PANCREATIC LIPASE INHIBITORY AND ANTIOXIDANT ACTIVITY OF METHANOLIC EXTRACT OF FLORETS OF ASTER SPECIES

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (12) ◽  
pp. 60-68
Author(s):  
R. R Shahu ◽  
◽  
P. Rathod ◽  
C Kulkarni ◽  
S. Mhatre ◽  
...  
Keyword(s):  
Free Radical ◽  
Pancreatic Lipase ◽  
Inhibitory Activity ◽  
Superoxide Radical ◽  
Methanolic Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Scavenging Activity

Pancreatic lipase inhibitory effect of methanolic extract of florets Aster sp. was studied. In case of Aster sp. (White florets) the pancreatic lipase inhibition recorded was 82.75% with an IC50 value of 38μg/mL. Aster sp. (light pink) showed 80.04 % inhibition with an IC50 of 72 μg/mL. On 2 h dialysis, both the extracts lost their significant pancreatic lipase inhibitory activity, indicating the reversible nature of inhibition. pH slightly affected the performance of pancreatic lipase inhibitory activity. Extract (white florets) also showed 22.03% superoxide radical scavenging activity and 22.73% free radical scavenging activity indicating the multifunctional nature of the extract. Light pink florets showed 40.67% superoxide radical scavenging activity and 24.10% free radical scavenging activity. Saponin and alkaloid molecule in white florets of Aster sp. and alkaloid in light pink florets were identified as active principles for pancreatic lipase inhibitory activity.

scholarly journals COMPARISON OF THREE HERBAL PLANTS FOR BEST FREE RADICAL SCAVENGING ACTIVITY

2017 ◽  
Vol 9 (3) ◽  
pp. 62
Author(s):  
Radha Palaniswamy ◽  
Palghat Raghunathan Padma
Keyword(s):  
Free Radical ◽  
Methanolic Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Scavenging Activity ◽  
Oxygen Species ◽  
Leaf Extracts ◽  
Herbal Plants

Objective: Excessive production of reactive oxygen species leads to oxidative stress. Antioxidants can prevent or retard the oxidation caused by free radicals and sufficient intake of antioxidants is supposed to protect against diseases. Candidate play  Methods: The leaf extracts of these plants were exposed to a battery of free radical scavenging assays like DPPH, ABTS, hydrogen peroxide, superoxide and nitric oxide to determine the free radical scavenging activity.Results: It was observed that the Majoranahortensis leaves in methanolic extract showed maximum scavenging activity.Conclusion: Several plants with free radical scavenging activity have been identified, where Majoranahortensis is one such leave.

scholarly journals Antioxidant Screening on the Whole Plant of Cyanthillium cinereum (L) H.Rob

2021 ◽  
Vol 8 (7) ◽  
pp. 458-461
Author(s):  
Mohammed Shihab K. K. ◽  
Rajagopal P. L. ◽  
Nasila K.
Keyword(s):  
Nitric Oxide ◽  
Free Radical ◽  
Methanolic Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Scavenging Activity ◽  
Flavonoid Content ◽  
Whole Plant

Methanolic extract of the whole plant of Cyanthillium cinereum (L) H.Robwasevaluated for free radical scavenging activity by using Nitric oxide scavenging activity (NO) and Reduction of 1, 1-Diphenyl -2-Picryl Hydrazyl (DPPH) free radical scavenging activity. Throughout the studies the plant extract showed potent antioxidant activity and the activity was found to be concentration dependent which may be attributed to the high flavonoid content of the plant. Keywords: Cyanthillium cinereum (L) H.Rob, DPPH, NO.

scholarly journals Extraction and Isolation of Kaempferol Glycosides from the Leaves and Twigs of Lindera neesiana

Separations ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. 10 ◽  
Author(s):  
Anjana Adhikari-Devkota ◽  
Amina Dirar ◽  
Ayumi Kurizaki ◽  
Kazuki Tsushiro ◽  
Hari Devkota
Keyword(s):  
Free Radical ◽  
Pancreatic Lipase ◽  
Inhibitory Activity ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Scavenging Activity ◽  
Hydroalcoholic Extract ◽  
Kaempferol Glycosides ◽  
Column Chromatographic

The hydroalcoholic extract of leaves and twigs of Lindera neesiana (Wall. ex Nees) Kurz (Lauraceae) was subjected to various column chromatographic methods that isolated five kaempferol glycosides: kaempferol 3-O-β-glucopyranosyl(1→2)-[α-rhamnopyranosyl-(1→6)]-β- glucopyranoside-7-O-α-rhamnopyranoside (1); kaempferol 3-O-β-glucopyranosyl-(1→2)-[α-rhamnopyranosyl (1→6)]-β-glucopyranoside (2); kaempferol 3-O-β-glucopyranosyl(1→2)- α-rhamnopyranoside-7-O-α-rhamnopyranoside (3); kaempferol 3-O-sophoroside (4); and kaempferol 3-O-α-rhamnopyranoside (5). The extract showed moderate free radical scavenging activity and potent pancreatic lipase inhibitory activity.

scholarly journals Phytochemical Analysis and Antimicrobial/Antioxidant Activity of Cynodon dactylon (L.) Pers. Rhizome Methanolic Extract

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Samira Savadi ◽  
Mohsen Vazifedoost ◽  
Zohre Didar ◽  
Mohammad Mahdi Nematshahi ◽  
Eisa Jahed
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Cynodon Dactylon ◽  
Methanolic Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Inhibition Zone ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Scavenging Activity

A proper use of medicinal plants requires accurate scientific information and understanding of their chemical constituents. The therapeutic effects in the plants are due to the chemical compounds therein. Cynodon dactylon (L.) Pers. of the family Poaceae is a perennial, pan-tropical species of grass which is a well-known traditional medicine and has a renowned position for treatment of many symptoms and diseases. The chemical composition, free radical scavenging activity, and antimicrobial properties of the methanolic extract of C. dactylon rhizomes against selected bacterial and fungal strains were investigated using disk-diffusion method. The results indicated that the major fatty acid structures of C. dactylon methanolic extract were palmitic acid (36.40%), oleic acid (28.26%), and linoleic acid (17.01%). Alpha-tocopherol (151.39 mg·kg−1) and sitosterol (3199.62 mg·kg−1) were the main tocopherols and sterols, respectively. According to the instrumental analysis, the total phenolic compounds of methanolic extract were equal to 917.08 mg·kg−1 and the main compound was hydroquinone (66.89%). Antioxidant activity of the methanolic extract at concentrations of 100–1000 ppm was 9.81–67.87%, which is significantly different from the 200 ppm synthetic antioxidant (BHT) with free radical scavenging activity equal to 48.93% (p<0.05). The antimicrobial study revealed that the methanolic extract of C. dactylon rhizomes was effective against all of the bacterial pathogens and the antibacterial activity increased with an increase in the concentration of extract. Therefore, the largest zone of inhibition was observed against Bacillus cereus (18.3 ± 0.4 mm) and Escherichia coli (16.8 ± 0.5 mm) at 1000 ppm. The highest resistance was observed with Pseudomonas aeruginosa (inhibition zone of 12.8 ± 0.15 mm). Methanolic extract at 200 ppm had no effect against fungus Aspergillus niger. However, at 1000 ppm concentration, an inhibition zone with a diameter of 14.4 ± 0.45 mm was formed.

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