scholarly journals pH OF BONE MARROW

2019 ◽  
Vol 16 (32) ◽  
pp. 388-394
Author(s):  
L. P. NIKOLAEVA
Keyword(s):  
Bone Marrow ◽  
Lower Limb ◽  
Ph Value ◽  
Long Bone ◽  
Acid Base Balance ◽  
Acid Base ◽  
Marrow Cavity ◽  
Base Balance ◽  
Bone Marrow Cavity

The bone marrow is a “niche” for stem cells; determining the bone marrow pH value is of great importance. It is very difficult, almost impossible, to carry out the intravital determination of pH. In surgical practice, there are situations when doctors have no way to save the patient's lower limb because of the threat to life. In such cases, it is possible to extract the bone marrow from the bone marrow cavity of the amputated femur and examine it. The purpose of this research was to study the acid-base balance peculiarities of the marrow of long bones and carry out a comparative analysis of the obtained data and the indicators of flat bones. The study included 40 test samples of bone marrow. Lower limb amputations were performed because of foot gangrene. Bone marrow was extracted from the femur. The marrow of flat bones was obtained by a sternal puncture. In the pH test of the sternal puncture, the data varied within the range of the blood pH, i.e., between 7.35-7.45 and 7.8. The pH and gas composition data of the sternal puncture were identical to the blood indicators. The data of bone marrow obtained from the long bone was completely different. The acid-base balance strictly ranged from 6.7 to 6.9.

Practical Evaluation of Acid-Base Balance

1957 ◽  
Vol 3 (5) ◽  
pp. 631-637
Author(s):  
Herbert P Jacobi ◽  
Anthony J Barak ◽  
Meyer Beber
Keyword(s):  
Respiratory Acidosis ◽  
Respiratory Alkalosis ◽  
Acid Base Balance ◽  
Bicarbonate Concentration ◽  
Acid Base ◽  
Plasma Bicarbonate ◽  
Practical Evaluation ◽  
Base Balance

Abstract The Co2 combining power bears a variable relationship to the in vivo plasma bicarbonate concentration, depending upon the type and severity of acid-base distortion. In respiratory alkalosis and metabolic acidosis the Co2 combining power will usually be greater than the in vivo plasma bicarbonate concentration; whereas, in respiratory acidosis and metabolic alkalosis the Co2 combining power will usually be less. Co2 content, on the other hand, will always parallel the in vivo plasma bicarbonate concentration quite closely, being only slightly greater. These facts, together with other considerations which are discussed, recommend the abandonment of the determination of CO2 combining power.

Determination of acid base balance and oil water partition coefficient of an atopy patch test of levofloxacin

2008 ◽  
Vol 62 (2) ◽  
pp. 136-138 ◽  
Author(s):  
Julien Lecordier ◽  
Jean-Jacques Lahet ◽  
Carol Courderot-Masuyer ◽  
Etienne Beaudoin ◽  
Bernard Chaillot
Keyword(s):  
Partition Coefficient ◽  
Patch Test ◽  
Atopy Patch Test ◽  
Acid Base Balance ◽  
Acid Base ◽  
Water Partition Coefficient ◽  
Base Balance ◽  
Oil Water

scholarly journals A new method of etiopathogenetic treatment of patients with influenza

2020 ◽  
Vol 11 (3) ◽  
pp. 34-39
Author(s):  
Yu. M. Ambalov ◽  
D. V. Sizyakin ◽  
D. V. Dontsov ◽  
A. A. Kurdin ◽  
A. P. Kovalenko ◽  
...  
Keyword(s):  
Antiviral Therapy ◽  
Standard Treatment ◽  
Antiviral Drug ◽  
Acid Base Balance ◽  
Acid Base ◽  
Safe Method ◽  
Corrective Effect ◽  
Mucous Membranes ◽  
Base Balance

Purpose: to develop an effective and safe method for the etiopathogenetic treatment of influenza patients, aimed at increasing the effectiveness of the existing standard treatment using the antiviral drug oseltamivir.Materials and methods: 150 patients with a verified diagnosis of influenza were taken under observation. All of the participants were divided by randomization into two groups (n1 = 77, n2 = 73) which had the same initial clinical and laboratory characteristics. I group’s patients received standard antiviral therapy using oseltamivir. Patients of the II group at the same time as oseltamivir additionally received an aqueous solution of rehydron for 5 days. All patients underwent determination of the acidity of the mucous membrane of the oropharynx immediately before the start of antiviral therapy and immediately after its completion.Results: patients additionally receiving rehydron had a more rapid leveling of the main symptoms of influenza and a decrease in the frequency of its complications compared with people who received only standard treatment.Conclusions: the developed method of etiopathogenetic treatment of patients with influenza is characterized by a proven level of effectiveness, which is associated with the corrective effect of rehydron on the acid-base balance of the mucous membranes of the respiratory tract. The data obtained in the course of the study indicate not only the absolute scientific novelty of the developed method, but also its applied significance for practical public health.

scholarly journals Comparing the Effects of Pre-loading with Gelatine 4% Plasma Volume Expander and 6% Hydroxyethyl Starch Solution Before Spinal Anaesthesia for Lower Limb Orthopaedic Surgery

2020 ◽  
Vol 27 (6) ◽  
pp. 68-78
Author(s):  
Nur Dyana Md Nizar ◽  
Shamsul Kamalrujan Hassan ◽  
Rhendra Hardy Mohamad Zaini ◽  
Mohamad Hasyizan Hassan ◽  
Wan Mohd Nazaruddin Wan Hassan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spinal Anaesthesia ◽  
Lower Limb ◽  
Orthopaedic Surgery ◽  
Venous Blood ◽  
Acid Base Balance ◽  
Acid Base ◽  
Significant Difference ◽  
Lower Limb Surgery ◽  
Base Balance

Background: Hypotension is a common complication following spinal anaesthesia. The administration of intravenous fluids prior to spinal anaesthesia, known as pre-loading, has been used to offset the hypotension effect; however, the ideal fluid for pre-loading is still a matter of debate. The objective of this study was to compare the effects of Gelaspan 4% and Volulyte 6% as pre-loading fluids. Methods: A total of 93 patients with American Society of Anaesthesiologists (ASA) physical status I or II having lower limb orthopaedic surgery under spinal anaesthesia were randomised into two groups that received either Volulyte (n = 47) or Gelaspan (n = 46). Before the spinal anaesthesia, these patients were pre-loaded with 500 mL of the fluid of their respective group. Blood samples were taken before pre-loading and again after spinal anaesthesia and sent for venous blood gas and electrolyte level measurement. Baseline and intraoperative records of systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR) and the requirement of ephedrine to treat hypotension were also recorded. Results: Both fluids could not prevent significant reductions in SBP (P = 0.011), DBP (P = 0.002) and MAP (P = 0.001). There was also significant reduction in HR over time (P < 0.001). There was no significant difference in terms of ephedrine usage between both groups. Neither Volulyte 6% nor Gelaspan 4% caused significant changes in acid-base status. Conclusion: The use of 500 mL of either Gelaspan 4% or Volulyte 6% as pre-loading fluids did not significantly prevent the incidence of post-spinal anaesthesia hypotension following orthopaedic lower limb surgery; however, both were useful in the maintenance normal acid-base balance.

scholarly journals Determination of NABE in urine of high-yield dairy cows in early lactation in conditions of moderate heat stress

2010 ◽  
Vol 64 (5-6) ◽  
pp. 349-358
Author(s):  
Natalija Fratric ◽  
Ivan Vujanac ◽  
Horea Samanc ◽  
Danijela Kirovski ◽  
Dragan Gvozdic ◽  
...  
Keyword(s):  
Heat Stress ◽  
Dairy Cows ◽  
High Yield ◽  
Early Lactation ◽  
Acid Base Balance ◽  
Acid Base ◽  
Urine Ph ◽  
Base Balance ◽  
Daily Milk Production

The work presents the results of investigations of the effect of moderate heat stress on the acidobasal status in high-yield dairy cows in early lactation. Improving performance in high-yield dairy cows increases their inclination toward metabolic disorders. The most likely to be affected is the acid-base balance, in particular when cows are exposed to heat stress. Investigations so far have shown that the taking of urine samples and their analysis is the best and fastest way to diagnose disorders in the acid-base balance. Investigations were carried out on 7 clinically healthy cows of the Holstein- Friesian breed in the phase of early lactation, 30 to 40 days (on days 30, 33 and 40 ) following calving during the summer period, during the month of July, when there were significant variations in daily and nightly temperatures. The cows were in the second and fourth lactation, the annual milk yield was 8000 L milk per cow. The average daily milk production in the early phase of lactation ranged from 35 to 40 L. The cows were fed mixed rations (TMR) twice daily. Lucerne hay in limited quantities was given to the cows prior to the mixed feed ration. The ration for this animal category was optimized on the grounds of the daily milk production. The balance of cations and anions in the feed ration stood at 95 mEq/kg DM. The results clearly demonstrate the cows' response to moderate heat stress through the defense parameters in urine (urine pH, NABE (net-acid-base-excretion), acids, bases, ammonium ion (NH4). The determination of the kidney NABE yields more correct data than the urine pH on acidotic conditions. The results of examinations of the urine pH do not show any digressions from physiological values and are approximately the same in all cows during the investigated periods. Normal NABE values are from 100-200 mmol/L. Burdening with acid products results in a NABE range from 0-100mmol/L, and metabolic acidosis results in NAB<0 mmol/L. NABE in the cows in this experiment revealed that the organism is burdened by acid metabolic products and it stood at 58.28?27.96 mmol/L on day 30, 69.28?29.89 mmol/L on day 33, and 60.60?26.88mmol/L on day 40. Consequently, it seems that NABE values are decreased in cases of acidosis due to stepped up H+ excretion and stepped up bicarbonate reabsorption.

Influence of the Method Used to Obtain Pleural Fluid on the Determination of the Acid-Base Balance

2008 ◽  
Vol 44 (8) ◽  
pp. 413-417
Author(s):  
Manuel Haro-Estarriol ◽  
Juan Carlos Calderón-López ◽  
Gladis Sabater-Talaverano ◽  
Núria Font Vall-Llobera ◽  
Luis Alberto Álvarez-Castillo ◽  
...  
Keyword(s):  
Pleural Fluid ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

Laboratory diagnostics in the urine of young and pregnant ewes

2011 ◽  
Vol 39 (02) ◽  
pp. 82-87 ◽  
Author(s):  
Y. Cetin ◽  
K. Failing ◽  
A. Wehrend ◽  
S. Sendag
Keyword(s):  
Dairy Cows ◽  
Ph Value ◽  
Urine Samples ◽  
Laboratory Diagnostics ◽  
Weak Correlation ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance ◽  
Weak Negative Correlation ◽  
First Time

Summary Objective: The purpose of this study was to identify values for net acid base excretion (NABE) which are significant indicators of the acidbase equilibrium in pregnant and young ewes and to show its relationship with other parameters (base, acid, ammonium [NH4], base-acid quotient, sodium [Na], potassium [K], calcium [Ca]) in ovine urine. In contrast to dairy cows, data are rare on these parameters in ewes. Material and methods: A total of 99 animals were used in the study, consisting of 56 young (average of 5.6 ± 1.1 months) and 43 pregnant ewes (average of 35.2 ± 18.8 months). Measurement of fractional NABE in urine samples was carried out according to the method reported by Kutas. The pH value of the urine was measured with a laboratory pH meter. Na, K and total Ca were measured with a flame photometer. Results: For all values except Na significant differences occurred between urine samples of pregnant ewes and young ewes (p < 0.001). Base, acid, NH4, NABE, K and Ca values were significantly higher in the urine of the youngs than in pregnant ewes. In young ewes, a strong correlation was found between NABE and base values while a weak correlation could be observed between pH and base values. In pregnant ewes, strong NABE-base, NABE-K, K-acid and K-base correlations were found as well as weak NH4-base, NH4-NABE and NH4-K correlations. There was a strongly positive correlation between NABE and NH4 in pregnant ewes, while a weak negative correlation between those values was observed in young ewes. Conclusion: For the first time, we established values for NABE and certain other parameters in urine of pregnant ewes and young ewes. It was shown that the acid-base balance in pregnant ewes and young ewes can be evaluated by measuring NABE and certain trace elements in urine like in cattle.

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