A comparative study of glycaemic variability using four different Point-of-Care Testing (POCT) devices

Background: Blood glucose measurement is a way of monitoring changes in glycaemia. Different point-of-care testing (POCT) glucose meters are on the market and hence there is an increase in variability of the results given by these meters. This study sought to measure the glycaemic variability using four different point-of-care glucose meters Methods: Four point of care glucometers namely; Accu-chek performer nano, OneTouch select plus flex, OneTouch Ultra 2 and Easy Check were used test blood samples from a total of 100 patients visiting the collection point of the Tamale Teaching Hospital Laboratory. A chemistry analyzer (Mindray BS 240 fully automated) was used as the reference method. Results: The median (interquartile range), Bland Altman Plot and Regression Equation were used to assess the agreement between the various meters and the reference method. The OneTouch Select plus had the least bias (-0.85) and the the OneTouch Ultra 2 had the highest bias (1.49). The OneTouch select had the best limits of agreement (-2.51 – 0.82) and the OneTouch Ultra 2 had the widest limits of agreement (-1.91 – 4.89) when compared to the reference method. Conclusion: OneTouch Select plus had the best agreement with the reference method and the OneTouch Ultra 2 had the least agreement with the reference method. Blood glucose meters should be used for the monitoring of blood glucose however, it should not be used as a diagnostic tool. Annals of Medical Laboratory Science (2021) 1(2), 1 - 8 Keywords: glucometer, point-of-care, blood glucose, glycaemia

Download Full-text

Applying the floating-reference method to improve the precision of noninvasive blood glucose measurement

10.1117/12.699501 ◽

2007 ◽

Cited By ~ 2

Author(s):

Wenliang Chen ◽

Zhen Ma ◽

Lin An ◽

Kexin Xu

Keyword(s):

Blood Glucose ◽

Reference Method ◽

Blood Glucose Measurement ◽

Glucose Measurement

Download Full-text

Blood Glucose: Measurement in the Point-of-Care Setting

Laboratory Medicine ◽

10.1309/4bf1-et6t-wfe3-m7xa ◽

2000 ◽

Vol 31 (5) ◽

pp. 276-282 ◽

Cited By ~ 19

Author(s):

Frederick L. Kiechle ◽

Rhonda Ingram Main

Keyword(s):

Blood Glucose ◽

Care Setting ◽

Point Of Care ◽

Blood Glucose Measurement ◽

Glucose Measurement

Download Full-text

Inaccurate point‐of‐care blood glucose measurement in a dog with secondary erythrocytosis

Journal of Veterinary Emergency and Critical Care ◽

10.1111/vec.12909 ◽

2019 ◽

Vol 30 (1) ◽

pp. 81-85

Author(s):

Erin R. McQuinn ◽

Austin K. Viall ◽

Margaret A. Hirschfield ◽

Jessica L. Ward ◽

Unity Jeffery ◽

...

Keyword(s):

Blood Glucose ◽

Point Of Care ◽

Blood Glucose Measurement ◽

Glucose Measurement

Download Full-text

Accuracy of Blood Glucose Measurement and Blood Glucose Targets

Journal of Diabetes Science and Technology ◽

10.1177/1932296820905581 ◽

2020 ◽

Vol 14 (3) ◽

pp. 553-559

Author(s):

Gert-Jan Eerdekens ◽

Steffen Rex ◽

Dieter Mesotten

Keyword(s):

Blood Glucose ◽

Glycemic Control ◽

Glucose Control ◽

Point Of Care ◽

Blood Glucose Control ◽

Daily Practice ◽

Tight Glycemic Control ◽

Blood Glucose Measurement ◽

Glucose Measurement ◽

Negative Results

Background: To summarize new evidence regarding the methodological aspects of blood glucose control in the intensive care unit (ICU). Methods: We reviewed the literature on blood glucose control in the ICU up to August 2019 through Ovid Medline and Pubmed. Results: Since the publication of the Leuven studies, the benefits of glycemic control have been recognized. However, the methodology of blood glucose control, notably the blood glucose measurement accuracy and the insulin titration protocol, plays an important but underestimated role. This may partially explain the negative results of the large, pragmatic multicenter trials and made everyone realize that tight glycemic control with less-frequent glucose measurements on less accurate blood glucose meters is neither feasible nor advisable in daily practice. Blood gas analyzers remain the gold standard. New generation point-of-care blood glucose meters may be an alternative when using whole blood of critically ill patients in combination with a clinically validated insulin dosing algorithm. Conclusion: When implementing blood glucose management in an ICU one needs to take into account the interaction between aimed glycemic target and blood glucose measurement methodology.

Download Full-text

Comparison of Accu Chek Inform II point-of-care test blood glucose meter with Hexokinase Plasma method for a diabetes mellitus population during surgery under general anesthesia

Journal of Clinical Monitoring and Computing ◽

10.1007/s10877-021-00656-6 ◽

2021 ◽

Author(s):

B. Lascaris ◽

H. G. Freling ◽

M. A. Edens ◽

M. J. Fokkert ◽

C. G. Olthof ◽

...

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

General Anesthesia ◽

Correlation Coefficient ◽

Clinical Laboratory ◽

Point Of Care ◽

Reference Method ◽

Glucose Measurement ◽

Point Of Care Test ◽

Arterial Blood

Abstract Purpose Blood glucose (BG) concentrations of patients with diabetes mellitus (DM) are monitored during surgery to prevent hypo- and hyperglycemia. Access to point-of-care test (POCT) glucose meters at an operating room will usually provide monitoring at shorter intervals and may improve glycemic control. However, these meters are not validated for patients under general anesthesia. Methods This cross-sectional study included 75 arterial BG measurements from 75 patients (71 with DM, mostly insulin dependent) who underwent elective non-cardiac surgery under general anesthesia. Arterial blood samples were taken at least 60 minutes after induction. One drop of blood was used for Accu Chek Inform II (ACI II) POCT BG meter and the residual blood was sent to the clinical laboratory for a Hexokinase Plasma reference method. A Bland–Altman plot was used to visualize the differences between both methods, and correlation was assessed using the intra-class correlation coefficient (ICC). Results The results showed an estimated mean difference of 0.8 mmol/L between ACI II and the reference method, with limits of agreement equal to -0.6 and 2.2 mmol/L. In general, the reference method produced higher values than ACI II. ICC was 0.955 (95% CI 0.634–0.986), P < 0.001, and concordance correlation coefficient (CCC) was 0.955 (95% CI 0.933–0.970). Conclusion Arterial BG measurements during surgery in patients with DM under general anesthesia using POCT BG meter are in general lower than laboratory measurements, but the ICC and CCC show a clinically acceptable correlation. We conclude that POCT measurements conducted on arterial specimens using the ACI II provide sufficiently accurate results for glucose measurement during surgery under general anesthesia.

Download Full-text

Point-of-care testing of blood glucose in the neonatal unit using the AVL Omni 9 analyser

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1258/000456302320314539 ◽

2002 ◽

Vol 39 (5) ◽

pp. 509-512 ◽

Cited By ~ 7

Author(s):

Julie D Newman ◽

Nerissa S Pecache ◽

Charles P Barfield ◽

Nicholas DH Balazs

Keyword(s):

Regression Analysis ◽

Blood Glucose ◽

Nursing Staff ◽

Plasma Glucose ◽

Point Of Care ◽

Neonatal Unit ◽

Blood Gas ◽

Central Laboratory ◽

Point Of Care Testing ◽

Limits Of Agreement

Background: Blood glucose measurements in newborns at risk of hypoglycaemia are an essential part of their medical management. Blood glucose measurements obtained by point-of-care testing using an AVL Omni 9 blood gas and metabolite analyser were compared with those obtained in the central laboratory using a Dade Dimension RXL analyser. Methods: Blood glucose was measured at the point of care by nursing staff using an AVL Omni 9 blood gas and metabolite analyser and compared to results obtained in the central laboratory using a DADE Dimension RXL analyser. In total, 123 samples were taken from 114 babies admitted to the neonatal unit. Results: The limits of agreement between the AVL Omni 9 and the central laboratory were 0·0±0·6 mmol/L for glucose values between 0·5 and 13 mmol/L. Regression analysis showed: AVL Omni 9 glucose = 0·977 x plasma glucose+0·14. There was also a good correlation ( r=0·92) between the AVL Omni 9 and the DADE Dimension RXL analyser for glucose values <3 mmol/L. The limits of agreement for the AVL Omni 9 when compared with the DADE Dimension RXL analyser were -0·1±0·5 mmol/L. Discussion: Point-of-care testing of blood glucose using the AVL Omni 9 blood gas and metabolite analyser is a reliable means of measuring blood glucose and has the advantage of providing a fast result using small volumes of blood.

Download Full-text

How Much Accuracy of Interstitial Glucose Measurement Is Enough? Is There a Need for New Evidence?

Journal of Diabetes Science and Technology ◽

10.1177/1932296816677578 ◽

2016 ◽

Vol 11 (2) ◽

pp. 296-298 ◽

Cited By ~ 3

Author(s):

Norbert Hermanns ◽

Dominic Ehrmann ◽

Bernhard Kulzer

Keyword(s):

Blood Glucose ◽

Point Of Care ◽

Glucose Monitoring ◽

Blood Glucose Measurement ◽

Capillary Blood ◽

Glucose Measurement ◽

Capillary Blood Glucose ◽

Measurement Systems ◽

Interstitial Glucose ◽

New Evidence

This analytical comment discusses what standards are needed for the evaluation of the accuracy of glucose measurement systems continuously measuring glucose in the interstitial fluid. Since accuracy standards for continuous glucose monitoring (CGM)/flash glucose monitoring (FGM) systems are currently based on modeling studies or consensus of experts, we raised the question whether non-inferiority trials evaluating the safety and efficacy of CGM/FGM measurements compared to capillary blood glucose measurement with point-of-care devices could help to establish clarity about the needed accuracy standards of CGM/FGM. Such trials could also support the replacement of capillary blood glucose measurements by modern CGM/FGM systems.

Download Full-text