scholarly journals DEVELOPMENT OF REFERENCE MATERIAL OF HOLMIUM OXIDE FOR SPECTROMETERS WAVELENGTH CALIBRATION: FEASIBILITY STUDIES

2018 ◽  
Vol 15 (29) ◽  
pp. 243-250
Author(s):  
D. E. GONÇALVES ◽  
J. F. S. GOMES ◽  
A. P. D. ALVARENGA ◽  
T. de O. ARAUJO ◽  
P. P. BORGES
Keyword(s):  
Quality Assurance ◽  
Reference Material ◽  
Wavelength Range ◽  
Certified Reference Material ◽  
Metrological Traceability ◽  
Feasibility Studies ◽  
Wavelength Calibration ◽  
Material Production ◽  
Important Requirement

The use of certified reference material (CRM) in chemical analyzes is an important requirement in quality assurance systems, since it allows the metrological traceability of results, thus achieving valid and comparable results. This work describes the development and production of holmium oxide reference material that, after certification, will be used in the calibration of the wavelength range of UV-Vis spectrometers and also the necessary feasibility studies to establish the measurement parameters to be used in the next steps of the material production and certification.

Certified reference material of bioethanol for metrological traceability in electrochemical parameters analyses

Talanta ◽  
2012 ◽  
Vol 99 ◽  
pp. 99-103 ◽  
Author(s):  
Isabel Cristina Serta Fraga ◽  
Carla Matos Ribeiro ◽  
Sidney Pereira Sobral ◽  
Júlio Cesar Dias ◽  
Mary Ane Gonçalves ◽  
...  
Keyword(s):  
Reference Material ◽  
Certified Reference Material ◽  
Metrological Traceability ◽  
Electrochemical Parameters

scholarly journals Certified Reference Material for Analytical Quality Assurance of Minor and Trace Elements in Food and Related Matrixes Based on a Typical Japanese Diet: Interlaboratory Study

2001 ◽  
Vol 84 (4) ◽  
pp. 1202-1208 ◽  
Author(s):  
Jun Yoshinaga ◽  
Masatoshi Morita ◽  
Masae Yukawa ◽  
Kunio Shiraishi ◽  
Hisao Kawamura ◽  
...  
Keyword(s):  
Trace Elements ◽  
Quality Assurance ◽  
Reference Material ◽  
Reference Values ◽  
Certified Reference Material ◽  
Analytical Quality ◽  
Analytical Quality Assurance ◽  
Minor And Trace Elements ◽  
Freeze Dried ◽  
Japanese Diet

Abstract A Certified Reference Material (CRM) was prepared at the National Institute for Environmental Studies (NIES), Japan, in collaboration with the National Institute of Radiological Sciences (NIRS), Japan, for the analytical quality assurance of minor and trace elements in food and related matrixes. The starting material for the CRM was all food served in 29 households in Japan over two 3-day periods in 1997–1998, and thus the CRM represented a typical Japanese diet. All foods (meals, snacks, and beverages) were homogenized, freeze-dried, pulverized, blended, dispensed into 1100 bottles, and sterilized. The within- and between-bottle homogeneity of the prepared CRM was satisfactory for most of the elements. The concentrations of 14 elements (Na, Mg, K, Ca, Mn, Cu, Zn, As, Se, Sr, Cd, Sn, Ba, and U) were certified based on a collaborative analysis involving NIES, NIRS, and 20 other laboratories. Reference values were given for the concentrations of 12 additional elements (P, Cl, Fe, Co, Ni, Br, Rb, Mo, I, Cs, Pb, and Th). The elements certified and those given reference values include minerals, essential trace elements, contaminant elements, and long-lived radionuclides. Thus, this CRM is of practical value in the quality assurance of element analysis of foods and diets in nutritional, environmental, and radiological research.

scholarly journals Certified reference material against PR3 ANCA IgG autoantibodies. From development to certification

2019 ◽  
Vol 57 (8) ◽  
pp. 1197-1206 ◽  
Author(s):  
Evanthia Monogioudi ◽  
Joanna Sheldon ◽  
Pier Luigi Meroni ◽  
Dana Petronela Hutu ◽  
Heinz Schimmel ◽  
...  
Keyword(s):  
Reference Material ◽  
Certified Reference Material ◽  
Certified Reference Materials ◽  
Feasibility Studies ◽  
Autoimmune Disorder ◽  
Accurate Diagnosis ◽  
Clinical Samples ◽  
Appropriate Use ◽  
Comparability Of Results

Abstract Background The importance of the standardisation of immunoassays for autoantibodies has been widely discussed. The appropriate use of certified reference materials (CRM) could contribute to a more accurate diagnosis and follow-up of a series of diseases such as small vessel-associated vasculitis. This is a systemic autoimmune disorder during which two autoantibodies can be present, MPO ANCA IgG and PR3 ANCA IgG. Results from different commercially available immunoassays used for PR3 ANCA IgG measurement can vary significantly. Therefore the potential for improvement using a suitable certified reference material was assessed and led to the development of a CRM. Methods Thirty clinical samples were evaluated using 10 immunoassays. The correlation between results from these assays was assessed in a pairwise manner. Feasibility studies were conducted in order to find a reference material format most suitable for the preparation of a CRM. Results The evaluation of two sets of 30 clinical samples with 10 assays showed that differences between assays can result in different interpretations for individual clinical samples. Most of the samples had the same result classification in all assays. However, six of the samples tested led to inconsistent results. Conclusions The correlation between results from clinical samples was systematically good for combinations of eight of those assays. Therefore, it should be possible to improve the comparability of results using a commutable CRM for calibration. Based on these studies, a final format for the CRM was selected and eventually produced and certified for its PR3 ANCA IgG content.

scholarly journals Metrological assurance of dioxin measurements. A certified reference material for measuring the dioxin mass fraction in animal fat

2019 ◽  
Vol 14 (3-4) ◽  
pp. 17-32 ◽  
Author(s):  
A. G. Budko ◽  
A. Y. Mikheeva ◽  
A. I. Krylov
Keyword(s):  
Reference Material ◽  
Certified Reference Material ◽  
Mass Fraction ◽  
Metrological Traceability ◽  
Isotopic Dilution ◽  
Animal Fat ◽  
Measurement Results ◽  
Mass Fractions ◽  
Certified Values ◽  
Good Agreement

The paper presents information on the development of a new certified reference material (CRM) for mass fraction of dioxins in animal fat, with established metrological traceability. A procedure for preparing and certifying CRM material is given. The GC–LRMS method with isotopic dilution was used as an analytical method for establishing certified characteristics. The uncertainties due to inhomogeneity and instability of the CRM material were estimated in order to account for their contribution to the uncertainty of certified values. In addition, the results of interlaboratory comparisons (ILC) for an experimental batch of the developed CRM are presented. Measurement results provided by ILC participants are shown to be in good agreement with the certified characteristics of the CRM. The certified values of dioxin mass fractions (PCDF group) in the CRM material are established to vary from 1 to 1000 ng / kg, with the relative expanded uncertainty ranging from 10 to 20 %.

scholarly journals IFCC Working Group Recommendations for Correction of Bias Caused by Noncommutability of a Certified Reference Material Used in the Calibration Hierarchy of an End-User Measurement Procedure

2020 ◽  
Vol 66 (6) ◽  
pp. 769-778 ◽  
Author(s):  
W Greg Miller ◽  
Jeffrey Budd ◽  
Neil Greenberg ◽  
Cas Weykamp ◽  
Harald Althaus ◽  
...  
Keyword(s):  
Reference Material ◽  
Certified Reference Material ◽  
Clinical Laboratory ◽  
Metrological Traceability ◽  
Measurement Procedure ◽  
Clinical Samples ◽  
End User ◽  
Assigned Value ◽  
The Difference ◽  
Specific Correction

Abstract Establishing metrological traceability to an assigned value of a matrix-based certified reference material (CRM) that has been validated to be commutable among available end-user measurement procedures (MPs) is central to producing equivalent results for the measurand in clinical samples (CSs) irrespective of the clinical laboratory MPs used. When a CRM is not commutable with CSs, the bias due to noncommutability will be propagated to the CS results causing incorrect metrological traceability to the CRM and nonequivalent CS results among different MPs. In a commutability assessment, a conclusion that a CRM is commutable or noncommutable for use with a specific MP is made when the difference in bias between the CRM and CSs meets or does not meet a criterion for that specific MP when compared to other MPs. A conclusion regarding commutability or noncommutability requires that the magnitude of the difference in bias observed in the commutability assessment remains unchanged over time. This conclusion requires the CRM to be stable and no substantive changes in the MPs. These conditions should be periodically reverified. If an available CRM is determined to be noncommutable for a specific MP, that CRM can be used in the calibration hierarchy for that MP when an appropriately validated MP-specific correction for the noncommutability bias is included. We describe with examples how a MP-specific correction and its uncertainty can be developed and applied in a calibration hierarchy to achieve metrological traceability of results for CSs to the CRM’s assigned value.

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