Comparative study of antidiabetic effect of Abroma augusta and Syzygium cumini on alloxan induced diabetic rat

Background: Therapies for hyperglycemic treatment, including insulin and oral diabetes medications, have been confirmed to cause several side effects. Thus, finding new drugs with fewer side effects is of high importance. Salung leaf herb (Psychotria malayana Jack) reported used in traditional societies as a treatment for diabetes. However, the scientific proof of this plant for diabetes treatment is still lacking.Objective: To evaluate the antidiabetic effect of the P. malayana jack in induced type 1 diabetic rats by assessing blood glucose level and pancreatic cells in white rats.Methods: Alloxan used to induce type I diabetes. Rats randomly divided into six groups. A Group P1 received 250 mg/kg BW; group P2 received 500 mg/kg BW, group P3 received 1000 mg/kg BW. While group 4 basal received no treatment, group 5 received distilled water as a negative control, and group 6 received glibenclamide as a positive control. Medications are given for six days. Glucose levels were measured, and observation of pancreatic Langerhans cell damages.Results: A decrease in blood glucose levels observed in all treatment groups. The most significant reduction (49.76%; 1000 mg/kg BW) occurred in the P3 group. Morphological features of pancreatic Langerhans cell damage were slightly high in the P1 group.Conclusion: P. malayana Jack can consider having an antidiabetic effect in a type 1 diabetic rat by reducing blood glucose levels.

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Comparative Study of the Metabolism of U-14C-Fructose, U-14C-Sorbitol and U-14C-Xylitol in the Normal and in the Streptozotocin-Diabetic Rat*

European Journal of Clinical Investigation ◽

10.1111/j.1365-2362.1971.tb00562.x ◽

1971 ◽

Vol 2 (1) ◽

pp. 8-14 ◽

Cited By ~ 21

Author(s):

E. R. Froesch ◽

J. Zapf ◽

U. Keller ◽

O. Oelz

Keyword(s):

Comparative Study ◽

Diabetic Rat ◽

Streptozotocin Diabetic Rat

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Immunohistochemical evaluation of antidiabetic effect ofMomordica charantiaextract in cow urine in streptozotocin-induced diabetic rat model

Indian Journal of Veterinary Pathology ◽

10.5958/0973-970x.2014.01184.5 ◽

2014 ◽

Vol 38 (4) ◽

pp. 239

Author(s):

S.M. Ayoub ◽

Suguna Rao ◽

S.M. Byregowda ◽

M.L. Satyanarayana

Keyword(s):

Rat Model ◽

Diabetic Rat ◽

Antidiabetic Effect ◽

Cow Urine ◽

Diabetic Rat Model

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Antidiabetic Effect of ethanol extract of Forsythia Koreana in Streptozotocin-Induced Diabetic Rat

Journal of the Korean Oil Chemists Society ◽

10.12925/jkocs.2015.32.2.226 ◽

2015 ◽

Vol 32 (2) ◽

pp. 226-231 ◽

Cited By ~ 1

Author(s):

Ok-Kyung Kim

Keyword(s):

Ethanol Extract ◽

Diabetic Rat ◽

Antidiabetic Effect ◽

Forsythia Koreana

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Corrigendum to “Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of Vernonia amygdalina: A Comparative Study”

Journal of Diabetes Research ◽

10.1155/2017/5618548 ◽

2017 ◽

Vol 2017 ◽

pp. 1-1 ◽

Cited By ~ 2

Author(s):

Du-Bois Asante ◽

Emmanuel Effah-Yeboah ◽

Precious Barnes ◽

Heckel Amoabeng Abban ◽

Elvis Ofori Ameyaw ◽

...

Keyword(s):

Comparative Study ◽

Vernonia Amygdalina ◽

Leaf Extracts ◽

Antidiabetic Effect

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A study to evaluate the antidiabetic effect of Syzygium cumini Linn. seed extract in high fructose diet induced diabetes in Albino Rats

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20172224 ◽

2017 ◽

Vol 6 (6) ◽

pp. 1363

Author(s):

Sandeep Vihan ◽

D. B. S. Brashier

Keyword(s):

Blood Glucose ◽

Phase I ◽

Seed Extract ◽

Syzygium Cumini ◽

Antidiabetic Effect ◽

High Fructose Diet ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Group I ◽

High Fructose

Background: The objective of the study was to evaluate the antidiabetic effect of syzygium cumini linn. Seed extract in high fructose diet induced diabetes in albino rats.Methods: This study was conducted in two phases. In Phase I acute and chronic effects of three doses of Syzygium cumini Linn 200mg/kg, 400mg/kg and 800mg/kg was seen in euglycaemic rats. In Phase II, the above doses of Syzygium cumini Linn were seen in diabetes induced by high fructose diet was evaluated. 5 groups of 06 animals each. Group I was given normal saline orally. Group II, III and IV were given oral Syzygium extract in the dose of 200mg/kg, 400mg/kg and 800mg/Kg respectively. Group V was given glibenclamide suspension 10 mg/Kg orally. Blood glucose was measured before starting this phase (Day 0), at the end of fructose feeding (day 28) and weekly thereafter up to the end of the treatment period (i.e. on days 35,42,49,56).Results: In phase I of the study, Syzygium extract had no effect on the mean blood glucose levels when given in the doses of 200, 400 and 800 mg/kg, from 1-24 hours. After chronic administration to euglycemic rats for 4 weeks, Syzygium extract also did not produce any significant change in blood glucose levels when given at various doses from 200-800 mg/kg. Treatment with all the three doses of Syzygium cumini extract (200,400 and 800mg/kg) produced a significant reduction in the blood glucose level. (P value <0.001 as compared to group I). The glucose lowering effect started at the end of 1 weeks and it increased till the end of the study in all the groups.Conclusions: Syzygium cumini Linn extract has no effect on the blood glucose levels of euglycemic animals. Syzygium cumini Linn extract can reduce blood glucose levels in high fructose diet induced diabetic rats, in a dose dependent and time dependent manner.

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Trace Mineral, Qualitative Phytochemical Composition and Antidiabetic Effect of Ethanol Extract of Citrullus lanatus Seeds on Diabetic Rats

Asian Journal of Biotechnology and Bioresource Technology ◽

10.9734/ajb2t/2021/v7i430111 ◽

2021 ◽

pp. 77-86

Author(s):

P. N. Okoroh ◽

M. C. Onuigbo ◽

E. U. Godwin-Nwakwasi ◽

O. C. Chukwuka ◽

Ephraim I. Ekanem

Keyword(s):

Cardiac Glycosides ◽

Diabetes Management ◽

Citrullus Lanatus ◽

Ethanol Extract ◽

Spectrophotometric Analysis ◽

Diabetic Rat ◽

Trace Mineral ◽

Mineral Concentration ◽

Antidiabetic Effect ◽

Phytochemical Composition

The trace mineral concentration, phytochemical composition and antidiabetic effect of the ethanol extract of C. lanatus seeds were carried out using standard methods. The preclinical experimental model was 120 mgkg-1 b.w. (via intraperitoneal) Alloxan induced diabetic rat model, with ethanol extract of C. lanatus seeds administered orally at 500mgkg-1 b.w. Qualitative phytochemical screening showed presence of alkaloids, flavonoids, saponins, cardiac glycosides, steroids/triterpenoids, tannins, carbohydrates and oils. Atomic Absorption Spectrophotometric analysis revealed that iron had the highest value (8.31mgkg-1), followed by zinc (5.78 mgkg-1), then manganese (4.28 mgkg-1). Selenium concentration was appreciable (0.85 mgkg-1). Ethanol extract of C. lanatus seeds significantly (p < 0.05), dose and time dependently reduced blood glucose level, increased body weights of rats and had positive effect on organ weights and organ volume. The results in this study showed that Citrullus lanatus seeds are rich in zinc, selenium, manganese, iron, alkaloids, flavonoids, saponins, cardiac glycosides, steroids/triterpenoids, and tannins. They may therefore serve as good sources of these trace mineral nutrients and bio actives for nutritional and medicinal purposes relating to diabetes management.

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