Antidiabetic Effect of ethanol extract of Forsythia Koreana in Streptozotocin-Induced Diabetic Rat

2015 ◽  
Vol 32 (2) ◽  
pp. 226-231 ◽  
Author(s):  
Ok-Kyung Kim
Keyword(s):  
Ethanol Extract ◽  
Diabetic Rat ◽  
Antidiabetic Effect ◽  
Forsythia Koreana

scholarly journals Trace Mineral, Qualitative Phytochemical Composition and Antidiabetic Effect of Ethanol Extract of Citrullus lanatus Seeds on Diabetic Rats

2021 ◽  
pp. 77-86
Author(s):  
P. N. Okoroh ◽  
M. C. Onuigbo ◽  
E. U. Godwin-Nwakwasi ◽  
O. C. Chukwuka ◽  
Ephraim I. Ekanem
Keyword(s):  
Cardiac Glycosides ◽  
Diabetes Management ◽  
Citrullus Lanatus ◽  
Ethanol Extract ◽  
Spectrophotometric Analysis ◽  
Diabetic Rat ◽  
Trace Mineral ◽  
Mineral Concentration ◽  
Antidiabetic Effect ◽  
Phytochemical Composition

The trace mineral concentration, phytochemical composition and antidiabetic effect of the ethanol extract of C. lanatus seeds were carried out using standard methods. The preclinical experimental model was 120 mgkg-1 b.w. (via intraperitoneal) Alloxan induced diabetic rat model, with ethanol extract of C. lanatus seeds administered orally at 500mgkg-1 b.w. Qualitative phytochemical screening showed presence of alkaloids, flavonoids, saponins, cardiac glycosides, steroids/triterpenoids, tannins, carbohydrates and oils. Atomic Absorption Spectrophotometric analysis revealed that iron had the highest value (8.31mgkg-1), followed by zinc (5.78 mgkg-1), then manganese (4.28 mgkg-1). Selenium concentration was appreciable (0.85 mgkg-1). Ethanol extract of C. lanatus seeds significantly (p < 0.05), dose and time dependently reduced blood glucose level, increased body weights of rats and had positive effect on organ weights and organ volume. The results in this study showed that Citrullus lanatus seeds are rich in zinc, selenium, manganese, iron, alkaloids, flavonoids, saponins, cardiac glycosides, steroids/triterpenoids, and tannins. They may therefore serve as good sources of these trace mineral nutrients and bio actives for nutritional and medicinal purposes relating to diabetes management.

Antidiabetic effect of Psychotria malayana Jack in induced type 1 diabetic rat

MEDISAINS ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 19
Author(s):  
Fairuz Fairuz ◽  
Hasna Dewi ◽  
Humaryanto Humaryanto
Keyword(s):  
Blood Glucose ◽  
Side Effects ◽  
Type I Diabetes ◽  
Langerhans Cell ◽  
Diabetic Rat ◽  
Type I ◽  
Antidiabetic Effect ◽  
Glucose Levels ◽  
Blood Glucose Levels

Background: Therapies for hyperglycemic treatment, including insulin and oral diabetes medications, have been confirmed to cause several side effects. Thus, finding new drugs with fewer side effects is of high importance. Salung leaf herb (Psychotria malayana Jack) reported used in traditional societies as a treatment for diabetes. However, the scientific proof of this plant for diabetes treatment is still lacking.Objective: To evaluate the antidiabetic effect of the P. malayana jack in induced type 1 diabetic rats by assessing blood glucose level and pancreatic cells in white rats.Methods: Alloxan used to induce type I diabetes. Rats randomly divided into six groups. A Group P1 received 250 mg/kg BW; group P2 received 500 mg/kg BW, group P3 received 1000 mg/kg BW. While group 4 basal received no treatment, group 5 received distilled water as a negative control, and group 6 received glibenclamide as a positive control. Medications are given for six days. Glucose levels were measured, and observation of pancreatic Langerhans cell damages.Results:  A decrease in blood glucose levels observed in all treatment groups. The most significant reduction (49.76%; 1000 mg/kg BW) occurred in the P3 group. Morphological features of pancreatic Langerhans cell damage were slightly high in the P1 group.Conclusion: P. malayana Jack can consider having an antidiabetic effect in a type 1 diabetic rat by reducing blood glucose levels.

scholarly journals Nephroprotective and antioxidant effects of ethanol extract of Coprinus comatus mushroom fruit-bodies on streptozotocin-induced diabetic rat models

2021 ◽  
Vol 948 (1) ◽  
pp. 012078
Author(s):  
N I Ratnaningtyas ◽  
Hernayanti ◽  
N Ekowati ◽  
F Husen
Keyword(s):  
Cell Damage ◽  
Fruit Body ◽  
Herbal Medicines ◽  
Ethanol Extract ◽  
Diabetic Rat ◽  
Glomerular Cell ◽  
Coprinus Comatus ◽  
Treatment Groups ◽  
Male Wistar Rats ◽  
Group 3

Abstract Diabetes mellitus (DM) is a metabolic disease with an increasing prevalence. An increase in free radicals and AGEs can cause glomerular cell damage which can lead to inflammation and DM nephropathy. WHO has recommended DM treatment by using herbal medicines that have minimal side effects and have a lot of biological activity to prevent complications. Coprinus comatus (O.F. Mull.) is known as immunomodulatory, anti-inflammatory and antidiabetic agent. The research used C. comatus cultivated in Cianjur. The basidiome of this mushroom has slightly oval and small with height of 8-12 cm and thickness of 2-3 cm. The research included six groups of male Wistar rats: Group 1 received no treatment, Groups 2–6 were administered 45 mg/kg BW streptozotocin once, Group 3 was administered 45 mg/kg BW metformin, Groups 4, 5, and 6 were administered 250, 500, and 750 mg/kg BW of C. comatus fruit body ethanol extract respectively for 14 days. The superoxide dismutase (SOD), malondialdehyde (MDA), hepcidin and β2 microglobulin (B2M) levels were evaluated. Data were analyzed using analysis of variance and Duncan’s multiple-range tests. The results showed that dose of 500 mg was effective in increasing SOD and decreasing hepcidin, B2M and MDA levels.

scholarly journals Ekstrak Etanol Daun Kacang Panjang (Vigna unguiculata (L.) Walp): Kajian Morfometri Insula Pankreatika Model Tikus Diabetes

2019 ◽  
Vol 5 (2) ◽  
pp. 183
Author(s):  
Puput Octaviani Solehah ◽  
Fikhta Agnesya Tarusu ◽  
Joni Tandi ◽  
Niluh Puspita Dewi ◽  
Gabriella Bamba Ratih Lintin ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Vigna Unguiculata ◽  
Therapy Group ◽  
Statistical Tests ◽  
Ethanol Extract ◽  
Diabetic Rat ◽  
Control Group ◽  
Blood Levels ◽  
Group A ◽  
Group B

Diabetes is characterized by an increasing of blood levels and progressive changes in the structure of pancreatic islet of pancreas. Natural ingredients that contain antioxidants such as some cowpea leaves can be an alternative treatment for diabetes. This study aims to examine the effect of ethanol extract of some cowepea leaves (Vigna unguiculata (L.) Walp) on morphometry (perimeter and diameter) of pancreatic islet of diabetic rat models. The type of research is quasi-experimental with posttest group design. Samples were 30 male wistar rats, age 8 weeks, BW 250-300 grams, that induced by single dose of STZ 40 mg/kg BW. Rats were divided into 5 groups. Group A: normal control, Group B: negative control, Group C: positive control, Group D: DM rats with 100mg/Kg BW extract therapy, Group E: DM rats with 200mg/Kg BW extract therapy, Group F: DM rats with extract therapy 300mg/Kg BW. Blood sugar levels were measured on days 7, 14 and 21. Pancreatic tissue was prepared with 5μm thickness and stained with Hematoxylin Eosin. The sample was observed under 400x magnification microscope. The observation uses Image J software to measure the perimeter and diameter of the pancreatic insula. Data were analyzed by non-parametric Kruskal Wallis and post hoct Mann Whitney statistical tests. Blood glucose level was obtained on 21st day with the highest mean in group B (246.8±156.3) and lowest in group A (67.2 ±7.85), perimeter of pancreatic islet was significantly different (p=0.026), the diameter is significantly different (p =0.046). Ethanol extract of some cowpea (Vigna unguiculata (L.) Walp) leaves with dose of 300mg/kgBB helps to restore the blood and morphometry of pancreatic islet model of diabetic rats.

scholarly journals Phytochemical Screening and Antidiabetic Activity Test of Extracts and Fractions of Lactuca Indica (L.) In Streptozotocin-Induced Diabetic Mice

1970 ◽  
Vol 8 (3) ◽  
pp. 62-65
Author(s):  
Tamba Rosanto ◽  
Nainggolan Marline ◽  
Rosidah Noersal
Keyword(s):  
Blood Glucose ◽  
Ethanol Extract ◽  
Negative Control ◽  
Antidiabetic Activity ◽  
Antidiabetic Effect ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Group I ◽  
Reduce Blood Glucose ◽  
Lactuca Indica

Objectives: The purpose of this study was to determine the antidiabetic effect of ethanol extract and Lactuca indica leaf fraction to determine the effective dose of mice induced with streptozotocin compared with metformin. Design: The design of this study was experimental in which the extraction and fraction of Lactuca indica leaves were tested for the value of decreasing blood glucose levels of mice after induction of streptozotocin. Antidiabetic activity tests were divided into 12 groups. Group I (baseline) group II (negative control) were given CMC 0.5%, Group III (positive control) were given metformin 65 mg/kg BW, while Groups IV to XII were given Lactuca indica leaf extract and fractions at their respective doses -each 100, 150 and 200 mg/kg BW Interventions: The variable that was intervened in this study was the concentration of extract used Main outcome measure: The main measurement results in this study were to determine extracts and fractions that we're able to reduce blood glucose levels in mice. Results: The antidiabetic effect of Lactuca indica leaves shows that EELL, EAFLL and NHFLL have antidiabetic effects, this is supported by the chemical content contained in the extracts, namely flavonoids, tannins, saponins, glycosides and triterpenoids/steroids. The most effective activity to reduce blood glucose levels in streptozotocin-induced mice is EAFLL 100 mg/kg BW Conclusion: ethyl acetate fraction of Lactuca indica leaves has an effective antidiabetic activity at a dose of 200 mg/kg BW has given antidiabetic activity in mice induced by STZ, on the 9th day BGL mice have dropped below 120 mg/dl.  

scholarly journals Antihyperglycemic and anti-oxidant activity of various fraction of Parmotrema hababianum in streptozotocin-induced diabetic rat

2016 ◽  
Vol 11 (4) ◽  
pp. 935 ◽  
Author(s):  
Ayyappadasan Ganesan ◽  
Amutha Mahesh ◽  
Jeya Prakash Sundararaj ◽  
Kalaiselvi Mani ◽  
Ponmurugan Ponnusamy
Keyword(s):  
Blood Glucose ◽  
Video Clip ◽  
Ethanol Extract ◽  
Dosage Level ◽  
Insulin Level ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Anti Oxidant

<p class="Abstract">The core objective of this study was to investigate the in vitro anti-oxidant and antihyperglycemic effect of the ethanol extract of <em>Parmotrema </em>hababianum in streptozocin-induced diabetic rats for 42 days. The extract showed nearly all anti-oxidant activities with maximum presence. The treatment with extract in diabetic rats at the dosage level of 100 and 200 mg/kg, which is compared with diabetic control and glibenclamide at a dosage level of 4 mg/kg and the biochemical parameters such as blood glucose, total cholesterol, triglycerides, HDL, LDL, insulin, total protein, urea and creatinine were assessed. The extract showed positive correlation (p&lt;0.001) in reducing blood glucose level as compared to the control. Moreover, there was a significant (p&lt;0.01) decrease in TC, TG, LDL, SGPT, SGOT, urea and creatinine level and significant (p&lt;0.01) increase in HDL and insulin level. Thus, the results of this study show considerable efficacy in curing diabetes with potent anti-oxidant and anti-hyperglycemic activity.</p><p class="Abstract"><strong>Video Clip of</strong>:</p><p class="Abstract"><a href="https://youtube.com/v/Lw2vvLpKNTE">Methodology</a>: 6 min 12 sec</p>

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