scholarly journals Comparison of High-Dose Corticosteroid Pulse Therapy and Combination Therapy Using Oral Cyclosporine with Low-Dose Corticosteroid in Severe Alopecia Areata

2015 ◽  
Vol 27 (6) ◽  
pp. 676 ◽  
Author(s):  
In Kwon Yeo ◽  
Eun Jung Ko ◽  
Yeon A No ◽  
Ee Seok Lim ◽  
Kui Young Park ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Alopecia Areata ◽  
Low Dose ◽  
Pulse Therapy ◽  
High Dose ◽  
High Dose Corticosteroid ◽  
Corticosteroid Pulse Therapy ◽  
Dose Corticosteroid

High-Dose Corticosteroid Pulse Therapy Increases the Survival Rate in COVID-19 Patients at Risk of Cytokine Storm

2020 ◽  
Author(s):  
Miguel Ángel López-Zúñiga ◽  
Aida Moreno-Moral ◽  
Ana Ocaña-Granados ◽  
Francisco Padilla-Moreno ◽  
Alba María Castillo-Fernández ◽  
...  
Keyword(s):  
At Risk ◽  
Survival Rate ◽  
Pulse Therapy ◽  
High Dose ◽  
Cytokine Storm ◽  
High Dose Corticosteroid ◽  
Patients At Risk ◽  
Corticosteroid Pulse Therapy ◽  
Dose Corticosteroid

scholarly journals Reversible blindness after erroneous prescription of closantel: A case report

2021 ◽  
Author(s):  
Hamed Cheraghmakani ◽  
Reza Jafari ◽  
Elahe Karimpour-razkenari ◽  
monireh Ghazaeian
Keyword(s):  
Case Report ◽  
Plasma Exchange ◽  
Vision Loss ◽  
Pulse Therapy ◽  
High Dose ◽  
High Dose Corticosteroid ◽  
Peripheral Nerve Fiber ◽  
Corticosteroid Pulse Therapy ◽  
Dose Corticosteroid

A 20-year-old girl referred with vision loss upon closantel use. Plasma exchange and high-dose corticosteroid pulse therapy were administered. A 2.5-year follow-up showed improved vision and increased layer thickness of the peripheral nerve fiber. Early treatment with plasma exchange and high-dose corticosteroid therapy can be beneficial to reverse closantel toxicity.

Electrocardiographic changes after high-dose corticosteroid pulse therapy in pemphigus patients

2018 ◽  
Vol 29 (8) ◽  
pp. 802-805 ◽  
Author(s):  
Mehdi Pishgahi ◽  
Sahar Dadkhahfar ◽  
Reza M. Robati ◽  
Zohreh Kheradmand ◽  
Mohammad Shahidi-Dadras ◽  
...  
Keyword(s):  
Pulse Therapy ◽  
High Dose ◽  
High Dose Corticosteroid ◽  
Electrocardiographic Changes ◽  
Corticosteroid Pulse Therapy ◽  
Dose Corticosteroid

Bone Complications of Corticosteroids

1996 ◽  
Vol 1 (1) ◽  
pp. 50-57 ◽  
Author(s):  
Robert S. Lester
Keyword(s):  
Corticosteroid Therapy ◽  
Low Dose ◽  
Treatment Options ◽  
Osteoporotic Fractures ◽  
High Dose ◽  
Systemic Complications ◽  
High Dose Corticosteroid ◽  
Systemic Corticosteroids ◽  
Dose Corticosteroid ◽  
Bone Complications

Background: Systemic corticosteroids, a mainstay of treatment for severe dermatosis, are associated with systemic complications. Adverse effects of corticosteroids to bone represent a significant adverse effect that, is poorly understood and poorly managed. Objectives: The purpose of this article is to educate dermatologists to the current understanding of the pathogenesis, diagnosis, and treatment options available for bone complications of corticosteroids. Results: Virtually all patients chronically exposed to high-dose corticosteroid therapy lose bone mass and are at risk for osteoporotic fractures. In addition, osteonecrosis is an unpredictable complication of corticosteroid therapy that may occur with even low-dose corticosteroids. Conclusion: Optimal risk management of corticosteroid therapy includes understanding the risk factors associated with bone complications and improving communication with patients.

scholarly journals High-dose corticosteroid pulse therapy increases the survival rate in COVID-19 patients at risk of hyper-inflammatory response

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0243964
Author(s):  
Miguel Ángel López Zúñiga ◽  
Aida Moreno-Moral ◽  
Ana Ocaña-Granados ◽  
Francisco Andrés Padilla-Moreno ◽  
Alba María Castillo-Fernández ◽  
...  
Keyword(s):  
At Risk ◽  
Inflammatory Response ◽  
Time Course ◽  
Survival Rates ◽  
Pulse Therapy ◽  
High Dose ◽  
High Dose Corticosteroid ◽  
Laboratory Markers ◽  
Patients At Risk ◽  
Dose Corticosteroid

Objective Test whether high dose corticosteroid pulse therapy (HDCPT) with either methylprednisolone or dexamethasone is associated with increased survival in COVID-19 patients at risk of hyper-inflammatory response. Provide some initial diagnostic criteria using laboratory markers to stratify these patients. Methods This is a prospective observational study, 318 met the inclusion criteria. 64 patients (20.1%) were treated with HDCPT by using at least 1.5mg/kg/24h of methylprednisolone or dexamethasone equivalent. A multivariate Cox regression (controlling for co-morbidities and other therapies) was carried out to determine whether HDCPT (among other interventions) was associated with decreased mortality. We also carried out a 30-day time course analysis of laboratory markers between survivors and non-survivors, to identify potential markers for patient stratification. Results HDCPT showed a statistically significant decrease in mortality (HR = 0.087 [95% CI 0.021–0.36]; P < 0.001). 30-day time course analysis of laboratory marker tests showed marked differences in pro-inflammatory markers between survivors and non-survivors. As diagnostic criteria to define the patients at risk of developing a COVID-19 hyper-inflammatory response, we propose the following parameters (IL-6 > = 40 pg/ml, and/or two of the following: C-reactive protein > = 100 mg/L, D-dimer > = 1000 ng/ml, ferritin > = 500 ng/ml and lactate dehydrogenase > = 300 U/L). Conclusions HDCPT can be an effective intervention to increase COVID-19 survival rates in patients at risk of developing a COVID-19 hyper-inflammatory response, laboratory marker tests can be used to stratify these patients who should be given HDCPT. This study is not a randomized clinical trial (RCT). Future RCTs should be carried out to confirm the efficacy of HDCPT to increase the survival rates of COVID-19.

scholarly journals Switch from previous major depression comorbid with CLIPPERS to mania-like episode following glucocorticosteroid therapy: a case report

2018 ◽  
Vol 31 (1) ◽  
pp. e000007
Author(s):  
Xiaohua Liu ◽  
Yan Wu
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Episode ◽  
Psychiatric Symptoms ◽  
Medical Condition ◽  
Pulse Therapy ◽  
High Dose ◽  
Major Depressive ◽  
High Dose Corticosteroid ◽  
Psychiatric Disturbances ◽  
Dose Corticosteroid

Bipolar disorder is associated with high rates of general medical conditions, but few cases of overlap between bipolar disorder and chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) have been reported in the current literature. The following is a case of a 29-year-old patient with a previous major depressive episode comorbid with CLIPPERS. Following glucocorticosteroid therapy, the patient switched to mania-like presentation and was diagnosed with bipolar disorder due to another medical condition. So it is strongly suggested that high-dose corticosteroid pulse therapy could easily induce psychiatric disturbances for patients with previous psychiatric symptoms, and there may be potential links between bipolar disorder and CLIPPERS in the area of inflammation.

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