Distinct abdominal adipose tissue depots: Are there differential contributions for cardiovascular disease risk?

2020 ◽  
2007 ◽  
Vol 292 (4) ◽  
pp. H1655-H1663 ◽  
Author(s):  
Paul E. Szmitko ◽  
Hwee Teoh ◽  
Duncan J. Stewart ◽  
Subodh Verma

The cardiometabolic syndrome, associated with increased cardiovascular disease risk in the industrialized world, is estimated to affect one in four adults. Although the mechanisms linking obesity and cardiovascular disease remain unclear, research continues to unravel the molecular pathways behind this pandemic. Adipose tissue has emerged as a metabolically active participant in mediating vascular complications, serving as an active endocrine and paracrine organ secreting adipokines, which participate in diverse metabolic processes. Among these adipokines is adiponectin, which seems to possess antiatherogenic and anti-inflammatory effects and may be protective against cardiovascular disease development. The current review describes the pathophysiology of adiponectin in atherosclerotic disease.


2015 ◽  
Vol 239 (2) ◽  
pp. 419-427 ◽  
Author(s):  
Mariëtte E.G. Kranendonk ◽  
Joost A. van Herwaarden ◽  
Tereza Stupkova ◽  
Wilco de Jager ◽  
Aryan Vink ◽  
...  

2007 ◽  
Vol 9 (4) ◽  
pp. 259-271 ◽  
Author(s):  
Harold Bays ◽  
Helena W. Rodbard ◽  
Alan Bruce Schorr ◽  
J. Michael González-Campoy

Obesity ◽  
2012 ◽  
Vol 20 (6) ◽  
pp. 1293-1300 ◽  
Author(s):  
Scott A. Lear ◽  
Arun Chockalingam ◽  
Simi Kohli ◽  
Chris G. Richardson ◽  
Karin H. Humphries

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