scholarly journals INVESTIGATION OF PLACENTAL HOFBAUER CELLS BY IMMUNOHISTCHEMSTRY METHODS IN COMPLICATED PREGNANCIES

2021 ◽  
Vol 7 (2) ◽  
pp. 150-159
Author(s):  
Yusuf NERGİZ ◽  
Şebnem NERGİZ ÖZTÜRK ◽  
Fırat AŞIR ◽  
Ayşe ŞAHİN ◽  
Elif AĞAÇAYAK
Keyword(s):  
Hofbauer Cells

scholarly journals Spontaneous Abortion and Chikungunya Infection: Pathological Findings

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 554
Author(s):  
Natália Salomão ◽  
Michelle Brendolin ◽  
Kíssila Rabelo ◽  
Mayumi Wakimoto ◽  
Ana Maria de Filippis ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Spontaneous Abortion ◽  
Ultrastructural Changes ◽  
Rt Pcr ◽  
Chorionic Villi ◽  
Decidual Cells ◽  
Hofbauer Cells ◽  
Hematoxylin And Eosin ◽  
Maternal Fetal Transmission

Intrauterine transmission of the Chikungunya virus (CHIKV) during early pregnancy has rarely been reported, although vertical transmission has been observed in newborns. Here, we report four cases of spontaneous abortion in women who became infected with CHIKV between the 11th and 17th weeks of pregnancy. Laboratorial confirmation of the infection was conducted by RT-PCR on a urine sample for one case, and the other three were by detection of IgM anti-CHIKV antibodies. Hematoxylin and eosin (H&E) staining and an electron microscopy assay allowed us to find histopathological, such as inflammatory infiltrate in the decidua and chorionic villi, as well as areas of calcification, edema and the deposition of fibrinoid material, and ultrastructural changes, such as mitochondria with fewer cristae and ruptured membranes, endoplasmic reticulum with dilated cisterns, dispersed chromatin in the nuclei and the presence of an apoptotic body in case 1. In addition, by immunohistochemistry (IHC), we found a positivity for the anti-CHIKV antibody in cells of the endometrial glands, decidual cells, syncytiotrophoblasts, cytotrophoblasts, Hofbauer cells and decidual macrophages. Electron microscopy also helped in identifying virus-like particles in the aborted material with a diameter of 40–50 nm, which was consistent with the size of CHIKV particles in the literature. Our findings in this study suggest early maternal fetal transmission, adding more evidence on the role of CHIKV in fetal death.

scholarly journals The Ontogeny and Function of Placental Macrophages

2021 ◽  
Vol 12 ◽  
Author(s):  
Jake R. Thomas ◽  
Praveena Naidu ◽  
Anna Appios ◽  
Naomi McGovern
Keyword(s):  
Human Placenta ◽  
Outer Layer ◽  
New Technologies ◽  
Placental Development ◽  
Fetal Health ◽  
Hofbauer Cells ◽  
Recent Developments ◽  
Placental Macrophages ◽  
And Function ◽  
Insight Into

The placenta is a fetal-derived organ whose function is crucial for both maternal and fetal health. The human placenta contains a population of fetal macrophages termed Hofbauer cells. These macrophages play diverse roles, aiding in placental development, function and defence. The outer layer of the human placenta is formed by syncytiotrophoblast cells, that fuse to form the syncytium. Adhered to the syncytium at sites of damage, on the maternal side of the placenta, is a population of macrophages termed placenta associated maternal macrophages (PAMM1a). Here we discuss recent developments that have led to renewed insight into our understanding of the ontogeny, phenotype and function of placental macrophages. Finally, we discuss how the application of new technologies within placental research are helping us to further understand these cells.

scholarly journals Gatekeepers of the fetus: Characterization of placental macrophages

2020 ◽  
Vol 218 (1) ◽  
Author(s):  
Christina Megli ◽  
Carolyn B. Coyne
Keyword(s):  
Immune Cells ◽  
Depth Analysis ◽  
Hofbauer Cells ◽  
Placental Macrophages ◽  
Maternal Fetal Interface

In this issue of JEM, Thomas et al. (https://doi.org/10.1084/jem.20200891) provide elegant technological and conceptual advances that further our understanding of the immune cells enriched at the maternal–fetal interface. Using new isolation strategies to better separate maternal- and fetal-derived cells, the authors identify previously undefined maternal-derived immune cells associated with the fetal-derived placenta and provide an in-depth analysis of the markers and characteristics of placental Hofbauer cells.

Enzyme-cytochemically Detectable Glucose-6-phosphate Dehydrogenase in Human Villous Macrophages (Hofbauer Cells)

Placenta ◽  
2001 ◽  
Vol 22 (10) ◽  
pp. 882-885 ◽  
Author(s):  
S. Matsubara ◽  
T. Takayama ◽  
R. Iwasaki ◽  
N. Komatsu ◽  
D. Matsubara ◽  
...  
Keyword(s):  
Hofbauer Cells ◽  
Glucose 6 Phosphate Dehydrogenase

Hofbauer cells and placental viral infection

2021 ◽  
pp. 295-309
Author(s):  
Victoria Chase ◽  
Seth Guller
Keyword(s):  
Viral Infection ◽  
Hofbauer Cells

scholarly journals Differential Activation of Fetal Hofbauer Cells in Primigravidas Is Associated with Decreased Birth Weight in Symptomatic Placental Malaria

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Stephanie L. Gaw ◽  
Bethann S. Hromatka ◽  
Sadiki Ngeleza ◽  
Sirirak Buarpung ◽  
Nida Ozarslan ◽  
...  
Keyword(s):  
Birth Weight ◽  
Placental Malaria ◽  
Perinatal Outcomes ◽  
Protective Role ◽  
Cross Sectional ◽  
Macrophage Response ◽  
Hofbauer Cells ◽  
Infant Birth ◽  
First Time

Background. Placental malaria is a leading global cause of low birth weight neonates, especially in first-time mothers. To better understand the role of innate immunity in placental malaria, we investigated the relationships between histopathological markers of placental malaria, fetal and maternal macrophage responses, and perinatal outcomes in a cross-sectional case control study of pregnant women presenting with symptomatic malaria at the time of delivery. Results. Primigravidas showed increased hemozoin deposition in placental villi (p=0.02), syncytiotrophoblasts (p=0.01), and fetal Hofbauer cells (p=0.01). The percentage of hemozoin-positive villi negatively correlated with infant birth weight (regression coefficient [b] = -0.03 kg decrease in birth weight per % increase in hemozoin-positive villi, p=0.035). Malaria-infected placentas showed a twofold increase in Hofbauer cells (p<0.001) and maternal macrophages (p<0.001). Placental malaria was associated with a threefold increase in the percentage of M2 maternal macrophages (19.2% vs 6.4%, p=0.01). Primigravidas showed a significant decrease in the Hofbauer cell M2-percentage in placental malaria (92.7% vs. 97.0%, p=0.04), which was predictive of infant birth weight (b=0.08 kg increase in birth weight per % increase in M2 Hofbauer cells, p=0.001). There was no association between maternal macrophage response and infant birth weights. Conclusions. Placentas with malarial infection had increased numbers of fetal Hofbauer cells in the villous stroma and maternal macrophages in the intervillous space. In primigravidas, decreased anti-inflammatory M2-type Hofbauer cells were predictive of lower birth weight. M2-type maternal macrophages were increased in placental malaria, but there was no association with gravidity or birth weight. These results suggested a protective role of M2 Hofbauer cells in fetal growth restriction.

scholarly journals Placental Hofbauer cells assemble and sequester HIV-1 in tetraspanin-positive compartments that are accessible to broadly neutralizing antibodies

2015 ◽  
Vol 18 (1) ◽  
pp. 19385 ◽  
Author(s):  
Erica L Johnson ◽  
Hin Chu ◽  
Siddappa Nagadenahalli Byrareddy ◽  
Paul Spearman ◽  
Rana Chakraborty
Keyword(s):  
Neutralizing Antibodies ◽  
Broadly Neutralizing Antibodies ◽  
Hofbauer Cells ◽  
Hiv 1

scholarly journals Characterization of Placental Infection by Zika Virus in Humans: A Review of the Literature

2020 ◽  
Vol 42 (09) ◽  
pp. 577-585
Author(s):  
Emanuella Meneses Venceslau ◽  
José Paulo Guida ◽  
Eliana Amaral ◽  
José Luis Proença Modena ◽  
Maria Laura Costa
Keyword(s):  
Zika Virus ◽  
Mononuclear Cells ◽  
Case Reports ◽  
Experimental Studies ◽  
Case Series ◽  
Perinatal Outcomes ◽  
Final Analysis ◽  
Systematic Evaluation ◽  
Congenital Diseases ◽  
Hofbauer Cells

Abstract Objective The aim of the current review is to present a systematic evaluation of reported human placental findings in cases of zika virus (ZIKV) infection. Data sources We reviewed the EMBASE, PUBMED, and SCIELO databases until June 2019, without language restrictions. Selection of studies The search terms placenta AND zika virus were used. The inclusion criteria of the studies were studies that reported placental findings in humans. Experimental studies, reviews, notes or editorials were excluded. A total of 436 studies were retrieved; after duplicate exclusion, 243 articles had their titles screened, and 128 had their abstract read; of those, 32 were included in the final analysis (18 case reports, 10 case series, and 4 cohorts) Data collection We collected data concerning the author, year of publication, study design, number of participants, number of placental samples, onset of symptoms, perinatal outcomes, and main findings on histological analysis. Data synthesis The placental pathologic findings were described as mild and nonspecific, similar to those of other placental infections, including chronic placentitis, chronic villitis, increased Hofbauer cells, irregular fibrin deposits, increased mononuclear cells in the villus stroma, villous immaturity, edema, hypervascularization, stromal fibrosis, calcification, and focal necrosis of syncytiotrophoblasts. Conclusion Zika infection presents unspecific placental findings, similar to other infections in the toxoplasmosis, other agents, rubella, cytomegalovirus, and herpes (TORCH)group. Characterizing and standardizing placental findings after zika virus infection is key to understanding the mechanisms of congenital diseases.

Some New Findings about Hofbauer Cells in the Chorionic Villi of the Human Placenta

1984 ◽  
Vol 119 (1) ◽  
pp. 18-26 ◽  
Author(s):  
Ramazan Demir ◽  
T&uuml;rk&acirc;n Erbengi
Keyword(s):  
Human Placenta ◽  
Chorionic Villi ◽  
New Findings ◽  
Hofbauer Cells
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