Comparison of inflammatory markers in non-dipper hypertension vs. dipper hypertension and in normotensive individuals: uric acid, C-reactive protein and red blood cell distribution width readings

Aims: Psoriasis is an inflammatory skin disease with several comorbidities. We aimed to evaluate red blood cell distribution width (RDW), platelet parameters and inflammatory markers in patients on antipsoriasis therapies. Methods: 94 psoriasis patients and 74 healthy controls were prospectively analyzed. Before and after 8 weeks of different therapies (calcipotriol+clobetasol propionate; narrow-band UVB; combined narrow-band UVB and acitretin; infliximab and adalimumab), red blood cell distribution width (RDW), platelet parameters, high sensitivity C reactive protein (hs-CRP), and erythrocyte sedimentation rate (ESR) levels were measured. Lipid profile and fasting blood glucose tests were also performed prior the treatment. Psoriasis severity and area index (PASI) and body mass index (BMI) were calculated for each patient. Results: RDW, hs-CRP, triglyceride, total cholesterol levels and BMI were higher in patients than in controls (p<0.05, for all four). No significant differences were observed in RDW, platelet parameters, hs-CRP and ESR levels after all therapies (p>0.05, for all). RDW was not correlated with PASI (p>0.05). Conclusion: Psoriasis patients should be screened for dyslipidemia and obesity. Antipsoriasis therapies do not have any effect on inflammatory markers. Further studies are needed to elucidate the use of RDW and platelet parameters as an inflammatory marker in psoriasis.

Download Full-text

Multimarker approach with cystatin C, N-terminal pro-brain natriuretic peptide, C-reactive protein and red blood cell distribution width in risk stratification of patients with acute coronary syndromes

Revista Portuguesa de Cardiologia (English Edition) ◽

10.1016/j.repce.2013.09.013 ◽

2014 ◽

Vol 33 (3) ◽

pp. 127-136

Author(s):

Catarina Vieira ◽

Sérgio Nabais ◽

Vítor Ramos ◽

Carlos Braga ◽

António Gaspar ◽

...

Keyword(s):

Risk Stratification ◽

Blood Cell ◽

Brain Natriuretic Peptide ◽

Acute Coronary Syndromes ◽

Cell Distribution ◽

C Reactive Protein ◽

Distribution Width ◽

Reactive Protein ◽

Coronary Syndromes ◽

Red Blood Cell Distribution

Download Full-text

The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke

Frontiers in Physiology ◽

10.3389/fphys.2021.631369 ◽

2021 ◽

Vol 12 ◽

Author(s):

Ning Rong ◽

Pei Zhao ◽

Jin Yang ◽

Qing-Lei Fan ◽

Qiang Zhang ◽

...

Keyword(s):

Uric Acid ◽

Ischemic Stroke ◽

Blood Cell ◽

Acute Ischemic Stroke ◽

Serum Uric Acid ◽

Red Blood Cell ◽

Turning Point ◽

Cell Distribution ◽

Distribution Width ◽

Red Blood Cell Distribution

Objective: The U-shaped association between serum uric acid (SUA) and the functional outcome has been found in acute ischemic stroke (AIS). However, it is unclear if SUA is associated with red blood cell morphology in AIS. This study aimed to determine the relationship between SUA and red blood cell distribution width (RDW) in patients with AIS.Methods: A cross-sectional study including 438 consecutive patients with AIS was conducted. SUA and RDW, biochemical parameters that reflect the heterogeneity of red blood cell volume, were evaluated on admission. We evaluated the association between SUA and RDW through linear curve fitting analyses and two-piecewise regression analyses.Results: The association between SUA levels and RDW followed a U-shape in all patients. In females, the values of RDW significantly decreased with the increment of SUA (per mg/dl: β, −1.45; 95% CI: −2.15 to −0.75; p < 0.001) in patients with SUA <3.86 mg/dl and increased with the increment of SUA (per mg/dl: β, 0.60; 95% CI: 0.22–0.97; p = 0.002) in patients with SUA ≥ 3.86 mg/dl. Similar results were observed in males with the turning point of SUA = 4.82 mg/dl. After adjusting for potential confounders, a U-shaped association between SUA and RDW was maintained in females, but no statistical significance was maintained in patients with SUA ≥ 4.82 mg/dl in males (p = 0.206).Conclusion: In the sample of patients with AIS, we found a U-shaped relationship between SUA levels and RDW, with the turning point of SUA (3.96 mg/dl in females and 4.82 mg/dl in males) by the threshold effect analysis.

Download Full-text