COMPARATIVE ANALYSIS OF BEHAVIOR OF THE NORTHERN RED-BACKED VOLE (MYODES RUTILUS) AND THE KOREAN FIELD MOUSE (APODEMUS PENINSULAE) IN THE OPEN FIELD TEST

Korean field mouse (Apodemus peninsulae) shows a wide variation in the number of B chromosomes composed of constitutive heterochromatin. For this reason, it provides a good model to study the influence of the number of centromeres and amount of heterochromatin on spatial organization of interphase nuclei. We analyzed the three-dimensional organization of fibroblast and spermatocyte nuclei of the field mice carrying a different number of B chromosomes using laser scanning microscopy and 3D fluorescence in situ hybridization. We detected a co-localization of the B chromosomes with constitutive heterochromatin of the chromosomes of the basic set. We showed a non-random distribution of B chromosomes in the spermatocyte nuclei. Unpaired B chromosomes showed a tendency to occur in the compartment formed by the unpaired part of the XY bivalent.

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Toxicity and Neuropharmacological Effects of Elenine

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2011/312524 ◽

2011 ◽

Vol 2011 ◽

pp. 1-10 ◽

Cited By ~ 6

Author(s):

Eduardo Navarro ◽

S. J. Alonso ◽

R. Navarro

Keyword(s):

Open Field ◽

Field Test ◽

Chemical Structure ◽

Open Field Test ◽

Control Group ◽

General Behaviour ◽

Similar Chemical ◽

Sedative Effects ◽

Traction Test ◽

Central Depressant

Elenine is the aglycone of elenoside, a cytotoxic arylnaphthalene lignan (NSC 644013-W/1) derived fromJusticia hyssopifolia. (Family: Acanthaceae). Elenoside is a β-D-glucoside, with a similar chemical structure to etoposide, exhibiting central depressant activity. In the present study, elenine was given to mice and rats at doses of 10, 20, and 40 mg/kg. Acute toxicity (24 h) and general behaviour in mice was studied as well as its effects on muscular relaxant activity, locomotor activity (Varimex test), and the open-field test and were compared with 10 mg/kg of chlorpromazine. Elenine produced a reduction in the permanence time in muscular relaxant activity (traction test). Spontaneous activity was lower in the Varimex test. The ambulation and rearing were lower compared with the control group, and an increase in boluses was observed in the open-field test. Thus, it can be concluded that elenine has central sedative effects at lower doses than those used with elenoside and has a possible application in conditions of anxiety.

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Participation ofGABAAChloride Channels in the Anxiolytic-Like Effects of a Fatty Acid Mixture

BioMed Research International ◽

10.1155/2013/121794 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 8

Author(s):

Juan Francisco Rodríguez-Landa ◽

Rosa Isela García-Ríos ◽

Jonathan Cueto-Escobedo ◽

Blandina Bernal-Morales ◽

Carlos M. Contreras

Keyword(s):

Open Field ◽

Field Test ◽

Chloride Channels ◽

Wistar Rats ◽

Elevated Plus Maze ◽

Open Field Test ◽

Acid Mixture ◽

Plus Maze ◽

Gaba Binding ◽

Defensive Burying

Human amniotic fluid and a mixture of eight fatty acids (FAT-M) identified in this maternal fluid (C12:0, lauric acid, 0.9 μg%; C14:0, myristic acid, 6.9 μg%; C16:0, palmitic acid, 35.3 μg%; C16:1, palmitoleic acid, 16.4 μg%; C18:0, stearic acid, 8.5 μg%; C18:1cis, oleic acid, 18.4 μg%; C18:1trans, elaidic acid, 3.5 μg%; C18:2, linoleic acid, 10.1 μg%) produce anxiolytic-like effects that are comparable to diazepam in Wistar rats, suggesting the involvement ofγ-aminobutyric acid-A (GABAA) receptors, a possibility not yet explored. Wistar rats were subjected to the defensive burying test, elevated plus maze, and open field test. In different groups, threeGABAAreceptor antagonists were administered 30 min before FAT-M administration, including the competitive GABA binding antagonist bicuculline (1 mg/kg),GABAAbenzodiazepine antagonist flumazenil (5 mg/kg), and noncompetitiveGABAAchloride channel antagonist picrotoxin (1 mg/kg). The FAT-M exerted anxiolytic-like effects in the defensive burying test and elevated plus maze, without affecting locomotor activity in the open field test. TheGABAAantagonists alone did not produce significant changes in the behavioral tests. Picrotoxin but not bicuculline or flumazenil blocked the anxiolytic-like effect of the FAT-M. Based on the specific blocking action of picrotoxin on the effects of the FAT-M, we conclude that the FAT-M exerted its anxiolytic-like effects throughGABAAreceptor chloride channels.

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Note on EMI Measurement at Open Field Test Site (2) - On the Shortened Dipole Antenna

1986 IEEE International Symposium on Electromagnetic Compatibility ◽

10.1109/isemc.1986.7568267 ◽

1986 ◽

Author(s):

Shigeru Takeya ◽

Atuya Maeda

Keyword(s):

Open Field ◽

Field Test ◽

Open Field Test ◽

Test Site ◽

Dipole Antenna

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Acute effects of ethanol on behavioral responses of male and female zebrafish in the open field test with the influence of a non-familiar object

Behavioural Processes ◽

10.1016/j.beproc.2021.104474 ◽

2021 ◽

pp. 104474

Author(s):

Thiele P. Souza ◽

Francini Franscescon ◽

Flavia V. Stefanello ◽

Talise E. Müller ◽

Laura W. Santos ◽

...

Keyword(s):

Open Field ◽

Field Test ◽

Open Field Test ◽

Behavioral Responses ◽

Familiar Object ◽

Acute Effects ◽

Male And Female ◽

Female Zebrafish

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Garcinia Camobogia Extract Alters Anxiety, Sociability, and Dopamine Turnover in Male Swiss Albino Mice

10.21203/rs.3.rs-1080894/v1 ◽

2021 ◽

Author(s):

Michael K. Ibrahim ◽

Marina Aboelsaad ◽

Fatma Tony ◽

Moustafa Sayed

Keyword(s):

Open Field ◽

Field Test ◽

Open Field Test ◽

Modern Medicine ◽

Receptor Expression ◽

Dopamine Turnover ◽

Male Mice ◽

Garcinia Cambogia ◽

Swiss Albino Mice ◽

Albino Mice

Abstract Background: Obesity is a global concern, closely allied with somatic and psychosomatic disorders. Herbal drugs are available in modern medicine to treat obesity. Garcinia camobogia being used by so many people trying to lose weight produces various systemic side effects. The study was conducted to assess its effect on anxiety, sociability, and dopamine turnover in male mice. Methodology: Male Swiss albino mice of either were divided into three groups with seven mice in each group. Different groups were given distilled water (0.5ml p.o.) and Garcinia cambogia extract at two different doses (100mg/kg and 500 mg/kg p.o.). Effect of test drugs on anxiety was evaluated using open field test. Sociability and social novelty were evaluated using three chambers test. Results (mean ± standard deviation) were analyzed using one-way ANOVA test followed by Tukey’s test. Result: Garcinia cambogia extract significantly increased the time spent in the corners in the open field test, significantly reduced sociability and social novelty in the three chamber test, significantly reduced dopamine turnover and increased D2 receptor expression in ventral tegmental area. Conclusion: Garcinia cambogia extract have significant anxiogenic effect along with reduced sociability and social novelty in male mice. Moreover, these effects could be related to the altered dopamine turnover and D2 receptor expression in mice brain.

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