scholarly journals Central giant cell granuloma: a case report

2018 ◽  
Vol 24 (1) ◽  
pp. 24-28
Author(s):  
Antoine Butel ◽  
Gemma Di Bernardo ◽  
Beatrice Louvet
Keyword(s):  
Giant Cell ◽  
Root Resorption ◽  
Surgical Excision ◽  
Normal Mucosa ◽  
Giant Cell Granuloma ◽  
Surgical Specimen ◽  
Central Giant Cell Granuloma ◽  
Bony Lesion ◽  
Radiolucent Lesion

Introduction: Central giant cell granuloma (CGCG) is an uncommon benign bony lesion that occurs in the mandible and maxilla. Observation: A 30-year-old woman was evaluated for a radiolucent lesion of the mandible, which was discovered by chance. This image was associated with a painless swelling covered by normal mucosa. No symptoms were associated. After surgical excision, histological examination of the surgical specimen concluded a CGCG. Surgical follow-up was simple, and the first radiological test performed 3 months after confirming the onset of bone healing. Comments: The clinical behavior of CGCG ranges from a slow-growing asymptomatic swelling to an aggressive lesion with pain, local osteolysis, root resorption and tooth displacement. Therapeutic options have greatly varied in recent years. Nonsurgical treatments with alpha-interferon, calcitonin, and corticosteroids have been described and their benefits may be worthy of consideration. Conclusion: A surgical approach is considered as the traditional treatment and is still the most accepted one. However, in some publications, authors disagree on the type of surgery that should be performed.

scholarly journals Aggressive Central Giant Cell Granuloma in the Posterior Region of Mandible – A Case Report

2021 ◽  
Vol 11 (4) ◽  
pp. 118-121
Author(s):  
Ajay Sutare ◽  
Ajay Pratap Singh Parihar ◽  
Varsha A.C.
Keyword(s):  
Case Report ◽  
Key Words ◽  
Giant Cell ◽  
Root Resorption ◽  
Osteolytic Lesion ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Mandibular Molar ◽  
Bony Lesion ◽  
Molar Region

Central giant cell granuloma (CGCG) is an uncommon, benign, intraosseous bony lesion of the mandible and maxilla which is variably aggressive in nature. The incidence of an aggressive and recurrence nature is greatest in a female with a ratio of 2:1. Based on the clinical and radiographic features, Central giant cell granuloma can be classified as aggressive and non-aggressive lesions. Here we report a case of central giant cell granuloma in the posterior mandibular molar region which was aggressive in nature. The clinically and radiographically swelling was evaluated with displaced tooth, pain, cortical expansion, and root resorption. The treatment varies according to the nature of the lesion, this case was treated by conservative excision with continuity of the mandible. Key words: Aggressive, central giant cell granuloma, osteolytic lesion.

scholarly journals Central giant cell granuloma of the maxilla: a case re-port

2017 ◽  
Vol 5 (2) ◽  
pp. 145
Author(s):  
Najwa Alchalabi ◽  
Hayder Salih ◽  
Ahmed Merza
Keyword(s):  
Giant Cell ◽  
Unusual Case ◽  
Clinical Presentation ◽  
Benign Lesion ◽  
Giant Cell Granuloma ◽  
Case Presentation ◽  
Central Giant Cell Granuloma ◽  
First Choice ◽  
Bone Cortex

Introduction: Central giant-cell is a benign lesion that predominantly involves the bone of the mandible and maxilla with a wide variation of its behavior. Surgery usually is the first choice in treatment of central giant cell granuloma.Case Report: In this case report we present a 29 years-old female with well define swelling on left maxilla. Diagnosis through incisional biopsy showed a central giant cell granuloma. Surgery with curettage was our treatment option with a follow up( 2 years ), No recurrence was reported.Discussion: Information on the maxillary central giant cell granuloma in published studies is insufficient. So here we present our case as unusual case presentation. Differential diagnosis of this case included osteosarcoma (parosteal type) since the tumor clinical presentation in periosteous tissue adjacent to the bone cortex and showed rapid growth. We chose the conventional surgical treatment by simple surgical curettage by mid-face degloving approach to avoid any facial scaring.

scholarly journals A rare coexistence of central giant cell granuloma and parathyroid adenoma: Case report

2021 ◽  
Vol 6 (2) ◽  
pp. 155-158
Author(s):  
Rohini Sebastian ◽  
Meethu Rappai
Keyword(s):  
Case Report ◽  
Connective Tissue ◽  
Parathyroid Adenoma ◽  
Giant Cell ◽  
Stromal Cells ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Central Giant Cell Granuloma ◽  
Bony Lesion

Central giant cell granuloma is a reparative bony lesion characterised by abundant multinucleated giant cells within a sea of spindle shaped mesenchymal stromal cells. Giant cells are scattered throughout the fibrovascular connective tissue stroma containing hemorrhage. Its coexistence with parathyroid adenoma is very rare. Brown tumour is a close differential in this scenario. Herein we present the case of a central giant cell granuloma of maxilla and parathyroid adenoma diagnosed almost during the same time in a 58 years old male.

scholarly journals “Central Giant Cell Granuloma of Maxilla- A Case Report”

2021 ◽  
Vol VOLUME 9 (ISSUE 1) ◽  
pp. 38-39
Author(s):  
Dhiraj Kr. Talukdar
Keyword(s):  
Giant Cell ◽  
Malignant Lesion ◽  
Radiographic Examination ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Fast Growing ◽  
Histological Appearance ◽  
Operative Complications ◽  
Bony Lesion ◽  
Slow Growing

Central giant Cell granuloma (CGCG) formerly called giant cell reparative granuloma is a benign bony lesion and etiology is unclear. It occurs most commonly in mandible and also occur in maxilla. 1%-7% of all benign lesions of jaws are central giant cell granuloma. It affects children and adults. it is usually a slow growing lesion, fast growing lesions also reported. The fast growing CGCG has an aggressive behavior mimicking a malignant lesion through it has the innocent histological appearance. CGCG sometimes resemble a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examination. Histological examination confirms as CGCG. The case described here involved maxilla which was treated with surgical curettage. The patient has been followed up for 11/2 years with no post operative complications and no recurrence. Keywords: Central giant cell granuloma, maxilla, benign, jaw

scholarly journals Central Giant Cell Granuloma

2019 ◽  
Vol 2 (1) ◽  
pp. 01-04
Author(s):  
Nilotpol Kashyap ◽  
Manisha Upadhyay ◽  
Rupam Tripathi ◽  
Pallavi Pawar ◽  
Ranjeet Kumar Prasad Sah ◽  
...  
Keyword(s):  
Giant Cell ◽  
Fibrous Tissue ◽  
Giant Cells ◽  
World Health ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Bony Lesion ◽  
Benign Tumours ◽  
Health Organization ◽  
Intraosseous Lesion

Central giant cell granuloma (central giant cell granuloma) is an uncommon benign bony lesion that occurs in the mandible and maxilla and accounts for approximately 7% of all benign tumours of the jaws [1]. The World Health Organization (WHO) has defined central giant cell granuloma as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of haemorrhage, aggregations of multinucleated giant cells and occasional trabeculae of woven bone [2]. Central giant cell granuloma occurs predominantly in children or young adults, with approximately 75%of cases presenting before 30 years of age although presentation can occur at any age [3]. Females are affected more frequently than males, with a ratio of 2:1

scholarly journals A Conservative Surgical Approach Towards Central Giant Cell Granuloma: A Case Report

2018 ◽  
Vol 30 (3) ◽  
pp. 1-4
Author(s):  
Ahmed Al-Qattan
Keyword(s):  
Case Report ◽  
Giant Cell ◽  
Surgical Approach ◽  
Pyogenic Granuloma ◽  
Histopathological Analysis ◽  
Giant Cell Granuloma ◽  
Case Presentation ◽  
Central Giant Cell Granuloma ◽  
History Of ◽  
Bony Lesion

Central giant cell granuloma (CGCG) is an infrequent benign bony lesion of unpredictably aggressive behavior. The precise lesion character is debatable and remains inconclusive. However, three main theories were proposed: a sensitive lesion, a kind of neoplasm, or a developmental anomaly. This is a case presentation of a 16-year-old boy with a dental history of extraction of the lower right first molar, presented to hospital with two months history of swelling in the aforementioned area after the procedure. First biopsy of the swelling was performed outside the Kingdom of Bahrain. As per histopathological findings, the swelling was described as pyogenic granuloma. Second biopsy with necessary workup was conducted in the Kingdom of Bahrain and was confirmed as central giant cell granuloma through histopathological analysis; it was removed surgically.

Surgical treatment and reconstruction of central giant cell granuloma (CGCG) of mandible of aggressive behaviour – case report and literature review

2019 ◽  
Vol 8 (3) ◽  
pp. 1-5
Author(s):  
Agnieszka Piotrowska-Seweryn ◽  
Krzysztof Oleś ◽  
Maciej Grajek ◽  
Mykola Chekan ◽  
Adam Maciejewski ◽  
...  
Keyword(s):  
Case Report ◽  
Giant Cell ◽  
Free Flap ◽  
Aggressive Behaviour ◽  
Positive Staining ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Dental Implantation ◽  
Fibular Free Flap

Introduction Central giant cell granuloma (CGCG) is a benign tumor-like lesion of a bone, mainly localized in mandible. It usually occurs in children and young adults under 30 y.o., predominantly in females. The etiology of the disease remains unknown. Clinically, two different types of CGCG have been distinguished – an unaggressive one, in which the granuloma grows slowly, often asymptomatically, and aggressive type which is characteristic for increased bone destruction, severe pain, large size, rapid growth, high recurrence rate and complications such as root resorption, tooth displacement or cortical bone perforation. The treatment of CGCG depends on its type. In cases of granulomas of aggressive behaviour the following therapeutic procedures have been proposed: intralesial corticosteroid injections, interferon and calcitonin therapy as well as immunotherapy with anti-bone resorptive human monoclonal antibody like denosumab. However, in most cases nonsurgical management remains insufficient. Also, local curettage of the lesion results in high risk of recurrence. Therefore, radical surgical resection, commonly combined with bone reconstruction, is the most recommended way of treatment for aggressive of CGCG. Case report The authors present a case of a 31-year-old female patient treated at the Department of Oncological and Reconstructive Surgery, Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology in Gliwice due to central giant cell granuloma of a mandible. The resection of CGCG localized in mandible on the right side together with fibular free flap reconstruction has been performed, with satisfactory aesthetic effect. Positive staining for CD68 and CD31 was found in immunohistochemic examination and expression of Ki67 marker was 13%. No complications were reported in the postoperative period. The six-month follow up revealed no recurrences. Conclusions The authors claim that radical surgical management should be performed in all patients with CGCG of aggressive behaviour. Fibular free flap is recommended for reconstruction in large bone defects. It results in tumor-free margins at the resection and satisfactory cosmetic outcome. Quality of life and facial appearance can be improved with dental implantation after certain disease-free period. A regular follow-up is essential as an element of holistic oncological process.

scholarly journals Central Giant Cell Granuloma Treated with Intralesional Corticosteroid Injections and Bisphosphonates: A Long-Term Follow-Up Case Study

2019 ◽  
Vol 14 (2) ◽  
pp. 497-502 ◽  
Author(s):  
Raíssa Pinheiro de Mendonça ◽  
Geovanni Pereira Mitre ◽  
Flavio Henrique Real ◽  
Maria Sueli da Silva Kataoka ◽  
Sérgio de Melo Alves Júnior ◽  
...  
Keyword(s):  
Giant Cell ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Intralesional Corticosteroid ◽  
Long Term Follow Up ◽  
Corticosteroid Injections

Management of recurrent central giant cell granuloma of mandible using intralesional corticosteroid with long-term follow-up

2020 ◽  
Vol 13 (9) ◽  
pp. e237200
Author(s):  
Kumar Nilesh ◽  
Anuj Dadhich ◽  
Rahul Patil
Keyword(s):  
Giant Cell ◽  
Osteolytic Lesion ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Intralesional Corticosteroid ◽  
Ablative Surgery ◽  
Long Term Follow Up ◽  
Intralesional Injections

Central giant cell granuloma (CGCG) is an expansile osteolytic lesion of the jawbone. Conventional treatment of CGCG is surgical and vary from simple curettage to more aggressive resection of the jaw. However, surgical management is associated with drawbacks including requirement of hospitalisation and general anaesthesia, damage to vital anatomic structures and continuity defect of the mandible requiring reconstruction surgery. Use of intralesional injections of corticosteroid for the management of CGCG have been inconsistently used as an alternative non-surgical method of management of CGCG with varying success. While the use of such conservative modality over ablative surgery can significantly reduce postoperative morbidity, follow-up of such cases for a long period is important to study the possible recurrence. This paper reports successful treatment of a recurrent CGCG of posterior mandible by intralesional administration of triamcinolone acetonide in a 27-year old female patient, with long-term follow-up of 10 years.

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