scholarly journals A double-blind placebo controlled homoeopathic proving of Malus domestica 30CH, with a subsequent comparison of proving symptomatology to homoeopathic remedies of repertorial similarity

2015 ◽  
Author(s):  
◽  
Brenton Ricardo Moonsamy
Keyword(s):  
Malus Domestica ◽  
Gastrointestinal Symptoms ◽  
Signs And Symptoms ◽  
Primary Data ◽  
Relative Location ◽  
Double Blind ◽  
Materia Medica ◽  
Double Blind Placebo ◽  
Physical Examinations ◽  
Similarities And Differences

Introduction The purpose of this investigation was to determine the effects of Malus domestica 30CH on a group of healthy provers and to compare these signs and symptoms to remedies of repertorial similarity. Malus domestica (common domestic apple) is an indigenous South African fruit which grows on the Drakensberg Mountains in Northern KwaZulu-Natal and is a regular part of the diet for those living there. This study hypothesized that Malus domestica 30CH would prove observable signs and symptoms in healthy individuals. Further it was hypothesized that the comparison of Malus domestica to remedies of reportorial similarity would highlight similarities and differences between existing homoeopathic remedies and Malus domestica 30CH thereby clarifying the therapeutic action of this new remedy and its relative location in the materia medica. The study was conducted by two researchers who each managed 15 provers and shared all primary data. The second researcher hypothesized that there would be a similarity between the proving symptoms of the remedy and the Doctrine of Signatures of the original substance (Ramnarayan 2014). Methodology A double blind placebo controlled proving of Malus domestica 30CH was conducted on 30 healthy volunteers who met specific inclusion criteria, with 6 receiving placebo and 24 receiving verum. A case history and thorough physical examination was performed on every prover before commencement of the proving. Recording of the data collected was in the form of a journal. Once the proving was completed information from each prover was collated and assessed by the two researchers. The symptoms elicited were then translated into materia medica and repertory language and a complete homoeopathic picture of the remedy appeared. Information from case histories and physical examinations were also considered. A repertorisation of 10 rubrics chosen to represent the essence of Malus domestica was conducted using Radar Opus software. Exclusion repertorization then followed in order to identify those remedies producing the highest numerical value and total number of rubrics within the animal, mineral and plant kingdoms in particular. Results Vast arrays of symptoms were experienced by the provers. Polarities in the symptoms were often displayed. On the emotional plane, there were symptoms of depression, sadness and cheerfulness. Some provers experienced tranquility and others felt anger, frustration and irritation. On the mental plane there were symptoms of clarity, focused concentration and confusion. The presence of delusions was marked. The most prominent delusion which infiltrated the mental and physical plane was of disconnection and separation. The main symptoms were sensations as if the extremities were separated from other areas. There was cramping and itching of the extremities as well. Pulsating headaches with perspiration of the scalp and eye pain were experienced. Various gastrointestinal symptoms were experienced ranging from distention, eructations, cramping, and diarrhea to hemorrhage after stool. Constriction of the chest and a loose, dry cough was also experienced. Cervical and lumbar back pain was reported. Sleep was described as unrefreshing with sleeplessness. The themes that emerged from the dreams were of danger (including danger to family), banquets, parties and helping others. The provers had a craving for tea. The similar remedies that emerged from the repertorial analysis were; Natrum muriaticum, Rhus toxicodendron, Lyssin, Cinchona officinalis and Pulsatilla pratensis. Conclusion The proving of Malus domestica 30CH did produce well defined symptoms that were clearly observed in healthy provers as proposed by the hypothesis. As hypothesized the comparison of Malus domestica to remedies of repertorial similarity did highlight similarities and differences between existing homoeopathic remedies and Malus domestica 30CH thereby clarifying the therapeutic range of this new remedy and its relative location in the materia medica.

scholarly journals A homoeopathic drug proving of Garcinia cambogia 30CH and a comparison of the substance to its repertorial differentials

2018 ◽  
Author(s):  
◽  
Leshmee Ramdiyal
Keyword(s):  
Controlled Trial ◽  
Signs And Symptoms ◽  
Physical Symptoms ◽  
Double Blind ◽  
Garcinia Cambogia ◽  
Materia Medica ◽  
Life Threatening ◽  
Similarities And Differences ◽  
The Law ◽  
Physical Symptomatology

Introduction ABSTRACT This homoeopathic drug proving was conducted to elucidate the symptomology produced in healthy provers in response to Garcinia cambogia, in the thirtieth potency, so that it may be prescribed according to the Law of Similars. A subsequent comparison was made to those remedies that, on repertorisation, yielded the greatest similarities to the Mental, General and Physical symptomatology of Garcinia cambogia. Objectives It was hypothesized that there would be clearly observable signs and symptoms produced by healthy provers in response to Garcinia cambogia 30CH. Hence the information extrapolated will provide the homoeopathic Materia medica of the substance so that it may be prescribed according to the Law of Similiars. A further hypothesis was made that the comparison between Garcinia cambogia and those remedies that yielded the highest numerical values and total number of rubrics on repertorisation of the proving symptoms would highlight the similarities and differences between the remedy symptoms so that confusion is avoided in the indication of the remedy. It was hypothesized that a greater understanding of Garcinia cambogia and its relationship to other remedies would be recognized as a result of this proving. Methodology A double blind, placebo controlled trial was carried out on 30 healthy, consenting participants whom were randomly divided into two groups, 6 were assigned to the placebo group and 24 to the experimental group. A homoeopathic case history was taken and a physical examination was performed on each prover prior to the commencement of the proving (Appendix D). Provers began recording their signs and symptoms in a blank journal one week prior to the administration of the remedy as a baseline for the proving, they then continued to record while taking the remedy and thereafter following the administration of the remedy for a period of six weeks. On completion of the proving, the data obtained was correlated and evaluated by the two researchers, Ramdiyal and Diplal. The symptoms produced during the proving were interpreted into Materia medica and repertory language, and a homoeopathic depiction of the remedy was subsequently formulated. Thereafter the comparison of the remedies yielding the highest numerical value and total number of rubrics on repertorisation of the proving symptoms was completed. Results 1 An extensive array of symptoms was documented by provers. The results depict an inclination towards the mental- emotional plane. There were often polarity of symptoms and changeability of symptoms. The following were keynote feature: • Anger/irritability vs. calmness/tranquility; • Anxiety vs. calmness in stressful situations; • Depression/sadness vs. cheerfulness; • Confusion vs. concentration/clarity of mind; • Connection vs. disconnection; • Exertion desire vs exertion aversion; • Positivity vs. pessimism Numerous themes arising from dreams were recorded by provers, with some notable signs of danger and life-threatening circumstances. The main physical symptoms that surfaced were; feelings of dizziness, excessive weakness or extreme desire for activity, headaches of a pounding, hammering nature. There was also abdominal discomfort, seen in distension, burning sensations and flatus. There was ravenous hunger or complete loss of it and an unquenchable thirst, especially for cold drinks. Allergy-type symptoms also arose. Patients documented excessive sneezing, coryza, itchy eyes, lachrymation and dry itchy throat. Sleeplessness at night with excessive sleepiness during the day was evident. There were strong cravings for chocolate, pizza and alcohol. The comparison between the homoeopathic drug proving of Garcinia cambogia 30CH and the repertorisation of remedies brought many similarities to light, with most of these similarities relating to the mind, head and nose. Conclusion The proving of Garcinia cambogia 30CH did produce well defined symptoms that were clearly observed in healthy provers as proposed by the hypothesis. As hypothesized the comparison of Garcinia cambogia to remedies of repertorial similarity did highlight similarities and differences between existing homoeopathic remedies and Garcinia cambogia 30CH thereby clarifying the therapeutic range of this new remedy and its relative location in the Materia medica.

scholarly journals Effectiveness ofLactobacillus helveticusandLactobacillus rhamnosusfor the management of antibiotic-associated diarrhoea in healthy adults: a randomised, double-blind, placebo-controlled trial

2016 ◽  
Vol 116 (1) ◽  
pp. 94-103 ◽  
Author(s):  
Malkanthi Evans ◽  
Ryan P. Salewski ◽  
Mary C. Christman ◽  
Stephanie-Anne Girard ◽  
Thomas A. Tompkins
Keyword(s):  
Rating Scale ◽  
Gastrointestinal Symptoms ◽  
Healthy Adults ◽  
Lactobacillus Helveticus ◽  
Primary Study ◽  
Gastrointestinal Microbiota ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Probiotic Intervention ◽  
Antibiotic Associated Diarrhoea

AbstractBroad-spectrum antibiotic use can disrupt the gastrointestinal microbiota resulting in diarrhoea. Probiotics may be beneficial in managing this type of diarrhoea. The aim of this 10-week randomised, double-blind, placebo-controlled, parallel study was to investigate the effect ofLactobacillus helveticusR0052 andLactobacillus rhamnosusR0011 supplementation on antibiotic-associated diarrhoea in healthy adults. Subjects were randomised to receive 1 week of amoxicillin–clavulanic acid (875 mg/125 mg) once per day, plus a daily dose of 8×109colony-forming units of a multi-strain probiotic (n80) or placebo (n80). The probiotic or placebo intervention was maintained for 1 week after completion of the antibiotic. Primary study outcomes of consistency and frequency of bowel movements were not significantly different between the probiotic and placebo groups. The secondary outcomes of diarrhoea-like defecations, Gastrointestinal Symptoms Rating Scale scores, safety parameters and adverse events were not significantly different between the probiotic intervention and the placebo. Apost hocanalysis on the duration of diarrhoea-like defecations showed that probiotic intervention reduced the length of these events by 1 full day (probiotic, 2·70(sem0·36) d; placebo, 3·71 (sem0·36) d;P=0·037; effect size=0·52). In conclusion, this study provides novel evidence thatL. helveticusR0052 andL. rhamnosusR0011 supplementation significantly reduced the duration of diarrhoea-like defecations in healthy adults receiving antibiotics.

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