Anti-proliferative Activity of Some Oleanolic Acid Derivatives with Potent Topoisomerase Inhibitory Activity on B16 Melanoma Cells
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Our previous study included the semisynthetic reactions on oleanolic acid, a common wood-derived oleanane-type triterpene. Ten rationally designed derivatives of oleanolic acid were synthesized based on docking studies and tested for their topoisomerase I and IIα inhibitory activity. Semisynthetic reactions targeted C-3, C-12, C-13 and C-17. Some of these compounds act as dual inhibitors for both topoisomerase I and IIα giving new anticancer agents. The cytotoxic activity of these compounds on B16 melanoma cancer cells was evaluated. Results showed that most of these compounds have a higher cytotoxic activity on B16 melanoma cells.
2013 ◽
Vol 21
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pp. 779-787
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2011 ◽
Vol 6
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pp. 1934578X1100600
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2018 ◽
Vol 28
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pp. 2518-2522
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2011 ◽
Vol 12
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pp. 8787-8796
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2015 ◽
Vol 69
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pp. 427-431
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1992 ◽
Vol 267
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pp. 17264-17270
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