Human Herpesvirus 6 Meningitis in a Neonatal Case

Incidence of human herpesvirus-6 (HHV-6) infection in the neonatal period has been reported in few cases. HHV-6, commonly responsible for roseola, is known to establish infection during infancy and early childhood. A 14-day-old neonate, presented with a fever of 38.3℃, primarily due to an HHV-6 infection, was admitted to our neonatal intensive care unit. A polymerase chain reaction (PCR) of his cerebrospinal fluid was positive for HHV-6. Additionally, serology for HHV-6 PCR was positive. We believe that HHV-6 can cause infection in febrile newborn infants.

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Frequent detection of human herpesvirus-6 sequences by polymerase chain reaction in paraffin-embedded lymph nodes from patients with angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma

Leukemia Research ◽

10.1016/0145-2126(93)90049-q ◽

1993 ◽

Vol 17 (11) ◽

pp. 1003-1011 ◽

Cited By ~ 37

Author(s):

Mario Luppi ◽

Roberto Marasca ◽

Patrizia Barozzi ◽

Tullio Artusi ◽

Giuseppe Torelli

Keyword(s):

Polymerase Chain Reaction ◽

Lymph Nodes ◽

Human Herpesvirus ◽

Human Herpesvirus 6 ◽

Chain Reaction ◽

Angioimmunoblastic Lymphadenopathy ◽

Polymerase Chain ◽

Herpesvirus 6

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Detection of human herpesvirus 6 DNA in throat swabs by polymerase chain reaction

International Journal of Pediatric Otorhinolaryngology ◽

10.1016/0165-5876(91)90020-c ◽

1991 ◽

Vol 21 (3) ◽

pp. 286

Keyword(s):

Polymerase Chain Reaction ◽

Human Herpesvirus ◽

Human Herpesvirus 6 ◽

Chain Reaction ◽

Polymerase Chain ◽

Herpesvirus 6

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Absence of Human Herpesvirus-6 Genome by Polymerase Chain Reaction in Children With Hodgkin Disease: A Children's Cancer Group Lymphoma Biology Study

Journal of Pediatric Hematology/Oncology ◽

10.1097/00043426-200106000-00009 ◽

2001 ◽

Vol 23 (5) ◽

pp. 282-285 ◽

Cited By ~ 9

Author(s):

Bruce Shiramizu ◽

Charmaine W. Chang ◽

Mitchell S. Cairo

Keyword(s):

Polymerase Chain Reaction ◽

Human Herpesvirus ◽

Hodgkin Disease ◽

Human Herpesvirus 6 ◽

Chain Reaction ◽

Cancer Group ◽

Polymerase Chain ◽

Herpesvirus 6

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Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reaction.

Journal of Clinical Microbiology ◽

10.1128/jcm.29.2.367-372.1991 ◽

1991 ◽

Vol 29 (2) ◽

pp. 367-372 ◽

Cited By ~ 154

Author(s):

J T Aubin ◽

H Collandre ◽

D Candotti ◽

D Ingrand ◽

C Rouzioux ◽

...

Keyword(s):

Polymerase Chain Reaction ◽

Southern Blotting ◽

Human Herpesvirus ◽

Human Herpesvirus 6 ◽

Chain Reaction ◽

Polymerase Chain ◽

Herpesvirus 6

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Human Herpesvirus-6 Meningitis in a Premature Infant with Fevers: A Case and Literature Review

Clinical Medicine Insights Case Reports ◽

10.1177/1179547620912952 ◽

2020 ◽

Vol 13 ◽

pp. 117954762091295 ◽

Cited By ~ 1

Author(s):

Faith Kim ◽

Victoria Reichman ◽

Thomas A Hooven

Keyword(s):

Literature Review ◽

Premature Infant ◽

Neonatal Intensive Care ◽

Human Herpesvirus ◽

Febrile Illness ◽

Aqueductal Stenosis ◽

Human Herpesvirus 6 ◽

Modes Of Transmission ◽

Herpesvirus 6 ◽

Infancy And Early Childhood

Human herpesvirus-6 (HHV-6) is a common virus that can cause nearly universal infection in infancy and early childhood. It typically manifests as an acute febrile illness. We describe a case of a premature infant with congenital hydrocephalus secondary to aqueductal stenosis with a ventriculoperitoneal shunt in place who developed intermittent fevers while she was admitted to the neonatal intensive care unit. She was ultimately diagnosed with acute HHV-6 meningitis. In addition to this report, we present a literature review regarding this virus’s potential modes of transmission and forms of clinical presentation in the neonatal period.

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