Elevated Serum Alanine Transaminase (ALT) in Patients of Type 2 Diabetes Mellitus

2021 ◽  
Vol 15 (11) ◽  
pp. 3096-3097
Author(s):  
Nasir Shah ◽  
Saqib Jahangir ◽  
Naeem Ahmed ◽  
Muhammad Saleem Hasan ◽  
Yasir Abbas Zaidi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Type Ii Diabetes ◽  
Transaminase Level ◽  
Elevated Serum ◽  
Alanine Transaminase ◽  
Type Ii

Objective: The objective of this study was to determine the prevalence of raised serum alanine transaminase level in patients of type 2 diabetes mellitus. Design: cross-sectional study Study Settings: This study was conducted at Department of Internal Medicine Abbas Institute of Medical Sciences Muzaffarabad from November 2020 to April 2021. Material and Methods: Total 144 patients were included in the study having age from 18 to 60 of both genders with Type 2 DM. It was labeled as elevated if it was ≥50 IU/L. A written informed consent was taken from each patient. Results: Patient’s age ranged from 36 to 70 years having mean value of 44.4±8.3 y. BMI ranged from 21.2 Kg/m2 to 34.7 Kg/m2 with a mean of 27.2±3.7 Kg/m2. Disease duration was from 2 to 14 years with a mean of 7.1±3.8 years. Elevated serum ALT was noted in 38 (26.4%) patients with type-II diabetes. Conclusion: Elevated serum ALT was noted in a substantial proportion of patients with type-II diabetes and was significantly more frequent in patients with poor glycemic control which warrants good glycemic control to prevent and routine screening of such patients in future practice to timely identify and manage this complication to improve the outcome. Keywords: Type 2 Diabetes Mellitus, Serum Alanine Transaminase, Prevalence

scholarly journals Influence of Glycated Haemoglobin Levels on Intraocular Pressure in patients with Type –II Diabetes Mellitus

2019 ◽  
Vol 11 (1) ◽  
pp. 19-23
Author(s):  
Ajai Agrawal ◽  
Shubham Ahuja ◽  
Anupam Singh ◽  
Ramanuj Samanta ◽  
Sanjeev Kumar Mittal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Intraocular Pressure ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Group I ◽  
Hba1c Levels

Introduction: Patients with diabetes mellitus are at a higher risk of developing primary open angle glaucoma (POAG) as compared to non-diabetic patients. Objectives: To determine whether there is a correlation between hyperglycemic levels and intraocular pressure (IOP) and to identify patients of Type II diabetes mellitus who are at a higher risk of developing glaucoma. Materials and Methods: This was a hospital based, cross sectional study performed on patients with type II diabetes mellitus, at a tertiary health care center in Uttarakhand, India between July, 2018 and September, 2018. 318 eyes of 159 patients with Type2 diabetes mellitus were included in the study. IOP was measured by Goldmannappla nation to no meter and central corneal thickness was measured with specula microscope in all patients, in addition to glycated hemoglobin levels (HbA1c) and fasting and post-prandial blood glucose levels. The data was analysed using SPSS 22 software. Results: Mean IOP was found to be 15.75 ± 3.18 mm Hg in patients with HbA1c levels between 6.5%-12% (Group I) and 17.42 ± 2.67 mm Hg in patients with HbA1c levels more than 12 % (Group II). The difference between the two groups was statistically significant (P =0.013). Out of 159 patients with Type 2 Diabetes mellitus, a total of 11 patients had IOP more than 21mm Hg in one or both the eyes. Conclusion: Hyperglycaemic levels as determined by raised HbA1c levels are associated with higher intraocular pressures in patients with type 2 diabetes mellitus.

scholarly journals Elevated serum alanine transaminase in patients with type 1 or type 2 diabetes mellitus

QJM ◽  
2006 ◽  
Vol 99 (12) ◽  
pp. 871-876 ◽  
Author(s):  
J. West ◽  
J. Brousil ◽  
A. Gazis ◽  
L. Jackson ◽  
P. Mansell ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Elevated Serum ◽  
Alanine Transaminase

scholarly journals 340. Prevalence of Type II Diabetes Mellitus Among Patients Living with HIV in the United States

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S180-S181
Author(s):  
Morgan Birabaharan ◽  
Andrew Strunk ◽  
Amit Garg ◽  
Stefan Hagmann
Keyword(s):  
Diabetes Mellitus ◽  
United States ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
The United States ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Living With Hiv

Abstract Background An aging HIV-infected population has growing recognition for its increasing prevalence of type 2 diabetes mellitus (T2DM). Most studies of T2DM prevalence among patients living with HIV involve selected samples and/or small cohorts which limit generalizability. We sought to evaluate the overall prevalence of T2DM among patients living with HIV in the United States as well as within specific demographic subgroups. Methods A cross-sectional analysis was performed using a large, multi-institutional database (Explorys), where clinical information across 27 healthcare networks are matched and standardized to create longitudinal records for each unique patient. At present, the database contains 63 million unique lives, representing 18% of the population across all 4 census regions of the United States. Patients with all types of insurance as well as those who are self-pay are represented. The analysis included adult patients with an active status in the database during April 2014- April 2019 who, not missing data on age, gender, race, and body mass index. The Systematized Nomenclature of Medicine—Clinical Terms (SNOMED-CT) of “Human Immunodeficiency Virus,” “diabetes mellitus type 2,” “disorder due to type 2 diabetes mellitus,” and “Type II diabetes mellitus uncontrolled” were used to identify patients with HIV and T2DM. Results We identified 90,900 patients with HIV. The overall prevalence of T2DM among patients with HIV was 22.1% (20,080/90,900) compared with 14.9% (2,679,490/17,946,580) in the general population. In subgroup analysis, the prevalence of T2DM was highest among patients with HIV who were female, older, other race, obese, hypertensive, hyperlipidemic, smokers, alcoholics, and those with a history of hepatitis C infection. Patients with no exposure to antiretroviral therapy (ART) had higher prevalence of T2DM than those with exposure (24.9% vs. 17.6%). Conclusion In this US population-based study, we found 1 in 5 people living with HIV had prevalent T2DM. In addition, we observed that HIV-associated T2DM may not depend on chronic ART exposure. Physicians caring for patients with HIV should be aware of the association and should monitor for signs and symptoms of T2DM. Disclosures All authors: No reported disclosures.

scholarly journals The Description of Sexual Dysfunction in Patients of Type II Diabetes Mellitus in Poly Disease In Mardi Hospital Waluyo City Blitar

2015 ◽  
Vol 2 (3) ◽  
pp. 216-221
Author(s):  
Sukma Puji Rahayu ◽  
Tri Cahyo Sepdianto ◽  
Arif Mulyadi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Sexual Dysfunction ◽  
Type Ii Diabetes ◽  
Sampling Technique ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Chronic Complications

Chronic complications of diabetes mellitus was the most common autonomic neuropathyresulted in sexual dysfunction. The aim of research was to described the sexual dysfunction in patientswith type 2 diabetes mellitus at Poli Penyakit Dalam Mardi Waluyo Hospital Blitar. The researchmethod used descriptive design. The population in this study were patients with type 2 diabetes mellituswho visited in poli penyakit dalam in Mardi Waluyo Hospital Blitar in April as many as 856 people, anda sample of 86 people were taken using purposive sampling technique. Collecting data used the FSFIquestionnaire for womens and IIEF for mens. These results indicate that the majority of patients withtype 2 diabetes mellitus sexual dysfunction. In patients 75% of women experience sexual dysfunction. At74% of men with erectile dysfunction, 88% experienced orgasm dysfunction, 85% experienced sexualdesire dysfunction, 86% experienced a satisfying sexual dysfunction, 89% overall satisfaction dysfunction.The suggestion in this research was expected FSFI and IIEF questionnaire could be used as a toolto monitor the presence of sexual dysfunction in Blitar.

scholarly journals Echocardiographic evaluation of diastolic dysfunction in type 2 diabetes mellitus without cardiac manifestations in rural hospital

2020 ◽  
Vol 7 (11) ◽  
pp. 1658
Author(s):  
Sachinkumar K Khade ◽  
Sudeep Kumar ◽  
Digvijay S. Hodgar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Informed Consent ◽  
Diastolic Dysfunction ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Cardiac Manifestations

Background: Diabetes is the commonest metabolic disorder affecting the people all over the world. Objective of the study was to identify the diastolic dysfunction in type 2 diabetes mellitus patient to recognize the early involvement of heart.Methods: This cross sectional study was conducted in tertiary care hospital cases of type II diabetes mellitus coming to our hospital and giving informed consent. Period of study was from September 2016 to February 2018. Consecutive type of non-probability sampling was used for the selection of study subjects. A total of 54 diagnosed patients of type II diabetes mellitus coming to our hospital and giving informed consent were included in the study.Results: Prevalence of diastolic dysfunction was observed to be 44.4% in patients of type 2 diabetes mellitus without cardiac manifestations. Prevalence of diastolic dysfunction was seen in 47.4% males in comparison to 42.9% females. Prevalence of diastolic dysfunction was 11.1%, 77.3% and 80% in cases with disease duration of 0-5 years, 6-10 years and more than 10 years respectively. Prevalence of diastolic dysfunction was more in cases with poor glycaemic control i.e. hemoglobin A1c (HbA1c) value >8% as compared to cases with good glycemic control.Conclusions: There was an association between the prevalence of diastolic dysfunction with the increasing age. We had higher percentage of patients with diastolic dysfunction as duration of diabetes increased. Diastolic dysfunction was seen in 55.2% patients receiving oral hypoglycaemic agents (OHAs) as compared to 23.5% patients who were on insulin and 50% patients who were on both insulin and OHAs.

scholarly journals Fibrinogen levels in type II diabetes mellitus patients with microvascular complications

2018 ◽  
Vol 5 (6) ◽  
pp. 1428
Author(s):  
Vijayalakshmi Chikkamath ◽  
Arathi Darshan ◽  
Jayaprakash S. Appajigol ◽  
Naveen Angadi ◽  
Abhishek T. G.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Type Ii Diabetes ◽  
Microvascular Complications ◽  
Type Ii Diabetes Mellitus ◽  
Plasma Fibrinogen ◽  
Type Ii

Background: Diabetes increases the morbidity and mortality due to its propensity to develop micro and macrovascular complications. Recently the role of haemostatic factors, particularly fibrinogen, in atherosclerosis and its complications has invited considerable attention. The present study was conducted to study plasma fibrinogen levels in type II diabetes mellitus patients with microvascular complications.Methods: One hundred patients aged 18years to 60years with type 2 diabetes mellitus with microvascular complications were included in the study. HBA1c, plasma fibrinogen, urine routine examination, fundoscopy, monofilament testing, FBS, PPBS were done. Descriptive statistics was used to analyse data.Results: Out of 100 diabetes patients with microvascular complication studies, 88 patients were found to have hyperfibrinogenaemia. Out of 100 patients 67 patients had HbA1c of more than 8%, and all of them had elevated fibrinogen levels (p <0.0001). The prevalence of hyperfibrinogenemia was higher in patients with diabetic retinopathy (90%), when compared to those without diabetic retinopathy (83.33%) although it was statistically not significant (p=0.266).Conclusions: Hyperfibrinogenemia among type 2 diabetes mellitus patients with microvascular complications was high. Glycaemic control has a significant impact on the fibrinogen levels. Longer the duration of diabetes, there was a higher prevalence of hyperfibrinogenemia.

scholarly journals Clinical and psychopathological features of patients with type II diabetes mellitus

2021 ◽  
Vol 11 (11) ◽  
pp. 182-187
Author(s):  
A. Kondratenko
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Emotional Disorders ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Visual Modality ◽  
Type Ii ◽  
Duration Of Diabetes

Today, type II diabetes mellitus (T2DM) is considered to be the most important nosological cause of decreased cognitive functions. A number of studies have found that hyperglycemia and duration of diabetes are associated with cognitive deficits, with the prevalence of cognitive impairment in type 2 diabetes mellitus being 20% in men and 18% in women over 60 years of age. To achieve this goal, it was conducted a comprehensive clinical-psychopathological and psychodiagnostic examination of 82 patients with moderate type 2 diabetes mellitus (46 women and 36 men) aged 35.9±10.1 years in accordance with the principles of bioethics and deontology. The mean duration of diabetes was 7.9±5.2 years. The severity of diabetes in most cases was defined as moderate (84.1%), and in 15.9% of cases corresponded to severe. 30.2% of patients used insulin as a basic hypoglycemic therapy, 69.8% - tablets. According to the analysis of the emotional state of patients with T2DM were characterized by complaints of low, depressed mood (69.5% of examined patients), uncontrolled emotional reactions (46.2%), feelings of anxiety, constant internal tension (44.7%), paresthesias (29.1%), sleep-wake cycle disorders (56.2%), general weakness, lethargy and fatigue (58.2%), fatigue (90.0%), frequent mood swings, with a predominance of decreased mood background (23.3%), emotional lability with excessive vulnerability and sensitivity (16.6%), irritability (16.6%). The clinical and psychopathological structure of emotional disorders is represented by anxious (43.4%), depressive (26.6%), astheno-hypochondriac (19.8%), hysteroform (10.2%) syndromes. Clinical examination of patients with DM showed that more often (in 95.0% of cases) in patients with T2DM there is a decrease in memory of auditory and visual modality, impaired intellectual abilities, slow thinking, lack of attention and information processing.

scholarly journals PROFILE OF TYPE II DIABETES MELLITUS WITH CENTRAL OBESITY IN DR. SOETOMO HOSPITAL

2016 ◽  
Vol 51 (3) ◽  
pp. 177
Author(s):  
Misbakhul Munir ◽  
Ari Sutjahjo ◽  
Florentina Sustini
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Waist Circumference ◽  
Type Ii Diabetes ◽  
Central Obesity ◽  
Sampling Technique ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii

Obesity, especially central obesity is often associated with insulin resistance and type 2 diabetes mellitus. Diabetes mellitus is a disease of the number six cause of death in Indonesia with the proportion of deaths by 5.8%. The purpose of this study was to identify central obesity in patients with type 2 diabetes mellitus in Poly Endocrine Dr. Soetomo Hospital, Surabaya. The study design was descriptive study. The sample was 100 type 2 diabetes mellitus patients taken with purposive sampling technique. The variable was central obesity and type 2 diabetes mellitus. The data obtained by interviewing patients and performing measurements on body weight, height and waist circumference. Data were analyzed by interpreting how the description of the variables studied and compared with other studies and theories. The results was the characteristics of patients most were female (66%), level of education was medium, unemployment, most of patient’s age was more than 50 years old, 43% for interval 51-60 years old, 43% were 1,50-1,59 meters in height and 28% were 50-59 kilograms and 28% were 60-69 kilograms in weight. According to Body Mass Index (BMI) measure that 54% the patients are normal in average 25,56 8,12 kg/m2. Measurement of waist circumference showed that 73.5% male and 81.8% female patients had central obesity. The conclusions, precentage of patients with type II diabetes mellitus who have central obesity were 81,82% female and 73, 53% male.

scholarly journals Comparative assessment of serum levels of vitamin d3 in chronic generalised periodontitis patients with type 2 diabetes mellitus and in simple gingivitis patients - A clinico-bio chemical study

2021 ◽  
Vol 6 (3) ◽  
pp. 161-164
Author(s):  
Gonabhavi Siri Chandana ◽  
Ramesh Amirisetty ◽  
Neelam Manojvaibhav ◽  
Ramesh Nichenametla ◽  
Shanti Prathyusham ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Periodontal Disease ◽  
Bone Metabolism ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii

The role of vitamin D was well established in bone metabolism as well as in the inflammatory process of a disease. The periodontal disease which is a chronic inflammatory condition with destructive bone metabolism and type II diabetes mellitus which is a metabolic condition with more prone to inflammatory reactions are prevalent in middle-aged patients. Hence the present study is done to assess the vitamin D levels in serum of chronic generalized periodontitis patients with type2 Diabetes mellitus and simple gingivitis patients  Two groups with 50 patients of both periodontal disease with type 2 diabetes and 50 simple gingivitis patients of age 35 to 55 years old were recruited in this study. For all the patient's serum 25(OH)D levels, oral hygiene index (OHI), Russel’s periodontal index, and presence of bony defects in radiographs were assessed.After assessment of all the parameters patients with periodontal disease and type 2 diabetes mellitus showed significantly higher proportion levels than the simple gingivitis patients and significantly lower levels in 25(OH)D (&#60;From the results, it was concluded that generalized periodontitis patients with type II diabetes mellitus showed higher levels of 25-hydroxyvitamin D levels than simple gingivitis patients.

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