The Relationship of Hyperlactatemia Following Paediatric Open Heart Surgery with Mortality, Morbidity and Risk Factors

Background: Acute stress response to heart surgery can cause major morbidity in patients. The trace of selenium is useful for preventing heart damage. Although the trend of selenium changes is of high importance for body balance, the usefulness of routine use and effectiveness of this element for patients under open-heart surgery is still unclear. Objectives: This study aimed at assessing serum selenium level before and after open-heart surgery and the relationship between selenium trace and patient outcome. Methods: This prospective analytical study was performed on 100 patients undergoing open-heart surgery using cardiopulmonary bypass (CPB). In all patients, the serum level was measured at a predetermined time (before surgery and one and two days after surgery). Then, the relationship between serum selenium and patient outcome was assessed. Results: The mean serum selenium level in patients on admission was 72.90 ± 14.62 μg/L, one day after surgery was 71.20 ± 15.84 μg/L, and two days after surgery was 71.54 ± 15.97 μg/L. Serum selenium levels were inversely and significantly associated with age (r = -0.183; P = 0.034, 013) duration of surgery (r = -221 and P = 0.014), duration of intensive care unit stay (r = 0.204, P = 0.021), and duration of CPB (r = 0.223, P = 013). Conclusions: Based on this study’s results, a low level of selenium can affect patients’ outcomes after open-heart surgery.

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Influence of biomarkers level during follow-up when operating under cardiopulmonary bypass

Patologiya krovoobrashcheniya i kardiokhirurgiya ◽

10.21688/1681-3472-2014-3-39-42 ◽

2015 ◽

Vol 18 (3) ◽

pp. 39

Author(s):

Yu. I. Petrishchev ◽

A. L. Levit ◽

I. N. Leyderman

Keyword(s):

Cardiac Surgery ◽

Length Of Stay ◽

Plasma Levels ◽

Heart Surgery ◽

Open Heart Surgery ◽

Open Heart ◽

Cardiac Surgeons ◽

The Given ◽

The Relationship

Systemic inflammatory response was first determined in 1980 and cardiac surgeons turned to it in 1996. At present, there are a lot of publications on this issue, however, the extent of operation and duration of CPB are considered in clinical practice as crucial indicators of severity of patient's condition following cardiac surgery. In our study we tried to look at this problem from a different perspective and draw a parallel between the severity of patient's condition resulting from operational trauma and CPB. We included 48 patients who under-went cardiac surgery under CPB. Plasma levels of procalcitonin (PCT), lactate and interleukin-6 were investigated before the operation, after CPB and at 24 hours. Also revealed was the relationship between the plasma levels of IL-6, lactate and PCT (r = 0.53; p = 0.000 in both cases). The level of PCT at the 3rd stage was found to relate to the duration of CPB (r = 0.4; p = 0.005), ALV (r = 0.44; p = 0.001) and length of stay at ICU (r = 0.53; p = 0.000). We didn't manage to find any relationship between the length of stay at ICU and the duration of CPB. Correlation between the PCT plasma level and the duration of intensive care indicates the importance of dynamics of the given biomarker for early prediction of follow-up course after open-heart surgery.

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P-70 Predictors of risk factors related to the development of hepatic dysfunction following open heart surgery

Journal of Cardiothoracic and Vascular Anesthesia ◽

10.1053/j.jvca.2011.03.163 ◽

2011 ◽

Vol 25 (3) ◽

pp. S62-S63

Author(s):

Ayse Baysal ◽

Buket Ozyaprak ◽

Ismail Ozkaynak ◽

Tuncer Kocak

Keyword(s):

Risk Factors ◽

Heart Surgery ◽

Hepatic Dysfunction ◽

Open Heart Surgery ◽

Open Heart

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Clinical and histological predictive risk factors of atrial fibrillation in patients undergoing open-heart surgery

Experimental and Therapeutic Medicine ◽

10.3892/etm.2015.2790 ◽

2015 ◽

Vol 10 (6) ◽

pp. 2299-2304 ◽

Cited By ~ 7

Author(s):

GRIGORE TINICA ◽

VERONICA MOCANU ◽

FLORIN ZUGUN-ELOAE ◽

DOINA BUTCOVAN

Keyword(s):

Risk Factors ◽

Atrial Fibrillation ◽

Heart Surgery ◽

Open Heart Surgery ◽

Open Heart ◽

Predictive Risk

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Risk Factors for Candidemia After Open Heart Surgery: Results From a Multicenter Case–Control Study

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa233 ◽

2020 ◽

Vol 7 (8) ◽

Author(s):

Daniele Roberto Giacobbe ◽

Antonio Salsano ◽

Filippo Del Puente ◽

Ambra Miette ◽

Antonio Vena ◽

...

Keyword(s):

Risk Factors ◽

Intensive Care Unit ◽

Intensive Care ◽

Heart Surgery ◽

Case Control Study ◽

Open Heart Surgery ◽

Case Control ◽

Open Heart ◽

Previous Therapy ◽

Control Study

Abstract Background Candida species are among the most frequent causative agents of health care–associated bloodstream infections, with mortality >40% in critically ill patients. Specific populations of critically ill patients may present peculiar risk factors related to their reason for intensive care unit admission. The primary objective of the present study was to assess the predictors of candidemia after open heart surgery. Methods This retrospective, matched case–control study was conducted in 8 Italian hospitals from 2009 to 2016. The primary study objective was to assess factors associated with the development of candidemia after open heart surgery. Results Overall, 222 patients (74 cases and 148 controls) were included in the study. Candidemia developed at a median time (interquartile range) of 23 (14–36) days after surgery. In multivariable analysis, independent predictors of candidemia were New York Heart Association class III or IV (odds ratio [OR], 23.81; 95% CI, 5.73–98.95; P < .001), previous therapy with carbapenems (OR, 8.87; 95% CI, 2.57–30.67; P = .001), and previous therapy with fluoroquinolones (OR, 5.73; 95% CI, 1.61–20.41; P = .007). Crude 30-day mortality of candidemia was 53% (39/74). Septic shock was independently associated with mortality in the multivariable model (OR, 5.64; 95% CI, 1.91–16.63; P = .002). No association between prolonged cardiopulmonary bypass time and candidemia was observed in this study. Conclusions Previous broad-spectrum antibiotic therapy and high NYHA class were independent predictors of candidemia in cardiac surgery patients with prolonged postoperative intensive care unit stay.

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