Interaction between hereditary spherocytosis and the beta-thalassemia trait: A case report

Thyroid cancer is the most frequent endocrine neoplasm in the general population. Common risk factors include gender, radiation exposure, and genetic backgrounds. The association of papillary thyroid cancer and celiac disease has frequently been reported in the literature; however, the association of papillary thyroid cancer and thalassemia trait is rare. Likewise, the association of thalassemia major and celiac disease is also rare. We hereby report a unique case of papillary thyroid cancer in a patient with celiac disease and thalassemia trait.

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Challenges and Results of Laparoscopic Splenectomy for Hematological Diseases in a Developing Country

Minimally Invasive Surgery ◽

10.1155/2018/4256570 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Vikal Chandra Shakya ◽

Bikram Byanjankar ◽

Rabin Pandit ◽

Anang Pangeni ◽

Anir Ram Moh Shrestha ◽

...

Keyword(s):

Laparoscopic Splenectomy ◽

Operative Time ◽

Hereditary Spherocytosis ◽

Developed Countries ◽

Beta Thalassemia ◽

Hematological Diseases ◽

Alpha Thalassemia ◽

Steroid Dependent ◽

The Mean ◽

Surgery Department

Introduction. Though, in developed countries, laparoscopy is now a gold standard for splenectomy, we are lacking in this aspect in the eastern world. Splenectomy has mostly been performed by open surgery in our region. This is our effort to introduce laparoscopic splenectomy in our country.Methods. This is a retrospective cohort study done in patients presenting to hematology and surgery department of our hospital who underwent laparoscopic splenectomy for hematological diseases from January 2013 to December 2016.Results. There were 50 patients (38 females, 12 males). The diagnoses were idiopathic thrombocytopenic purpura in 31, (steroid/azathioprine-resistant, steroid dependent), hereditary spherocytosis in 9, alpha-thalassemia in 3, beta-thalassemia in 2, autoimmune hemolytic anemia in 4, and isolated splenic tuberculosis in 1. Average platelet counts preoperatively were62000±11000/mm3 (range 52000-325000/mm3). The mean operative time was130±49minutes (range 108-224 min). The mean postoperative stay was4±2.11days (range 3-9 days). Laparoscopic splenectomy could be completed in 45 (90%) patients.Conclusion. Laparoscopic splenectomy could be successfully contemplated in patients with hematological diseases, especially if spleen is normal or only mildly enlarged, and is an advantageous alternative to open splenectomy. Absence of ideal resources has not limited our progress in minimal access approach.

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A Young Child with Sickle Cell Beta Thalassemia: A Case Report and Review of Literatures

Journal of Dhaka Medical College ◽

10.3329/jdmc.v21i2.15368 ◽

2013 ◽

Vol 21 (2) ◽

pp. 245-249

Author(s):

Md. Abid Hossain Mollah ◽

Ekhlasur Rahman ◽

Saiful Islam ◽

AKM Amirul Morshed ◽

Farzana Rahman Munmun ◽

...

Keyword(s):

Case Report ◽

Young Child ◽

Sickle Cell ◽

Beta Thalassemia ◽

Medical College

J Dhaka Medical College, Vol. 21, No. 2, October, 2012, Page 245-249 DOI: http://dx.doi.org/10.3329/jdmc.v21i2.15368

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Application of Bayesian Decision Tree in Hematology Research: Differential Diagnosis of β-Thalassemia Trait from Iron Deficiency Anemia

Computational and Mathematical Methods in Medicine ◽

10.1155/2021/6401105 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

Mina Jahangiri ◽

Fakher Rahim ◽

Najmaldin Saki ◽

Amal Saki Malehi

Keyword(s):

Differential Diagnosis ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Hematological Parameters ◽

False Positive Rate ◽

Deficiency Anemia ◽

Beta Thalassemia ◽

Bayesian Tree ◽

Thalassemia Trait ◽

Cart Algorithm

Objective. Several discriminating techniques have been proposed to discriminate between β-thalassemia trait (βTT) and iron deficiency anemia (IDA). These discrimination techniques are essential clinically, but they are challenging and typically difficult. This study is the first application of the Bayesian tree-based method for differential diagnosis of βTT from IDA. Method. This cross-sectional study included 907 patients with ages over 18 years old and a mean (±SD) age of 25 ± 16.1 with either βTT or IDA. Hematological parameters were measured using a Sysmex KX-21 automated hematology analyzer. Bayesian Logit Treed (BLTREED) and Classification and Regression Trees (CART) were implemented to discriminate βTT from IDA based on the hematological parameters. Results. This study proposes an automatic detection model of beta-thalassemia carriers based on a Bayesian tree-based method. The BLTREED model and CART showed that mean corpuscular volume (MCV) was the main predictor in diagnostic discrimination. According to the test dataset, CART indicated higher sensitivity and negative predictive value than BLTREED for differential diagnosis of βTT from IDA. However, the CART algorithm had a high false-positive rate. Overall, the BLTREED model showed better performance concerning the area under the curve (AUC). Conclusions. The BLTREED model showed excellent diagnostic accuracy for differentiating βTT from IDA. In addition, understanding tree-based methods are easy and do not need statistical experience. Thus, it can help physicians in making the right clinical decision. So, the proposed model could support medical decisions in the differential diagnosis of βTT from IDA to avoid much more expensive, time-consuming laboratory tests, especially in countries with limited recourses or poor health services.

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