scholarly journals Caracterización de personas con enfermedad de chagas en el Centro de Salud Familiar Valle Los Libertadores y establecimientos dependientes en Putaendo

2021 ◽  
Vol 24 (2) ◽  
pp. 161
Author(s):  
Alberto Oyarzún-Serrano ◽  
Paula Guevara-Zamora ◽  
Camila Martínez-Silva ◽  
Gustavo Espinoza-Olguín ◽  
Oscar Valencia-Caicedo ◽  
...  
Keyword(s):  
V Region

Introducción: La enfermedad de Chagas es una patología parasitaria crónica y sistémica; Chile tiene una incidencia de 11,6 por 100.000 habitantes, presentándose mayoritariamente en zonas rurales y precordilleranas. Putaendo es una comuna de la V región ubicada en una zona endémica, donde se desconoce la realidad epidemiológica actual de la enfermedad. El objetivo del estudio es caracterizar a los pacientes con Chagas inscritos en el Centro de Salud Familiar (CESFAM) Valle Los Libertadores en Putaendo. Material y Métodos: El estudio tuvo un diseño transversal. Se incluyeron todos los registros de pacientes con diagnóstico de enfermedad de Chagas hasta el 30 de junio de año 2019, excluyéndose a pacientes fallecidos. Los datos fueron obtenidos de una base de datos anonimizada de dicho centro. Resultados: Se encontró una prevalencia de Chagas de 108 enfermos por 100.000 personas registradas vivas; 98 de sexo femenino y 56 masculino, con mayor frecuencia entre los 50-59 años. Respecto al Fondo Nacional de Salud (FONASA), los tramos A y B (las personas con menores ingresos) concentran la mayor cantidad de pacientes con Chagas (87%). Discusión: Si bien se pudo caracterizar a la enfermedad, siendo más prevalente en personas adultas, mujeres y de bajos recursos, se requieren más estudios para objetivar el real estado de salud de estos pacientes.

scholarly journals Gamma heavy chain disease: clinical aspects and characterization of a deleted, noncovalently linked gamma1 heavy chain dimer (BAZ)

Blood ◽  
1977 ◽  
Vol 49 (4) ◽  
pp. 495-505 ◽  
Author(s):  
GB Faguet ◽  
BP Barton ◽  
LL Smith ◽  
FA Garver
Keyword(s):  
Heavy Chain ◽  
Plasma Cells ◽  
Clinical Feature ◽  
Clinical Aspects ◽  
Submaxillary Glands ◽  
Underlying Malignancy ◽  
V Region ◽  
Allotypic Marker ◽  
Heavy Chain Disease

Abstract This report describes the clinical and immunoglobulin features of a patient with gamma heavy chain disease (HCD), who presented with a clinical picture suggestive of an underlying malignancy rather than the usual picture of lymphoma or granulomatous disease. A unique clinical feature was the nearly total replacement of the submaxillary glands by plasma cells. The patient's serum and urine contained a paraprotein, gammaHCD protein BAZ, which belongs to the gamma1 subclass and forms noncovalently linked dimers with a molecular weight of approximately 60,000 daltons. This mutant protein exhibited a deletion which encompassed most of the variable (V) region, the first constant domain (CH 1), and the hinge region. In addition, preliminary structural analyses demonstrated the replacement of alanine by glycine in position 431 of the carboxyterminal octadecapeptide. This substitution may possibly represent another allotypic marker on IgG1 proteins.

scholarly journals Multiple Distinct Sets of Stereotyped Antigen Receptors Indicate a Role for Antigen in Promoting Chronic Lymphocytic Leukemia

2004 ◽  
Vol 200 (4) ◽  
pp. 519-525 ◽  
Author(s):  
Bradley T. Messmer ◽  
Emilia Albesiano ◽  
Dimitar G. Efremov ◽  
Fabio Ghiotto ◽  
Steven L. Allen ◽  
...  
Keyword(s):  
Amino Acid ◽  
B Cell ◽  
Structural Features ◽  
Lymphocytic Leukemia ◽  
Cell Subpopulation ◽  
Amino Acid Residues ◽  
Antigen Receptors ◽  
Region Gene ◽  
V Region ◽  
Unique Amino Acid

Previous studies suggest that the diversity of the expressed variable (V) region repertoire of the immunoglobulin (Ig)H chain of B-CLL cells is restricted. Although limited examples of marked constraint in the primary structure of the H and L chain V regions exist, the possibility that this level of restriction is a general principle in this disease has not been accepted. This report describes five sets of patients, mostly with unmutated or minimally mutated IgV genes, with strikingly similar B cell antigen receptors (BCRs) arising from the use of common H and L chain V region gene segments that share CDR3 structural features such as length, amino acid composition, and unique amino acid residues at recombination junctions. Thus, a much more striking degree of structural restriction of the entire BCR and a much higher frequency of receptor sharing exists among patients than appreciated previously. The data imply that either a significant fraction of B-CLL cells was selected by a limited set of antigenic epitopes at some point in their development and/or that they derive from a distinct B cell subpopulation with limited Ig V region diversity. These shared, stereotyped Ig molecules may be valuable probes for antigen identification and important targets for cross-reactive idiotypic therapy.

A Simple Method for Prediction of Effective Core Area and Index of Refraction of Single-mode Graded Index Fiber in the Low V Region

2014 ◽  
Vol 35 (4) ◽  
Author(s):  
Angshuman Majumdar ◽  
Satabdi Das ◽  
Sankar Gangopadhyay
Keyword(s):  
Refractive Index ◽  
Single Mode ◽  
Index Of Refraction ◽  
Core Area ◽  
Exact Results ◽  
Simple Method ◽  
Graded Index ◽  
Core Areas ◽  
V Region ◽  
User Friendly

AbstractBased on the simple power series formulation of fundamental mode developed by Chebyshev formalism in the low V region, we prescribe analytical expression for effective core area of graded index fiber. Taking step and parabolic index fibers as examples, we estimate the effective core areas as well as effective refractive index for different normalized frequencies (V number) having low values. We also show that our estimations match excellently with the available exact results. The concerned predictions by our method require little computation. Thus, this simple but accurate formalism will be user friendly for the system engineers.

The V-region disease hypothesis: evidence from autoimmune encephalomyelitis

1989 ◽  
Vol 10 (5) ◽  
pp. 164-169 ◽  
Author(s):  
Ellen Heber-Katz ◽  
Hans Acha-Orbea
Keyword(s):  
Autoimmune Encephalomyelitis ◽  
V Region

scholarly journals Human Anti-CXCR4 Antibodies Undergo VHReplacement, Exhibit Functional V-Region Sulfation, and Define CXCR4 Antigenic Heterogeneity

2007 ◽  
Vol 179 (4) ◽  
pp. 2408-2418 ◽  
Author(s):  
Chen Xu ◽  
Jianhua Sui ◽  
Hong Tao ◽  
Quan Zhu ◽  
Wayne A. Marasco
Keyword(s):  
V Region ◽  
Antigenic Heterogeneity

scholarly journals The D-JHcomplex is an intermediate to the complete immunoglobulin beavy-chain V-region gene

1983 ◽  
Vol 11 (21) ◽  
pp. 7303-7316 ◽  
Author(s):  
Yoshio Yaoita ◽  
Norisada Matsunami ◽  
Cha Yong Choi ◽  
Haruo Sugiyama ◽  
Tadamitsu Kishimoto ◽  
...  
Keyword(s):  
Region Gene ◽  
V Region
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