Health Care Analysis Using Machine Learning for Mortality Risk and Readmission Risk Prediction based on EHR Data

Author(s):  
Shaik Shabbeer
2021 ◽  
Author(s):  
Celia ALVAREZ-ROMERO ◽  
Alicia MARTÍNEZ-GARCÍA ◽  
Jara Eloisa TERNERO-VEGA ◽  
Pablo DÍAZ-JIMÉNEZ ◽  
Carlos JIMÉNEZ-DE-JUAN ◽  
...  

BACKGROUND Due to the nature of health data, its sharing and reuse for research are limited by legal, technical and ethical implications. In this sense, to address that challenge, and facilitate and promote the discovery of scientific knowledge, the FAIR (Findable, Accessible, Interoperable, and Reusable) principles help organizations to share research data in a secure, appropriate and useful way for other researchers. OBJECTIVE The objective of this study was the FAIRification of health research existing datasets and applying a federated machine learning architecture on top of the FAIRified datasets of different health research performing organizations. The whole FAIR4Health solution was validated through the assessment of the generated model for real-time prediction of 30-days readmission risk in patients with Chronic Obstructive Pulmonary Disease (COPD). METHODS The application of the FAIR principles in health research datasets in three different health care settings enabled a retrospective multicenter study for the generation of federated machine learning models, aiming to develop the early prediction model for 30-days readmission risk in COPD patients. This prediction model was implemented upon the FAIR4Health platform and, finally, an observational prospective study with 30-days follow-up was carried out in two health care centers from different countries. The same inclusion and exclusion criteria were used in both retrospective and prospective parts of the study. RESULTS The prediction model for the 30-days hospital readmission risk was trained using the retrospective data of 4.944 COPD patients. The assessment of the prediction model was performed using the data of 100 recruited (22 from Spain and 78 from Serbia) out of 2070 observed (records viewed) patients in total for the observational prospective study from April 2021 to September 2021. The significant accuracy (0.98) and precision (0.25) of the prediction model generated upon the FAIR4Health platform was observed and, as a result, the generated prediction of 30-day readmission risk was confirmed in 87% of the cases. CONCLUSIONS A clinical validation was demonstrated through the implementation of federated machine learning models on top of the FAIRified datasets from different health research performing organizations, providing an assessment for predicting 30-days readmission risk in COPD patients. This demonstration allowed to state the relevance and need of implementing a FAIR data policy to facilitate data sharing and reuse in health research.


2021 ◽  
Author(s):  
Kuan-Chi Tu ◽  
Che-Chuan Che-Chuan Wang ◽  
Nai-Ching Chen ◽  
Kuo-Tai Chen ◽  
Chia-Jung Chen ◽  
...  

BACKGROUND Traumatic brain injury (TBI) remains a critical public health challenge. Although studies have found several prognostic factors for TBI, a useful early predictive model for mortality has yet to be developed for TBI patients in the emergency room. OBJECTIVE The objective of this study was to use artificial intelligence (AI) and machine learning algorithms to develop predictive models for TBI patients in the emergency room triage. This could provide scientific data for healthcare providers which they could use as a reference when deciding which treatment to give and when informing and educating patient’s family members. METHODS From January 2010 to December 2019, this study retrospectively enrolled 18,249 TBI patients (9908 males and 8341 females; mean age: 57.85 ± 19.44 years) in the electronic medical records of three Chi-Mei Medical Centers, and investigated the 12 potentially predictive feature variables. Mortality during hospitalization was designated as the outcome variable. The correlation coefficient matrix was used to analyze the feature variables and mortality using Spearman rank order correlation methods. Further, the present study constructed six machine learning models including logistic regression (LR) random forest (RF), support vector machines (SVM), Light GBM, XGBoost and Multilayer Perceptron (MLP) to predict mortality risk. Next, following the model training and building, we conducted area under the receiver operating characteristic curve (AUC) for six models performance evaluation. Finally, we deployed and installed the model in the hospital information system for clinical practice in the triage setting. RESULTS The results showed that all six predictive models had high AUC from 0.851 to 0.925. Among these predictive models, LR-based model was the best model for mortality risk prediction with sensitivity of 0.812, specificity of 0.894, and accuracy of 0.89 for the 12 feature variables; thus, this was used to develop an application to assist in clinical decision making. CONCLUSIONS These results revealed that the LR model was the best model to predict the mortality risk in patients with TBI in the emergency room. Since the developed AI system can easily obtain the 12 feature variables during the initial triage, it can provide quick outcome prediction to clinicians to help them explain the patient’s condition to family members and to guide them in deciding further treatment.


Burns ◽  
2015 ◽  
Vol 41 (5) ◽  
pp. 925-934 ◽  
Author(s):  
Neophytos Stylianou ◽  
Artur Akbarov ◽  
Evangelos Kontopantelis ◽  
Iain Buchan ◽  
Ken W. Dunn

2018 ◽  
Author(s):  
Simone Orlowski ◽  
Sunetra Bane ◽  
Jaclyn Hirschey ◽  
Sujay Kakarmath ◽  
Jennifer Felsted ◽  
...  

BACKGROUND Despite widespread adoption and demonstrated value in a range of industries, machine learning predictive algorithms are yet to be routinely used in frontline medical care. Significant health system and industry-based resources are allocated towards validating and refining predictive algorithms for a range of applications to ensure accuracy and reliability. For these algorithms to be useful and useable, further work is required to understand how and why they might fit into, and augment existing clinical workflows. OBJECTIVE This qualitative study assessed the value and usability of a novel machine learning technology to predict and explain the risk of 30-day hospital readmission in patients with heart failure (HF). It involved exploring opportunities for integration of the technology within existing clinical workflows, and investigating key roles that use current readmission risk scores and may use future scores. METHODS Semi-structured interviews (n=27) and targeted observations (n=3) were carried out with key stakeholders, including physicians, nurses, hospital administration, and non-clinical support staff. Participants were recruited from cardiology and general medicine units at an academic medical center within the Partners HealthCare system. Data was analyzed via inductive thematic and workflow analysis. Findings were validated via member checking across limited key roles (n=3). RESULTS Results highlighted a number of factors that were deemed necessary by staff for successful integration of a risk prediction tool into existing clinical workflow. These included, but were not limited to the following. Staff clearly stated that any new tool must be easily accessible from within the electronic health record, which dictates the majority of existing clinical workflow. Staff emphasized that information should be consistently accurate and that any display must be digestible efficiently, intuitively and quickly (ie, within <5 seconds). Additionally, staff discussed that outputs of the risk prediction tool must match their clinical intuition, experience and interactions with the patient. To be truly valuable, the tool must also provide added value over and above these factors: some staff indicated that provision of role-specific and actionable next steps based on the system output would provide novel value to their daily work. Using these considerations, a number of role groups were identified as potentially able to derive value from the proposed risk prediction tool, including case managers, attending RNs, responding clinicians, hospital administration staff, nursing directors and attending physicians. Acceptability and value varied by role, specialization and clinical context. For example, cardiology-trained clinicians reported feeling well-versed in providing good clinical care and minimizing preventable readmissions, and thus saw less value in the tool. General medicine staff, however, indicated that a HF-specific tool may be impractical for their day-to-day work given the range of clinical presentations seen by them. CONCLUSIONS Findings resonate with existing literature around successful implementation and adoption of technologies in health care. Frontline clinicians are incredibly discerning around proposed changes to their existing workflow. Many HF readmission risk tools and initiatives have been trialled with mixed success; frontline staff demonstrated fatigue around piloting new initiatives. However, given the right conditions, staff reported some perceived value in machine learning-based tools to improve their daily work.


2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Yunlong Fan ◽  
Junfeng Dong ◽  
Yuanbin Wu ◽  
Ming Shen ◽  
Siming Zhu ◽  
...  

10.2196/15901 ◽  
2020 ◽  
Vol 8 (6) ◽  
pp. e15901 ◽  
Author(s):  
Alina Haines-Delmont ◽  
Gurdit Chahal ◽  
Ashley Jane Bruen ◽  
Abbie Wall ◽  
Christina Tara Khan ◽  
...  

Background Digital phenotyping and machine learning are currently being used to augment or even replace traditional analytic procedures in many domains, including health care. Given the heavy reliance on smartphones and mobile devices around the world, this readily available source of data is an important and highly underutilized source that has the potential to improve mental health risk prediction and prevention and advance mental health globally. Objective This study aimed to apply machine learning in an acute mental health setting for suicide risk prediction. This study uses a nascent approach, adding to existing knowledge by using data collected through a smartphone in place of clinical data, which have typically been collected from health care records. Methods We created a smartphone app called Strength Within Me, which was linked to Fitbit, Apple Health kit, and Facebook, to collect salient clinical information such as sleep behavior and mood, step frequency and count, and engagement patterns with the phone from a cohort of inpatients with acute mental health (n=66). In addition, clinical research interviews were used to assess mood, sleep, and suicide risk. Multiple machine learning algorithms were tested to determine the best fit. Results K-nearest neighbors (KNN; k=2) with uniform weighting and the Euclidean distance metric emerged as the most promising algorithm, with 68% mean accuracy (averaged over 10,000 simulations of splitting the training and testing data via 10-fold cross-validation) and an average area under the curve of 0.65. We applied a combined 5×2 F test to test the model performance of KNN against the baseline classifier that guesses training majority, random forest, support vector machine and logistic regression, and achieved F statistics of 10.7 (P=.009) and 17.6 (P=.003) for training majority and random forest, respectively, rejecting the null of performance being the same. Therefore, we have taken the first steps in prototyping a system that could continuously and accurately assess the risk of suicide via mobile devices. Conclusions Predicting for suicidality is an underaddressed area of research to which this paper makes a useful contribution. This is part of the first generation of studies to suggest that it is feasible to utilize smartphone-generated user input and passive sensor data to generate a risk algorithm among inpatients at suicide risk. The model reveals fair concordance between phone-derived and research-generated clinical data, and with iterative development, it has the potential for accurate discriminant risk prediction. However, although full automation and independence of clinical judgment or input would be a worthy development for those individuals who are less likely to access specialist mental health services, and for providing a timely response in a crisis situation, the ethical and legal implications of such advances in the field of psychiatry need to be acknowledged.


2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Yue Gao ◽  
Guang-Yao Cai ◽  
Wei Fang ◽  
Hua-Yi Li ◽  
Si-Yuan Wang ◽  
...  

Abstract Soaring cases of coronavirus disease (COVID-19) are pummeling the global health system. Overwhelmed health facilities have endeavored to mitigate the pandemic, but mortality of COVID-19 continues to increase. Here, we present a mortality risk prediction model for COVID-19 (MRPMC) that uses patients’ clinical data on admission to stratify patients by mortality risk, which enables prediction of physiological deterioration and death up to 20 days in advance. This ensemble model is built using four machine learning methods including Logistic Regression, Support Vector Machine, Gradient Boosted Decision Tree, and Neural Network. We validate MRPMC in an internal validation cohort and two external validation cohorts, where it achieves an AUC of 0.9621 (95% CI: 0.9464–0.9778), 0.9760 (0.9613–0.9906), and 0.9246 (0.8763–0.9729), respectively. This model enables expeditious and accurate mortality risk stratification of patients with COVID-19, and potentially facilitates more responsive health systems that are conducive to high risk COVID-19 patients.


Author(s):  
Alina Haines-Delmont ◽  
Gurdit Chahal ◽  
Ashley Jane Bruen ◽  
Abbie Wall ◽  
Christina Tara Khan ◽  
...  

BACKGROUND Digital phenotyping and machine learning are currently being used to augment or even replace traditional analytic procedures in many domains, including health care. Given the heavy reliance on smartphones and mobile devices around the world, this readily available source of data is an important and highly underutilized source that has the potential to improve mental health risk prediction and prevention and advance mental health globally. OBJECTIVE This study aimed to apply machine learning in an acute mental health setting for suicide risk prediction. This study uses a nascent approach, adding to existing knowledge by using data collected through a smartphone in place of clinical data, which have typically been collected from health care records. METHODS We created a smartphone app called Strength Within Me, which was linked to Fitbit, Apple Health kit, and Facebook, to collect salient clinical information such as sleep behavior and mood, step frequency and count, and engagement patterns with the phone from a cohort of inpatients with acute mental health (n=66). In addition, clinical research interviews were used to assess mood, sleep, and suicide risk. Multiple machine learning algorithms were tested to determine the best fit. RESULTS K-nearest neighbors (KNN; k=2) with uniform weighting and the Euclidean distance metric emerged as the most promising algorithm, with 68% mean accuracy (averaged over 10,000 simulations of splitting the training and testing data via 10-fold cross-validation) and an average area under the curve of 0.65. We applied a combined 5×2 <i>F</i> test to test the model performance of KNN against the baseline classifier that guesses training majority, random forest, support vector machine and logistic regression, and achieved <i>F</i> statistics of 10.7 (<i>P</i>=.009) and 17.6 (<i>P</i>=.003) for training majority and random forest, respectively, rejecting the null of performance being the same. Therefore, we have taken the first steps in prototyping a system that could continuously and accurately assess the risk of suicide via mobile devices. CONCLUSIONS Predicting for suicidality is an underaddressed area of research to which this paper makes a useful contribution. This is part of the first generation of studies to suggest that it is feasible to utilize smartphone-generated user input and passive sensor data to generate a risk algorithm among inpatients at suicide risk. The model reveals fair concordance between phone-derived and research-generated clinical data, and with iterative development, it has the potential for accurate discriminant risk prediction. However, although full automation and independence of clinical judgment or input would be a worthy development for those individuals who are less likely to access specialist mental health services, and for providing a timely response in a crisis situation, the ethical and legal implications of such advances in the field of psychiatry need to be acknowledged. CLINICALTRIAL


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