Estrous Cycle Alters Micturition Pattern in Conscious Rat

Background The present study aims to investigate the influence of estrous cycle on micturition pattern in conscious spontaneously hypertensive rat. Methods Micturition pattern was evaluated by measuring void volume, void interval and void pressure in each stage of the estrous cycle by cystometry. Results A higher bladder capacity and a decrease in the frequency of micturition occurred in the pro-estrus and estrus stage, while a lower bladder capacity and an increase in the frequency of micturition occurred in the diestrus stage. Conclusions It is suggested that these remarkable variations in the physiology of the micturition pattern during different stages of the estrous cycle might be due to the effects of estrogen and progesterone because the level of these hormones fluctuate during each stage of the cycle. Therefore, monitoring the estrous cycle prior to any cystometry experiment in conscious rat is recommended for a better understanding of the effects of these hormones on bladder function.

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Voltage-gated Na+ Channel Blockers Reduce Functional Bladder Capacity in the Conscious Spontaneously Hypertensive Rat

Urology ◽

10.1016/j.urology.2012.02.016 ◽

2012 ◽

Vol 79 (6) ◽

pp. 1410.e1-1410.e6 ◽

Cited By ~ 2

Author(s):

Angela K. Clouse ◽

Malcolm J. Jugus ◽

Stephen H. Eisennagel ◽

Nicholas J. Laping ◽

Timothy D. Westfall ◽

...

Keyword(s):

Spontaneously Hypertensive Rat ◽

Bladder Capacity ◽

Na Channel ◽

Channel Blockers ◽

Spontaneously Hypertensive ◽

Voltage Gated ◽

Hypertensive Rat

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L-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat

Metabolites ◽

10.3390/metabo11110778 ◽

2021 ◽

Vol 11 (11) ◽

pp. 778

Author(s):

Kanako Matsuoka ◽

Hidenori Akaihata ◽

Junya Hata ◽

Ryo Tanji ◽

Ruriko Honda-Takinami ◽

...

Keyword(s):

Bladder Dysfunction ◽

Spontaneously Hypertensive Rat ◽

Bladder Capacity ◽

Organ Damage ◽

Bladder Function ◽

Daily Consumption ◽

Bladder Tissue ◽

Spontaneously Hypertensive ◽

Sympathetic Hyperactivity ◽

Water Group

Chronic sympathetic hyperactivity is known to affect metabolism and cause various organ damage including bladder dysfunction. In this study, we evaluated whether L-theanine, a major amino acid found in green tea, ameliorates bladder dysfunction induced by chronic sympathetic hyperactivity as a dietary component for daily consumption. Spontaneously hypertensive rats (SHRs), as an animal model of bladder dysfunction, were divided into SHR–water and SHR–theanine groups. After 6 weeks of oral administration, the sympathetic nervous system, bladder function, and oxidative stress of bladder tissue were evaluated. The mean blood pressure, serum noradrenaline level, and media-to-lumen ratio of small arteries in the suburothelium were significantly lower in the SHR–theanine than in the SHR–water group. Micturition interval was significantly longer, and bladder capacity was significantly higher in the SHR–theanine than in the SHR–water group. Bladder strip contractility was also higher in the SHR–theanine than in the SHR–water group. Western blotting of bladder showed that expression of malondialdehyde was significantly lower in the SHR–theanine than in the SHR–water group. These results suggested that orally administered L-theanine may contribute at least partly to the prevention of bladder dysfunctions by inhibiting chronic sympathetic hyperactivity and protecting bladder contractility.

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