Factors Influencing Quality of Life in Thyroid Cancer Patients with Thyroidectomy

6606 Background: In thyroid cancer patients, follow-up is designed to detect recurrent disease and consists of neck- ultrasonography (US), thyroglobulin measurement (Tg) and radioiodine whole body scan (WBS). Recent guidelines have restricted the use of WBS to suspicious cases. To insure diagnostic accuracy, follow-up control requires TSH stimulation, either with thyroid hormone withdrawal (THW) or rhTSH, which have demonstrated similar diagnostic accuracy. THW induces significant morbidity associated with hypothyroidism, leading to a decrease in patient quality of life and ability to work, whereas rhTSH is an innovative costly drug that avoids such patient burden. A societal cost-utility analysis was conducted to compare 4 follow-up strategies, combining a method of stimulation (rhTSH or THW) and a testing protocol (US+Tg+WBS or US+Tg alone). Methods: A Markov model was built to describe the follow-up of thyroid cancer patients first treated by thyroidectomy and radioiodine ablation, over 5 years. Estimates for diagnostic accuracy values and recurrence rate were extracted from a French multicenter randomized trial. Costs were computed from the perspective of the society, including medical resources consumed (hospitalisation, rhTSH, tests, treatment of recurrence). The model also incorporated the benefits of rhTSH in terms of quality of life (utility scores derived from SF36) and the reduction in duration and overall cost of sick leave. Results: Among the 753 patients included, 13 patients presented recurrence. rhTSH stimulation resulted in a higher utility score (0.802 vs. 0.637) over the period of stimulation and a reduction of 1083 € of absenteeism costs in active patients. As compared to the THW+Tg+US+WBS strategy, the incremental cost-utility ratios (ICER) showed economic dominance for the rhTSH strategies with ratios of −16,876 and −19,297 €/QALY with and without WBS respectively. The ICER for the strategy THW+US+Tg reached 29,333 €/QALY, as compared to THW+Tg+US+WBS strategy. Conclusions: the recommended strategy combining Tg determination and US after rhTSH stimulation appears the most cost-effective in the follow-up of thyroid cancer patients, as it is the strategy the less costly and associated with improved patient quality of life. No significant financial relationships to disclose.

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Persistent quality of life impairments in differentiated thyroid cancer patients: results from a monitoring programme

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-015-3022-9 ◽

2015 ◽

Vol 42 (8) ◽

pp. 1179-1188 ◽

Cited By ~ 33

Author(s):

Eva-Maria Gamper ◽

Lisa M. Wintner ◽

Margarida Rodrigues ◽

Sabine Buxbaum ◽

Bernhard Nilica ◽

...

Keyword(s):

Quality Of Life ◽

Thyroid Cancer ◽

Cancer Patients ◽

Differentiated Thyroid Cancer ◽

Monitoring Programme

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Factors influencing childhood cancer patients to participate in a combined physical and psychosocial intervention program: Quality of Life in Motion

Psycho-Oncology ◽

10.1002/pon.3677 ◽

2014 ◽

Vol 24 (4) ◽

pp. 465-471 ◽

Cited By ~ 13

Author(s):

Elisabeth M. van Dijk-Lokkart ◽

Katja I. Braam ◽

Jaap Huisman ◽

Gertjan JL Kaspers ◽

Tim Takken ◽

...

Keyword(s):

Quality Of Life ◽

Childhood Cancer ◽

Cancer Patients ◽

Psychosocial Intervention ◽

Intervention Program ◽

Program Quality ◽

Factors Influencing

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Health Related Quality of Life of Thyroid Cancer Patients

Journal of Preventive and Social Medicine ◽

10.3329/jopsom.v38i2.47858 ◽

2020 ◽

Vol 38 (2) ◽

pp. 1-8

Author(s):

AKM Farhad Hossain ◽

Md Ziaul Islam ◽

Sayada Fatema Khatun

Keyword(s):

Quality Of Life ◽

Thyroid Cancer ◽

Cancer Patients ◽

Clinical Condition ◽

Family Income ◽

Health Related Quality ◽

Hrqol Score ◽

Related Quality ◽

Health Related

Background: Having the longevity of thyroid cancer patients, any impairment in health-related quality of life (HRQOL) during the follow-up period is of great importance. Objective: The study was conducted to determine the health related quality of life of thyroid cancer patients. Material and methods: This cross sectional study was conducted among 246thyroid cancer patients. Data were collected by face-to-face interview and reviewing medical records with semi-structured questionnaire and checklist with validated scale. The subjects were purposively selected following specific selection criteria and maintaining ethical issues. Place and period of study: The study was conducted during the period from July 2018-June 2019 in two tertiary hospitals of Dhaka city: Bangabandhu Sheikh Mujib Medical University and Dhaka Medical College Hospital, Dhaka. Results: This study revealed that majority (74.4%) of respondents was female, married (72%), housewife (61.4%), rural respondent (41.1%) and had primary education (69%). Mean (± SD) age of the respondent was 37.85(±12.20) years (range 14-70 years) and mean (± SD) monthly family income was Tk.17681(±10602). Out of 246 cases, 204 (82.9%) was papillary and 42 (17.1%) was follicular carcinoma. Main presenting features were neck swelling (91.5%), swollen lymph node (41.9%), dysphonia (57.3%) and dysphagia (35.4%). Mean (± SD) of total HRQOL score was 73.7 ± 8.39. HRQOL score of students and higher educated patients were better among the respective groups (p <.001). The study showed the association of HRQOL with clinical condition of thyroid cancer patients (R2=.025). HRQOL revealed the strong prediction with education (β=-0.888, p<.05), family income (β=0.05, p<.05), marital status (β=-0.1.384, p<.05), clinical condition (β=-0.522, p<.05) and perceived stress (β=-0.632, p<.001). Conclusion: The overall HRQOL score was considerably good in this study. Timely detection, regular motivation and attending clinical condition may significantly improve the HRQOL of thyroid cancer patients JOPSOM 2019; 38(2): 1-8

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Factors Influencing Quality of Life Among Breast Cancer Patients Following Immediate Breast Reconstruction

Asian Oncology Nursing ◽

10.5388/aon.2020.20.1.1 ◽

2020 ◽

Vol 20 (1) ◽

pp. 1

Author(s):

A Young Kim ◽

Jeong Hye Kim

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Breast Reconstruction ◽

Cancer Patients ◽

Immediate Breast Reconstruction ◽

Breast Cancer Patients ◽

Factors Influencing

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The Use of Complementary and Alternative Medicine in Thai Gynecologic Oncology Patients: Influencing Factors

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/1322390 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Nuntorn Chukasemrat ◽

Chuenkamon Charakorn ◽

Arb-aroon Lertkhachonsuk

Keyword(s):

Quality Of Life ◽

Alternative Medicine ◽

Cancer Treatment ◽

Cancer Patients ◽

Gynecologic Cancer ◽

Role Functioning ◽

Multiple Modalities ◽

Factors Influencing ◽

Cam Use

Background. To determine the factors influencing the use of complementary and alternative medicine (CAM) in gynecologic cancer patients and the prevalence and pattern of CAM use. Methods. This was a cross-sectional study of 370 gynecologic cancer patients conducted at the outpatient clinic, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. After obtaining informed consent, participants were asked to complete a standardized questionnaire including sociodemographic and clinical characteristics, detail of CAM use, attitude of CAM use, and quality of life using EORTC-QLQ-C30. Results. The prevalence of CAM use was 25.13%. The most common type was herbal medicine (55.90%). The participants who resided or had a birthplace in rural areas presented with a higher proportion of CAM use than those in urban areas ( P = 0.470 and P = 0.004 , respectively). Participants who received multiple modalities of cancer treatment reported a significantly higher proportion of CAM use ( P = 0.024 ). Most CAM users agreed that the CAM could be used in combination with standard treatment, and some rather disagreed that CAM could interrupt the treatment effect of the conventional treatment. CAM users had significantly higher role functioning in quality-of-life scores. Conclusion. Factors influencing CAM use in gynecologic cancer patients were rural area birthplace or residency, receiving multiple modalities of cancer treatment, having positive attitude toward CAM use. CAM users had better performance in role functioning in the quality-of-life score. Therefore, gynecologic oncologists should pay attention to these factors in order to communicate with gynecologic cancer patients about CAM use.

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