scholarly journals The role of tissue kallikrein in helicobacter pylori-associated gastric disease

1999 ◽  
Author(s):  
◽  
Strinivasen Naidoo
Keyword(s):  
Helicobacter Pylori ◽  
World Wide ◽  
Current Therapy ◽  
Gastric Disease ◽  
Tissue Kallikrein ◽  
Gastric Diseases ◽  
Triple Regimen ◽  
Clinical Conditions ◽  
Wide Population

Today, the number one income-generating drugs are remedies prescribed for gastric disorders, in particular dyspepsia. These clinical conditions have a multi-faceted aetiology and pathology of dysfunction. One likely causal factor is the entero-pathogen Helicobacter pylori. It has been shown to be more than just a commensal related to gastric diseases like dyspepsia (80-90% incidence) and duodenal ulcer sufferers (100% incidence), with a total estimated world-wide population infection of 50%. The current therapy offered to dyspepsia sufferers is a triple regimen of an anti-bacterial, an Ir proton-pump inhibitor, and bismuth colloidal salts.

scholarly journals APLIKASI KESEHATAN MENENTUKAN JENIS PENYAKIT LAMBUNG DENGAN MENGAMBIL BEBERAPA GEJALA MENGGUNAKAN METODE FUZZY - MAMDANI

2021 ◽  
Vol 4 (1) ◽  
pp. 32
Author(s):  
Devri Suherdi Chaniago
Keyword(s):  
Expert System ◽  
Health Sector ◽  
Gastrointestinal Symptoms ◽  
Gastric Disease ◽  
Gastric Diseases ◽  
Web Based ◽  
Patient Will ◽  
Database File ◽  
Specific Symptoms

Penelitian ini dilakukan untuk mendiagnosa penyakit lambung yang lebih spesifik pada manusia yaitu grastitis, maag, kanker lambung, tumor lambung / polip lambung, dispesia, gerd, gastroparesis dan gastroenteritis,  dengan adanya gejala yang lebih spesifik maka persentase kemungkinan terjangkitnya penyakit lambung akan lebih besar. Sistem pakar untuk mendiagnosa penyakit lambung dengan menggunakan metode Fuzzy Mamdani dapat membantu meminimalisir peran dokter penyakit dalam sehingga pasien dapat lebih dini mendeteksi jenis penyakit lambung apa yang dideritanya. Sistem pakar berbasis web memungkinkan adanya peranan bidang informatika dalam bidang kesehatan dan dapat disimpan dalam file database yang besar sehingga lebih efisien, tepat sasaran dan mengikuti perkembangan dunia kedokteran. Dengan adanya gejala-gejala penyakit pecernaan yang dideteksi maka akan dapat didiagnosa jenis penyakit lambung apa yang di derita oleh pasien dengan hasil penelitian dapat mendeteksi jenis penyakit lambung, gejala-gejala dan solusi pengobatannya. This research was conducted to diagnose gastric diseases that are more specific to humans, namely grastitis, ulcers, gastric cancer, gastric tumors / gastric polyps, dyspesia, gerd, gastroparesis and gastroenteritis. With more specific symptoms, the percentage of gastric disease will be greater. An expert system for diagnosing gastric disease using the Fuzzy Mamdani method can help minimize the role of internal medicine doctors so that patients can detect what type of gastric disease they have early. The web-based expert system allows the role of informatics in the health sector and can be stored in a large database file so that it is more efficient, on target and follows developments in the medical world. With the detected gastrointestinal symptoms, the patient will be able to diagnose what type of gastric disease suffered by the patient with the results of the research being able to detect the type of gastric disease, its symptoms and treatment solutions.

OralHelicobacter pylori: Can We Stomach It?

2003 ◽  
Vol 14 (3) ◽  
pp. 226-233 ◽  
Author(s):  
S.A. Dowsett ◽  
M.J. Kowolik
Keyword(s):  
Helicobacter Pylori ◽  
Oral Cavity ◽  
Dental Plaque ◽  
Human Stomach ◽  
Future Research ◽  
Gastric Disease ◽  
Transmission Process ◽  
Dental Profession ◽  
H Pylori

Helicobacter pylori infection is one of the most common in man. The bacterium primarily resides in the human stomach, where it plays a significant role in gastric disease. If the spread of H. pylori is to be prevented, an understanding of the transmission process is essential. The oral cavity has been proposed as a reservoir for gastric H. pylori, which has been detected by culture and PCR in both dental plaque and saliva. This review will discuss the evidence for the role of the oral cavity in the transmission of gastric H. pylori. Moreover, the difficulties encountered in addressing this topic, possible directions for future research, and the implications for the dental profession are discussed.

scholarly journals Medium pH-dependent redistribution of the urease of Helicobacter pylori

2003 ◽  
Vol 52 (3) ◽  
pp. 211-216 ◽  
Author(s):  
Wu Hong ◽  
Kouichi Sano ◽  
Shinichi Morimatsu ◽  
David R. Scott ◽  
David L. Weeks ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Intracellular Transport ◽  
Acid Resistance ◽  
Gastric Disease ◽  
Acidic Ph ◽  
Gold Particles ◽  
Outer Portion ◽  
H Pylori ◽  
Extracellular Environment

Helicobacter pylori is an aetiological agent of gastric disease. Although the role of urease in gastric colonization of H. pylori has been shown, it remains unclear as to where urease is located in this bacterial cell. The purpose of this study was to define the urease-associated apparatus in the H. pylori cytoplasm. H. pylori was incubated at both a neutral and an acidic pH in the presence or absence of urea and examined by double indirect immunoelectron microscopy. The density of gold particles for UreA was greatest in the inner portion of the wild-type H. pylori cytoplasm at neutral pH but was greatest in the outer portion at acidic pH. This difference was independent of the presence of urea and was not observed in the ureI-deletion mutant. Also, the eccentric shift of urease in acidic pH was not observed in UreI. After a 2 day incubation period at acidic pH, it was observed that the urease gold particles in H. pylori assembled and were associated with UreI gold particles. Urease immunoreactivity shifted from the inner to the outer portion of H. pylori as a result of an extracellular decrease in pH. This shift was urea-independent and UreI-dependent, suggesting an additional role of UreI in urease-dependent acid resistance. This is the first report of the intracellular transport of molecules in bacteria in response to changes in the extracellular environment.

scholarly journals Immunoregulatory role of melatonin in Helicobacter pylori ‐induced gastric diseases

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Luo Jianhua ◽  
Zhang Hui ◽  
Zhang Mi ◽  
Song Jun ◽  
Li Li ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Diseases

The Role of E-cadherin in Helicobacter pylori-Related Gastric Diseases

2019 ◽  
Vol 20 (1) ◽  
pp. 23-28
Author(s):  
Yunzhan Zhang ◽  
Danyan Li ◽  
Yunkai Dai ◽  
Ruliu Li ◽  
Yong Gao ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Precancerous Lesions ◽  
Research Literature ◽  
Gastric Diseases ◽  
H Pylori ◽  
The Relationship ◽  
E Cadherin

Background: Helicobacter pylori (H. pylori)-related gastric diseases are a series of gastric mucosal disorders associated with H. pylori infection. Gastric cancer (GC) is widely believed to evolve from gastritis and gastric ulcer. As an important adhesion molecule of epithelial cells, E-cadherin plays a key role in the development of gastric diseases. In this review, we aim to seek the characteristic of E-cadherin expression at different stages of gastric diseases. Methods: We searched plenty of databases for research literature about E-cadherin expression in H. pylori-related gastric diseases, and reviewed the relationship of E-cadherin and H. pylori, and the role of E-cadherin at different stages of gastric diseases. Results: H. pylori was shown to decrease E-cadherin expression by various ways in vitro, while most of clinical studies have not found the relationship between H. pylori and E-cadherin expression. It is defined that poor outcome of GC is related to loss expression of E-cadherin, but it is still unclear when qualitative change of E-cadherin expression in gastric mucosa emerges. Conclusion: Expression level of E-cadherin in gastric cells may be a consequence of injury factors and body’s selfrepairing ability. More studies on E-cadherin expression in gastric mucosa with precancerous lesions need to be performed, which may be potential and useful for early detection, prevention and treatment of GC.

scholarly journals Current Therapy forHelicobacter pyloriInfection in Children and Adolescents

1999 ◽  
Vol 13 (7) ◽  
pp. 571-579 ◽  
Author(s):  
Benjamin D Gold
Keyword(s):  
Health Care ◽  
Helicobacter Pylori ◽  
Consensus Conference ◽  
Gastric Ulcers ◽  
Current Therapy ◽  
Consensus Conferences ◽  
Gastroduodenal Disease ◽  
Practical Guidelines ◽  
H Pylori

Helicobacter pyloriinfects approximately 50% of the world’s population and is a definitive cause of gastroduodenal disease (ie, gastritis, duodenal and gastric ulcers) in children and adults. Four consensus conferences held around the globe have brought together clinicians, scientists, epidemiologists and health care economists to discuss the role of the gastric pathogenH pyloriin human gastroduodenal disease. At each of these conferences, the overriding objective was to reach a consensus on the development of practical guidelines for the diagnosis and treatment ofH pylori-infected individuals. However, it was not until the CanadianH pyloriConsensus Conference, held in November 1997, that the issues ofH pyloriinfection in children were addressed. Therapies forH pyloriinfection in children, presented in part at the First Canadian PaediatricH pyloriConsensus Conference, held in Victoria, British Columbia, November 1998, are reviewed in this paper.

Role of Helicobacter pylori in gastric diseases pathogenesis cannot be ignored

Gut ◽  
2020 ◽  
pp. gutjnl-2020-322629
Author(s):  
Xianzhu Zhou ◽  
Huiyun Zhu ◽  
Yan Chen ◽  
Zhaoshen Li ◽  
Yiqi Du
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Diseases

scholarly journals Extra-Gastric Manifestations of Helicobacter pylori Infection

2020 ◽  
Vol 9 (12) ◽  
pp. 3887
Author(s):  
Antonietta G. Gravina ◽  
Kateryna Priadko ◽  
Paola Ciamarra ◽  
Lucia Granata ◽  
Angela Facchiano ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Metabolic Diseases ◽  
Causative Factor ◽  
Deficiency Anemia ◽  
Gastric Diseases ◽  
Neurologic Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
H Pylori

Helicobacter Pylori (H. pylori) is a Gram-negative flagellated microorganism that has been extensively studied since its first isolation due to its widespread diffusion and association with numerous diseases. While the bacterium is proved to be a causative factor for a number of gastric diseases such as gastritis, gastric adenocarcinoma, and MALT-lymphoma, its role at other gastrointestinal levels and in other systems is being thoroughly studied. In this article, we reviewed the latest published clinical and laboratory studies that investigated associations of H. pylori with hematologic diseases such as Vitamin B12- and iron-deficiency anemia, primary immune thrombocytopenia, and with a number of dermatologic and ophthalmic diseases. In addition, the putative role of the bacterium in inflammatory bowel diseases, esophageal disorders, metabolic, diseases, neurologic diseases and allergy were outlined.

scholarly journals The role of Helicobacter pylori in preeclampsia and in gastric diseases in pregnant women

2020 ◽  
Vol 7 (7) ◽  
pp. 2097
Author(s):  
Jehan Sabah Hasan ◽  
Mohammed Ahmed Alshami
Keyword(s):  
Helicobacter Pylori ◽  
Pregnant Women ◽  
Epigastric Pain ◽  
Peptic Ulcers ◽  
Gastric Diseases ◽  
Number Of Patients ◽  
Mild Preeclampsia ◽  
Laboratory Investigations ◽  
H Pylori

Background: Helicobacter pylori is a gastric organism was first observed more than 100 years ago. It may cause chronic gastritis, peptic ulcers and gastric adenocarcinoma and lymphoma. It can produce some extragastric disorders including preeclampsia. This study aimed to focus on the importance of H. pylori and its relationship with preeclampsia and gastric illnesses in pregnant patients.Methods: This study includeed 100 pregnant women, half of them were healthy and the other half with preeclampsia. Patients with chronic medical illnesses were excluded. Data was collected and laboratory investigations were done including that for H. pylori. Oesophagogastroduodenoscopy then was done 6 weeks post-delivery or termination of pregnancy for symptomatic H. pylori positive women.Results: 50% of the total number were healthy, 17% had mild preeclampsia, 33% suffering from severe preeclampsia. Seropositivity for H. pylori is significantly higher in preeclampsia and significantly related to severity of preeclampsia and complications of pregnancy. Positive H. pylori test in stool was seen in (45%) of total number of patients. Epigastric pain persist in 41 (91%) of patients with positive H. pylori test in stool. Gastritis, duodenal ulcer, and gastric ulcer were found in 85.3%, 12.1% and 2.4% of symptomatic patients respectively.Conclusions: Significant correlation between Helicobacter pylori seropositivity and preeclampsia may indicate the benefit of using this parameter in the prediction and management of preeclampsia and its severity. H. pylori infection plays an important role in gastric pathologies in pregnant women that can be dealt with or may be prevented more efficiently in future. 

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