Aggressive Central Giant Cell Granuloma in the Posterior Region of Mandible – A Case Report

Central giant cell granuloma (CGCG) is an uncommon, benign, intraosseous bony lesion of the mandible and maxilla which is variably aggressive in nature. The incidence of an aggressive and recurrence nature is greatest in a female with a ratio of 2:1. Based on the clinical and radiographic features, Central giant cell granuloma can be classified as aggressive and non-aggressive lesions. Here we report a case of central giant cell granuloma in the posterior mandibular molar region which was aggressive in nature. The clinically and radiographically swelling was evaluated with displaced tooth, pain, cortical expansion, and root resorption. The treatment varies according to the nature of the lesion, this case was treated by conservative excision with continuity of the mandible. Key words: Aggressive, central giant cell granuloma, osteolytic lesion.

Download Full-text

A rare coexistence of central giant cell granuloma and parathyroid adenoma: Case report

IP Journal of Diagnostic Pathology and Oncology ◽

10.18231/j.jdpo.2021.034 ◽

2021 ◽

Vol 6 (2) ◽

pp. 155-158

Author(s):

Rohini Sebastian ◽

Meethu Rappai

Keyword(s):

Case Report ◽

Connective Tissue ◽

Parathyroid Adenoma ◽

Giant Cell ◽

Stromal Cells ◽

Giant Cells ◽

Giant Cell Granuloma ◽

Multinucleated Giant Cells ◽

Central Giant Cell Granuloma ◽

Bony Lesion

Central giant cell granuloma is a reparative bony lesion characterised by abundant multinucleated giant cells within a sea of spindle shaped mesenchymal stromal cells. Giant cells are scattered throughout the fibrovascular connective tissue stroma containing hemorrhage. Its coexistence with parathyroid adenoma is very rare. Brown tumour is a close differential in this scenario. Herein we present the case of a central giant cell granuloma of maxilla and parathyroid adenoma diagnosed almost during the same time in a 58 years old male.

Download Full-text

A Case of Central Giant Cell Granuloma in the Mandibular Molar Region

Japanese Journal of Oral Diagnosis / Oral Medicine ◽

10.15214/jsodom.29.76 ◽

2016 ◽

Vol 29 (2) ◽

pp. 76-80

Author(s):

TETSUO YAMAMURA ◽

SAYOKO NAGAI ◽

KIYOHIRO KASAHARA ◽

MASAYUKI TAKANO ◽

AKIRA KATAKURA ◽

...

Keyword(s):

Giant Cell ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Mandibular Molar ◽

Molar Region

Download Full-text

Central giant cell granuloma of the mandibular molar region: Report of a case

Japanese Journal of Oral & Maxillofacial Surgery ◽

10.5794/jjoms.26.1557 ◽

1980 ◽

Vol 26 (6) ◽

pp. 1557-1562

Author(s):

Takanori OYA ◽

Osamu MATSUMOTO ◽

Mitsuyasu WATANABE ◽

Tadashi OTSU ◽

Kaoru ISHIBASHI ◽

...

Keyword(s):

Giant Cell ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Mandibular Molar ◽

Molar Region

Download Full-text

A Conservative Surgical Approach Towards Central Giant Cell Granuloma: A Case Report

Journal of the Bahrain Medical Society ◽

10.26715/jbms.3_18112018 ◽

2018 ◽

Vol 30 (3) ◽

pp. 1-4

Author(s):

Ahmed Al-Qattan

Keyword(s):

Case Report ◽

Giant Cell ◽

Surgical Approach ◽

Pyogenic Granuloma ◽

Histopathological Analysis ◽

Giant Cell Granuloma ◽

Case Presentation ◽

Central Giant Cell Granuloma ◽

History Of ◽

Bony Lesion

Central giant cell granuloma (CGCG) is an infrequent benign bony lesion of unpredictably aggressive behavior. The precise lesion character is debatable and remains inconclusive. However, three main theories were proposed: a sensitive lesion, a kind of neoplasm, or a developmental anomaly. This is a case presentation of a 16-year-old boy with a dental history of extraction of the lower right first molar, presented to hospital with two months history of swelling in the aforementioned area after the procedure. First biopsy of the swelling was performed outside the Kingdom of Bahrain. As per histopathological findings, the swelling was described as pyogenic granuloma. Second biopsy with necessary workup was conducted in the Kingdom of Bahrain and was confirmed as central giant cell granuloma through histopathological analysis; it was removed surgically.

Download Full-text

Central giant cell granuloma: a case report

Journal of Oral Medicine and Oral Surgery ◽

10.1051/mbcb/2017024 ◽

2018 ◽

Vol 24 (1) ◽

pp. 24-28

Author(s):

Antoine Butel ◽

Gemma Di Bernardo ◽

Beatrice Louvet

Keyword(s):

Giant Cell ◽

Root Resorption ◽

Surgical Excision ◽

Normal Mucosa ◽

Giant Cell Granuloma ◽

Surgical Specimen ◽

Central Giant Cell Granuloma ◽

Bony Lesion ◽

Radiolucent Lesion

Introduction: Central giant cell granuloma (CGCG) is an uncommon benign bony lesion that occurs in the mandible and maxilla. Observation: A 30-year-old woman was evaluated for a radiolucent lesion of the mandible, which was discovered by chance. This image was associated with a painless swelling covered by normal mucosa. No symptoms were associated. After surgical excision, histological examination of the surgical specimen concluded a CGCG. Surgical follow-up was simple, and the first radiological test performed 3 months after confirming the onset of bone healing. Comments: The clinical behavior of CGCG ranges from a slow-growing asymptomatic swelling to an aggressive lesion with pain, local osteolysis, root resorption and tooth displacement. Therapeutic options have greatly varied in recent years. Nonsurgical treatments with alpha-interferon, calcitonin, and corticosteroids have been described and their benefits may be worthy of consideration. Conclusion: A surgical approach is considered as the traditional treatment and is still the most accepted one. However, in some publications, authors disagree on the type of surgery that should be performed.

Download Full-text