scholarly journals Effects of Doinsenggitang on Melanin Synthesis and Gene Expression Inhibition in B16F10 Melanoma Cells

2012 ◽  
Vol 22 (3) ◽  
pp. 318-323 ◽  
Author(s):  
Ju-Young Hwang ◽  
Dong-Hee Kim ◽  
Hui-Jung Kim ◽  
Eun-Young Hwang ◽  
Tae-Soon Park ◽  
...  
Keyword(s):  
Gene Expression ◽  
Melanoma Cells ◽  
Melanin Synthesis ◽  
B16f10 Melanoma ◽  
B16f10 Melanoma Cells

scholarly journals Grape Extract Promoted α-MSH-Induced Melanogenesis in B16F10 Melanoma Cells, Which Was Inverse to Resveratrol

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5959
Author(s):  
Siqi Zhou ◽  
Drira Riadh ◽  
Kazuichi Sakamoto
Keyword(s):  
Biological Activities ◽  
Melanoma Cells ◽  
Positive Control ◽  
Point Of View ◽  
Melanin Synthesis ◽  
Related Protein ◽  
B16f10 Melanoma ◽  
Grape Extract ◽  
B16f10 Melanoma Cells ◽  
Tyrosinase Related Protein

Melanin is a natural pigment produced by cells to prevent damage caused by ultraviolet radiation. Previously, resveratrol was shown to reduce melanin synthesis. As a natural polyphenol with various biological activities, resveratrol occurs in a variety of beverages and plant foods, such as grapes. Therefore, we investigated whether grape extracts containing resveratrol also had the ability to regulate melanin synthesis. In this study, we used mouse B16F10 melanoma cells as a model for melanin synthesis with the melanogenesis-inducing α-melanocyte-stimulating hormone (α-MSH) as a positive control. Our results confirmed previous reports that resveratrol reduces melanin synthesis by reducing the activity of the rate-limiting enzyme tyrosinase. In contrast, the grape extract could not reduce melanin synthesis, and in fact promoted melanogenesis in the presence of α-MSH. The expression of genes related to melanin synthesis, such as tyrosinase, tyrosinase-related protein-1, tyrosinase-related protein-2, and microphthalmia-associated transcription factor, also supports these phenomena, which means that even in the presence of resveratrol, grape extract will strengthen the function of α-MSH in promoting melanin synthesis. Therefore, these results also provide a point of view for research on cosmetics.

Effect of apigenin-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells

Life Sciences ◽  
2016 ◽  
Vol 144 ◽  
pp. 80-85 ◽  
Author(s):  
Nouha Nasr Bouzaiene ◽  
Fadwa Chaabane ◽  
Aicha Sassi ◽  
Leila Chekir-Ghedira ◽  
Kamel Ghedira
Keyword(s):  
Melanoma Cells ◽  
Tyrosinase Activity ◽  
Melanin Synthesis ◽  
B16f10 Melanoma ◽  
B16f10 Melanoma Cells

scholarly journals Berberine regulates melanin synthesis by activating PI3K/AKT, ERK and GSK3β in B16F10 melanoma cells

2015 ◽  
Vol 35 (4) ◽  
pp. 1011-1016 ◽  
Author(s):  
YOUNG CHAN SONG ◽  
YONGHEE LEE ◽  
HYEONG MI KIM ◽  
MOO YEOL HYUN ◽  
YUN YOUNG LIM ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Melanin Synthesis ◽  
B16f10 Melanoma ◽  
B16f10 Melanoma Cells

scholarly journals Anti-melanogenesis Constituents from the Seaweed Dictyota Coriacea

2013 ◽  
Vol 8 (4) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Ryeo Kyeong Ko ◽  
Min-Chul Kang ◽  
Sang Suk Kim ◽  
Tae Heon Oh ◽  
Gi-Ok Kim ◽  
...  
Keyword(s):  
Substrate Concentration ◽  
Ethanol Extract ◽  
Melanoma Cells ◽  
Positive Control ◽  
Therapeutic Agents ◽  
Melanin Synthesis ◽  
B16f10 Melanoma ◽  
Synthesis Inhibition ◽  
Effective Components ◽  
B16f10 Melanoma Cells

This study was conducted to identify the anti-melanogenesis constituents from a seaweed Dictyota coriacea (Holmes). Three known compounds, viz. 1,9-dihydroxycrenulide (1), epiloliolide (2) and D-mannitol (3), were isolated from the ethanol extract. The melanin synthesis inhibition activities were evaluated using B16F10 melanoma cells for the isolates. Compared with the positive control, arbutin, compounds 1 and 2 exhibited more potency, showing 27.8 and 22.6 % inhibition activities at a substrate concentration of 30 μg/mL. Our studies also indicate that these compounds are not cytotoxic. Hence, they might prove to be useful therapeutic agents for treating hyperpigmentation and effective components of whitening cosmetics.

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