Investigation of the effects of continuous theta  burst transcranial magnetic stimulation  in patients with migraine

Background: Repetitive transcranial magnetic stimulation (rTMS) has therapeutic effects on craving in methamphetamine (METH) use disorder (MUD). The chronic abuse of METH causes impairments in executive function, and improving executive function reduces relapse and improves treatment outcomes for drug use disorder. The purpose of this study was to determine whether executive function helped predict patients' responses to rTMS treatment.Methods: This study employed intermittent theta burst stimulation (iTBS) rTMS modalities and observed their therapeutic effects on executive function and craving in MUD patients. MUD patients from an isolated Drug Rehabilitation Institute in China were chosen and randomly allocated to the iTBS group and sham-stimulation group. All participants underwent the Behavior Rating Inventory of Executive Function - Adult Version Scale (BRIEF-A) and Visual Analog Scales (VAS) measurements. Sixty-five healthy adults matched to the general condition of MUD patients were also recruited as healthy controls.Findings: Patients with MUD had significantly worse executive function. iTBS groups had better treatment effects on the MUD group than the sham-stimulation group. Further Spearman rank correlation and stepwise multivariate regression analysis revealed that reduction rates of the total score of the BRIEF-A and subscale scores of the inhibition factor and working memory factor in the iTBS group positively correlated with improvements in craving. ROC curve analysis showed that working memory (AUC = 87.4%; 95% CI = 0.220, 0.631) and GEC (AUC = 0.761%; 95% CI = 0.209, 0.659) had predictive power to iTBS therapeutic efficacy. The cutoff values are 13.393 and 59.804, respectively.Conclusions: The iTBS rTMS had a better therapeutic effect on the executive function of patients with MUD, and the improved executive function had the potential to become a predictor for the efficacy of iTBS modality for MUD treatment.Clinical Trial Registration:ClinicalTrials.gov, identifier: ChiCTR2100046954.

Download Full-text

Analgesic effects of repetitive transcranial magnetic stimulation of the motor cortex in neuropathic pain: Influence of theta burst stimulation priming

European Journal of Pain ◽

10.1002/j.1532-2149.2012.00150.x ◽

2012 ◽

Vol 16 (10) ◽

pp. 1403-1413 ◽

Cited By ~ 57

Author(s):

J.-P. Lefaucheur ◽

S.S. Ayache ◽

M. Sorel ◽

W.H. Farhat ◽

H.G. Zouari ◽

...

Keyword(s):

Neuropathic Pain ◽

Transcranial Magnetic Stimulation ◽

Motor Cortex ◽

Magnetic Stimulation ◽

Repetitive Transcranial Magnetic Stimulation ◽

Theta Burst Stimulation ◽

Burst Stimulation ◽

Analgesic Effects ◽

Theta Burst ◽

Stimulation Of

Download Full-text

The Effects of Theta Burst Transcranial Magnetic Stimulation over the Human Primary Motor and Sensory Cortices on Cortico-Muscular Coherence

Neural Information Processing - Lecture Notes in Computer Science ◽

10.1007/978-3-540-69158-7_15 ◽

2008 ◽

pp. 135-141

Author(s):

Murat Saglam ◽

Kaoru Matsunaga ◽

Yuki Hayashida ◽

Nobuki Murayama ◽

Ryoji Nakanishi

Keyword(s):

Transcranial Magnetic Stimulation ◽

Magnetic Stimulation ◽

Sensory Cortices ◽

Theta Burst

Download Full-text

The effects of 30 Hz, 50 Hz AND 100 Hz continuous theta burst stimulation via transcranial magnetic stimulation on the electrophysiological parameters in healthy individuals

Ideggyógyászati Szemle ◽

10.18071/isz.74.0041 ◽

2021 ◽

Vol 74 (1-2) ◽

pp. 41-49

Author(s):

Zeynep Ozdemir ◽

Erkan Acar ◽

Aysun Soysal

Keyword(s):

Transcranial Magnetic Stimulation ◽

Magnetic Stimulation ◽

Short Interval ◽

Motor Evoked Potential ◽

Individual Variability ◽

Theta Burst Stimulation ◽

Burst Stimulation ◽

Resting Motor Threshold ◽

Theta Burst ◽

Continuous Theta Burst Stimulation

Transcranial magnetic stimulation is a non-invasive procedure that uses robust magnetic fields to create an electrical current in the cerebral cortex. Dual stimulation consists of administering subthreshold conditioning stimulation (CS), then suprathreshold test stimulation (TS). When the interstimulus interval (ISI) is 1-6 msec, the motor evoked potential (MEP) decreases in amplitude; this decrease is termed “short interval intracortical inhibition” (SICI); when the ISI is 7-30 msec, an increase in MEP amplitude occurs, termed “short interval intracortical facilitation” (SICF). Continuous theta burst stimulation (cTBS), often applied at a frequency of 50 Hz, has been shown to decrease cortical excitability. The primary objective is to determine which duration of cTBS achieves better inhibition or excitation. The secondary objective is to compare 50 Hz cTBS to 30 Hz and 100 Hz cTBS. The resting motor threshold (rMT), MEP, SICI, and SICF were studied in 30 healthy volunteers. CS and TS were administered at 80%-120% and 70%-140% of rMT at 2 and 3-millisecond (msec) intervals for SICI, and 10- and 12-msec intervals for SICF. Ten individuals in each group received 30, 50, or 100 Hz, followed by administration of rMT, MT-MEP, SICI, SICF immediately and at 30 minutes. Greater inhibition was achieved with 3 msec than 2 msec in SICI, whereas better facilitation occurred at 12 msec than 10 msec in SICF. At 30 Hz, cTBS augmented inhibition and suppressed facilitation, while 50 Hz yielded less inhibition and greater inter-individual variability. At 100 Hz, cTBS provided slight facilitation in MEP amplitudes with less interindividual variability. SICI and SICF did not differ significantly between 50 Hz and 100 Hz cTBS. Our results suggest that performing SICI and SICF for 3 and 12 msec, respectively, and CS and TS at 80%-120% of rMT, demonstrate safer inhibition and facilitation. Recently, TBS has been used in the treatment of various neurological diseases, and we recommend preferentially 30 Hz over 50 Hz cTBS for better inhibition with greater safety and less inter-individual variability.

Download Full-text

Theta-Burst Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder

American Journal of Psychiatry ◽

10.1176/appi.ajp.2019.18101160 ◽

2019 ◽

Vol 176 (11) ◽

pp. 939-948 ◽

Cited By ~ 29

Author(s):

Noah S. Philip ◽

Jennifer Barredo ◽

Emily Aiken ◽

Victoria Larson ◽

Richard N. Jones ◽

...

Keyword(s):

Posttraumatic Stress Disorder ◽

Transcranial Magnetic Stimulation ◽

Posttraumatic Stress ◽

Magnetic Stimulation ◽

Stress Disorder ◽

Theta Burst

Download Full-text

One-year clinical outcomes following theta burst stimulation for post-traumatic stress disorder

Neuropsychopharmacology ◽

10.1038/s41386-019-0584-4 ◽

2019 ◽

Vol 45 (6) ◽

pp. 940-946 ◽

Cited By ~ 4

Author(s):

Nicholas J. Petrosino ◽

Mascha van ’t Wout-Frank ◽

Emily Aiken ◽

Hannah R. Swearingen ◽

Jennifer Barredo ◽

...

Keyword(s):

Transcranial Magnetic Stimulation ◽

Clinical Outcomes ◽

Post Traumatic Stress Disorder ◽

Traumatic Stress ◽

Magnetic Stimulation ◽

Stress Disorder ◽

Post Traumatic Stress ◽

Post Traumatic ◽

One Year ◽

Theta Burst

AbstractTheta burst transcranial magnetic stimulation (TBS) is a potential new treatment for post-traumatic stress disorder (PTSD). We previously reported active intermittent TBS (iTBS) was associated with superior clinical outcomes for up to 1-month, in a sample of fifty veterans with PTSD, using a crossover design. In that study, participants randomized to the active group received a total of 4-weeks of active iTBS, or 2-weeks if randomized to sham. Results were superior with greater exposure to active iTBS, which raised the question of whether observed effects persisted over the longer-term. This study reviewed naturalistic outcomes up to 1-year from study endpoint, to test the hypothesis that greater exposure to active iTBS would be associated with superior outcomes. The primary outcome measure was clinical relapse, defined as any serious adverse event (e.g., suicide, psychiatric hospitalization, etc.,) or need for retreatment with repetitive transcranial magnetic stimulation (rTMS). Forty-six (92%) of the initial study’s intent-to-treat participants were included. Mean age was 51.0 ± 12.3 years and seven (15.2%) were female. The group originally randomized to active iTBS (4-weeks active iTBS) demonstrated superior outcomes at one year compared to those originally randomized to sham (2-weeks active iTBS); log-rank ChiSq = 5.871, df = 1, p = 0.015; OR = 3.50, 95% CI = 1.04–11.79. Mean days to relapse were 296.0 ± 22.1 in the 4-week group, and 182.0 ± 31.9 in the 2-week group. When used, rTMS retreatment was generally effective. Exploratory neuroimaging revealed default mode network connectivity was predictive of 1-year outcomes (corrected p < 0.05). In summary, greater accumulated exposure to active iTBS demonstrated clinically meaningful improvements in the year following stimulation, and default mode connectivity could be used to predict longer-term outcomes.

Download Full-text