scholarly journals Hypercoagulable Thrombophilic Defect and Hyperhomocysteinemia with Recurrent Pregnancy Loss

2016 ◽  
Vol 2 (3) ◽  
pp. 50-52
Author(s):  
PG Rooplata ◽  
Nagendra Prasad
Keyword(s):  
Pregnancy Loss ◽  
Intrauterine Growth Retardation ◽  
Recurrent Pregnancy Loss ◽  
Placental Abruption ◽  
Fetal Outcome ◽  
Intrauterine Fetal Death ◽  
Placental Perfusion ◽  
Intrauterine Growth ◽  
Changes In Pregnancy ◽  
Physiological Changes In Pregnancy

ABSTRACT Successful fetal outcome in any pregnancy is dependent on adequate placental circulation. Normal physiological changes in pregnancy produce a hypercoagulable state. Placental vasculature abnormalities may result in a number of gestational defects. They also can cause loss of pregnancy, intrauterine fetal death, intrauterine growth retardation, placental abruption, and preeclampsia. Hereditary thrombophilias are usually undiagnosed because most carriers are asymptomatic. Placental perfusion may be compromised by increased thrombosis that leads to pregnancy complications and recurrent pregnancy loss (RPL). We report a case of hypercoagulable thrombophilic defect and hyperhomocysteinemia with RPL. How to cite this article Rooplata PG, Nagarathnamma R, Prasad N. Hypercoagulable Thrombophilic Defect and Hyperhomocysteinemia with Recurrent Pregnancy Loss. J Med Sci 2016;2(3):50-52.

O-008 Improving outcomes in women with Mullerian anomalies

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
J Malhotra ◽  
N Malhotra ◽  
N Malhotra
Keyword(s):  
Pregnancy Loss ◽  
Intrauterine Growth Retardation ◽  
Recurrent Pregnancy Loss ◽  
Recurrent Miscarriage ◽  
Obstetric Outcome ◽  
Mullerian Anomalies ◽  
Intrauterine Growth ◽  
Müllerian Anomalies ◽  
Different Types ◽  
Registration Number

Abstract text Mullerian Anomalies are present in approximately 5% to 7% of the general population and the incidence is a little more in infertile and recurrent miscarriage women. Most of the recent studies have reported that the obstetric outcome is compromised in this group with greater risk of infertility, recurrent pregnancy loss, intrauterine growth retardation, preterm birth and many other obstetric complications, which may be individually related to the different types of Mullerian Anomalies. In this presentation, We are going to discuss on how the outcomes are different in the various Mullerian Anomalies depending upon the degree of the defects related to different complications with more profound defects. We will also discuss on how to optimize the pregnancy outcomes with various interventions and what the literature review supports. Trial registration number Study funding Funding source

scholarly journals Hyperhomocysteinemia in Recurrent pregnancy loss

2017 ◽  
Vol 6 (7) ◽  
pp. 2919 ◽  
Author(s):  
Nisha Bhatia ◽  
Hemanshu B.
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Growth Retardation ◽  
Pregnancy Complications ◽  
Pregnancy Loss ◽  
Intrauterine Growth Retardation ◽  
Low Birthweight ◽  
Recurrent Pregnancy Loss ◽  
Hypertensive Disorder ◽  
Intrauterine Growth

Background: Hyperhomocysteinemia is associated with many pregnancy related complications. Its association with recurrent pregnancy loss has been investigated recently. Not only it is associated with recurrent pregnancy loss but also associated with complications like Preeclampsia, intrauterine growth retardation and low birth weight. The objective of this study to assess the prevalence of Hyperhomocysteinemia in patients with unexplained recurrent pregnancy loss and to evaluate the association of hyperhomocysteinemia with pregnancy complications in patients of recurrent pregnancy loss.Methods: 50 Patients of unexplained recurrent pregnancy loss were selected as cases and 50 patients with atleast one successful pregnancy were taken as controls. Their blood sample was assayed for Fasting Homocysteine levels. They were followed up throughout pregnancy for any complications and neonatal outcome was recorded.Results: 19 patients out of the 50 cases had Hyperhomocysteinemia. Hyperhomocysteinemia was thrice more common in Primary aborters when compared to secondary aborters. Out of 19 patients with hyperhomocysteinemia in patients with recurrent pregnancy loss, 14 patients also developed Hypertensive disorder of pregnancy during their antenatal period. Among patients with Hyperhomocysteinemia in study group, 47% had low birthweight babies when compared to 25% among control group.Conclusions: Hyperhomocysteinemia is associated with recurrent pregnancy loss and patients of Recurrent pregnancy loss who have Hyperhomocysteinemia have a higher risk of developing pregnancy complications like Preeclampsia, low birth weight and Intrauterine growth retardation.

scholarly journals Women with a History of Recurrent Pregnancy Loss Are a High-Risk Population for Adverse Obstetrical Outcome: A Retrospective Cohort Study

2021 ◽  
Vol 10 (2) ◽  
pp. 179
Author(s):  
Emma Rasmark Roepke ◽  
Ole Bjarne Christiansen ◽  
Karin Källén ◽  
Stefan R. Hansson
Keyword(s):  
Cohort Study ◽  
Preterm Birth ◽  
Pregnancy Complications ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Placental Abruption ◽  
Late Pregnancy ◽  
High Risk Population ◽  
Risk Population ◽  
Increased Risk

Recurrent pregnancy loss (RPL), defined as three or more consecutive miscarriages, is hypothesized to share some of the same pathogenic factors as placenta-associated disorders. It has been hypothesized that a defect implantation causes pregnancy loss, while a partially impaired implantation may lead to late pregnancy complications. The aim of this retrospective register-based cohort study was to study the association between RPL and such disorders including pre-eclampsia, stillbirth, small for gestational age (SGA) birth, preterm birth and placental abruption. Women registered with childbirth(s) in the Swedish Medical Birth Register (MFR) were included in the cohort. Pregnancies of women diagnosed with RPL (exposed) in the National Patient Register (NPR), were compared with pregnancies of women without RPL (unexposed/reference). Obstetrical outcomes, in the first pregnancy subsequent to the diagnosis of RPL (n = 4971), were compared with outcomes in reference-pregnancies (n = 57,410). Associations between RPL and placental dysfunctional disorders were estimated by odds ratios (AORs) adjusting for confounders, with logistic regression. RPL women had an increased risk for pre-eclampsia (AOR 1.45; 95% CI; 1.24–1.69), stillbirth <37 gestational weeks (GWs) (AOR 1.92; 95% CI; 1.22–3.02), SGA birth (AOR 1.97; 95% CI; 1.42–2.74), preterm birth (AOR 1.46; 95% CI; 1.20–1.77), and placental abruption <37 GWs (AOR 2.47; 95% CI; 1.62–3.76) compared with pregnancies by women without RPL. Women with RPL had an increased risk of pregnancy complications associated with placental dysfunction. This risk population is, therefore, in need of improved antenatal surveillance.

scholarly journals Pregnancy-Related Complications in Women with Recurrent Pregnancy Loss: A Prospective Cohort Study

2020 ◽  
Vol 9 (9) ◽  
pp. 2833 ◽  
Author(s):  
Carlo Ticconi ◽  
Adalgisa Pietropolli ◽  
Monia Specchia ◽  
Elena Nicastri ◽  
Carlo Chiaramonte ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Pregnancy Complications ◽  
Prospective Cohort ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Placenta Previa ◽  
Intrauterine Fetal Death ◽  
Healthy Women ◽  
Increased Risk

The aim of this prospective cohort study was to determine whether women with recurrent pregnancy loss (RPL) have an increased risk of pregnancy complications compared to normal pregnant women. A total of 1092 singleton pregnancies were followed, 431 in women with RPL and 661 in normal healthy women. The prevalence of the following complications was observed: threatened miscarriage, miscarriage, cervical insufficiency, chromosomal/genetic abnormalities, fetal anomalies, oligohydramnios, polyhydramnios, fetal growth restriction, intrauterine fetal death, gestational diabetes mellitus (GDM), preeclampsia, placenta previa, abruptio placentae, pregnancy-related liver disorders, and preterm premature rupture of the membranes. The odds ratio and 95% CI for each pregnancy complication considered were determined by comparing women with RPL and normal healthy women. Women with RPL had an overall rate of pregnancy complications higher than normal women (OR = 4.37; 95% CI: 3.353–5.714; p < 0.0001). Their risk was increased for nearly all the conditions considered. They also had an increased risk of multiple concomitant pregnancy complications (OR = 4.64; 95% CI: 3.10–6.94, p < 0.0001). Considering only women with RPL, women with ≥3 losses had a higher risk of pregnancy complications than women with two losses (OR = 1.269; 95% CI: 1.112–2.386, p < 0.02). No differences were found in the overall risk of pregnancy complications according to the type, explained or unexplained, of RPL. Women with secondary RPL had an increased risk of GDM than women with primary RPL. Pregnancy in women with RPL should be considered at high risk.

Blood viscosity and placental perfusion in intrauterine growth retardation

2016 ◽  
Vol 7 (2) ◽  
pp. 305-310
Author(s):  
J. Bodis ◽  
L. Bogar ◽  
K. Zambo ◽  
Z. Nemessanyi ◽  
M. Tekeres ◽  
...  
Keyword(s):  
Growth Retardation ◽  
Blood Viscosity ◽  
Intrauterine Growth Retardation ◽  
Placental Perfusion ◽  
Intrauterine Growth

scholarly journals Oligohydramnios and fetal outcome in term pregnancy

2020 ◽  
Vol 24 (3) ◽  
pp. 347-353
Author(s):  
Hazha Ibrahim ◽  
Zainab Zween
Keyword(s):  
Birth Weight ◽  
Cesarean Section ◽  
Amniotic Fluid ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Comparison Group ◽  
Fetal Outcome ◽  
Perinatal Morbidity ◽  
Amniotic Fluid Index ◽  
Intrauterine Growth

Background and objective: Oligohydramnios is defined as an amniotic fluid index less than 5th centile for gestation. It presents a threat to the fetus and has been correlated with increased risk of intrauterine growth retardation, meconium aspiration syndrome, severe birth asphyxia, low APGAR scores, and congenital abnormalities. It is associated with perinatal morbidity and mortality and maternal morbidity in a significant number of cases. Therefore, early detection of oligohydramnios and its management is important. This study aimed to determine the perinatal and maternal outcomes in oligohydramnios. Methods: This retrospective cohort study was carried out at the Maternity Teaching Hospital in Erbil from March 2018 to March 2019. A total of 300 patients were recruited, including 150 pregnant women with oligohydramnios and 150 with normal amniotic fluid index. Results: There was a significant difference between the oligohydramnios group and the comparison group in relation to parity and gestational age. Oligohydramnios was more among primigravids. The rate of cesarean section was higher in oligohydramnios group compared to the comparison group. Intrauterine growth retardation among oligohydramnios group was 13%. Oligohydramnios was associated with birth weight <2500 gm (21.3%). Conclusion: Antepartum diagnosis of severe oligohydramnios at term was associated with an increased cesarean section rate, a higher rate of admission of neonatal care unit, and low birth weight. Therefore, antepartum oligohydramnios is associated with increased perinatal morbidity and mortality. Keywords: Amniotic fluid index; Maternal outcome; Fetal outcome; Oligohydramnios.

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