scholarly journals CHANGES IN HUMAN EPITHELIAL TISSUE IN CHRONIC ALCOHOL INTOXICATION AND ADVERSE ENVIRONMENTAL CONDITIONS IN THE AGE ASPECT. PARTICIPATION OF MORPHOFUNCTIONAL ZONES AND SRC KINASE IN THIS PROCESS

2021 ◽  
Vol 6 (3(53)) ◽  
pp. 14-24
Author(s):  
T. M. Yavisheva ◽  
S. D. Shcherbakov
Keyword(s):  
Human Body ◽  
Environmental Conditions ◽  
Alcohol Intoxication ◽  
Age Groups ◽  
Src Kinase ◽  
Epithelial Tissue ◽  
Chronic Alcohol ◽  
Chronic Alcohol Intoxication ◽  
Adverse Environmental Conditions ◽  
Two Age Groups

The reaction of human epithelial tissue to the effects of various pathological agents mainly depends on both the total amount of key protein in the organism – Src-kinase and the quantity of its active and inactive portions. In the age aspect, there is a decrease in Src-kinase content in the human body. The epithelial tissue of two age groups: 20-40 and 75 years and older responds most vigorously to pathological effects, including the entering of viruses, since in 20-40 years the number of Src-kinases is the largest of all age groups, and 75 years and older — the smallest. Under conditions of pathology, this leads to a decrease in the reactivity of organism tissues at 20-40 years and hyperactivity at 75 years and older.

scholarly journals Epithelial tissue response to pathological effects in various age groups. Participation of morphofunctional zones and Src-kinase in this process

2021 ◽  
pp. 81
Author(s):  
Keyword(s):  
Proliferative Activity ◽  
Age Groups ◽  
Src Kinase ◽  
Tissue Response ◽  
Active Part ◽  
Human Organism ◽  
Epithelial Tissue ◽  
Two Age Groups

The response of human organism tissues to various pathological effects depends to a large extent on the presence of the total amount of key protein in the organism – Src-kinase and the ratio of its active part to inactive. With a sharp preponderance of an inactive portion of this protein over the active, the proliferative activity of cells is suppressed, and with a significant preponderance of the active part, proliferation is inadequately increased. The amount of this protein is embedded in embryogenesis and individually in each person. In the age aspect, a decrease in the Src-kinase content in the human organism is observed. The epithelial tissue of two age groups: 20-40 and 75 years and older responds most acutely to pathological effects, including the entering of viruses, since in 20-40 years the number of Src-kinase is the greatest in relation to other age groups, and in 75 years and older – the least, which causes a decrease in the reactivity of organism tissues or, conversely, hyperactivity.

Features of the sensitivity of the central nervous system of the organism of experimental animals to the effects of certain psychotropic drugs and their combinations against the background of chronic alcohol intoxication in a chronopharmacological experiment

2020 ◽  
pp. 56-62
Author(s):  
E.V. Filippova
Keyword(s):  
Alcohol Intoxication ◽  
Laboratory Animals ◽  
Histological Structure ◽  
Chronic Alcohol ◽  
Behavioral Reactions ◽  
Experimental Animals ◽  
Chronic Alcohol Intoxication ◽  
Psychotropic Action ◽  
Adaptive Effect ◽  
The Central Nervous System

In a chronopharmacological experiment, the effect of two drugs with psychotropic action in combinations on the behavior of laboratory animals subjected to chronic alcohol intoxication was examined. Against the background of a deprimating agent, a decrease in the threshold of sensitivity to electrical irritation and the duration of an aggressive reaction was revealed; an increase in these indicators was established with a combination of a deprimating drug with an antioxidant. It has been shown that the antioxidant has a desynchronizing effect on the behavioral reactions of laboratory animals for two days, which indicates a pronounced adaptive effect. In the case of using combinations of a deprimating agent with an antioxidant, a decrease in the destruction of the histological structure of the myocardium against the background of chronic alcoholization was established.

scholarly journals The effect of chronic alcohol intoxication and smoking on the output of salivary immunoglobulin A

2012 ◽  
Vol 50 (4) ◽  
pp. 605-608 ◽  
Author(s):  
Napoleon Waszkiewicz ◽  
Anna Zalewska ◽  
Slawomir Dariusz Szajda ◽  
Magdalena Waszkiewicz ◽  
Agata Szulc ◽  
...  
Keyword(s):  
Alcohol Intoxication ◽  
Immunoglobulin A ◽  
Chronic Alcohol ◽  
Chronic Alcohol Intoxication ◽  
Salivary Immunoglobulin A

scholarly journals Nervous system injury in alcoholic disease

2019 ◽  
Vol 11 (2S) ◽  
pp. 83-88
Author(s):  
O. E. Zinovyeva ◽  
N. V. Vashchenko ◽  
O. E. Mozgovaya ◽  
T. A. Yanakaeva ◽  
A. Yu. Emelyanova
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Alcohol Intoxication ◽  
Clinical Manifestations ◽  
Symptomatic Treatment ◽  
Chronic Alcohol ◽  
Neurological Manifestations ◽  
Chronic Alcohol Intoxication ◽  
Alcoholic Disease

The paper considers various variants of nervous system injury in alcoholic disease. It discusses the epidemiology, pathogenesis, diagnosis, and clinical manifestations of central and peripheral nervous system lesions in the presence of acute and chronic alcohol intoxication. Attention is paid to the issues of etiotropic, pathogenetic, and symptomatic treatment for neurological manifestations of alcoholic disease and to the role of neurotropic B vitamins in the treatment of alcohol-induced deficiency and non-deficiency states.

scholarly journals Development of a prediabetic state under chronic alcohol intoxication

2013 ◽  
Vol 59 (4) ◽  
pp. 33-39 ◽  
Author(s):  
VV Voĭtenko ◽  
◽  
VV Konopel'niuk ◽  
OM Savchuk ◽  
LI Ostapchenko ◽  
...  
Keyword(s):  
Alcohol Intoxication ◽  
Chronic Alcohol ◽  
Prediabetic State ◽  
Chronic Alcohol Intoxication

scholarly journals The effect of chronic alcohol intoxication and smoking on the activity of oral peroxidase

2012 ◽  
Vol 50 (3) ◽  
pp. 450-455 ◽  
Author(s):  
Napoleon Waszkiewicz ◽  
Anna Zalewska ◽  
Sławomir Dariusz Szajda ◽  
Agata Szulc ◽  
Alina Kępka ◽  
...  
Keyword(s):  
Alcohol Intoxication ◽  
Chronic Alcohol ◽  
Chronic Alcohol Intoxication

Alcohol-induced damage to skeletal muscles in women with chronic alcohol intoxication

2021 ◽  
Vol 26 (4) ◽  
pp. 23-30
Author(s):  
N. S. Shcheglova ◽  
E. O. Zinovyeva ◽  
B. S. Shenkman
Keyword(s):  
Skeletal Muscle ◽  
Blood Plasma ◽  
Skeletal Muscles ◽  
Alcohol Intoxication ◽  
Femoral Nerve ◽  
Chronic Alcohol ◽  
Chronic Alcoholic ◽  
Chronic Alcohol Intoxication ◽  
Alcoholic Myopathy ◽  
In Blood Plasma

In Russia, there is a high level of alcohol consumption among women in doses that represent a high risk of developing alcoholic diseases, manifested, in particular, by damage to skeletal muscles.The purpose of the study. Analysis of clinical, biochemical, neurophysiological, as well as morphometric and immunohistochemical features of alcoholic skeletal muscle damage in women with chronic alcohol intoxication.Material and methods. A clinical and laboratory examination of 30 women aged 20 to 60 years with chronic alcohol intoxication was performed, which included the determination of creatine phosphokinase (CPK) and insulin-like growth factor I (IGF-I) in blood plasma, stimulation and needle electromyography (EMG), as well as morphological and immunohistochemical examination of biopsies of the quadriceps femoris.Results. Myopathic syndrome in the form of proximal para-or tetraparesis was observed in 73.3% of the examined women in combination with a decrease in IGF-1 at normal values of CPK in blood plasma. The EMG results indicated the absence of changes in the parameters of the potentials of motor units, characteristic of primary muscular lesions, and of conduction disturbances along the femoral nerve. Morphometric and immunohistochemical studies of skeletal muscle biopsies showed a decrease in the cross-sectional area of muscle fibers of types I and II without signs of muscle tissue necrosis.Conclusion. Chronic alcoholic myopathy is a common manifestation of alcoholic disease in women with long-term alcohol intoxication. The severity of the atrophic process in the skeletal muscle is comparable to the degree of proximal paresis. Violations of systemic protein synthesis and acceleration of apoptosis are considered as pathogenetic mechanisms of the atrophic process in the muscles in chronic alcoholic myopathy in women.

Age-Related Changes in the Functional Indices of Cardiac Mitochondria in Chronic Alcohol Intoxication in Rats

2019 ◽  
Vol 9 (3) ◽  
pp. 274-282
Author(s):  
T. A. Popova ◽  
I. I. Prokofiev ◽  
G. Kh. Khusainova ◽  
V. N. Perfilova ◽  
M. V. Kustova ◽  
...  
Keyword(s):  
Alcohol Intoxication ◽  
Chronic Alcohol ◽  
Cardiac Mitochondria ◽  
Chronic Alcohol Intoxication ◽  
Age Related ◽  
Functional Indices ◽  
Age Related Changes
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