular pressure (IOP) measurements obtained by Goldmann applanation tonometry (GAT), non-contact tonometry (NCT), rebound tonometry (RT), and dynamic contour tonometry (DCT). A cross-sectional prospective study involving 40 participants was performed. Corneal measurements were obtained using Pentacam (Oculus GMbH, Wetzlar, Germany), densitometry was measured at annuli of 0–2, 2–6, 6–10 and 10–12 mm. The relationship between corneal thickness (central, 4 and 6 mm), corneal astigmatism and corneal densitometry and IOP was examined. There was a significant relationship between corneal thickness (central, 4 and 6 mm) and GAT180, GAT90, RT, and NCT (P < 0.001 for all comparisons) but not for DCT. Higher corneal densitometry (6–10 mm and 10–12 mm zones) was associated with higher IOP from GAT180 and GAT90, and higher densitometry in the 6–10 mm zone correlated with higher IOP from NCT, however corneal densitometry increased with age. Accounting for age, the relationship between corneal densitometry and IOP measurements was not significant. In eyes with greater corneal astigmatism there was a greater difference between GAT90 and GAT180 measurements. IOP measurements may be affected by corneal thickness, densitometry and curvature. DCT was less affected by properties of the cornea compared to other devices.

scholarly journals Ocular Rigidity and Outflow Facility in Nonproliferative Diabetic Retinopathy

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Theonitsa Panagiotoglou ◽  
Miltiadis Tsilimbaris ◽  
Harilaos Ginis ◽  
Nikos Karyotakis ◽  
Vaggelis Georgiou ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Intraocular Pressure ◽  
Cataract Surgery ◽  
Anterior Chamber ◽  
Control Group ◽  
Diabetic Patients ◽  
Outflow Facility ◽  
Nonproliferative Diabetic Retinopathy ◽  
Computer Controlled ◽  
And Control

Purpose.To compare ocular rigidity (OR) and outflow facility (C) in patients with nonproliferative diabetic retinopathy (NPDR) and control subjects.Methods. Twenty-four patients with NPDR (NPDR group) and 24 controls (control group) undergoing cataract surgery were enrolled. NPDR group was further divided into patients with mild NPDR (NPDR1-group) and patients with moderate and/or severe NPDR (NPDR2-group). After cannulation of the anterior chamber, a computer-controlled device was used to infuse saline and increase the intraocular pressure (IOP) in a stepping procedure from 15 to 40 mmHg. Ocular rigidity and outflow facility coefficients were estimated from IOP and volume recordings.Results. Ocular rigidity was 0.0205 μL−1in NPDR group and 0.0202 μL−1in control group (P=0.942). In NPDR1-group, OR was 0.017 μL−1and in NPDR2-group it was 0.025μL−1(P=0.192). Outflow facility was 0.120 μL/min/mmHg in NPDR-group compared to 0.153 μL/min/mmHg in the control group at an IOP of 35 mmHg (P=0.151). There was no difference in C between NPDR1-group and NPDR2-group (P=0.709).Conclusions. No statistically significant differences in ocular rigidity and outflow facility could be documented between diabetic patients and controls. No difference in OR and C was detected between mild NPDR and severe NPDR.

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