Synthesis, Characterization and Biocompatibility of Holmium Zirconate/Zinc Sulphide Nanocomposite in Albino Mice in a Gender Specific Manner

Aim of this study was to report the biocompatibility of Holmium zirconate, zinc sulphide and holmium zirconate/zinc sulphide (HO2Zr2O7/ZnS) nanocomposite in albino mice. Holmium zirconate, zinc sulphide and holmium zirconate/zinc sulphide (Ho2Zr2O7/ZnS) nanocomposite were synthesized by, normal microemulsion, chemical co-precipitation and two step synthesis method, respectively. The synthesized materials were characterized by X-ray diffraction (XRD) for the confirmation of phase while scanning electron microscopy (SEM) was used morphological analysis. The composition and the particle size distribution were confirmed by energy dispersive spectroscopy and particle size analysis respectively. Seven week old mice were divided into two groups in a gender specific manner: control group that were intraperitoneally injected with saline solution and treated group were administered with 50 mg/ml solvent/Kg body weight of Holmium zirconate/zinc sulphide nanocomposite for 22 days. A series of neurological tests, blood cell count, selected serum parameters and biomarkers of oxidative stress were analysed in vital organs of both treatments. It was observed that nanocomposite treated female mice remained mobile (P = 0.05) for longer time while both male (P = 0.03) and female (P = 0.02) mice had more rotations than saline treated mice during open field test. Nanocomposite treated male had reduced stretch attend reflex during light dark box test. Blood and serum parameters remained unaffected (P ˃ 0.05) when compared between nanocomposite treated and untreated mice of both genders. Malondialdehyde concentration was significantly elevated (P = 0.04) in liver of male while superoxide dismutase concentrations were significantly reduced (P = 0.05) in brain of female albino mice treated with nanocomposite than their respective control groups.

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Synthesis, Characterization and Biocompatibility of Holmium Zirconate/Zinc Sulphide Nanocomposite in Albino Mice in a Gender Specific Manner

Journal of the chemical society of pakistan ◽

10.52568/000552/jcsp/43.01.2021 ◽

2021 ◽

Vol 43 (1) ◽

pp. 46-46

Author(s):

Hafsa Noureen Hafsa Noureen ◽

Mubashra Salim Mubashra Salim ◽

Amjad Nadeem Amjad Nadeem ◽

Sana Shafiq Sana Shafiq ◽

Samia Yousuf Samia Yousuf ◽

...

Keyword(s):

Particle Size ◽

Synthesis Method ◽

Particle Size Analysis ◽

Zinc Sulphide ◽

Size Analysis ◽

Control Group ◽

Serum Parameters ◽

Specific Manner ◽

Albino Mice ◽

Gender Specific

Aim of this study was to report the biocompatibility of Holmium zirconate, zinc sulphide and holmium zirconate/zinc sulphide (HO2Zr2O7/ZnS) nanocomposite in albino mice. Holmium zirconate, zinc sulphide and holmium zirconate/zinc sulphide (Ho2Zr2O7/ZnS) nanocomposite were synthesized by, normal microemulsion, chemical co-precipitation and two step synthesis method, respectively. The synthesized materials were characterized by X-ray diffraction (XRD) for the confirmation of phase while scanning electron microscopy (SEM) was used morphological analysis. The composition and the particle size distribution were confirmed by energy dispersive spectroscopy and particle size analysis respectively. Seven week old mice were divided into two groups in a gender specific manner: control group that were intraperitoneally injected with saline solution and treated group were administered with 50 mg/ml solvent/Kg body weight of Holmium zirconate/zinc sulphide nanocomposite for 22 days. A series of neurological tests, blood cell count, selected serum parameters and biomarkers of oxidative stress were analysed in vital organs of both treatments. It was observed that nanocomposite treated female mice remained mobile (P = 0.05) for longer time while both male (P = 0.03) and female (P = 0.02) mice had more rotations than saline treated mice during open field test. Nanocomposite treated male had reduced stretch attend reflex during light dark box test. Blood and serum parameters remained unaffected (P ˃ 0.05) when compared between nanocomposite treated and untreated mice of both genders. Malondialdehyde concentration was significantly elevated (P = 0.04) in liver of male while superoxide dismutase concentrations were significantly reduced (P = 0.05) in brain of female albino mice treated with nanocomposite than their respective control groups.

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Novelty of Bioengineered Iron Nanoparticles in Nanocoated Surgical Cotton: A Green Chemistry

Advances in Pharmacological Sciences ◽

10.1155/2019/9825969 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10 ◽

Cited By ~ 6

Author(s):

Bhavika Turakhia ◽

Saujanya Chikkala ◽

Sejal Shah

Keyword(s):

Antimicrobial Activity ◽

Particle Size ◽

Green Chemistry ◽

Iron Nanoparticles ◽

Synthesis Method ◽

Cost Effective ◽

Zingiber Officinale ◽

Particle Size Analysis ◽

Size Analysis ◽

Ginger Extract

The current focus of nanotechnology is to develop environmentally safe methodologies for the formulation of nanoparticles. The phytochemistry of Zingiber officinale inspired us to utilize it for the synthesis of iron nanoparticles. GC-MS analysis revealed the phytochemical profile of ginger. Out of 20 different chemicals, gingerol was found to be the most potent phytochemical with a retention time of 40.48 min. The present study reports a rapid synthesis method for the formation of iron nanoparticles and its potential efficacy as an antibacterial agent and an antioxidant. Because of its antibacterial property, ginger extract was used to coat surgical cotton. Synthesized ginger root iron nanoparticles (GR-FeNPs) were characterized by UV-visible spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction analysis, and particle size analysis. XRD confirmed the crystalline structure of iron oxide nanoparticles as it showed the crystal plane (2 2 0), (3 1 1), (2 2 2), and (4 0 0). The particle size analyzer (PSA) showed the average size of the particles, 56.2 nm. The antimicrobial activity of the FeNPs was tested against different Gram-positive and Gram-negative bacteria. E. coli showed maximum inhibition as compared with the other organisms. Antioxidant activity proved the maximum rate of free radicals at 160 µg/mL produced by nanoparticles. In addition, the antimicrobial activity of nanocoated surgical cotton was evaluated on the first day and 30th day after coating, which clearly showed excellent growth inhibition of organisms, setting a new path in the field of medical microbiology. Hence, iron-nanocoated surgical cotton synthesized using green chemistry, which is antimicrobial and cost effective, might be economically helpful and provide insights to the medical field, replacing conventional wound healing treatments, for better prognosis.

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Large-Scale Fabrication of Ti3AlC2 Powder with High-Purity

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.336-338.948 ◽

2007 ◽

Vol 336-338 ◽

pp. 948-951

Author(s):

Chang An Wang ◽

Chun Qing Peng ◽

Yang Song ◽

Yong Huang

Keyword(s):

Particle Size ◽

High Purity ◽

Mass Production ◽

Large Scale ◽

Raw Materials ◽

Synthesis Method ◽

Particle Size Analysis ◽

Raw Material ◽

Size Analysis ◽

Sem Observation

A synthesis method of high-pure Ti3AlC2 powder with a large scale was presented as pressureless synthesis using TiC, Ti and Al powders as starting materials at 1300~1450°C in flow Ar. The different raw material scales were tested from 2 g to 1.0 kg, and the results showed that the purities of Ti3AlC2 powders could be kept around 97 wt% at different scales of raw materials. SEM observation and particle size analysis revealed that the synthesized Ti3AlC2 powders were uniform and around 5 μm in particle size. This method can be used for mass production of Ti3AlC2 powders with high-purity.

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Oral Supplementation of Bauhinia variegata affects the Behavior of Albino Mice in a Gender Specific Manner

Pakistan Journal of Zoology ◽

10.17582/journal.pjz/20171213171244 ◽

2020 ◽

Vol 53 (1) ◽

Author(s):

Asmat Ullah ◽

Shahid Iqbal ◽

Furhan Iqbal

Keyword(s):

Body Weight ◽

Leaf Extract ◽

Morris Water Maze Test ◽

Control Group ◽

Object A ◽

Maze Test ◽

Plus Maze ◽

Specific Manner ◽

Albino Mice ◽

Gender Specific

Present study was designed to investigate the effects of 300 mg/ml solvent/Kg of body weight of Bauhinia variegata’s leaf extract on selective aspects of albino mice behavior in a gender specific manner. Seven week old female and male albino mice were used as experimental animals. Mice were orally supplemented either with 300 mg/ml solvent/Kg of body weight Bauhinia variegata’s leaf extract or with saline solution (0.9% NaCl) for 17 days. Behavioral observations were made by applying a series of neurological tests (Rota rod, Elevated plus maze, Light and dark box, Open field, Novel object and Morris water maze test). It was observed that Bauhinia variegata’s leaf extract supplementation improved neuromuscular co-ordination in female albino mice during rota rod test (P = 0.002), had more rotations (P = 0.02) and clockwise rotations (P = 0.01) during plus maze test and had more stretch attend reflex (P = 0.005) than control group. During the second trial of novel object test, Bauhinia variegata’s leaf extract treated male albino mice approached old object A (P = 0.04) and spend more time with object A (P = 0.05) as compared to control group. Open filed, light dark test and probe trial of Morris water maze test performances remain unaffected in both genders (P > 0.05) when compared between 300 mg/ml solvent/Kg body weight of Bauhinia variegata’s leaf extract treated and untreated albino mice of both genders. We concluded that applied dose of Bauhinia variegata’s leaf extract has the potential to improve neuromuscular co-ordination in female albino and should be explored further as potential treatment for neuromuscular problems.

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