scholarly journals Vitamin B12 concentrations and clinical spectrum of apparently healthy elderly population

2020 ◽  
Vol 8 (1) ◽  
pp. 48-54
Author(s):  
Darshana Makwana ◽  
Deepak Kumar P ◽  
Pragathi Wadkar
Keyword(s):  
Vitamin B12 ◽  
Elderly Population ◽  
Vitamin B12 Deficiency ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Healthy Elderly ◽  
Normal Vitamin ◽  
B12 Deficiency ◽  
High Index Of Suspicion ◽  
Apparently Healthy

Introduction : Prevalence of vitamin B12 deficiency is believed to increase with aging. The wide and non-specific spectrum of clinical presentations in patients poses a tough challenge to physicians suspecting vitamin B12 deficiency. Objectives : This study was conducted to collect data on prevalence and clinical features of vitamin B12 deficiency in apparently healthy elderly population visiting hospitals, as the results could help rationalize and direct the appropriate management of vitamin B12 status in elderly. Methods : This was a time bound cross sectional study where apparently healthy individuals >50 years of age were interviewed, examined and investigated in order to study their vitamin B12 concentrations and associated clinical profile. Results: A total of 103 participants were included. The mean vitamin B12 level of the study population was 327.07 pg/ml (S.D= 268.00). In the study, 43.7% (n=45 patients) had low vitamin B12 levels (vitamin B12 deficiency) and 17.5 % (n=18 patients) had subnormal vitamin B12 levels. Among all the symptoms recorded neurological followed by cardiovascular symptoms were more commonly recorded in the patients with vitamin B12 deficiency. Distal dysesthesia was more commonly present in patients with deficient (p 0.044) than in patients with normal vitamin B12 levels. Ataxia and Romberg’s sign positivity were more common in patients with vitamin B12 deficiency when compares to normal vitamin B12 levels (p 0.002 and 0.006, respectively). Conclusion: The study shows that vitamin B12 deficiency is a common problem among elderly and the treating physician should have high index of suspicion when they present with neurological complaints

scholarly journals ANEMIA AND VITAMIN B12 DEFICIENCY IN ELDERLY.

2018 ◽  
Vol 11 (1) ◽  
pp. 402
Author(s):  
Zaozianlungliu Gonmei ◽  
Supriya Dwivedi ◽  
Gurudayal Singh Toteja ◽  
Karuna Singh ◽  
Naval Kishore Vikram ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Elderly Population ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Serum Homocysteine ◽  
B12 Deficiency ◽  
Prevalence Of Anemia

 Objective: The present study was carried out to assess the prevalence of anemia, vitamin B12 deficiency and hyperhomocysteinemia among elderly in slums of West Delhi.Methods: A cross-sectional study was carried out among 234 elderly aged 60 and above in slums of West Delhi. 5 ml blood was collected from 116 elderly and was analyzed for hemoglobin, Vitamin B12 and homocysteine. Anemia was defined as hemoglobin <130 g/L and <120 g/l for male and female, respectively, Vitamin B12 deficiency as serum Vitamin B12 <203 pg/ml and hyperhomocysteinemia as serum homocysteine >15 μmol/l.Results: The overall prevalence of anemia, Vitamin B12 deficiency, and hyperhomocysteinemia among elderly was 57.76%, 36.36%, and 57.57%, respectively. Among anemic elderly, 33.33% and 64.15% had Vitamin B12 deficiency and hyperhomocysteinemia, respectively.Conclusion: More than half of the elderly population was anemic, while one-third was having Vitamin B12 deficiency.

scholarly journals ANEMIA AND VITAMIN B12 DEFICIENCY IN ELDERLY.

2018 ◽  
Vol 11 (1) ◽  
pp. 402 ◽  
Author(s):  
Zaozianlungliu Gonmei ◽  
Supriya Dwivedi ◽  
Gurudayal Singh Toteja ◽  
Karuna Singh ◽  
Naval Kishore Vikram ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Elderly Population ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Serum Homocysteine ◽  
B12 Deficiency ◽  
Prevalence Of Anemia

 Objective: The present study was carried out to assess the prevalence of anemia, vitamin B12 deficiency and hyperhomocysteinemia among elderly in slums of West Delhi.Methods: A cross-sectional study was carried out among 234 elderly aged 60 and above in slums of West Delhi. 5 ml blood was collected from 116 elderly and was analyzed for hemoglobin, Vitamin B12 and homocysteine. Anemia was defined as hemoglobin <130 g/L and <120 g/l for male and female, respectively, Vitamin B12 deficiency as serum Vitamin B12 <203 pg/ml and hyperhomocysteinemia as serum homocysteine >15 μmol/l.Results: The overall prevalence of anemia, Vitamin B12 deficiency, and hyperhomocysteinemia among elderly was 57.76%, 36.36%, and 57.57%, respectively. Among anemic elderly, 33.33% and 64.15% had Vitamin B12 deficiency and hyperhomocysteinemia, respectively.Conclusion: More than half of the elderly population was anemic, while one-third was having Vitamin B12 deficiency.

scholarly journals Prevalence of vitamin B12 deficiency in type 2 diabetic patients using metformin: a cross-sectional study

2016 ◽  
Vol 134 (6) ◽  
pp. 473-479 ◽  
Author(s):  
Charbel Pereira Damião ◽  
Amannda Oliveira Rodrigues ◽  
Maria Fernanda Miguens Castellar Pinheiro ◽  
Rubens Antunes da Cruz Filho ◽  
Gilberto Peres Cardoso ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
H2 Antagonists ◽  
H2 Antagonist ◽  
B12 Deficiency

ABSTRACT: CONTEXT AND OBJECTIVE: The prevalence of vitamin B12 deficiency varies from 5.8% to 30% among patients undergoing long-term treatment with metformin. Because of the paucity of data on Brazilian patients, this study aimed to determine the frequency of B12 deficiency and related factors among Brazilian patients with type 2 diabetes mellitus (T2DM) using metformin. DESIGN AND SETTING: Cross-sectional study at a public university hospital. METHODS: Patients with T2DM and a control group of non-diabetics were included. Serum B12 levels were measured and biochemical B12 deficiency was defined as serum levels < 180 pg/ml. Associations between B12 deficiency and age, duration of T2DM, duration of use and dosage of metformin, and use of proton pump inhibitors (PPIs) or histamine H2 antagonists were determined. RESULTS: 231 T2DM patients using metformin (T2DM-met) and 231 controls were included. No difference in the frequency of PPI or H2-antagonist use was seen between the groups. B12 deficiency was more frequent in the T2DM-met group (22.5% versus 7.4%) and this difference persisted after excluding PPI/H2-antagonist users (17.9% versus 5.6%). The factors that interfered with serum B12 levels were PPI/H2-antagonist use and duration of metformin use ≥ 10 years. Use of PPI/H2-antagonists was associated with B12 deficiency, with an odds ratio of 2.60 (95% confidence interval, 1.34-5.04). CONCLUSIONS: Among T2DM patients, treatment with metformin and concomitant use of PPI/H2-antagonists are associated with a higher chance of developing B12 deficiency than among non-diabetics.

scholarly journals Vitamin B12 Deficiency in Diabetic Patients on Metformin Therapy: A cross-sectional study from Oman

2020 ◽  
Vol 20 (1) ◽  
pp. 90
Author(s):  
Ahmed Al-Hamdi ◽  
Mohammed Al-Gahhafi ◽  
Shihab Al-Roshdi ◽  
Sanjay Jaju ◽  
Ali Al-Mamari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
Metformin Therapy ◽  
B12 Deficiency

Objectives: This study aimed to determine the prevalence of vitamin B12 deficiency amongst diabetic patients on metformin therapy. Methods: This cross-sectional study was conducted at general clinics at the University Health Center and diabetes outpatient clinics at Sultan Qaboos University Hospital, Muscat, Oman, between January and December 2017. All Omani adults who were diagnosed with type 2 diabetes mellitus and took metformin were invited to participate in the study. The variables included in this study were age, gender, duration of diabetes, dose and duration of metformin therapy, haemoglobin and glycosylated haemoglobin level. Results: A total of 248 subjects were included (response rate = 95.4%) of which 26 (10.5%) were vitamin B12 deficient and 53 (21.4%) were borderline deficient. The mean daily dose of metformin was highest among vitamin B12 deficient group (1,981 ± 222 mg; P = 0.004). Conclusion: The prevalence of vitamin B12 deficiency is considerable among diabetic patients on metformin therapy. Further research is needed to confirm the need for routine screening and monitoring.Keywords: Type 2 Diabetes Mellitus; Prevalence; Metformin; Vitamin B12 Deficiency; Oman.

Vitamin B12 Deficiency and the Role of Gender: A Cross-Sectional Study of a Large Cohort

2018 ◽  
Vol 72 (4) ◽  
pp. 265-271 ◽  
Author(s):  
Ili Margalit ◽  
Eytan Cohen ◽  
Elad Goldberg ◽  
Ilan Krause
Keyword(s):  
Gender Differences ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Folate Deficiency ◽  
Cross Sectional Study ◽  
Sensitivity Analyses ◽  
Healthy Population ◽  
Sectional Study ◽  
Cross Sectional ◽  
B12 Deficiency

Background: Vitamin B12 deficiency is associated with hematological, neurological, and cardiovascular consequences. Epidemiologic data on these related illnesses indicate gender differences. Methods: A cross-sectional study was designed to examine gender differences in vitamin B12 deficiency among a healthy population. Data from healthy individuals aged 18–65, who were provided with a routine medical evaluation during 2000–2014, were retrieved from the medical charts. Individuals with background illnesses and those who had used medications or nutritional supplements were excluded. Vitamin B12 deficiency was defined by 2 cutoff values (206 and 140 pmol/L). The multivariate analysis was adjusted for age, body mass index, estimated glomerular filtration rate, hyperhomocysteinemia, folate deficiency, albumin, and transferrin saturation. Sensitivity analyses were implemented by excluding individuals with anemia, hyperhomocysteinemia, or folate deficiency and by age stratification. Results: In all, 7,963 individuals met the inclusion criteria. Serum vitamin B12 mean levels were 312.36 and 284.31 pmol/L for women and men respectively (p < 0.001). Deficiency prevalence was greater for men (25.5%) in comparison with women (18.9%; p < 0.001). Men were strongly associated with severe deficiency (adjusted OR 2.26; 95% CI 1.43–3.56). Conclusions: Among the healthy population, men are susceptible to vitamin B12 deficiency. This can be explained by neither diet habits nor estrogen effects. Genetic variations are therefore hypothesized to play a role.

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