Spectrum of Histopathological Lesions in Cholecystectomy Specimens at Pak Red Crescent Teaching Hospital

Objective: To study the spectrum of histopathological lesions found on surgically resected gallbladder to quantify the various abnormalities in gallbladder specimen. Methodology: A descriptive observational study was carried out from Nov 2017 to Oct 2021. All the patients undergoing emergency and elective cholecystectomy regardless of age and sex were included in the study. After cholecystectomy, gallbladder specimen along with history and ultrasound findings was sent for histopathology to our own institution. Department of histopathology has the standardized method to process the gallbladder specimens. Demographic data along with diagnosis, ultrasound finding and histopathology report were collected and analyzed with Excel 2019. Results: Total number of patients in this study was 395, out of which 93 patients were male and 302 patients were female. Average age of our patients was 43.05± 13 years. Acute calculus cholecystitis was found in 55 (13.92%) patients, 298 (75.44) patents had chronic calculus cholecystitis, empyema was found in 15 (3.80) patients, cholestrolosis was found in 5 (1.27%) patients, gallbladder polyp was found in 02 (0.51%) patients, gangrenous gall bladder was found in 01 (0.25%) patient and adenocarcinoma in situ was found in 01 (0.25%) patient. Conclusion: Our study shows that, chronic cholecystitis is the most common presentation followed by acute cholecystitis in surgically resected gallbladders. Females are predominantly suffering from the gallbladder diseases. The frequency of malignant lesion was very low. Keywords: Gallbladder-histopathology, Acute Cholecystitis, Chronic Cholecystitis, Gallstones.

Download Full-text

Histological evaluation of 400 cholecystectomy specimens

Journal of Pathology of Nepal ◽

10.3126/jpn.v5i10.15640 ◽

2015 ◽

Vol 5 (10) ◽

pp. 834-840 ◽

Cited By ~ 1

Author(s):

H Kumar ◽

H Kini ◽

A Tiwari

Keyword(s):

Acute Cholecystitis ◽

Choledochal Cyst ◽

Chronic Cholecystitis ◽

Histological Evaluation ◽

P Value ◽

Kasturba Medical College ◽

Xanthogranulomatous Cholecystitis ◽

Medical College ◽

Number Of Patients ◽

Common Diagnosis

Background: A majority of gallbladder specimens show changes associated with chronic cholecystitis; however few harbour a highly lethal carcinoma. This study was conducted to review the significant histopathological findings encountered in gallbladder specimens received in our laboratory.Materials and Methods: Four hundred cholecystectomy specimens were studied over a period of five years (May, 2002 to April, 2007) received at department of pathology, Kasturba Medical College, Mangalore, India. Results: Gallstones and associated diseases were more common in women in the 4th to 5th decade as compared to men with M: F ratio of 1:1.33. Maximum number of patients (28.25%) being 41 to 50 years old. Histopathologically, the most common diagnosis was chronic cholecystitis (66.75%), followed by chronic active cholecystitis (20.25%), acute cholecystitis (6%), gangrenous cholecystitis (2.25%),xanthogranulomatous cholecystitis (0.50%), empyema (1%), mucocele (0.25%), choledochal cyst (0.25%), adenocarcinoma gallbladder (1.25%) and normal gallbladders (1%).Conclusion: All lesions were found more frequently in women except chronic active cholecystitis. Gallstones were present in (80.25%) cases, and significantly associated with various lesions (P value 0.009). Pigment stones were most common, followed by cholesterol stones and mixed stones. Adequate sectioning is mandatory in all cases to assess epithelial changes arising from cholelithiasis and chronic cholecystitis as it has been known to progress to malignancy in some cases.

Download Full-text

Effects of COVID-19 pandemic on general surgical emergencies: Are some emergencies really urgent? Level 1 Trauma center experience

10.21203/rs.3.rs-37618/v1 ◽

2020 ◽

Author(s):

Ahmet Surek ◽

Sina Ferahman ◽

Eyup Gemici ◽

Ahmet Cem Dural ◽

Turgut Donmez ◽

...

Keyword(s):

Acute Cholecystitis ◽

General Surgery ◽

Emergency Surgery ◽

Demographic Data ◽

Control Group ◽

Surgical Emergencies ◽

Mechanical Intestinal Obstruction ◽

Number Of Patients ◽

Uncomplicated Appendicitis ◽

Surgery Department

Abstract Purpose: We aimed to investigate the effect of COVID-19 pandemic on general surgical emergencies. On the other hand, we analyzed the effectiveness of the measures we have taken and the incidence of COVID-19 of patients and healthcare professionals.Method: In the pandemic period between March 14 and May 15, 2020, and in the same period of the previous year, the files of patients who underwent emergency surgery and followed up nonoperatively were reviewed retrospectively. The incidence of COVID-19 was questioned in patients operated on in the pandemic period and in health professionals working in the general surgery department.Results: Demographic data were similar between the two groups. The number of patients operated on in the pandemic group (n = 103) was lower than during the control group (n = 252) (p = 0.001). In the pandemic group, there was a significant decrease in the number of surgeries of uncomplicated appendicitis, acute cholecystitis and incarcerated hernia (p=0.001, p=0.005, p=0.001, respectively). Others surgeries were similar in both groups. In the pandemic group, nonoperatively follow-up rates were significantly lower in acute mechanical intestinal obstruction and acute cholecystitis (p=0.001, p=0.011, respectively). The findings of COVID-19 were positive in 6(6/103, %5.82) patients undergoing emergency surgery. None of our doctors had COVID-19 infection (0/20). The findings were positive only in 2 nurses from the general surgery department(2/24, %8,33).Conclusion: In these and similar pandemics, we think that a new algorithm is needed to approach emergencies and the results of this study can help for that.

Download Full-text

Tissue Factor (TF) and Urokinase Plasminogen Activator Receptor (uPAR) and Bleeding Complications in Leukemic Patients

Thrombosis and Haemostasis ◽

10.1055/s-0038-1655908 ◽

1997 ◽

Vol 77 (01) ◽

pp. 062-070 ◽

Cited By ~ 15

Author(s):

Chary López-Pedrera ◽

Merce Jardí ◽

Maria del Mar Malagón ◽

Julia Inglés-Esteve ◽

Gabriel Dorado ◽

...

Keyword(s):

Tissue Factor ◽

Leukemic Cell ◽

Bleeding Complications ◽

Urokinase Plasminogen Activator Receptor ◽

Leukemic Cell Lines ◽

Number Of Patients ◽

Blast Cells ◽

Plasminogen Activator Receptor ◽

Hemostatic Disorder

SummaryTissue factor (TF) and urokinase receptor (uPAR) are key cellular receptors triggering, respectively, coagulation and fibrinolysis. Bleeding complications among leukemic patients have been related to an abnormal expression of TF by blast cells and/or to an abnormal fibrinolytic response. In this study the expression of TF and uPAR has been assessed in 18 acute non-lymphoblastic and 8 lymphoblastic leukemic blast cells using several methodological approaches. TF mRNA was evaluated by in situ hybridization and TF and uPAR antigen were evaluated immunologically in cell lysates and on the cell surface by flow cytometry. In addition, TF-procoagulant activity was measured in coagulation-based assays. The reliability of these methods was corroborated in six leukemic cell lines of different lineages and states of maturation. Disseminated intravascular coagulation was detected in two M3 leukemia patients whose blast cells expressed high amounts of TF. Hyperfibrinolysis was detected in one M1 and two M2 patients, whose blast cells displayed a high content of uPAR antigen, but no TF. Furthermore, M5 leukemia blast cells expressed both TF and uPAR, although no hemostatic defects or bleeding complications were detected in these patients. Taken together, although a limited number of patients was included in this study, these data suggest that in leukemia patients exhibiting bleeding, either TF or uPAR are expressed by their blast cells. However, the presence of these receptors does not necessarily imply the existence of a hemostatic disorder.

Download Full-text

CERVICAL ADENOCARCINOMA IN SITU DIAGNOSED IN A LATE SECOND TRIMESTER PREGNANCY: A CASE REPORT

10.26226/morressier.5f5634191bffda7af85eb48f ◽

2020 ◽

Author(s):

Mariana Francisca Lira Morais

Keyword(s):

Case Report ◽

Cervical Adenocarcinoma ◽

Adenocarcinoma In Situ ◽

Second Trimester ◽

Trimester Pregnancy ◽

Second Trimester Pregnancy

Download Full-text

An Analysis of Dental Implants Survival and Success

Revista de Chimie ◽

10.37358/rc.18.9.6554 ◽

2018 ◽

Vol 69 (9) ◽

pp. 2465-2466

Author(s):

Iustin Olariu ◽

Roxana Radu ◽

Teodora Olariu ◽

Andrada Christine Serafim ◽

Ramona Amina Popovici ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Medical History ◽

Retrospective Cohort Study ◽

Odds Ratio ◽

Retrospective Cohort ◽

Demographic Data ◽

Kaplan Meier ◽

Number Of Patients ◽

Health Related

Osseointegration of a dental implant may encounter a variety of problems caused by various factors, as prior health-related problems, patients� habits and the technique of the implant inserting. Retrospective cohort study of 70 patients who received implants between January 2011- April 2016 in one dental unit, with Kaplan-Meier method to calculate the probability of implants�s survival at 60 months. The analysis included demographic data, age, gender, medical history, behavior risk factors, type and location of the implant. For this cohort the implants�survival for the first 6 months was 92.86% compared to the number of patients and 97.56% compared to the number of total implants performed, with a cumulative failure rate of 2.43% after 60 months. Failures were focused exclusively on posterior mandible implants, on the percentage of 6.17%, odds ratio (OR) for these failures being 16.76 (P = 0.05) compared with other localisations of implants, exclusively in men with median age of 42 years.

Download Full-text

Concurrent metastatic ovarian adenocarcinoma of endocervical adenocarcinoma in situ: A case report emphasizing pathologic diagnostic key points and clinical progress

Gynecologic Oncology Reports ◽

10.1016/j.gore.2021.100766 ◽

2021 ◽

Vol 36 ◽

pp. 100766

Author(s):

In Ok Lee ◽

Yee Jung Kim ◽

Hanna Moon ◽

Jae Eun Chung

Keyword(s):

Case Report ◽

Adenocarcinoma In Situ ◽

Ovarian Adenocarcinoma ◽

Endocervical Adenocarcinoma ◽

Key Points ◽

Diagnostic Key

Download Full-text

Predictive Factors for Patients’ Failure to Show for Initial Outpatient Physical Therapist Evaluation

Physical Therapy ◽

10.1093/ptj/pzab047 ◽

2021 ◽

Author(s):

Matthew Briggs ◽

Christine Ulses ◽

Lucas VanEtten ◽

Cody Mansfield ◽

Anthony Ganim ◽

...

Keyword(s):

Predictive Factors ◽

Employment Status ◽

Physical Therapist ◽

Demographic Data ◽

Binary Logistic Regression ◽

Final Analysis ◽

Outpatient Setting ◽

Binary Logistic Regression Model ◽

Number Of Patients ◽

Payer Source

Abstract Objective The objective of this study was to xamine primary factors which may predict patients’ failure to show at initial physical therapist evaluation in an orthopedic and sports outpatient setting. Methods A retrospective analysis of patients’ demographic data for physical therapist evaluations between January 2013 and April 2015 was performed. A binary logistic regression model was used to evaluate the odds of a no-show at evaluation. Demographic variables of age, employment status, days waited for the appointment, payer source, and distance traveled to clinic were analyzed. Independent variables were considered significant if the 95% Cis of the odds ratios did not include 1.0. Results A total of 6971 patients were included in the final analysis with 10% (n = 698) of the scheduled patients having a no-show event for their initial evaluation. The following factors increased the odds of patients having a no-show event: days to appointment (OR = 1.058; 95% CI = 1.042 to 1.074), unemployment status (OR = 1.96; 95% CI = 1.41 to 2.73), unknown employment status (OR = 3.22; 95% CI = 1.12 to 8.69), Medicaid insurance (OR = 4.87; 95% CI = 3.43 to 6.93), Medicare insurance (OR = 2.22; 95% CI = 1.10 to 4.49), unknown payer source (OR = 262.84; 95% CI = 188.72 to 366.08), and distance traveled ≥5 miles (OR = 1.31; 95% CI = 1.01 to 1.70). Female sex [OR = 0.73; 95% CI = 0.57 to 0.95) and age ≥ 40 years (OR = 0.44; 95% CI = 0.33 to 0.60) decreased the odds of a no-show event. Conclusion Results from this study indicate there may be some demographic factors that are predictive of patients failing to attend their first physical therapist visit. Impact Understanding the predictive factors and identifying potential opportunities for improvements in scheduling processes might help decrease the number of patients failing to show for their initial physical therapy appointment, with the ultimate goal of positively influencing patient outcomes.

Download Full-text