scholarly journals Clinical, Neurophysiological and Histopatological correlations in Pure Neural Leprosy

2021 ◽  
Vol 1 (4) ◽  
pp. 105-113
Author(s):  
Izabela Jardim Rodrigues Pitta ◽  
Bruno de Siqueira Mietto ◽  
Aron dos Santos Camilo ◽  
Sergio Luiz Gomes Antunes ◽  
Euzenir Nunes Sarno ◽  
...  
Keyword(s):  
Neurological Examination ◽  
Nerve Conduction ◽  
Nerve Conduction Studies ◽  
Axonal Damage ◽  
Ulnar Neuropathy ◽  
Duration Of Symptoms ◽  
Conduction Velocities ◽  
Leprosy Patients ◽  
The Moment ◽  
Focal Demyelination

Although neuropathy remains one of the most problematic issues faced by leprosy patients, the evolving process of its findings continues a challenge particularly in pure neural leprosy (PNL). We evaluated neurological examination, nerve conduction studies and histhopathological data of patients with PNL and ulnar neuropathy. Patients with longer duration of symptoms had reduction in the motor conduction velocities and patients with fibrosis in the biopsy had axonal damage in the nerve conduction studies. This suggests that focal demyelination may be present in leprosy patients at the moment of the diagnosis and be related to the duration of the neuropathy.

Sensory and mixed nerve conduction studies in the evaluation of ulnar neuropathy at the elbow

1994 ◽  
Vol 17 (7) ◽  
pp. 785-792 ◽  
Author(s):  
Elizabeth M. Raynor ◽  
Jeremy M. Shefner ◽  
David C. Preston ◽  
Eric L. Logician
Keyword(s):  
Nerve Conduction ◽  
Nerve Conduction Studies ◽  
Ulnar Neuropathy ◽  
Mixed Nerve

Neurofascin-155 IgM autoantibodies in patients with inflammatory neuropathies

2018 ◽  
Vol 89 (11) ◽  
pp. 1145-1151 ◽  
Author(s):  
Kathrin Doppler ◽  
Helena Stengel ◽  
Luise Appeltshauser ◽  
Julian Grosskreutz ◽  
Judy King Man Ng ◽  
...  
Keyword(s):  
Western Blot ◽  
Acute Phase ◽  
Nerve Conduction ◽  
Nerve Conduction Studies ◽  
Axonal Damage ◽  
Large Cohort ◽  
Guillain Barre Syndrome ◽  
Pathogenic Role ◽  
Inflammatory Neuropathies ◽  
F Wave

ObjectivesRecently, IgG autoantibodies against different paranodal proteins have been detected and this has led to important advances in the management of inflammatory neuropathies. In contrast, not much is known on IgM autoantibodies against paranodal proteins.MethodsIn the present study, we screened a large cohort of patients (n=140) with inflammatory neuropathies for IgM autoantibodies against neurofascin-155, neurofascin-186 or contactin-1.ResultsIgM autoantibodies against neurofascin-155 were detected by ELISA in five patients, four with inflammatory demyelinating polyradiculoneuropathy (CIDP) and one with Guillain-Barré syndrome (GBS), and were confirmed by ELISA-based preabsorption experiments and Western blot. Titres ranged from 1:100 to 1:400. We did not detect IgM anti-neurofascin-186 or anti-contactin-1 antibodies in this cohort. All patients presented with distally accentuated tetraparesis and hypesthesia. Remarkably, tremor was present in three of the patients with CIDP and occurred in the patients with GBS after the acute phase of disease. Nerve conduction studies revealed prolonged distal motor latencies and F wave latencies. Nerve biopsies showed signs of secondary axonal damage in three of the patients, demyelinating features in one patient. Teased fibre preparations did not demonstrate paranodal damage.ConclusionIn summary, IgM neurofascin-155 autoantibodies may be worth testing in patients with inflammatory neuropathies. Their pathogenic role needs to be determined in future experiments.

scholarly journals Does gender have a significant effect on normal nerve conduction studies values?

2019 ◽  
Vol 9 (6) ◽  
Author(s):  
Kawthar AL-Salmi ◽  
Farook S Wali ◽  
Ahmed SM Nadeem ◽  
Abdullah AL-Salti
Keyword(s):  
Nerve Conduction Study ◽  
Nerve Conduction ◽  
Peripheral Nerves ◽  
Normative Data ◽  
Tertiary Care ◽  
Nerve Conduction Studies ◽  
Lower Limbs ◽  
Care Hospital ◽  
Upper Limbs ◽  
Conduction Velocities

Background: nerve conduction study (NCS) is a neurophysiologic medical diagnostic test used commonly to evaluate the function of the peripheral nerves. It is an extension to the clinical examination and extremely useful to diagnose and document a peripheral nerve disorder, localize the lesion, and to establish underlying pathophysiology. Objective: The aim of this study is to evaluate the influence of gender on nerve conduction study values and to generate reference nerve conduction studies (NCS) data for the commonly tested nerves among healthy adults in Oman. Subjects and methods: This study was conducted in the Neurology Department at the Royal Hospital, a tertiary care hospital in Muscat-Oman, for a period of four years (from March 2015 until May 2019) which included a total of 143 (80 females and 63 males) healthy Omani subjects. Sensory and motor nerve conduction studies were performed to the Median, Ulnar, Peroneal and Tibial nerves to establish the normative data. Statistical analysis was performed using Minitab comparing the mean values of all NCS parameters for both genders. Results: Gender comparison concluded that Omani males have longer distal motor latencies for all of the tested nerves and slower motor conduction velocities for the lower limbs’ nerves (p <0.005) than the females. While sensory latencies were significantly delayed in males as compared to Omani females for the upper limbs’ nerves and the ensory nerve potential amplitudes in the upper limbs were greater in females (p<0.0001) than males. A normative data for distal latencies, conduction velocities and responses amplitudes for motor and sensory nerves were sat up for the first time for normal adult Omani population. Conclusion: Gender has a significant influence on distal latencies and conduction velocities of some peripheral nerves in healthy Omani adult subjects, suggesting that different cut-off values for the two genders may be needed for interpreting such studies. These differences could be related to anatomical (height and limbs’ length gender differences) and/or physiological factors. Our normative data for nerve conduction study values are comparable to other published studies in the literature.

Segmental Mixed Nerve Conduction Studies in Ulnar Neuropathy at the Elbow

2001 ◽  
Vol 18 (5) ◽  
pp. 456-459 ◽  
Author(s):  
Yew Long Lo ◽  
Yang Fang Dan ◽  
Moi Pin Lee ◽  
Pavanni Ratnagopal
Keyword(s):  
Nerve Conduction ◽  
Nerve Conduction Studies ◽  
Ulnar Neuropathy ◽  
Mixed Nerve

Simple Decompression of the Ulnar Nerve: An Alternative to Anterior Transposition

1992 ◽  
Vol 17 (3) ◽  
pp. 251-254 ◽  
Author(s):  
P. A. NATHAN ◽  
L. D. MYERS ◽  
R. C. KENISTON ◽  
K. D. MEADOWS
Keyword(s):  
Clinical Outcome ◽  
Nerve Conduction ◽  
Clinical Results ◽  
Ulnar Neuropathy ◽  
Work Time ◽  
Average Return ◽  
Anterior Transposition ◽  
Conduction Velocities ◽  
Simple Decompression ◽  
Rehabilitation Time

Anterior transposition and/or medial epicondylectomy are often considered procedures of choice for ulnar neuropathy at the elbow. Much experience suggests simple decompression to be a comparably effective alternative which involves less trauma, morbidity, and rehabilitation time. The post-operative clinical and electrophysiological results of 52 cases of simple decompression (41 patients) are summarized. Excellent or good clinical results were found in 75% of the nerves. Mean ulnar motor conduction velocities were significantly improved post-operatively, although nerve conduction parameters did not consistently correlate with clinical outcome. The average return-to-work time was 5.1 weeks. The advantages of simple decompression make it the procedure of choice for most cases of ulnar neuropathy.

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