scholarly journals How Not to Save the University

2021 ◽  
Vol 34 (4) ◽  
pp. 135-138
Author(s):  
Robert Weissberg
Keyword(s):  
Princeton University ◽  
The University

A review of Minds Wide Shut: How the New Fundamentalism Divides Us," Gary Saul Morson, Morton Schapiro, Princeton University Press, 202, pp. 289, $28.00 hardcover.

Betrayal of betrothed in Sunetra Gupta’s Memories of rain

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
K. RUBY VANEESA ◽  
Dr. S. AYYAPPA RAJA
Keyword(s):  
Rabindranath Tagore ◽  
Oxford University ◽  
Princeton University ◽  
Profound Influence ◽  
The University

Sunetra Gupta was born in Calcutta in 1965 and is an established translator of the poetry of Rabindranath Tagore. She is a well known novelist, essayist and scientist. She is working as Professor of Theoretical Epidemiology at Oxford University in the Department of Zoology. From Princeton University she got graduation in 1987 and from the University of London she received Ph.D. in 1992. Her father, Dhruba Gupta had a profound influence on every view of her thinking

Byzantine-period lamps from Antioch-on-the-Orontes and its hinterland

2019 ◽  
Author(s):  
Ani Eblighatian
Keyword(s):  
United States ◽  
The United States ◽  
Art Museum ◽  
Archaeological Sites ◽  
Museum Collections ◽  
Doctoral Research ◽  
Princeton University ◽  
Byzantine Period ◽  
The University ◽  
Roman Syria

The paper is an off-shoot of the author's PhD project on lamps from Roman Syria (at the University of Geneva in Switzerland), centered mainly on the collection preserved at the Art Museum of Princeton University in the United States. One of the outcomes of the research is a review of parallels from archaeological sites and museum collections and despite the incomplete documentation i most cases, much new insight could be gleaned, for the author's doctoral research and for other issues related to lychnological studies. The present paper collects the data on oil lamps from byzantine layers excavated in 1932–1939 at Antioch-on-the-Orontes and at sites in its vicinity (published only in part so far) and considers the finds in their archaeological context.

Reform and Revisionism in the Study of Henrician England - Edward Stafford, Third Duke of Buckingham. By Barbara J. Harris. Stanford, Calif.: Stanford University Press, 1986. Pp. viii + 334. $37.50. - The Power of the Tudor Nobility. By G. W. Bernard. Totowa, N.J.: Barnes & Noble Books, 1985. Pp. 228. - Rome ou l'Angleterre? Les reactions politiques des Catholiques Anglais au moment du schisme. By Jean-Pierre Moreau. Paris: Presses Universitaires de France, 1984. Pp. 377. - Humanism in the Age of Henry VIII. By Maria Dowling. London: Croom Helm, 1986. Pp. 283. $43.00. - Reassessing the Henrician Age: Humanism, Politics, and Reform, 1500–1550. Edited by Alistair Fox and John Guy. Oxford: Basil Black well, 1986. Pp. vi + 242. - The History of the University of Oxford, vol. 3: The Collegiate University. Edited by James McConica. Oxford: Oxford University Press, 1986. $125.00. - Revolution Reassessed: Revisions in the History of Tudor Government and Administration. Edited by Christopher Coleman and David Starkey. Oxford: Oxford University Press, 1986. Pp. viii + 219. - Treason in Tudor England: Politics and Paranoia. By Lacey Baldwin Smith. Princeton, N.J.: Princeton University Press, 1986. Pp. 342. $25.00. - Venetian Humanism in an Age of Patrician Dominance. By Margaret King. Princeton, N.J.: Princeton University Press, 1986. Pp. xxi + 524.

1988 ◽  
Vol 27 (2) ◽  
pp. 190-197
Author(s):  
Thomas F. Mayer
Keyword(s):  
Henry Viii ◽  
Stanford University ◽  
Tudor England ◽  
Oxford University ◽  
University Of Oxford ◽  
Princeton University ◽  
History Of ◽  
History Of The University ◽  
The University ◽  
Oxford University Press

Enantioselective Assembly of Alkylated Stereogenic Centers

2011 ◽  
Author(s):  
Douglass Taber
Keyword(s):  
Limited Range ◽  
Geometric Isomer ◽  
High Yield ◽  
Enantioselective Reduction ◽  
Carbon Nucleophiles ◽  
Princeton University ◽  
University Of Wisconsin ◽  
Silyl Enol Ether ◽  
Stereogenic Centers ◽  
The University

Oxygenated secondary stereogenic centers are readily available. There is a limited range of carbon nucleophiles that will displace a secondary leaving group in high yield with clean inversion. Teruaki Mukaiyama of the Kitasato Institute has described (Chem. Lett. 2007, 36, 2) an elegant addition to this list. Phosphinites such as 1 are easily prepared from the corresponding alcohols. Quinone oxidation in the presence of a nucleophile led via efficient displacement to the coupled product 2. The sulfone could be reduced with SmI2 to give 3. Enantioselective reduction of trisubstituted alkenes is also a powerful method for establishing alkylated stereogenic centers. Juan C. Carretero of the Universidad Autonoma de Madrid has found (Angew. Chem. Int. Ed. 2007, 46, 3329) that the enantioselective reduction of unsaturated pyridyl sulfones such as 4 was directed by the sulfone, so the other geometric isomer of 4 gave the opposite enantiomer of 5. The protected hydroxy sulfone 5 is a versatile chiral building block. Samuel H. Gellman of the University of Wisconsin has reported (J. Am. Chem. Soc. 2007, 129, 6050) an improved procedure for the aminomethylation of aldehydes. L-Proline-catalyzed condensation with the matched α-methyl benzylamine derivavative 7 gave the aldehyde, which was immediately reduced to the alcohol 8 to avoid racemization. The amino alcohol 8 was easily separated in diastereomerically-pure form. In the past, aldehydes have been efficiently α-alkylated using two-electron chemistry. David W. C. Macmillan of Princeton University has developed (Science 2007, 316, 582; J. Am. Chem. Soc. 2007, 129, 7004) a one-electron alternative. The organocatalyst 9 formed an imine with the aldehyde. One-electron oxidation led to an α-radical, which was trapped by the allyl silane (or, not pictured, a silyl enol ether) leading to the α-alkylated aldehyde 10. This is mechnistically related to the work reported independently by Mukund P. Sibi (J. Am. Chem. Soc. 2007, 129, 4124; OHL Feb. 11, 2008) on one-electron α-oxygenation of aldehydes. Secondary alkylated centers can also be prepared by SN2’ alkylation of prochiral substrates such as 11. Ben L. Feringa of the University of Groningen has shown (J. Org. Chem. 2007, 72, 2558) that the displacement proceeded with high ee even with conventional Grignard reagents.

Functionalization and Homologation of C-H Bonds

2013 ◽  
Author(s):  
Douglass F. Taber
Keyword(s):  
Crop Protection ◽  
Oxidative Cyclization ◽  
South Florida ◽  
State University ◽  
Ru Catalyst ◽  
University Of Oklahoma ◽  
Princeton University ◽  
La Jolla ◽  
The University ◽  
Technological University

Justin Du Bois of Stanford University developed (J. Am. Chem. Soc. 2010, 132, 10202) a Ru catalyst for the stereoretentive hydroxylation of 1 to 2. John T. Groves of Princeton University effected (J. Am. Chem. Soc. 2010, 132, 12847) equatorial chlorination of the test substrate 3. Kenneth M. Nicholas of the University of Oklahoma found (J. Org. Chem. 2010, 75, 7644) that I2 catalyzed the amination of 5. Thorsten Bach of the Technische Universität München established (Org. Lett. 2010, 12, 3690) that the amination of 7 proceeded with significant diastereoselectivity. Phil S. Baran of Scripps/La Jolla compiled (Synlett 2010, 1733) an overview of the development of C-H oxidation. Tethering can improve the selectivity of C-H functionalization. X. Peter Zhang of the University of South Florida devised (Angew. Chem. Int. Ed. 2010, 49, 10192) a Co catalyst for the cyclization of 9 to 10. Teck-Peng Loh of Nanyang Technological University established (Angew. Chem. Int. Ed. 2010, 49, 8417) conditions for the oxidation of 11 to 12. Jin-Quan Yu, also of Scripps/La Jolla, effected (J. Am. Chem. Soc. 2010, 132, 17378) carbonylation of methyl C-H of 13 to give 14. Sunggak Kim, now also at Nanyang Technological University, established (Synlett 2010, 1647) conditions for the free-radical homologation of 15 to 17. Gong Chen of Pennsylvania State University extended (Org. Lett. 2010, 12, 3414) his work on remote Pd-mediated activation by cyclizing 18 to 19. Many schemes have been developed in recent years for the oxidation of substrates to reactive electrophiles. Gonghua Song of the East China University of Science and Technology and Chao-Jun Li of McGill University reported (Synlett 2010, 2002) Fe nanoparticles for the oxidative coupling of 20 with 21. Zhi-Zhen Huang of Nanjing University found (Org. Lett. 2010, 12, 5214) that protonated pyrrolidine 25 was important for mediating the site-selective coupling of 24 with 23. Y. Venkateswarlu of the Indian Institute of Chemical Technology, Hyderabad, was even able (Tetrahedron Lett. 2010, 51, 4898) to effect coupling with a cyclic alkene 28. AB3217-A 32, isolated in 1992, was shown to have marked activity against two spotted spider mites. Christopher R. A. Godfrey of Syngenta Crop Protection, Münchwilen, prepared (Synlett 2010, 2721) 32 from commercial anisomycin 30a. The key step in the synthesis was the oxidative cyclization of 30b to 31.

C–N Ring Construction: The Waser Synthesis of Jerantinine E

2017 ◽  
Author(s):  
Douglass F. Taber
Keyword(s):  
Ni Catalyst ◽  
University Of Alberta ◽  
Princeton University ◽  
In Situ Preparation ◽  
National University ◽  
The University ◽  
École Polytechnique ◽  
Pais Vasco ◽  
Multicomponent Coupling

James A. Bull of Imperial College London prepared (J. Org. Chem. 2013, 78, 6632) the aziridine 2 with high diastereocontrol by adding the anion of diiodomethane to the imine 1. Karl Anker Jørgensen of Aarhus University observed (Chem. Commun. 2013, 49, 6382) high ee in the distal aziridination of 3 to give 4. Benito Alcaide of the Universidad Complutense de Madrid and Pedro Almendros of ICOQ- CSIC Madrid reduced (Adv. Synth. Catal. 2013, 355, 2089) the β-lactam 5 to the azetidine 6. Hiroaki Sasai of Osaka University added (Org. Lett. 2013, 15, 4142) the allenoate 8 to the imine 7, delivering the azetidine 9 in high ee. Tamio Hayashi of Kyoto University, the National University of Singapore, and A*STAR devised (J. Am. Chem. Soc. 2013, 135, 10990) a Pd catalyst for the enanti­oselective addition of the areneboronic acid 11 to the pyrroline 10 to give 12. Ryan A. Brawn of Pfizer (Org. Lett. 2013, 15, 3424) reported related results. Nicolai Cramer of the Ecole Polytechnique Fédérale de Lausanne developed (J. Am. Chem. Soc. 2013, 135, 11772) a Ni catalyst for the cyclization of the formamide 13 to the lactam 14. Andrew D. Smith of the University of St. Andrews used (Org. Lett. 2013, 15, 3472) an organocatalyst to cyclize 15 to 16. Jose L. Vicario of the Universidad del Pais Vasco effected (Synthesis 2013, 45, 2669) the multicomponent coupling of 17, 18, and 19, mediated by an organocatalyst, to construct 20 in high ee. André Beauchemin of the University of Ottawa explored (J. Org. Chem. 2013, 78, 12735) the thermal cyclization of ω-alkenyl hydroxyl amines such as 21. Abigail G. Doyle of Princeton University developed (Angew. Chem. Int. Ed. 2013, 52, 9153) a Ni catalyst for the enantioselective addition of aryl zinc bromides such as 24 to the pro­chiral 23, to give 25 in high ee. Dennis G. Hall of the University of Alberta developed (Angew. Chem. Int. Ed. 2013, 52, 8069) an in situ preparation of the allyl boronate 26 in high ee. Addition to the aldehyde 27 proceeded with high diasteroselectivity.

New Methods for Reduction and for Oxidation

2017 ◽  
Author(s):  
Douglass F. Taber
Keyword(s):  
Carboxylic Acid ◽  
Primary Alcohol ◽  
Direct Oxidation ◽  
University Of Florida ◽  
Co Catalyst ◽  
Princeton University ◽  
National University ◽  
Texas Tech University ◽  
Seoul National University ◽  
The University

Clemens Krempner of Texas Tech University devised (Chem. Eur. J. 2014, 20, 14959) a very active Al catalyst for the Meerwein-Ponndorf-Verley reduction of a ketone 1 to the alcohol 2. Louis Fensterbank and Cyril Ollivier of UMPC and Jean-Philippe Goddard of the Université de Haute-Alsace showed (Adv. Synth. Catal. 2014, 356, 2756) that visible light could mediate the reduction of the O-thiocarbamate 3 to 4. Soon Hyeok Hong of Seoul National University used (Org. Lett. 2014, 16, 4404) hydrogen from the diol 6 to reduce the nitrile 5, leading directly to the protected amine 7. Alex Adronov of McMaster University (J. Org. Chem. 2014, 79, 7728) and Thibault Cantat of Gif- sur-Yvette (Chem. Commun. 2014, 50, 9349) observed that an aryl amide 8 could be reduced to the amine 9 under conditions that left alkyl amides unchanged. Paul J. Chirik of Princeton University developed (J. Am. Chem. Soc. 2014, 136, 13178) a Co catalyst for the alcohol- directed reduction of a proximal alkene, converting 10 selectively to 11. Yoichiro Kuninobu and Motomu Kanai of the University of Tokyo used (Synlett 2014, 25, 1869) stoichiometric Mo(CO)₆ to desulfurize 12 to 13. Utpal Bora of Tezpur University oxidized (Tetrahedron Lett. 2014, 55, 5029) the alcohol 14 to the aldehyde 15 with t-butyl hydroperoxide, using the inexpensive and reusable VOSO₄ as the catalyst. The oxidation of an alcohol to the acid is often car­ried out in two steps, alcohol to aldehyde and aldehyde to carboxylic acid. Kenneth B. Wagener of the University of Florida developed (Tetrahedron Lett. 2014, 55, 4452) a protocol for the direct oxidation of an alcohol 16 to the acid 17. Prodeep Phukan of Gauhati University devised (Tetrahedron Lett. 2014, 55, 5358) a catalyst-free procedure for the oxidation of a primary alcohol 18 to the ester 19. The aldehyde cor­responding to 18 (not illustrated) was also efficiently oxidized to 19. Katsuhiko Moriyama and Hideo Togo of Chiba University effected (Org. Lett. 2014, 16, 3812) the oxidative debenzylation of 20 to the ketone 21.

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