Effects of the L-Carnitine Acute Administration on Venous Blood Gases and Exercise Performance during Exercise

2002 ◽  
Vol 18 ◽  
pp. 1271-1282
Author(s):  
Jin Hwan Yoon ◽  
Jong Oh Kim ◽  
Bong Seock Oh
Keyword(s):  
Exercise Performance ◽  
Venous Blood ◽  
Blood Gases ◽  
Acute Administration

Dobutamine as a countermeasure for reduced exercise performance of rats exposed to simulated microgravity

1997 ◽  
Vol 82 (5) ◽  
pp. 1607-1615 ◽  
Author(s):  
Charles M. Tipton ◽  
Lisa A. Sebastian
Keyword(s):  
Lactic Acid ◽  
Exercise Performance ◽  
Simulated Microgravity ◽  
Maximal Exercise ◽  
Blood Gases ◽  
Chronic Administration ◽  
Mechanical Efficiency ◽  
Male Rats ◽  
Double Product ◽  
Run Time

Tipton, Charles M., and Lisa A. Sebastian. Dobutamine as a countermeasure for reduced exercise performance of rats exposed to simulated microgravity. J. Appl. Physiol. 82(5): 1607–1615, 1997.—Post-spaceflight results and findings from humans and rodents after conditions of bed rest or simulated microgravity indicate maximum exercise performance is significantly compromised. However, the chronic administration of dobutamine (a synthetic adrenomimetic) to humans in relevant experiments improves exercise performance by mechanisms that prevent the decline in peak O2 consumption (V˙o 2 peak) and reduce the concentration of lactic acid measured in the blood. Although dobutamine restores maximumV˙o 2values in animals participating in simulated microgravity studies, it is unknown whether injections of this α1-, β1-, and β2-adrenoceptor agonist in rats will enhance exercise performance. To investigate this, adult male rats were assigned to three experimental groups: caged control receiving saline; head-down, tail-suspended (HDS) receiving saline (HDS-S); and an HDS group receiving dobutamine hydrochloride injections (1.8 mg/kg twice daily per rat). Treadmill tests were performed before suspension, at 14 days, and after 21 days.V˙o 2 peak, run time, and the rate of rise in colonic temperature (heating index) were evaluated after 14 days, whereas at 21 days, hemodynamic responses (heart rate, systolic blood pressure, and double product) were determined during submaximal exercise with blood pH, blood gases, and lactic acid concentration values obtained during maximal exercise. In contrast to the results for the HDS-S rats, dobutamine administration did restore V˙o 2 peakand “normalized” lactic acid concentrations during maximal exercise. However, daily injections were unable to enhance exercise performance aspects associated with treadmill run time, the mechanical efficiency of running, the heating index, or the retention of muscle and body mass. These simulated microgravity findings suggest that dobutamine’s potential value as a countermeasure for postflight maximal performance or for egress emergencies is limited and that other countermeasures must be considered.

A comparison of blood gases and acid-base measurements in arterial, arterialized venous, and venous blood during short-term maximal exercise

1990 ◽  
Vol 61 (3-4) ◽  
pp. 294-301 ◽  
Author(s):  
Jon Linderman ◽  
Thomas D. Fahey ◽  
Gregory Lauten ◽  
Alan S. Brooker ◽  
Doug Bird ◽  
...  
Keyword(s):  
Maximal Exercise ◽  
Venous Blood ◽  
Blood Gases ◽  
Acid Base ◽  
Short Term

Abstract P22: An Impedance Threshold Device Combined with an Automated Active Compression Decompression CPR Device (LUCAS) Improves the Chances For Survival in Pigs in Cardiac Arrest

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Timothy R Matsuura ◽  
Scott H McKnite ◽  
Anja K Metzger ◽  
Demetris Yannopoulos ◽  
Tom P Aufderheide ◽  
...  
Keyword(s):  
Venous Blood ◽  
Blood Gases ◽  
Intrathoracic Pressure ◽  
Organ Damage ◽  
Coronary Perfusion Pressure ◽  
Spontaneous Circulation ◽  
Adverse Outcomes ◽  
Coronary Perfusion ◽  
Threshold Device ◽  
Impedance Threshold Device

Background: By lowering intrathoracic pressure during the chest recoil phase of CPR, the impedance threshold device (ITD) increases circulation and the rate of return of spontaneous circulation (ROSC). This study evaluated the ITD combined with a new automated CPR device, the US version of the LUCAS, that compresses the chest and then pulls upwards with a 3 lb force. Methods and Results: After 6 min of untreated ventricular fibrillation, anesthetized female pigs (40.0±0.7 kg) were randomized to 6 min of CPR (100 compressions/min with LUCAS and ventilation: 1.0 FiO2, tidal volume of 10ml/kg, rate 12/min) with an active (−10 cm H2O resistance) (n=12) or sham ITD (n=12), and then shocked once with 120 joules of direct current. Epinephrine (0.04 mg/kg) and more CPR and shocks were used if ROSC was not achieved. Results (in mmHg) after 6 min of CPR with an active vs. sham ITD were: coronary perfusion pressure (PP) 20.8±1.2 vs. 21.0±0.9 (p=0.94); cerebral PP 8.8±1.0 vs. 10.0±0.9 (p=0.62); and end tidal CO2 38.1±1.5 and 37.1±1.3 (p=0.61). Peak and mean carotid artery blood flow (ml/min) was 323.9±15.2 vs. 256.6±21.1 (p=0.17) and 95.3±5.4 vs. 77.0±6.0 (p=0.22) with an active vs. sham ITD, respectively. Mean endotracheal pressures (mmHg) during chest recoil with an active vs. sham ITD were −2.0±0.5 vs. −0.2±0.2 (p<0.01). Arterial and venous blood gases were similar after 6 min of CPR between groups. ROSC, the primary survival endpoint for comparing the active vs. sham ITD, was 7/12 vs. 2/12 after 1 shock (p= 0.09), 12/12 vs. 5/12 after 2 shocks (p<0.01), and 12/12 vs. 7/12 after 3 shocks (p=0.04). With up to 14 shocks, 10/12 sham animals had a ROSC. All animals with ROSC lived for 30 min. There was no evidence of pulmonary edema or organ damage on autopsy with either ITD. Conclusions: After 6 min of CPR, LUCAS and active ITD resulted in lower mean airway pressures during chest recoil versus controls but hemodynamic findings were similar. However, ROSC was significantly easier to achieve with an active ITD; with up to 3 shocks twice as many animals were resuscitated with an active ITD. This benefit is most likely explained by carotid blood flows that trended higher with the active ITD. These positive findings and lack of any adverse outcomes support the safety and efficacy of this device combination.

scholarly journals Maximal Fat Oxidation: Comparison between Treadmill, Elliptical and Rowing Exercises

2021 ◽  
pp. 170-178
Author(s):  
Michelle Filipovic ◽  
Stephanie Munten ◽  
Karl-Heinz Herzig ◽  
Dominique D. Gagnon
Keyword(s):  
Oxygen Consumption ◽  
Venous Blood ◽  
Maximal Oxygen Consumption ◽  
Blood Gases ◽  
Fat Oxidation ◽  
Peak Oxygen Consumption ◽  
Whole Body ◽  
Mixed Venous Blood ◽  
Exercise Modality ◽  
Maximal Fat Oxidation

Fat oxidation during exercise is associated with cardio-metabolic benefits, but the extent of which whole-body exercise modality elicits the greatest fat oxidation remains unclear. We investigated the effects of treadmill, elliptical and rowing exercise on fat oxidation in healthy individuals. Nine healthy males participated in three, peak oxygen consumption tests, on a treadmill, elliptical and rowing ergometer. Indirect calorimetry was used to assess maximal oxygen consumption (V̇O2peak), maximal fat oxidation (MFO) rates, and the exercise intensity MFO occurred (Fatmax). Mixed venous blood was collected to assess lactate and blood gases concentrations. While V̇O2peak was similar between exercise modalities, MFO rates were higher on the treadmill (mean ± SD; 0.61 ± 0.06 g·min-1) compared to both the elliptical (0.41 ± 0.08 g·min-1, p = 0.022) and the rower (0.40 ± 0.08 g·min-1, p = 0.017). Fatmax values were also significantly higher on the treadmill (56.0 ± 6.2 %V̇O2peak) compared to both the elliptical (36.8 ± 5.4 %V̇O2peak, p = 0.049) and rower (31.6 ± 5.0 %V̇O2peak, p = 0.021). Post-exercise blood lactate concentrations were also significantly lower following treadmill exercise (p = 0.021). Exercising on a treadmill maximizes fat oxidation to a greater extent than elliptical and rowing exercises, and remains an important exercise modality to improve fat oxidation, and consequently, cardio-metabolic health.

Catecholamine Levels and Their Correlation to Blood Gases in Umbilical Venous Blood Obtained by Cordocentesis

1990 ◽  
Vol 5 (3-4) ◽  
pp. 147-152 ◽  
Author(s):  
Kunihiro Okamura ◽  
Takanori Watanabe ◽  
Shingo Tanigawara ◽  
Hidetaka Endo ◽  
Mitsuru Iwamoto ◽  
...  
Keyword(s):  
Venous Blood ◽  
Blood Gases ◽  
Catecholamine Levels

Diagnostic Validity of Ratio between Differences of Central Venous to Arterial CO2 and Arterial to Central Venous O2 Content in Diagnosis of Anaerobic Metabolism among Septic Patients

2021 ◽  
Vol 8 (1) ◽  
pp. 34-38
Author(s):  
Subroto Kumar Sarker ◽  
Umme Kulsum Choudhury ◽  
Mohammad Mohsin ◽  
Subrata Kumar Mondal ◽  
Muslema Begum
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Intensive Care ◽  
Anaerobic Metabolism ◽  
Venous Blood ◽  
Blood Gases ◽  
Serum Lactate ◽  
Central Venous ◽  
College Hospital ◽  
Sepsis And Septic Shock

Background: Detection of anaerobic metabolism is very crucial for the management of the septic patients. Objective: The purpose of the present study was to validate the ratio between differences of central venous to arterial CO2 and arterial to central venous O2 content in diagnosis of anaerobic metabolism among septic patients. Methodology: This prospective observational study was conducted in the Intensive Care Unit of the department of Anaesthesia Analgesia, Palliative and Intensive Care Medicine at Dhaka Medical College Hospital, Dhaka, Bangladesh from January 2016 to December 2016. All patients admitted to ICU with the features of severe sepsis and septic shock according to SSC guidelines with the age of more than or equal to 18 years in both sexes were included in this study. The arterial and central venous blood gases were measure simultaneously. At the same time serum lactate was measured. Result: Among the 69 patients, 31(44.9%) were of severe sepsis and 38(55%) were of septic shock patients. In the severe sepsis and septic shock patients the mean P(v-a)CO2/C(a-v)O2 is 1.39±0.41 and 1.11±0.40 respectively. Serum lactate in case of severe sepsis and septic shock patients is 2.85±1.40 and 3.85±1.04 respectively. The ROC analysis showed an area under curve 0.89 and P(v-a)CO2/C(a-v)O2 ratio cutoff value of 1.21 showed sensitivity 0.84 and specificity 0.94. Conclusion: The P(v-a)CO2/C(a-v)O2  ratio is also a another marker of global anaerobic metabolism and it would be used for diagnosis as well as management of septic patient.  Journal of Current and Advance Medical Research, January 2021;8(1):34-38

Sign in / Sign up

Export Citation Format

Share Document