scholarly journals Spray dried proliposomes of Rosmarinus officinalis polyphenols: a quality by design approach

2018 ◽  
Author(s):  
Wanderley Pereira Oliveira ◽  
Victor Oloruntoba Bankole ◽  
Claudia Regina F. Souza
Keyword(s):  
Statistical Analysis ◽  
Quality By Design ◽  
Viable Option ◽  
Replacement Method ◽  
Bioactive Content ◽  
Liposomal Suspension ◽  
Solvent Replacement ◽  
Quality By Design Approach ◽  
Central Composite ◽  
Spray Dried

Harnessing the benefits of rosemary polyphenols is limited by variability in their physicochemical properties. These limitations may be overcome by encapsulation in systems possessing hydro-lipophilic centers thereby accommodating molecules of different polarities. Proliposomes offer a viable option in this regards, being particles which form liposomal suspension in water. Lyophilized extracts of rosemary was encapsulated in hydrogenatedsoyphosphatidylcholine/cholesterol by solvent replacement method. Spray dried proliposomes were obtained with lactose as carrier. Using Central Composite Design, the effects of lipid, extract and carrier concentrations on response variables including bioactive content and retention, moisture content characteristics, recuperation and redispersibility were evaluated by statistical analysis. Keywords: Polyphenols; antioxidant;  proliposomes; spray drying

scholarly journals Spray drying of lipid nanosystems (SLN and NLC) loaded with Syzygium aromaticum essential oil

2018 ◽  
Author(s):  
Debora Morais Rosa ◽  
Wanderley Pereira Oliveira
Keyword(s):  
Oleic Acid ◽  
Essential Oil ◽  
Physicochemical Properties ◽  
Spray Drying ◽  
Quality By Design ◽  
Syzygium Aromaticum ◽  
Independent Variables ◽  
Quality By Design Approach ◽  
Drying Conditions ◽  
Spray Dried

A quality by design approach was used to investigate the influence of formulation composition and spray drying conditions on physicochemical properties of redispersable lipid based nanosystems loaded with Syzygium aromaticum essential oil. Four critical independent variables were studied: presence or absence of the liquid lipid oleic acid (0% - 1%), of the cationic surfactant CTAB (0% and 1%), inlet drying temperature (60 ºC -80 ºC), and ratio of the drying aids (ADJ) regarded to total formulation constituents weight (1:1 and 2:1). Resuls showed the production of spray dried redispersable  lipid systems loaded with essential is feasible under very restrict conditions. Keywords: Encapsulation; lipid systems; essential oil; spray drying; redispersable.

Spray dried amikacin powder for inhalation in cystic fibrosis patients: A quality by design approach for product construction

2014 ◽  
Vol 471 (1-2) ◽  
pp. 507-515 ◽  
Author(s):  
Silvia Belotti ◽  
Alessandra Rossi ◽  
Paolo Colombo ◽  
Ruggero Bettini ◽  
Dimitrios Rekkas ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Quality By Design ◽  
Design Approach ◽  
Product Construction ◽  
Quality By Design Approach ◽  
Spray Dried

Statistical analysis on conductivity of MC-KOH-PEG membrane using central composite design

2021 ◽  
Author(s):  
S. Abdullah ◽  
K.S.A. Latif ◽  
M.B. Besar ◽  
N.A.M. Zu ◽  
N. Hashim ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Central Composite Design ◽  
Central Composite

Development of novel cocrystal-based active food packaging by a Quality by Design approach

2021 ◽  
Vol 347 ◽  
pp. 129051
Author(s):  
Federica Bianchi ◽  
Fabio Fornari ◽  
Nicolò Riboni ◽  
Costanza Spadini ◽  
Clotilde Silvia Cabassi ◽  
...  
Keyword(s):  
Food Packaging ◽  
Quality By Design ◽  
Design Approach ◽  
Active Food Packaging ◽  
Quality By Design Approach

A SIMPLE AND SELECTIVE ELECTROCHEMICAL MAGNETO-ASSAY FOR SEA LICE eDNA DETECTION DEVELOPED WITH A QUALITY BY DESIGN APPROACH

2021 ◽  
pp. 148111
Author(s):  
Francesca Bettazzi ◽  
Serena Orlandini ◽  
Luna Zhang ◽  
Serena Laschi ◽  
Mari Mæland Nilsen ◽  
...  
Keyword(s):  
Quality By Design ◽  
Design Approach ◽  
Sea Lice ◽  
Quality By Design Approach

Quality by design approach in the optimization of the spray-drying process

2011 ◽  
Vol 17 (4) ◽  
pp. 389-397 ◽  
Author(s):  
Arnaud Baldinger ◽  
Lucas Clerdent ◽  
Jukka Rantanen ◽  
Mingshi Yang ◽  
Holger Grohganz
Keyword(s):  
Spray Drying ◽  
Quality By Design ◽  
Design Approach ◽  
Drying Process ◽  
Quality By Design Approach
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