scholarly journals Antioxidant Effects of Fermented Red Ginseng Extracts in Streptozotocin-Induced Diabetic Rats

2011 ◽  
Vol 35 (2) ◽  
pp. 129-137 ◽  
Author(s):  
Hyun-Jeong Kim ◽  
Sung-Gyu Lee ◽  
In-Gyeong Chae ◽  
Mi-Jin Kim ◽  
Nam-Kyung Im ◽  
...  
2012 ◽  
Vol 44 (3) ◽  
pp. 367-372 ◽  
Author(s):  
Hyun-Jeong Kim ◽  
Sung-Gyu Lee ◽  
Sung-Jin Park ◽  
Mi-Hee Yu ◽  
Eun-Ju Lee ◽  
...  

2007 ◽  
Vol 36 (5) ◽  
pp. 521-526 ◽  
Author(s):  
Hyun-Jeong Kim ◽  
Ji-Won Lee ◽  
Young-Ju Ji ◽  
Me-Hei Yu ◽  
Jung-Hyun Park ◽  
...  

2021 ◽  
pp. 114883
Author(s):  
Santiagu Stephen Irudayaraj ◽  
Jacob Jincy ◽  
Christudas Sunil ◽  
Veeramuthu Duraipandiyan ◽  
Savarimuthu Ignacimuthu ◽  
...  

2011 ◽  
Vol 25 (2) ◽  
pp. 207-213 ◽  
Author(s):  
Xin-Zhong Hu ◽  
Xiao-Hui Xing ◽  
Zheng-Mao Zhang ◽  
Rui-Qin Wu ◽  
Qingbin Guo ◽  
...  

2018 ◽  
Vol 6 (5) ◽  
Author(s):  
Diana García-Cerrillo ◽  
Ruth Noriega-Cisneros ◽  
Donovan Peña-Montes ◽  
Maribel Huerta-Cervantes ◽  
Mónica Silva-Ríos ◽  
...  

Metabolic diseases have increased considerably such as diabetes mellitus (DM). Since diabetes is a systemic disease, it implies high cardiovascular risks. It has been widely established that cardiac injury is related to mitochondrial dysfunction through increment of reactive oxygen species (ROS). Synthetic antioxidants can have important side effects; therefore natural sources may represent a better option. Traditional Mexican medicine has been using Eryngium carlinae (EC) for medical treatment. Also our group showed that hexanic extract possesses in vitro antioxidant capacity. Experimental diabetes in Wistar rats was generated by streptozotocin (STZ) and hexanic extract of EC was supplied for 7 weeks (30 mg/kg). Cholesterol, triacylglycerides, glucose, and thiobarbituric acid reactive substances (TBARS) levels were determined in serum. Mitochondria from left ventricle were used in the quantification of TBARS, reduced glutathione, nitric oxide (NO) levels and activity of superoxide dismutase (SOD) enzyme was performed.  Biochemical parameters of glucose and triacylglycerides, as well as TBARS levels in serum show a significant reduction in diabetic group supplied with EC hexanic extract. Thus, we can conclude that the EC hexanic extract possesses antioxidant activity in vitro, and in vivo, by reducing glucose and triacylglycerides levels during hyperglycemia, which may eventually reduce the risk of developing diabetic cardiomyopathy.


Author(s):  
Kamadyaapa Davie Rexon ◽  
Gondwe Mavuto Masopera ◽  
Shauli Mathulo ◽  
Sewani Rusike Constance ◽  
Nkeh Chungag Benedicta

  Objective: This study was conducted to scientifically evaluate the antidiabetic and antioxidant effects of ethanolic leaf extract of Erythrina abbysinica (EEA).Methods: Acute and sub-chronic effects of EEA at 100, 200, and 400 mg/kg/bwt and glibenclamide (GL) at 5 mg/kg/bwt. were evaluated in both normal and streptozotocin (STZ)-induced diabetic male Wistar rats (250–300 g). The acute studies were performed using oral glucose tolerance test (OGTT). In sub-chronic studies, animals were orally administered with EEA and GL daily for 6 w. Brine shrimp assay was used to determine the toxicity of EEA. 1, 1-diphenyl-2-picrylhydrazyl, ferric reducing capacity of plasma, and thiobarbituric acid reactive substances assays were used to determine antioxidant properties of EEA.Results: Following OGTT, EEA significantly (p<0.05) and dose-dependently (100, 200, and 400 mg/kg/bwt) decreased blood glucose levels in both normal and STZ-induced diabetic rats when compared with positive and negative control counterparts at all-time points, whereas GL significantly (p<0.05) decreased blood glucose only in normal rats but not in diabetic rats. Daily, oral administration of EEA for 6 w significantly (p<0.05) and dose-dependently (100, 200, and 400 mg/kg/bwt) decreased blood glucose levels in STZ-induced diabetic rats when compared with the diabetic control group. EEA revealed weak toxicity with a lethal concentration50 value of 997 μg/ml). Furthermore, EEA showed significant free radical scavenging, total antioxidant, and anti-lipid peroxidative capacities.Conclusion: The study has shed more light on the scientific basis for the use of E. abbysinica in management of diabetes in some communities of Eastern Cape of South Africa.


2017 ◽  
Vol 32 (23) ◽  
pp. 2840-2843 ◽  
Author(s):  
Esquivel-Gutiérrez Edgar Romualdo ◽  
Alcaraz-Meléndez Lilia ◽  
Salgado-Garciglia Rafael ◽  
Saavedra-Molina Alfredo

2012 ◽  
Vol 11 (1) ◽  
pp. 81 ◽  
Author(s):  
Maher Boukhris ◽  
Mohamed Bouaziz ◽  
Ines Feki ◽  
Hedya Jemai ◽  
Abdelfattah El Feki ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document