Characterization of laribacter hongkongensis isolated from a patient with severe underlying liver disease

2019 ◽  
Author(s):  
Qiong Wang
Keyword(s):  
Liver Disease ◽  
Underlying Liver Disease ◽  
Laribacter Hongkongensis

Characterization of Patients with Arthritis Referred for Gold Therapy in the Era of Biologics

2012 ◽  
Vol 39 (4) ◽  
pp. 716-719 ◽  
Author(s):  
JESSICA M. CHEUNG ◽  
DEBRA SCARSBROOK ◽  
ALICE V. KLINKHOFF
Keyword(s):  
Liver Disease ◽  
Chart Review ◽  
Biologic Therapy ◽  
Patient Choice ◽  
Gold Therapy ◽  
Underlying Liver Disease ◽  
High Alcohol Consumption ◽  
Biologic Dmard ◽  
Male Patients

Objective.To describe the clinical characteristics of patients referred for gold therapy and determine the reason for referral.Methods.We conducted a chart review of patients referred for gold at the Mary Pack Arthritis Program, Vancouver, Canada, from July 2007 to July 2009.Results.The sample included 69 female and 12 male patients. Diagnosis was rheumatoid arthritis (RA) in 71/81, psoriatic arthritis in 5, juvenile idiopathic arthritis (JIA) in 2, Sjögren syndrome in 1, undifferentiated polyarthritis in 1, and spondyloarthritis in 1. Twenty of 81 patients had received gold before: 15 were referred for a second course, 4 a third course, and 1 a fourth course. Ten of 81 patients were referred for gold as their first disease-modifying antirheumatic drug (DMARD). Seventy-one had received prior DMARD: 1 prior DMARD in 22 patients, 2 in 24 patients, 3 in 15 patients, and > 3 in 6 patients. Four patients had received prior biologic therapy plus 2 to 4 prior DMARD. Twelve of 71 received gold monotherapy, 56/71 received gold/DMARD combinations, and 3 received gold/biologic/DMARD combinations. Reasons for referral included failure of other DMARD in 54 patients, limited DMARD options in 50 (chronic liver disease in 34, sulfa allergy in 7, high alcohol consumption in 5, and planning pregnancy in 4), physician choice in 12, previous benefit from gold in 10, benefit of clinic support in 10, inappropriate for biologics in 7, patient choice in 4, and failure of biologics in 3.Conclusion.The most common reasons for referral to gold clinic in 2007 to 2009 are failure of other DMARD and limited DMARD options due to underlying liver disease.

Characterization of type I-F CRISPR-Cas system in Laribacter hongkongensis isolates from animals, the environment and diarrhea patients

2021 ◽  
Vol 346 ◽  
pp. 109153
Author(s):  
Ling Wang ◽  
Li Wang ◽  
Youzhao Liu ◽  
Zhiyun Wang ◽  
Qing Chen ◽  
...  
Keyword(s):  
Type I ◽  
Laribacter Hongkongensis

scholarly journals Cloning and Characterization of a Chromosomal Class C β-Lactamase and Its Regulatory Gene in Laribacter hongkongensis

2005 ◽  
Vol 49 (5) ◽  
pp. 1957-1964 ◽  
Author(s):  
Susanna K. P. Lau ◽  
Pak-leung Ho ◽  
Maria W. S. Li ◽  
Hoi-wah Tsoi ◽  
Raymond W. H. Yung ◽  
...  
Keyword(s):  
Genomic Dna ◽  
Southern Hybridization ◽  
Regulatory Gene ◽  
Kinetic Properties ◽  
Restriction Fragments ◽  
Regulatory Systems ◽  
Laribacter Hongkongensis ◽  
Consensus Motifs ◽  
Class C

ABSTRACT Laribacter hongkongensis, a newly discovered bacterium recently shown to be associated with community-acquired gastroenteritis, is generally resistant to most β-lactams except the carbapenems. We describe the cloning and characterization of a novel chromosomal class C β-lactamase and its regulatory gene in L. hongkongensis. Two genes, ampC and ampR, were cloned by inserting restriction fragments of genomic DNA from L. hongkongensis strain HLHK5 into pBK-CMV to give the recombinant plasmid pBK-LHK-5. The ampR and ampC genes and their promoters were divergently oriented, with the ampR gene immediately upstream of the ampC gene and an intercistronic Lys-R motif, typical of inducible ampC-ampR regulatory systems. The deduced amino acid sequence of the cloned AmpC β-lactamase (pI 8.1) contained consensus motifs characteristic of class C β-lactamases but had identities no greater than 46% to known class C β-lactamases. The kinetic properties of this AmpC were also compatible with those of a class C β-lactamase. PCR of 20 clinical isolates of L. hongkongensis, including HLHK5, showed the presence of both ampC and ampR genes in all isolates. Southern hybridization suggested that the ampC gene of HLHK5 was chromosomally encoded. Subcloning experiments showed that the expression of the ampC gene of HLHK5 was regulated by its ampR gene, which acts as a repressor. The β-lactamase characterized from strain HLHK5 was named LHK-5 (gene, bla LHK-5) and represents the first example of AmpC β-lactamase in the β subdivision of proteobacteria.

Detection and characterization of Leptospira spp. in dogs diagnosed with kidney and/or liver disease in Selangor, Malaysia

2021 ◽  
pp. 104063872110245
Author(s):  
Sabri A. Rahman ◽  
Kuan H. Khor ◽  
Siti Khairani-Bejo ◽  
Seng F. Lau ◽  
Mazlina Mazlan ◽  
...  
Keyword(s):  
Liver Disease ◽  
Mortality Rate ◽  
Direct Detection ◽  
Bacterial Disease ◽  
Pathogenic Leptospira ◽  
Wide Range ◽  
Leptospira Spp ◽  
Rrna Sequencing ◽  
The Common

Leptospirosis is a serious bacterial disease that affects both humans and animals. A wide range of symptoms have been described in humans; the disease in dogs is commonly associated with kidney and/or liver disease. In Malaysia, information about the common serovars infecting dogs is limited. Therefore, we investigated the occurrences of leptospirosis in 124 pet dogs diagnosed with kidney and/or liver disease. Blood, urine, abdominal effusion, and/or kidney and liver were collected from the dogs. Based on microscopic agglutination testing, 53 of 124 (42.7%) dogs were seropositive for leptospiral exposure. Sera were frequently positive to serovars Bataviae ( n = 12), Javanica ( n = 10), and Icterohaemorrhagiae ( n = 10). Direct detection using PCR showed that 42 of 124 (33.9%) of the whole blood and 36 of 113 (31.9%) urine samples were positive for pathogenic Leptospira spp. By PCR, 2 of 23 (9.1%) kidney and 2 of 23 (9.1%) liver were positive for pathogenic Leptospira spp. Abdominal effusion from 4 dogs were PCR-positive for pathogenic Leptospira spp. The species detected were L. interrogans, L. borgpetersenii, L. kirschneri, and L. kmetyi by partial 16S rRNA sequencing. We further identified and characterized 11 Leptospira spp. isolates from 8 dogs as serovars Bataviae, Javanica, and Australis. The mortality rate of the Leptospira-infected dogs was high (18 of 53; 34%).

Background incidence of liver chemistry abnormalities in a clinical trial population without underlying liver disease

2008 ◽  
Vol 52 (2) ◽  
pp. 85-88 ◽  
Author(s):  
John G. Weil ◽  
Chanchal Bains ◽  
Adam Linke ◽  
Douglas W. Clark ◽  
Heide A. Stirnadel ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Liver Disease ◽  
Underlying Liver Disease

Autologous blood storage before hepatectomy for hepatocellular carcinoma with underlying liver disease

2003 ◽  
Vol 90 (1) ◽  
pp. 23-28 ◽  
Author(s):  
T. Itamoto ◽  
K. Katayama ◽  
H. Nakahara ◽  
H. Tashiro ◽  
T. Asahara
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Autologous Blood ◽  
Blood Storage ◽  
Underlying Liver Disease

scholarly journals An overview of the cutaneous porphyrias

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1906 ◽  
Author(s):  
Robert Dawe
Keyword(s):  
Liver Disease ◽  
Visible Light ◽  
Porphyria Cutanea Tarda ◽  
Marrow Transplant ◽  
Ultraviolet B ◽  
Erythropoietic Protoporphyria ◽  
Liver Iron ◽  
Underlying Liver Disease ◽  
Liver Iron Overload ◽  
Enzyme Defects

This is an overview of the cutaneous porphyrias. It is a narrative review based on the published literature and my personal experience; it is not based on a formal systematic search of the literature. The cutaneous porphyrias are a diverse group of conditions due to inherited or acquired enzyme defects in the porphyrin–haem biosynthetic pathway. All the cutaneous porphyrias can have (either as a consequence of the porphyria or as part of the cause of the porphyria) involvement of other organs as well as the skin. The single commonest cutaneous porphyria in most parts of the world is acquired porphyria cutanea tarda, which is usually due to chronic liver disease and liver iron overload. The next most common cutaneous porphyria, erythropoietic protoporphyria, is an inherited disorder in which the accumulation of bile-excreted protoporphyrin can cause gallstones and, rarely, liver disease. Some of the porphyrias that cause blistering (usually bullae) and fragility (clinically and histologically identical to porphyria cutanea tarda) can also be associated with acute neurovisceral porphyria attacks, particularly variegate porphyria and hereditary coproporphyria. Management of porphyria cutanea tarda mainly consists of visible-light photoprotection measures while awaiting the effects of treating the underlying liver disease (if possible) and treatments to reduce serum iron and porphyrin levels. In erythropoietic protoporphyria, the underlying cause can be resolved only with a bone marrow transplant (which is rarely justifiable in this condition), so management consists particularly of visible-light photoprotection and, in some countries, narrowband ultraviolet B phototherapy. Afamelanotide is a promising and newly available treatment for erythropoietic protoporphyria and has been approved in Europe since 2014.

Observer error in the characterization of hepatic lesions in patients with neoplastic liver disease

1988 ◽  
Vol 16 (8) ◽  
pp. 577-579 ◽  
Author(s):  
Neill A Iscoe ◽  
John D McKee ◽  
Anna Marie Arenson ◽  
John P Szalai
Keyword(s):  
Liver Disease ◽  
Observer Error ◽  
Hepatic Lesions
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