scholarly journals A homoeopathic drug proving of Garcinia cambogia 30CH and a comparison of the substance to its repertorial differentials

2018 ◽  
Author(s):  
◽  
Leshmee Ramdiyal
Keyword(s):  
Controlled Trial ◽  
Signs And Symptoms ◽  
Physical Symptoms ◽  
Double Blind ◽  
Garcinia Cambogia ◽  
Materia Medica ◽  
Life Threatening ◽  
Similarities And Differences ◽  
The Law ◽  
Physical Symptomatology

Introduction ABSTRACT This homoeopathic drug proving was conducted to elucidate the symptomology produced in healthy provers in response to Garcinia cambogia, in the thirtieth potency, so that it may be prescribed according to the Law of Similars. A subsequent comparison was made to those remedies that, on repertorisation, yielded the greatest similarities to the Mental, General and Physical symptomatology of Garcinia cambogia. Objectives It was hypothesized that there would be clearly observable signs and symptoms produced by healthy provers in response to Garcinia cambogia 30CH. Hence the information extrapolated will provide the homoeopathic Materia medica of the substance so that it may be prescribed according to the Law of Similiars. A further hypothesis was made that the comparison between Garcinia cambogia and those remedies that yielded the highest numerical values and total number of rubrics on repertorisation of the proving symptoms would highlight the similarities and differences between the remedy symptoms so that confusion is avoided in the indication of the remedy. It was hypothesized that a greater understanding of Garcinia cambogia and its relationship to other remedies would be recognized as a result of this proving. Methodology A double blind, placebo controlled trial was carried out on 30 healthy, consenting participants whom were randomly divided into two groups, 6 were assigned to the placebo group and 24 to the experimental group. A homoeopathic case history was taken and a physical examination was performed on each prover prior to the commencement of the proving (Appendix D). Provers began recording their signs and symptoms in a blank journal one week prior to the administration of the remedy as a baseline for the proving, they then continued to record while taking the remedy and thereafter following the administration of the remedy for a period of six weeks. On completion of the proving, the data obtained was correlated and evaluated by the two researchers, Ramdiyal and Diplal. The symptoms produced during the proving were interpreted into Materia medica and repertory language, and a homoeopathic depiction of the remedy was subsequently formulated. Thereafter the comparison of the remedies yielding the highest numerical value and total number of rubrics on repertorisation of the proving symptoms was completed. Results 1 An extensive array of symptoms was documented by provers. The results depict an inclination towards the mental- emotional plane. There were often polarity of symptoms and changeability of symptoms. The following were keynote feature: • Anger/irritability vs. calmness/tranquility; • Anxiety vs. calmness in stressful situations; • Depression/sadness vs. cheerfulness; • Confusion vs. concentration/clarity of mind; • Connection vs. disconnection; • Exertion desire vs exertion aversion; • Positivity vs. pessimism Numerous themes arising from dreams were recorded by provers, with some notable signs of danger and life-threatening circumstances. The main physical symptoms that surfaced were; feelings of dizziness, excessive weakness or extreme desire for activity, headaches of a pounding, hammering nature. There was also abdominal discomfort, seen in distension, burning sensations and flatus. There was ravenous hunger or complete loss of it and an unquenchable thirst, especially for cold drinks. Allergy-type symptoms also arose. Patients documented excessive sneezing, coryza, itchy eyes, lachrymation and dry itchy throat. Sleeplessness at night with excessive sleepiness during the day was evident. There were strong cravings for chocolate, pizza and alcohol. The comparison between the homoeopathic drug proving of Garcinia cambogia 30CH and the repertorisation of remedies brought many similarities to light, with most of these similarities relating to the mind, head and nose. Conclusion The proving of Garcinia cambogia 30CH did produce well defined symptoms that were clearly observed in healthy provers as proposed by the hypothesis. As hypothesized the comparison of Garcinia cambogia to remedies of repertorial similarity did highlight similarities and differences between existing homoeopathic remedies and Garcinia cambogia 30CH thereby clarifying the therapeutic range of this new remedy and its relative location in the Materia medica.

scholarly journals A double-blind placebo controlled homoeopathic proving of Malus domestica 30CH, with a subsequent comparison of proving symptomatology to homoeopathic remedies of repertorial similarity

2015 ◽  
Author(s):  
◽  
Brenton Ricardo Moonsamy
Keyword(s):  
Malus Domestica ◽  
Gastrointestinal Symptoms ◽  
Signs And Symptoms ◽  
Primary Data ◽  
Relative Location ◽  
Double Blind ◽  
Materia Medica ◽  
Double Blind Placebo ◽  
Physical Examinations ◽  
Similarities And Differences

Introduction The purpose of this investigation was to determine the effects of Malus domestica 30CH on a group of healthy provers and to compare these signs and symptoms to remedies of repertorial similarity. Malus domestica (common domestic apple) is an indigenous South African fruit which grows on the Drakensberg Mountains in Northern KwaZulu-Natal and is a regular part of the diet for those living there. This study hypothesized that Malus domestica 30CH would prove observable signs and symptoms in healthy individuals. Further it was hypothesized that the comparison of Malus domestica to remedies of reportorial similarity would highlight similarities and differences between existing homoeopathic remedies and Malus domestica 30CH thereby clarifying the therapeutic action of this new remedy and its relative location in the materia medica. The study was conducted by two researchers who each managed 15 provers and shared all primary data. The second researcher hypothesized that there would be a similarity between the proving symptoms of the remedy and the Doctrine of Signatures of the original substance (Ramnarayan 2014). Methodology A double blind placebo controlled proving of Malus domestica 30CH was conducted on 30 healthy volunteers who met specific inclusion criteria, with 6 receiving placebo and 24 receiving verum. A case history and thorough physical examination was performed on every prover before commencement of the proving. Recording of the data collected was in the form of a journal. Once the proving was completed information from each prover was collated and assessed by the two researchers. The symptoms elicited were then translated into materia medica and repertory language and a complete homoeopathic picture of the remedy appeared. Information from case histories and physical examinations were also considered. A repertorisation of 10 rubrics chosen to represent the essence of Malus domestica was conducted using Radar Opus software. Exclusion repertorization then followed in order to identify those remedies producing the highest numerical value and total number of rubrics within the animal, mineral and plant kingdoms in particular. Results Vast arrays of symptoms were experienced by the provers. Polarities in the symptoms were often displayed. On the emotional plane, there were symptoms of depression, sadness and cheerfulness. Some provers experienced tranquility and others felt anger, frustration and irritation. On the mental plane there were symptoms of clarity, focused concentration and confusion. The presence of delusions was marked. The most prominent delusion which infiltrated the mental and physical plane was of disconnection and separation. The main symptoms were sensations as if the extremities were separated from other areas. There was cramping and itching of the extremities as well. Pulsating headaches with perspiration of the scalp and eye pain were experienced. Various gastrointestinal symptoms were experienced ranging from distention, eructations, cramping, and diarrhea to hemorrhage after stool. Constriction of the chest and a loose, dry cough was also experienced. Cervical and lumbar back pain was reported. Sleep was described as unrefreshing with sleeplessness. The themes that emerged from the dreams were of danger (including danger to family), banquets, parties and helping others. The provers had a craving for tea. The similar remedies that emerged from the repertorial analysis were; Natrum muriaticum, Rhus toxicodendron, Lyssin, Cinchona officinalis and Pulsatilla pratensis. Conclusion The proving of Malus domestica 30CH did produce well defined symptoms that were clearly observed in healthy provers as proposed by the hypothesis. As hypothesized the comparison of Malus domestica to remedies of repertorial similarity did highlight similarities and differences between existing homoeopathic remedies and Malus domestica 30CH thereby clarifying the therapeutic range of this new remedy and its relative location in the materia medica.

A homoeopathic drug proving of Hoodia gordonii 30CH, with a subsequent comparison of proving symptomatology to its toxicology as a raw substance and to homoeopathic remedies of repertorial similarity

2016 ◽  
Author(s):  
◽  
Tembeka Stella Swana-Sikwata
Keyword(s):  
Nasal Congestion ◽  
Controlled Trial ◽  
Signs And Symptoms ◽  
Good Health ◽  
Daily Basis ◽  
Control Group ◽  
Extensive Literature ◽  
Double Blind ◽  
Hoodia Gordonii ◽  
Subsequent Comparison

Introduction The aim of this study was to determine the effect of Hoodia gordonii 30CH on healthy provers, and to record the clearly observable signs and symptoms produced and the subsequent comparison to its toxicology as a raw substance and to homoeopathic remedies of reportorial similarity. Methodology The investigation was a randomised, double-blind placebo controlled trial, using the substance in the 30th potency. This was prepared according to the German Homoeopathic Pharmacopoeia. A sample of 20 provers, in good health, was recruited. Sixteen received verum as the experimental group and four in the control group received a placebo. Each of the 20 provers received a journal in which they recorded symptoms on a daily basis for a period of six weeks, including a one week observation prior to taking the powders, and a period of five weeks after administration of the powders. The information from the journals and case histories was edited, collated and translated into materia medica and repertory language and used to compile a proving profile of the remedy by qualitative methods. The remedy was only revealed to the participants after completion of the proving study period. The researcher compared the similarities and new symptoms of the remedy with the existing knowledge of its toxicology to prove the first hypothesis. A detailed and extensive literature review of Hoodia gordonii’s unique characteristics was conducted. A further comparison with other similar remedies according to the highest numerical number of rubrics on repertorisation was conducted. Results The proving remedy produced a wide variety of symptoms on the mental, emotional and physical levels of which many had polarities. In broad terms the following were identified from the proving symptoms of Hoodia gordonii: • Increased confidence and feeling refreshed, renewed energy, cheerfulness, concentration, alertness, calm, forgetfulness, unhappy, sadness and depression with desire to be left alone. • Anxiety for unknown reason and for the future, about finances; restlessness and busyness. • Tiredness, fatigue and exhaustion. • Positive feeling regarding home and family. • Mental exhaustion and aversion to study. • Common sensations were throbbing, pulsating, sharp, aching, heat, pressing, heavy, pulling, splitting, cramps. • Perceived attack or danger in dreams. • Painless diarrhea and constipation, nausea, headaches, vertigo, sore red eyes, nasal congestion and sinuses, toothache, tonsillitis and dryness of throat; bronchitis, heart palpitations. • Menses with breast tenderness and increased sexual stimulation, joint pain. • Unquenchable thirst, polyuria, appetite increase and decrease, sleeplessness and sleepiness with deep sleep, cold, increase perspiration, influenza and depressed immune function. Conclusion The data obtained from this proving study of Hoodia gordonii when comparing the new symptoms of the remedy with similarities to the existing knowledge of its toxicology proved the first hypothesis to be true. Three hundred and twenty four rubrics were produced and 17 were new rubrics; of these a total of 20 rubrics that represented the essence of the remedy were selected and used in the repertorisation process. A comparison of the highest numerical value of rubrics with other similar remedies on repertorisation found Hoodia gordonii 30CH to be most similar to: Atropa belladonna, Phosphorus, Lachesis mutus, Sulphur and Veratrum album.

scholarly journals Use of Lozenges Containing Lactobacillus brevis CD2 in Recurrent Aphthous Stomatitis: A Double-Blind Placebo-Controlled Trial

Ulcers ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Vito Trinchieri ◽  
Stefano Di Carlo ◽  
Maurizio Bossu' ◽  
Antonella Polimeni
Keyword(s):  
Controlled Trial ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Lactobacillus Brevis ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Rapid Improvement ◽  
Double Blind ◽  
Rapid Healing ◽  
Clinical Signs And Symptoms

Recurrent aphthous stomatitis is a common disorder of the oral cavity, affecting mainly young people. It is characterized by small ulcers which can be very painful and generally heal spontaneously within 7–14 days. There is currently no therapy that can provide rapid healing. This study evaluated the efficacy and rapidity of response of a lozenge containing Lactobacillus brevis CD2. 30 patients were randomized to take 4 lozenges a day of active product or placebo for 7 days. Signs and symptoms as well as laboratory parameters in the saliva were assessed at the start of the study and after 7 days of treatment. The study demonstrated the efficacy and the rapidity of response of the Lactobacillus brevis CD2 lozenges in resolving the clinical signs and symptoms of aphthous stomatitis, with a significantly rapid improvement of pain. This is the first study confirming the efficacy of a probiotic product in this pathology.

scholarly journals A homoeopathic drug proving of Carcharhinus leucas 30CH and a subsequent comparison with that of Galeocerdo cuvier hepar 30CH

2018 ◽  
Author(s):  
◽  
Nalini Naidoo
Keyword(s):  
Controlled Trial ◽  
Controlled Study ◽  
Double Blind ◽  
Materia Medica ◽  
Double Blind Placebo ◽  
Galeocerdo Cuvier ◽  
Carcharhinus Leucas ◽  
Before And After ◽  
History Of ◽  
The Mind

Introduction The aim of this study was to conduct a homoeopathic proving of Carcharhinus leucas in the thirtieth centesimal potency (30CH) and to subsequently establish and describe the symptomatology in standard materia medica format and then compare this symptomatology to Galeocerdo cuvier hepar 30CH. Methodology The homoeopathic proving of Carcharhinus leucas 30CH was conducted at the Durban University of Technology and was accomplished by means of a randomised, double blind, placebo controlled trial. Carcharhinus leucas 30CH was manufactured by the researchers according to Method 6, Method 8a and 10 of the German Homoeopathic Pharmacopoeia (Benyunes, 2005: 36-39). The homoeopathic proving was conducted in the form of a double blind placebo controlled study of Carcharhinus leucas 30CH with a total of 30 healthy provers. The prover sample was divided into two groups by a process of randomisation. Twenty four provers (80%) comprised the verum group and the remaining 6 provers (20%) comprised the placebo group. The identity of the proving substance and the potency used was not disclosed to provers. Provers documented their physical, mental and emotional status for one week preceding the administration of the proving remedy. A comprehensive physical examination and case history of every prover was taken before and after the proving period. Provers were instructed to ingest one powder three times a day for two days but were told to discontinue the powders once symptoms arose. The duration of the proving spanned 6 weeks and throughout the proving process, researchers were in constant communication with all the participants. Upon completion of the proving process, journals were collected and the information therein was translated into materia medica and repertory format. This was done in order to acquire the remedy picture of Carcharhinus leucas 30CH. Thereafter, the symptomatology of Carcharhinus leucas 30CH was compared to the symptomatology of Galeocerdo cuvier hepar 30CH. Results The proving of Carcharhinus leucas 30CH produced a total of 590 already existing rubrics and 43 new rubrics. The majority of these rubrics were located in the MIND (127), GENERALS (64), HEAD (55), EXTREMITIES (50), and EYE (34). In regard to the mind, prominent features were apparent such as anger, anxiety, cheerfulness, an aversion or amelioration within company, difficulty concentrating or increased focus, varying delusions and fears and irritability. Pertaining to the head, headaches were evident with varying concomitants and modalities, with headaches predominantly affecting the forehead and sides. Sensations included dryness, heat, heaviness, perspiration and shaking. The extremities displayed symptoms primarily in the forearms, legs and thighs and sensations included paralysis, shaking, swelling and weakness. In regard to the eye, eye pain with multiple modalities were apparent, with symptoms related to the canthi and eyelids. Sensations included heat, heaviness, inflammation, itching and photophobia as well as a visible discolouration of the eye. Analysis of the results presented an understanding of the similarities and differences between Carcharhinus leucas 30CH and Galeocerdo cuvier hepar 30CH. Conclusion As hypothesised, it was evident that administering Carcharhinus leucas 30CH to healthy individuals did yield observable symptomatology. Additionally, it was apparent that various correlations between Carcharhinus leucas 30CH and Galeocerdo cuvier hepar 30CH existed

scholarly journals Profiling Serum Antibodies with a Pan Allergen Phage Library Identifies Key Wheat Allergy Epitopes

2021 ◽  
Author(s):  
Daniel R. Monaco ◽  
Brandon M. Sie ◽  
Thomas R. Nirschl ◽  
Audrey C. Knight ◽  
Hugh A. Sampson ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Oral Immunotherapy ◽  
Phage Library ◽  
Igg Antibody ◽  
Double Blind ◽  
Bacteriophage Display ◽  
Allergenic Proteins ◽  
Life Threatening ◽  
Wheat Allergen

Abstract Allergic reactions occur when IgE molecules become crosslinked by antigens such food proteins. The physiologic consequences range from mild to life-threatening. Here we create the ‘AllerScan’ bacteriophage display library for efficiently profiling allergic antibodies to characterize binding specificities associated with known allergens. AllerScan enables sensitive and unbiased characterization of circulating IgE and IgG antibody reactivities against thousands of allergenic proteins from hundreds of organisms at peptide resolution. Using AllerScan to analyze food allergy reactivities, we identify robust anti-wheat IgE reactivities in wheat allergic patients but not in wheat-sensitized individuals. Meanwhile, a wheat allergen epitope, alpha purothionin, elicits dominant IgE responses among allergic patients but frequent IgG responses among sensitized and non-allergic patients; a double-blind placebo-controlled trial shows that alpha purothionin reactivity, among others, is strongly modulated by oral immunotherapy. Our proof-of-principle results thus suggest that AllerScan to be a high-throughput platform for unbiased analysis of allergic antibody fine specificities.

scholarly journals Clinical Efficacy and Safety of Benjakul Remedy Extract for Treating Primary Osteoarthritis of Knee Compared with Diclofenac: Double Blind, Randomized Controlled Trial

2017 ◽  
Vol 2017 ◽  
pp. 1-9
Author(s):  
Patamaporn Rachawat ◽  
Piya Pinsornsak ◽  
Puritat Kanokkangsadal ◽  
Arunporn Itharat
Keyword(s):  
Clinical Efficacy ◽  
Safety Issue ◽  
Controlled Trial ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Controlled Study ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Primary Osteoarthritis ◽  
Clinical Signs And Symptoms

Background. The purpose of this study was to investigate the clinical efficacy and safety of Benjakul (BJK) extract for treating primary osteoarthritis (OA) of the knee compared with diclofenac. Methods. A phase 2, double blind, randomized, and controlled study was conducted. The BJK group received 300 mg of BJK extract per day, while another group received 75 mg of diclofenac per day. All patients were followed up at 14 and 28 days. The changing of visual analogue scale (VAS) for pain, 100-meter walking times, the modified Thai WOMAC index scores, and the global assessment were evaluated for efficacy. For safety issue, clinical signs and symptoms, complete physical examination, and renal and liver function were evaluated. Results. 39 and 38 patients for BJK extract group and diclofenac group were evaluated. For efficacy, all patients from both groups reported a decrease in the VAS pain score and 100-meter walking times but only the diclofenac group showed significant reduction of both measurements when compared with day 0. The modified Thai WOMAC scores of both groups were significantly reduced from baseline. However, all efficacy outcomes were not significantly different for both groups. For safety outcomes, the patients from both groups had no severe adverse events reported and only BJK had no toxicity in renal and liver functions. Conclusions. The BJK remedy extract showed equal clinical efficacy in relieving symptoms of OA knee when compared with diclofenac.

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